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Hydralazine Lowers Serum Triglyceride Levels by Enhancing Farnesoid X Receptor Signaling and Adipose Triglyceride Lipase Expression: In Vivo Evidence from Male Spontaneously Hypertensive Rats（ヒドララジンはファルネソイドX受容体シグナルと脂肪細胞特異的トリグリセリドリパーゼ発現を増強することにより血清トリグリセリドを低下させる：雄性自然発症高血圧ラットでのエビデンス）
Full text link信州大学Shinshu University博士（医学）次の雑誌に発表。 /信州医学雑誌 73(3) :165-177(2025); doi:10.11441/shinshumedj.73.165 © 2025 Shinshu Medical Society.doctoral thesi
Investigation of pure lung microbiota in patients with lung cancer after eliminating upper airway contamination: a prospective cohort study（肺癌患者における上気道常在菌を排除した純粋な肺内微生物叢の検討）
Full text link信州大学Shinshu University博士（医学）次の雑誌に発表。 /Journal of Thoracic Disease 16(11) :7329-7341(2024); doi:10.21037/jtd-24-933 © AME Publishing Company. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International.doctoral thesi
Study on sustainable smart halochromic sensors for protein based food monitoring.(タンパク質食品のモニタリングのための持続可能なスマートハロクロミックセンサーに関する研究)
No full text信州大学Shinshu University博士（工学）この博士論文は、次の学術雑誌論文を一部に使用しています。 || Current Research in Biotechnology 7 :100192(2024); doi:10.1016/j.crbiot.2024.100192 © 2024 The Author(s). Published by Elsevier B.V.|| International Journal of Biological Macromolecules 266(1) :131089(2024); doi:10.1016/j.ijbiomac.2024.131089 © 2024 Elsevier B.V. All rights reserved.|| Materials Today Sustainability 31 :101125(2025); doi:10.1016/j.mtsust.2025.101125 © 2025 The Authors. Published by Elsevier Ltd.doctoral thesi
MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration
Full text linkMuscular dystrophy is a group of diseases characterized by progressive weakness and degeneration of skeletal muscles, for which there is currently no cure. Here, we show that microRNA (miR)-33a/b play a crucial role in muscle regeneration. miR-33a was upregulated during myoblast differentiation and in skeletal muscles of mdx mice, a genetic model of Duchenne muscular dystrophy (DMD). miR-33a deficiency enhanced muscle regeneration response to cardiotoxin injury and attenuated muscle degeneration and fibrosis in mdx mice. Conversely, a humanized mouse model expressing miR-33a and miR-33b showed exacerbated muscle degeneration and fibrosis. Mechanistically, miR-33a/b inhibited satellite cell proliferation, leading to reduced muscle regeneration and increased fibrosis by targeting Cdk6, Fst, and Abca1. Local and systemic administration of anti-miRNA oligonucleotides targeting miR-33a/b ameliorated the dystrophic phenotype in mdx mice. Furthermore, miR-33b inhibition upregulated these target genes in myotubes differentiated from human induced pluripotent stem cells derived from a patient with DMD. These findings indicate that miR-33a/b are involved in muscle regeneration and their inhibition may represent a potential therapeutic strategy for muscular dystrophy.journal articl
Thromboembolism during immune checkpoint inhibitor therapy: frequency and risk factors（免疫チェックポイント阻害薬治療中の血栓症：頻度とリスク因子）
Full text link信州大学Shinshu University博士（医学）次の雑誌に発表。 /Discover Oncology 15 :527(2024); doi:10.1007/s12672-024-01416-z © The Author(s) 2024.This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.doctoral thesi
Predictability of combining Technetium‐99m‐galactosyl human serum albumin single‐photon emission computed tomography/ computed tomography and indocyanine green clearance test for posthepatectomy liver failure（Technetium-99m-galactosyl human serum albumin SPECT/CTとインドシアニン. グリーンクリアランステストの併用による術後肝不全予測能の検討）
Full text link信州大学Shinshu University博士（医学）次の雑誌に発表。 /Japanese Journal of Radiology 42(11) :1280-1289(2024); doi:10.1007/s11604-024-01613-4 © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License.doctoral thesi
