Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry)
Not a member yet
300 research outputs found
Sort by
PENENTUAN KADMIUM DALAM PRODUK PERIKANAN DENGAN GRAPHITE FURNACE ATOMIC ABSORPTION SPECTROMETRY
Get PDFPenentuan kadmium dalam produk perikanan telah dilakukan menggunakan Graphite Furnace AtomicAbsorption Spectrometry (GF-AAS) dengan magnesium nitrat sebagai matrix modifier, platform atomizationtype A dengan sensitifitas yang tinggi untuk pengukuran kadmium, dan koreksi latar belakang Zeeman. Metodeanalisis telah divalidasi berdasarkan parameter-parameter kimia analitik. Sebanyak 0,5 g sampel produkperikanan didestruksi menggunakan microwave digestion systems dengan menambahkan 5 mL asam nitrat pekatdan 2 mL hidrogen peroksida 30%, kemudian larutan hasil destruksi diencerkan hingga 25 g. Dari larutan inidibuat sederet larutan untuk pengukuran secara adisi standar, dan diukur dengan GF-AAS. Akurasi metodedilakukan dengan menganalisis bahan acuan bersertifikat DORM 3 Fish Protein Certified Reference Materialfor Trace Metals dari National Research Council Canada dengan nilai recovery sebesar 99,9 0,8%. Dari hasilpenelitian ini diperoleh kadar kadmium dan ketidakpastiannya sebesar 0,273 0,025 mg kg-1berdasarkan beratkering.Kata kunci: GF-AAS, Microwave digestion systems, kadmium, validasi metod
MOLECULAR DOCKING TURUNAN KALKON TERHADAP RESEPTOR ESTROGEN B (ER- B) SEBAGAI ANTIKANKER PAYUDARA
Get PDFEstrogen receptor-S (ER- ft) was also shown to be the important factor to inhibits proliferation and invasion of breast cancer cells. Estrogen receptor-S complexed with genistein is taken as a role model to target the drug action. Docking molecule chalcone derivatives on Estrogen receptor-S have been done to test the docking energy that associated with binding affinity between ligand and receptor. Based on docking result, Kalkon XII has shown best docking energy (MoIDockScore). Thus Kalkon XII can be synthesized and usedfor in vitro cytotoxic activity
PENAPISAN VIRTUAL SENYAWA TURUNAN METIL SINAMAT PADA ENZIM SIKLOOKSIGENASE-2 (COX-2
No full textInflammation is the response of living tissue to vascular injury. Non-Steroid Anti-Inflammatory Drugs(NSAIDs) could control pain caused by inflammation. Therapeutic effects of NSAIDs are related to themechanism of the cyclooxygenase-1 (COX-1) enzyme and the cyclooxygenase-2 (COX-2) enzyme in inhibiting theproduction of prostaglandins. In this paper, we report the virtual screening of methyl cinnamate derivativecompounds against the COX-2. All methyl cinnamate derivative compounds were molecular docking simulatedusing the Protein-Ligand ANT System (PLANTS) software with ZINC03814717 as the reference compound. Fromthe results of virtual screening, it was obtained that derivative compounds of methyl cinnamate were predicted asactive COX-2 inhibitors because they have ChemPLP score better than that of the reference compoundsZINC03814717. The compound of acid 3- (4-benzoylphenyl) propionate was predicted as having the best score ofChemPLP.Keywords: Non-Steroid Anti-Inflammatory (NSAID), virtual screening, enzyme cyclooxygenase-2 (COX-2), methyl cinnamate derivativ
POTENTIAL OF COGON GRASS AS AN OIL SORBENT
No full textExperiments on the potential of Cogon grass (lmperata cylindrica), a weed harmful to other plants, for use as a low-cost and biodegradable oil sorbent were carried out under various spill conditions. Flowers of Cogon grass adsorbed much larger amount of high-viscosity lubricating oil (57.9 g-oil/g-sorbent) than that adsorbed by Peat Sorb (7.7 g-oil/g-sorbent), a commercial oilsorbent based on peat. However, the flowers adsorbed only 27.9 g of low-viscosity crude oillgsorbent. In an oil-water system, the mount of oil adsorbed was influenced by the level with which the two were mixed: vigorous stirring reduced the sorption capacity by 36%. The high sorptive capacity of the flowers can be attributed to their hydrophobic nature and good oil-wettability. The flowers showed good buoyancy even after 24 hours of shaking under conditions that simulated water ripple (gentle wary motion) in sea, which suggests their potential in combating oil spills both on land and in water.Keywords: Sorbent; Oil spill,' Oil sorption; Cogon grass;Imperata cylindric
Aktivitas Anti Jamur 2,3-dihidroksipentadekanoat dari Kayu Mahalilis (Palaquium sp.)
Get PDFThe objectives of this research were to evaluate the extractive content of hartdwood of mahalilis wood (palaquium sp.) and identification of bio-acttve compounds wood decay fungi. Mahalilis wood was macerated with MeOH and then partitioned in stages wiht the n-hexane, CHCI31 EtOAc and n-BuOH, respectively. The result of antifungal test, show the most active 14 fraction CHCl3 comparedfraction and negative controls (CCB and itraconazole). Purification of CHCl3 fraction was column chromatographedproduced five fraction (M-I-M-5). TheM2 active fraction shown inhibited the growth to Schizophyllum communeFries withIC(so) is 56ppm and Pleurotus ostreatus with IC(so)= 55 ppm. The M2 fraction of dark brownish yellow color oil, was identified by LC-MS and IH NMR, as 2,3-dihydroxypropylpentadecanoate.Key words: Palaquium sp., antifungal, Schizophyllumcommune Fries, Pleurotus ostreatus, 2,3-dihydroxypropylpentadecanote
SINTESIS DAN KARAKTERISASI PERAK NANOPARTIKELBAKTERIAL SELULOSA BIONANOFIBER NANOKOMPOSIT
No full textSilver nanoparticle-bacterial cellulose bionanofiber nanocomposite (nano Ag-BSB) has been synthesized by using trisodium nitrate as reducing agent. The arrangement offiber in nano Ag-BSB nanocomposite has random shape after 26 confirmed by scanning electron microscopy (SEM)analysis. Nano Ag-BSB nanocomposite has average 64.1 nm in nanofiber diameter. Fourier infra red spectroscopy and X-ray diffraction analysis showed crystal structure in Ag-BSB nanocomposite is cellulose type L Crystalinity of BSB and Ag-BSB are 94 % and 89 %, respectively.This result showed that presence of silver nanoparticles in BSB decreased crystalinity of BSB. Ag-BSB nanocomposite has good performance in inhibitingE-Coli growth.Keywords: Silver nanoparticle; nanocomposite, bacterial cellulose bionanofibet; silver nanoparticlebacterial cellulose bionanofiber nanocomposi
PEMANFAATAN SISTEM MICROBIAL FUEL CELL DALAM MENGHASILKAN LISTRIK PADA PENGOLAHAN AIR LIMBAH INDUSTRI PANGAN
No full textMicrobial Fuel Cell (MFC) dapat langsung menghasilkan listrik dari oksidasi bahan organik yangterkandung dalam suatu larutan. Dibutuhkan suatu optimalisasi sistem MFC yang mencakup beberapa faktoruntuk meningkatkan hasil listrik seperti jenis media penukar kation, elektroda, luas permukaan elektroda, dandurasi reaksi. Penelitian dilakukan untuk melihat kinerja sistem MFC pada pengolahan air limbah industripangan, dalam hal ini tahu dan cucian beras (catering), dengan menggunakan tembaga sebagai elektroda,membran Poli Eter Eter Keton Tersulfonasi (SPEEK) sebagai media penukar kation, dan menggunakan mediasubstrat limbah. MFC diamati selama 80 jam. Pengukuran tegangan yang dihasilkan dilakukan setiap 4 jam.Tegangan maksimum yang dihasilkan pada media limbah tahu mencapai 80 mV (pada jam ke-28). Selama 52jam berikutnya, tegangan sedikit menurun. Sedangkan pada air limbah cucian beras, tegangan maksimum terjadipada jam ke-60 yaitu 234 mV. Selama proses 80 jam, melalui sistem MFC pada media limbah tahu, CODmampu turun 49,33% dari 6750 mg/L menjadi 3420 mg/L. Sedangkan pada limbah cucian beras, COD turundari 18840 mg/L menjadi 10560 mg/L atau sebesar 43,95 % selama 80 jam.Kata Kunci: Microbial Fuel Cell, listrik, limbah pangan
