Indian Institute of Technology Gandhinagar

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    AUTONOMOUS DOME FOR A ROBOTIC TELESCOPE

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    The Physical Research Laboratory operates a 50 cm robotic observatory at Mount Abu (Rajsthan, India). This Automated Telescope for Variability Studies (ATVS) makes use of the Remote Telescope System 2 (RTS2) for autonomous operations. The observatory uses a 3.5 m dome from Sirius Observatories. We have developed electronics using Arduino electronic circuit boards with home grown logic and software to control the dome operations. We are in the process of completing the drivers to link our Arduino based dome controller with RTS2. This document is a short description of the various phases of the development and their integration to achieve the required objective

    2D Nanomaterials for Energy- and Environment-oriented Applications: Scalable Production and Environmental Concerns

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    [No abstract available

    Least Privilege Access for Persistent Storage Mechanisms in Web Browsers

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    Web applications often include third-party content to personalize a user’s online experience. These scripts have unrestricted access to a user’s private data stored in the browser’s persistent storage, associated with the host page. Various mechanisms have been implemented to restrict access to these storage objects. However, the existing mechanisms provide an all-or-none access and do not work in scenarios where web applications need to allow controlled access to cookies and localstorage objects by third-party scripts. If some of these scripts behave maliciously, they can easily access and modify private user information that is stored in the browser objects. The goal of our work is to design a mechanism to enforce fine-grained control of persistent storage objects. We perform an empirical study of persistent storage access by third-party scripts on Tranco’s top 10,000 websites and find that 89.84% of all cookie accesses, 90.98% of all localstorage accesses, and 72.49% of IndexedDB accesses are done by third-party scripts. Our approach enforces least privilege access for third-party scripts on these objects to ensure their security by attaching labels to the storage objects that specify which domains are allowed to read from and write to these objects. We implement our approach on the Firefox browser and show that it effectively blocks scripts from other domains, which are not allowed access based on these labels, from accessing the storage objects. We show that our enforcement results in some functionality breakage in websites with the default settings, which can be fixed by correctly labeling the storage objects used by the third-party scripts

    Hybrid Ag-mesh/Ta-doped TiO2 thin film configuration as a visible and near-infrared transparent electrode

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    This study focuses on the fabrication of a hybrid Ag-mesh/Ta-doped TiO2 (TTO) electrode that has a low sheet resistance and high transparency in the visible and near-infrared region, thereby holding significant commercialization potential. Here, ∼82 nm thick TTO film is deposited on the glass substrate using radio frequency magnetron sputtering technique, over which Ag mesh is carved using the metal aerosol jet printing method. As compared to TTO, sheet resistance of the entire hybrid configuration is found to show a 2-3 order improvement, with the loss of a mere ∼12 % in the visible and ∼8 % in NIR transmittance. The electronic structure of the Ag/TTO interface demonstrates the formation of an ohmic junction, thereby making it suitable for the fabrication of a network-based transparent electrode. Moreover, the overall functionality and preparation route of this electrode makes it more promising as compared to those of the conventional metal mesh and metal-oxide electrodes

    Customary law and gender in Northeast India

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    One of the dominant issues in writings on the tribal societies of Northeast India is the liberal use of concepts like custom, customary law, and law without clarity about the distinctions and overlaps between them. It is also observed that the literature on customary laws relates only to the tribal communities, as if the caste societies are bereft of any customs or customary laws, which is certainly not true but is not the subject matter of the present lecture. Further, it is observed that customary laws are seen as forces perpetuating gender inequality, which to me is more a political than an academic statement. This valedictory address will address some of the issues mentioned above with suitable examples from India’s Northeast. In conclusion, the address will also try and reflect on the future of the region that continues to be guided by numerous customary laws that are sometimes in conflict with state laws and occasionally even with the Constitution of India

    Food matters: shaping new gastronomic culture(s) in Western India, 1875-1947

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    Novel pyrazolo[4, 3-c]quinolin-3-one derivatives as PDE5A inhibitors

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    Background: PDE5A is a phosphodiesterase which specifically hydrolyzes the cGMP to GMP. It takes part in several physiological and pathological pathways and is considered an important drug target. Currently, PDE5 inhibitors (ex; Sildenafil, Tadalafil) available in the market are not only being used for the treatment of erectile dysfunction but at the same time, they are also in clinical trials being investigated as anticancer agents. Materials & Methods: In this work, we have examined pyrazolo [4,3-c]quinolin-3-ones as PDE5A inhibitors. Pyrazolo [4,3-c]quinolin-3-ones are the class of tricyclic heterocyclic derivatives having a variety of therapeutically interesting drug candidates known for their anti-inflammatory, anti-viral, anti-anxiety and anti-cancer activity. Therefore, synthetic methods providing access to pyrazolo [4, 3-c] quinolin-3-ones are immensely valuable. Here, we are reporting a simple but efficient route for the synthesis of novel 8�morpholino-2-aryl � 2, 5-dihydro-3H-pyrazolo [4, 3-c] quinolin-3-one derivatives. Results: Further, molecular docking studies of synthesized compounds with human PDE5A protein showed that all the compounds exhibited good docking score in comparison with known inhibitors. In addition, all the synthesized molecules were evaluated against HCT116 cell lines for their antitumor activity. Conclusion: Among all the synthesized compounds, compound 5a, 5d, and 6e showed better cytotoxicity. Thus, these derivatives can be studied as potential inhibitors of PDE5A. � 2019 Elsevier B.V., All rights reserved

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