5324 research outputs found
Sort by
Clinical Data Integration Model: Core Interoperability Ontology for Research Using Primary Care Data
No full textComputer ScienceBackground
Primary care data is the single richest source of routine health care data. However its use,
both in research and clinical work, often requires data from multiple clinical sites, clinical
trials databases and registries. Data integration and interoperability are therefore of
utmost importance.
Objectives
TRANSFoRm’s general approach relies on a unified interoperability framework,
described in a previous paper. We developed a core ontology for an interoperability
framework based on data mediation. This article presents how such an ontology, the
Clinical Data Integration Model (CDIM), can be designed to support, in conjunction with
appropriate terminologies, biomedical data federation within TRANSFoRm, an EU FP7
project that aims to develop the digital infrastructure for a learning healthcare system in
European Primary Care.
Methods
TRANSFoRm utilizes a unified structural/terminological interoperability framework,
based on the local-as-view mediation paradigm. Such an approach mandates the global
information model to describe the domain of interest independently of the data sources to
be explored. Following a requirement analysis process, no ontology focusing on primary
care research was identified and, thus we designed a realist ontology based on Basic
Formal Ontology to support our framework in collaboration with various terminologies
used in primary care.
Results
The resulting ontology has 549 classes and 82 object properties and is used to support
data integration for TRANSFoRm’s use cases. Concepts identified by researchers were
successfully expressed in queries using CDIM and pertinent terminologies. As an
example, we illustrate how, in TRANSFoRm, the Query Formulation Workbench can
capture eligibility criteria in a computable representation, which is based on CDIM.
Conclusion
A unified mediation approach to semantic interoperability provides a flexible and
extensible framework for all types of interaction between health record systems and
research systems. CDIM, as core ontology of such an approach, enables simplicity and
consistency of design across the heterogeneous software landscape and can support the
specific needs of EHR-driven phenotyping research using primary care data
Applying Blended Learning to English Communication Cources 101 and 102 at BZU - Palestine (Case Study)
No full textLanguage
Biomimetic catalytic activities of copper (II) ferrocenecarboxylate complexes with nitrogen based ligands as catechol oxidase and phenoxazinone synthase and for oxidative coupling of 2,6-dimethylphenol
No full textBiomimetic catalytic activities of copper (II) ferrocenecarboxylate complexes with nitrogen based ligands as catechol oxidase and phenoxazinone synthase and for oxidative coupling of 2,6-dimethylphenol
A.Latif Abuhijleh
Chemistry Department, Birzeit University, P.O.Box14, West Bank, Palestine. E-Mail: [email protected]
Copper is one of the most important metals ,beside Fe and Zn, present in several metalloenzymes and is involved in a large number of biological functions including enzyme-catalyzed reactions [1]. Binary and ternary copper carboxylate complexes have been used as biomimetic of copper containing enzymes.
As part of our ongoing research on the study of biomimetic activities of copper (II) carboxylate complexes with biologically important nitrogen based ligands, we report here the results of our studies on the synthesis and oxidase catalytic activities of copper(II) complexes of ferrocenecarboxylate with nitrogen donor ligands pyrazole and 1,2-dimethylimidazole. The complexes, bis(ferrocenecarboxylato) tetrakis(pyrazole) copper(II) (1) and cis-bis (ferrocenecarboxylato) bis(1,2-dimethylimidazole) copper(II) (2) have been prepared from the reaction of tetrakis(ferrocenecarboxylato) bis(tetrahydrofuran) dicopper(II) and the appropriate base. Based on the spectral results for complex (1), the Cu(II) ion is coordinated in the plan with four nitrogen atoms of pyrazoles and the axial sites are occupied by oxygen atoms from two ferrocenecarboxylato groups to yield Cu[N]sub4+ O[sub]2 chromophore. We had previously determined crystal structure of complex (2) by X-ray crystallography. In this complex the copper ion is in a cis- square-planar environment consisting of two imidazole nitrogen atoms and a carboxylate oxygen atom from each ferrocenecarboxylato ligand . The second oxygen atoms of the carboxylate functionalities are involved in weak interactions with the copper ion in the axial positions.
The biomimetic catalytic oxidase activities of complexes 1 and 2 toward the aerobic oxidations of 3,5-di-tert-butylcatechol (3,5-DTBC) to 3,5-di-tert-butyl-o-benzoquinone (3,5-DTBQ) (catecholase activity), and o-aminophenol (OAP) to o-amino-3H-phenoxazine-3-one (APX) (phenoxazinone synthase activity) have been studied and the results will be presented. In addition, the results of the catalytic activities of these complexes for C-O polymerization or C-C dimerization coupling of 2,6-dimethylphenol (DMP) will be presented
[1] S.E. Allen, R.R.Walvoord, R. Padilla-Salinas, and M.C.Kozlowski, Chem.Rev. 2013 ,113, 6214Birzeit Universit
14. GI/ITG KuVS Fachgespr ach Sensornetze
No full textWe present a prototype implementation for autonomous sensor network deployment. The utilized deployment algorithm considers two conflicting goals: (1) maximizing the coverage area while (2) maintaining good multi-hop connectivity from sensor nodes to a data sink. In an interdisciplinary research project we have built tiny sensor nodes fitting into bionic winged seeds that can be deployed with a flying drone. We had a couple of successful test flights with 15 nodes deployed on a soccer field. In this work we present these preliminary results as a proof of concept to demonstrate the principal applicability of the syste
An empirical discharge prediction model for smooth asymmetric compound rectangular channel validated using area method
No full textPublished in : ISH Journal of Hydraulic EngineeringThis paper presents an empirical, non-linear, multivariable regression model for predicting discharge in smooth asymmetric compound rectangular channel. The model is developed using experimental discharge data generated from testing nine different channel cross-sections with varied geometric dimensions. The predictive strength of the developed regression model is validated using several major statistics. All deployed statistics have indicated that the developed model is highly significant. In addition, the area method has been used to validate the model’s discharge predictive strength. The area method predicts discharge mainly based on the cross-section geometry and apparent shear stress. As obtained from the literature, a sample of three different regression-based models has been used to
estimate the apparent shear stress. Therefore, three different sets of discharge have been predicted using the area method. The four sets of discharge predicted using the developed regression model and area method have been compared to their corresponding experimental values using the sum of squared errors (SSE). The outcome is that seven channel cross-sections out of nine tested ones resulted in minimum SSE values when discharge predicted using the
developed regression model.Birzeit Universit
Illustration of Palestinian criminal procedures law : interpretation and critique
No full textقانون الإجراءات الجزائية هو مجموعة القواعد القانونية التي تحكم إجراءات البحث عن الجريمة وضبطها ووسائل إثباتها، وتحدد السلطة المختصة بملاحقة مرتكبها ومحاكمته، كما تبين إجراءات المحاكمة وطرق الطعن بالأحكام الجزائية وتنفيذها. وقد حرص المشرع الإجرائي الجزائي على رسم الخطوات والإجراءات الواجب اتباعها لدى التحقيق في الجرائم، ووزّع الأدوار والمهام بين أكثر من جهة، وذلك لتجنب حدوث خروقات في حقوق الإنسان، وضمان تحقيق العدالة والمساواة، وسيادة القانون، وحسن سير العدالة وانتظام الحياة في المجتمع في ظل قضاء مستقل. فالقواعد الشكلية تشكّل قيداً على سلطات التحقيق والمحاكمة فيما يقومون به ويتخذونه من إجراءات ابتداء من لحظة تحريك الدعوى الجزائية مروراً بإجراءات التحقيق والمحاكمة وحتى تنفيذ الحكم.
يتناول هذ الكتاب نظام العدالة الجزائية الفلسطيني، ومؤسسات العدالة الجزائية الرئيسة والمساندة وحدود صلاحياتها وعلاقتها ببعضها وبالسلطات الثلاث، والأنظمة القانونية الجزائية في العالم وموقع نظامنا القانوني منها، والمبادئ التي تحكم الدعوى الجزائية وفقا للقوانين المحلية والمعايير الدولية، ومراحل الدعوى الجزائية وهي: التحقيق الابتدائي، المحاكمة، والطعن في الأحكام، وشروط المحاكمة العادلة، وضمانات المتهم، وتقييم الوسائل البديلة لحل المنازعات الجزائية في النظام الفلسطيني والنظم المقارنة.
يعتمد هذا العمل الأسلوب التحليلي للنصوص القانونية ونقدها موضوعياً في ضوء النظريات الحديثة والمعايير الدولية التي تضمنتها الاتفاقيات والمواثيق والإعلانات الدولية لحقوق الإنسان. وقد رُبطت النظريات القانونية بالعلوم الاجتماعية والتطبيقية أيضاً مثل علم الإجرام، علم العقاب، علم النفس، علم الاجتماع، الطب الشرعي، وغيرها. كما رُبطت موضوعات الكتاب بالواقع الفلسطيني السياسي والثقافي والاقتصادي، وخاصة في المرحلة الانتقالية وما بعدها
Printed Arabic optical character segmentation
No full textVan Gucht,Dirk:
Purdom,Paul:A considerable progress in recognition techniques for many non-Arabic characters has been
achieved. In contrary, few efforts have been put on the research of Arabic characters. In any Optical
Character Recognition (OCR) system the segmentation step is usually the essential stage in which an
extensive portion of processing is devoted and a considerable share of recognition errors is
attributed. In this research, a novel segmentation approach for machine Arabic printed text with
diacritics is proposed. The proposed method reduces computation, errors, gives a clear description
for the sub-word and has advantages over using the skeleton approach in which the data and
information of the character can be lost. Both of initial evaluation and testing of the proposed
method have been developed using MATLAB and shows 98.7% promising result
