Journal for ReAttach Therapy and Developmental Diversities (JRTDD)
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Profile Of Vaginal Discharge Among Reproductive Women- A Hospital-Based Cross-Sectional Study
No full textBackground: Women of reproductive age frequently experience vaginal discharge, which is a typical gynaecological symptom that may indicate several underlying medical issues. The reproductive period in a woman\u27s life is marked by dynamic hormonal fluctuations, making the female reproductive system vulnerable to infections, hormonal imbalances, and other health-related issues. Determining the characteristics of vaginal discharge and associated factors is essential to comprehending the impact of reproductive health problems and creating efficient treatment and preventive measures.
Aims: This study aims to describe the profile of vaginal discharge among married women and to determine the various factors associated with different types of discharge.
Methods: This is a hospital-based, cross-sectional study conducted in the Gynaecology OPD of Velammal Medical College Hospital and Research Institute, Madurai. This study included 299 participants through convenient sampling. Ethical approval was obtained from the institutional ethical committee of Velammal Medical College Hospital and Research Institute. A structured questionnaire was administered to the participants for data collection. Statistical analysis was performed using PSPP v1.6.2.
Results: 299 women with vaginal discharge were studied. The discharge varied in colour and almost two-third had accompanying symptoms. Itching (61.20%) and white discharge (54.52%) were the most prevalent symptoms. 26.75% of women had pathological vaginal discharge. Statistical analysis revealed significant associations between age at marriage and parity with pathological vaginal discharge. Women using permanent contraception had a significant association with pathological vaginal discharge.
Conclusions: In conclusion, a good proportion of vaginal discharges are pathological and hence all vaginal discharge needs to be evaluated and treated as soon as possible
Stability Indicating Hptlc Method Development And Validation For Simultaneous Estimation Of Rosuvastatin Calcium And Ezetimibe In Bulk Form And Pharmaceutical Formulation
No full textValidated stability indicating high performance thin layer chromatography method has been developed for simultaneous estimation of Rosuvastatin calcium (ROS) and Ezetimibe (EZT) in bulk and pharmaceutical dosage form. The stationary phase consists of Silica Gel G 60 F254 and mobile phase consists of Toluene: Methanol: Ethyl acetate: Formic acid (8:2:1:0.01v/v/v/v) and detection was carried out at 245 nm. The Rf values of ROS and EZT were found to be 0.28 ±0.02 and 0.48 ±0.02 respectively. Validation of method was carried out as per ICH guidelines. Good linear relationship was found with the calibration curve for linearity in the concentration range of 300-800ng/spot and 300-800ng/spot for ROS and EZT with r2 value 0.9997 and 0.999 respectively. For ROS and EZT the LOD was found to be 92ng/spot and 100ng/spot respectively. The LOQ value for ROS and EZT was found to be280ng/spot and 300ng/spot respectively. % recovery for ROS was found to be 98.46% to 102.1% and for EZT was found to be 99.6% to 100%. Both drugs have been exposed to the acidic, basic, neutral, oxidative, photolytic and thermal conditions for forced degradation studies. The degradation products obtained from degradation studies were resolved from the principle drug peak with different Rf values
Market Authorization Process for Medicinal Products in Eurasian Economic Union Council
No full textThe study aims to discuss about history and structure of the Eurasian Economic Union (EAEU) has been shaped by numerous agreements and treaties aimed at promoting economic cooperation among member states. The EAEU is an international organization comprising the countries of the Eurasian region. Its major treaties and agreements, such as the Partnership and Cooperation Agreement (PCA) of 1997, passed the way for further integration. The Treaty establishing the Eurasian Economic Union, signed on May 29, 2014, marked an important step forward. This treaty established the framework for the EAEU, with its provisions entering into force on 1 January 2015. The treaty covers several key aspects, including the creation of four common spaces: Economy and environment, freedom, security and justice, foreign security, research and education, including cultural cooperation among Member States. The main objective of the EAEU is to facilitate the movement of goods, services, capital and labor within its borders, and to coordinate policies in specific economic sectors as defined by the EAEU. It aims to promote sustainable economic development, improve living standards, create a single market and enhance competitiveness in the global economy. The structure of the EAEU includes key agencies responsible for decision-making and implementation. The Supreme Eurasian Economic Council, composed of the heads of member states, is the highest governing body. The executive functions are performed by the Eurasian Economic Commission, which is responsible for the practical aspects of the EAEU\u27s operations. One notable aspect is the agreement on the general principles and rules of drug marketing within the EAEU. This agreement underscores the EAEU\u27s commitment to ensuring access to safe, high-quality medicines, with an emphasis on distribution coordination and consumer protection. The agreement defines the principles of drug regulation in the member states. The EAEU drug registration procedure includes several routes: mutual recognition, decentralized procedure and national procedure. These procedures are designed to harmonize registration requirements and streamline the delivery process in compliance with EAEU standards. The mutual recognition procedure includes the selection of a Reference Member State (RM) and a Member State of Concern (EMC) for the assessment of the application. Decentralized process allows RMS and CMS to evaluate simultaneously. The national procedure is available to those who wish to register in only one country. Adaptation of old records to EAEU requirements related to RMS selection, followed by assessment and feasibility testing. Successful compliance leads to a harmonized registration certificate and, if eligible, the registration certificate is valid indefinitel
An Experimental Study To Assess The Effectiveness Of Laughter Therapy In The Selected Old Age Home Of New Delhi
No full textThe aging process introduces multifaceted challenges, impacting the physical, emotional, and psychological aspects of individuals. Amidst these challenges, unconventional therapeutic interventions gain prominence. Laughter therapy, explored in the unique context of an old age home in New Delhi, emerges as a captivating avenue to enhance the well-being of elderly residents. The study, rooted in the biopsychosocial model, draws theoretical support from psychology, physiology, and alternative medicine. Laughter therapy, a holistic intervention rooted in joy, is posited to address the diverse dimensions of aging. The research objectives focus on evaluating the therapy\u27s impact on psychological well-being, physiological measures, and social engagement among elderly residents. A purposive sample of 100 participants engaged in laughter therapy sessions, revealing diverse demographics and participation in previous therapies. The eight-week intervention, facilitated by a certified laughter yoga instructor, integrated laughter exercises, deep breathing, and stretching. Statistical analyses unveil significant improvements in psychological measures, including reduced depressive symptoms and increased positive affect. Physiological changes encompass decreased heart rate, blood pressure, and cortisol levels, aligning with laughter\u27s cardiovascular benefits and stress reduction. The correlation matrix underscores the interconnectedness of mental and physical well-being. In conclusion, laughter therapy exhibits a profound positive impact on the holistic well-being of elderly individuals, making a case for its integration into geriatric care. The study\u27s outcomes advocate for innovative approaches in global healthcare, emphasizing laughter therapy\u27s potential to enrich the lives of the elderly. Cultural nuances in the Indian context are acknowledged, contributing to a nuanced understanding of its applicability
Narcissism And Forgiveness: A Conceptual Review
No full textNarcissism and forgiveness are two important psychological constructs that have received significant attention in the literature. Narcissism refers to a personality trait characterized by grandiosity, high self-importance, and a lack of empathy, while forgiveness is a complex process that involves letting go of negative feelings and emotions towards oneself or others. Despite their importance, the relationship between narcissism and forgiveness remains poorly understood. The present study reviewed the available literature in the field of narcissism and forgiveness and proposed a conceptual framework for understanding the relationship between narcissism and forgiveness, and the potential mediating and moderating variables that may impact this relationship. It has become evident that the ability to forgive is impacted by a range of factors, including self-esteem, gratitude, repentance, and relationship closeness. Narcissism, which is characterized by feelings of entitlement, superiority, and lack of empathy, can make it difficult for individuals to forgive others who have wronged them. However, by understanding the mediating and moderating variables that impact this relationship, it may be possible to develop interventions that can increase forgiveness in individuals with high levels of narcissism
Investigating the Wound Healing Perspectives of Silver Nanoparticles Loaded Topical Nanogels
No full textThe primary objective of the present investigation revolves around the development and evaluation of nanogel formulations by incorporating oleanolic acid-loaded silver nanoparticles. The formulation underwent a comprehensive assessment to evaluate its therapeutic attributes and topical delivery. The formulation was prepared by using carbopol 940 and triethanolamine. The parameters were analyzed as pH 5.5, viscosity 3500 cps, spreadability 6.9 g/cm/sec, and skin irritation tests showed no skin rashes. Ex-vivo drug release shows a slow release of the drug. There was 84.66% drug release in 12 hours. Additionally, Swiss albino rats were employed in this research to investigate the wound-healing capabilities of topical gel containing silver nanoparticles. Stability studies of the nanogel formulation were done. The results confirmed the spherical shape and uniform particle size of silver nanoparticles and the good stability of the nanogel. This study has provided a way for novel approaches to address wounds of various origins. The formulated topical gels loaded with silver nanoparticles exhibit promising prospects as wound healing agents. They are anticipated to enhance the natural wound healing process significantly and play a pivotal role in rat wound closure rate and epithelization. In comparison to the standard pharmaceutical agent betadine, the nanogel formulation exhibited equivalent efficacy. This discovery sheds light on the potential applications of nanoparticle-infused formulations in the conventional management of severe wound conditions, thereby revitalizing therapeutic principles within the field of modern medicine
Treatment of Race and Class in Harlem Shuffle of Colson Whitehead
No full textThis study aims at an analysis of the novel Harlem Shuffle of Colson Whitehead so as to bring out his treatment of race and class. When it comes to race, Whitehead is familiar with the mindset of Americans and their conscience. The novel is a kind of crime fiction and it revolves around the protagonist namely Ray Carney, the salesman of furniture who travels on the wrong side of the life track. He dresses professionally and wants to lead a safe and secure life for his family. He desires to prove his worth to his in-laws who always look down at him. In the radio repair shop, he is neglected because of his race and they opt for other White customers. Later, they question him about his overstaying at the shop. When he has tried to explain about the complaint, the workers do not pay attention and he leaves the place. The White supremacists always want to bring the Blacks under their control. Ray Carney is not treated as an equal human being. He is pressurized by his cousin Freddie to commit a crime which reveals his shady lifestyle to others. It begins the inner struggle of him. Though he does not want to be a thief, the White society makes him such one. His father is shot by the White supremacists as he has stolen a cough syrup from pharmacy. Colson Whitehead delineates the riots and violence caused by the brutal killing of a Black Boy by a White Police officer. The biased White Reporters project badly the violent acts of the Black youth. They fail to address the main issue of racism which is prevalent in the American society. Instead, they would like to portray the Blacks as violent mongers. In Harlem Shuffle, Colson Whitehead has artistically recreated New York of the early 1960’s. Colson Whitehead has brought out effectively the racism of the Whites and the state of subjugation of the Blacks
The Doctorine Res Ipsa Loquitur (The Things Speaks Itselfs) and its medicolegal aspects according to Ayurveda w.s.r. Panchkarma Procedures
No full textIntroduction: Res Ipsa Loquitur is a Latin phrase that means the thing speaks for itself. It is a very popular doctrine, in the law of torts. In cases, where the evidence is itself sufficient to prove the guilt of the defendant, so out of any circumstantial evidence or an object which itself show that an act has been committed. It shows that the accident would not have occurred if the defendant had not been negligent. If the complainant cannot prove negligence on the defendant\u27s part, the defendant cannot be made liable. So, the principle of Res Ipsa Loquitor came into action under which a litigant can use circumstantial evidence to establish negligence.
Aim: To Study the situations where Res Ipsa Loquitur is applicable related to Panchkarma procedures Objectives:
To Study the Res Ipsa Loquitur
To create awareness about medical negligence in Ayurveda practitioners
Material and Method:Several Ayurvedic classic texts, research journals, and websites were consulted as sources for this study.
Discussion: In Ayurveda in many situations Res Ipsa Loquitur is applicable. Ayurvedic treatment, especially Panchakarma therapy, is successfully receiving greater attention in this day and age of new emerging diseases. However, Panchkarma treatment can even be fatal if it is administered by an unqualified individual, performed incorrectly, or without following the necessary safety protocols.
Conclusion: Before performing Panchkarma procedures, Ayurvedacharyas must be aware of the potential complications along with suitable treatments, as well as the laws concerning medical practice. Therefore, it\u27s important to increase awareness among Ayurvedic professionals. 
Effectiveness of Educational Program on Knowledge and Expressed Practice Regarding Home Based New Born Care among ASHA Workers at District Mandi Himachal Pradesh
No full textHome-based newborn care (HBNC) is crucial beyond the first day, extending through the critical first week and month, where neonatal mortality rates remain high. This study aims to assess the effectiveness of an educational program targeting ASHA workers in improving HBNC practices. A true experimental pre-test, post-test, control group design was employed, with 70 ASHA workers selected via Probability Stratified Random sampling from PHCs in district Mandi (H.P). A self-structured tool assessed knowledge and expressed practice regarding HBNC before and after the intervention. Results indicated a significant increase in knowledge among the experimental group (pre-test: M=27.51, SD=2.71; post-test: M=33.77, SD=1.73, p<0.001) compared to the control group (pre-test: M=23.91, SD=3.55; post-test: M=26.17, SD=4.05, p=0.014). Practice levels also improved, albeit not significantly. Fisher exact test revealed significant associations between knowledge and educational status (p=0.014) and family income (p=0.005) in the experimental group. These findings underscore the effectiveness of the educational intervention in enhancing ASHA workers\u27 knowledge of HBNC, thereby potentially reducing neonatal mortality rates.  
Biophilic Design Integration In Primary School Fosters Holistic Development In Pre-Teen
No full textThe term "biophilic design" is derived from the Greek word "biophilia," with meaning "love of nature." The human race has lost its connection to nature as a result of growing urbanization and modernization. The idea of biophilic design has grown in popularity recently because it can improve well-being and promote holistic development in people of all ages. The incorporation of nature into our constructed environment is crucial because it can activate physiological mechanisms that promote healing. The study focuses on the notion of biophilic design and the key developmental changes that pre-teen experience in primary school. Along with their interdependence, it also addresses the close relationship between the human body and its environment. The objective is to gauge knowledge of biophilic design and its effect on preteens\u27 cognitive development because they represent the next generation. The study includes case study results, academic articles on biophilic design and its use, as well as publications on the consequences of biophilic design. This review article emphasizes the value of implementing biophilia and its design principles in elementary schools. The research focuses on the biophilic design ideas and components that can promote pre-teen (age group 5–12) development. Finally, it will offer a few design principles and tactics that might help schools adopt biophilic design