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PREDIKSI POTENSI (Pluchea indica) SEBAGAI BAHAN OBAT ANTIKANKER PAYUDARA MENGGUNAKAN METODE ANALISIS SECARA IN SILICO
No full textBackground: Cancer is a disease characterized by uncontrolled growth of abnormal cells. In silico research is important to find out quickly through predictive methods compounds that have potential as anticancer in various types of plants, one of which is P. indica.
Objective: The purpose of this study was to predict the bioavailability profile, affinity, and interactions of secondary metabolite compounds of P. indica using in silico analysis.
Methods: The methods used in this study were PubChem and Dr. Duke's Phytochemical webserver to find out secondary metabolite compounds contained in P.indica, SwissADME webserver obtained bioavailability data, GFN.xTB for energy stability, PDB webserver was used to search for target receptor structure, PyRx, Avogadro, and Discovery Studio software was used to perform docking, and protein.plus webserver was used for visualization of test compounds.
Results and Conclusions: Of the 122 secondary metabolite compounds of P. indica, 47 compounds were found to have good bioreliability. There are 20 compounds that have an inhibition constant bond lower than 3PP0. There are 14 compounds that have hydrogen bonds with 3PP0. P. indica has potential as a HER-2 receptor because it has less energy and pKi compared to 3PP0, P. indica also has the same amino acid residual bonds as 3PP0 in hydrogen bonds, namely Gln39 and Asn72
PENGEMBANGAN MEDIA SCRAPBOOK BERBASIS DIGITAL PADA MATERI KEBERAGAMAN BUDAYA KELAS 4 SDN 260 GRESIK
No full textBased on the results of the analysis, fourth grade students at SDN 260 Gresik still lack understanding regarding various types of cultural diversity and cultural origins. Based on this, researchers developed digital-based scrapbook media to support the learning process to make it more interesting. The aim of this research is to produce digital-based scrapbook media products for class IV Pancasila Education subjects in elementary schools.
This type of research uses the ADDIE model which consists of five stages, namely analysis, design, development, implementation and evaluation. The data collection techniques used were observation, interviews, questionnaires and documentation. The data analysis techniques used are qualitative descriptive data and quantitative data analysis.
The results of developing Digital-Based Scrapbook Media in Cultural Diversity material show a percentage of assessment by material experts of 91%, media validation gets a percentage of 88% which states that the material and media are suitable for implementation. Meanwhile, the response from teachers to scrapbook media got a percentage of 95% and the response from students got 98%. Based on the results obtained, it shows that the development of digital-based scrapbook media is suitable for use and can support the learning process of students in class IV elementary schools. However, this research certainly still has shortcomings so innovation and creativity are needed from future researchers
Analisis Yuridis Sistem Penyelenggaraan Perizinan Berusaha Di Indonesia Pasca Lahirnya Peraturan Pemerintah Nomor 5 Tahun 2021
No full textThe enactment of Law Number 11 of 2020 concerning Job Creation requires implementing regulations to implement it in Government Regulation Number 5 of 2021 concerning the Implementation of Risk-Based Licensing. The purpose of writing this research is to describe and analyze how changes in the business licensing registration system in Indonesia and the juridical consequences that occur after the birth of Government Regulation Number 5 of 2021. Based on the scope of the research, in writing this research the author uses normative research methods. The results show that there are several changes. System changes from the original OSS to OSS RBA. However, this simplification only results in a reduction in the number of rules without fully improving the quality of the licensing registration process. There is still disharmonization of regulations. GR 5/2021 does not regulate in detail the timeframe or Service Level Agreement (SLA) for the license registration process, which can lead to uncertainty in license completion time and potentially hamper economic competitiveness and the investment climate
PERTANGGUNGJAWABAN PERDATA TERHADAP KORBAN KECELAKAAN YANG TERJADI AKIBAT KELALAIAN PIHAK BANDAR UDARA
No full textThe incident that caused a woman to die under an elevator due to negligence in airport operations has become a big public question as to how the services provided were not in accordance with established standards, resulting in victims. Upon closer examination, the process of civil accountability to victims is considered lacking so that it is not clear regarding the fulfillment of victims' rights. The purpose of this writing is to find out how civil liability is and the fulfillment of aspects of legal certainty and justice for deaths caused by airport negligence in accordance with the Aviation Law. The research method used in this final assignment is normative juridical research by collecting legal materials consisting of primary materials in the form of legislation and secondary materials in the form of supporting literature such as books and journals. The results of the research show that the provisions regarding civil liability in the Aviation Law are regulated in article 240 by adhering to the principle of liability based on fault. Meanwhile, regarding certainty and justice, it is considered sufficient, but it is necessary to increase the nominal amount and other details as a form of fulfilling justice to the community
The controversial mathematical reasoning process of prospective teachers when solving mathematical problems
No full textAn important aspect of the learning process is reasoning. One of the studied reasonings is controversial reasoning. Controversial reasoning can be used to determine the understanding of prospective teachers. The purpose of this study is to explain the controversial reasoning of prospective teachers when solving problems. This research is descriptive qualitative. The instruments used are tests and interviews. There are 50 prospective teachers who are given a problem, then their work is analyzed to find out their reasoning. Data analysis in this study is a) reviewing tests and interviews, b) determining the data used, c) analyzing test and interview results, d) making patterns, and e) presenting data. The conclusion of this study is the controversial reasoning process of prospective teachers, namely a) logically concluding, b) explaining the model, facts, and concept relationships, c) determining the conjecture, and d) using the conjecture to analyze the situation and make an analogy with the given problem. Suggestions for other researchers are to develop appropriate instruments for generating controversial reasoning for prospective teachers. In addition, after prospective teachers solve controversial problems, they can explore their critical and creative thinking processes
PENGARUH KEUNTUNGAN DI MASA DEPAN TERHADAP NIAT DAN PERILAKU INVESTASI: APLIKASI TPB PADA PELAKU UKM DI PURWOSARI
No full textThis research aims to test the influence of attitudes, perceived behavioural control, subjective norms, and behaviour about future profits on investment intentions among SMEs in Purwosari. The type of research used is explanatory research with a quantitative approach. Data collection uses survey techniques with the help of
questionnaires. The data analysis method used is path analysis (path analysis). The results of the research show that attitudes about future profits have a positive and significant effect on investment intentions, subjective norms about future profits
have a positive and significant impact on investment intentions, perceived behavioural control about future profits has a positive and significant effect on investment intentions, and investment intentions have a positive and significant impact on investment behaviour
KONSTRUKSI TANDA-TANDA MASALAH SOSIAL DALAM VIDEO GAME (Analisis Semiotika pada Video Game Stray)
No full textThe world faces challenges from an increasing population growth, which brings various social issues. These social issues are often turned into themes that are packaged and communicated through media. Media plays a crucial role due to its ability to construct reality both actively and passively. Following technological advancements, the term "new media" has become common, with video games being one example. Video games can create depictions that mimic the real world, making their presentations appear as constructions of reality. One video game that highlights and constructs social issues is Stray.
This research seeks to understand how Stray constructs social issues through the signs present within it. The study employs Roland Barthes' semiotic analysis method with an interpretative qualitative approach, focusing on the elements of the game's world or the cutscenes in Stray.
The results of the research show that the video game Stray constructs social issues such as poverty, population problems, and environmental issues through the signs of a slum area. Signs such as characters, narrative, background decorations, and dialogue are used to construct the reality of life in a slum area, where people live in difficult economic conditions, with limited access to improve their lives, and in an unhealthy environment neglected by the government. Stray also highlights that social issues are not only caused by external structures but also by human nature, such as greed, selfishness, and indifference
PENGARUH FINANCIAL TECHNOLOGY, FINANCIAL LITERACY DAN FINANCIAL ATTITUDE TERHADAP FINANCIAL MANAGEMENT BEHAVIOR GENERASI Z DESA NGABAN, KEC. TANGGULANGIN, KAB. SIDOARJO
No full textThis study aims to determine and analyze the positive and significant effect of Financial Technology, Financial Literacy and Financial Attitude partially and simultaneously on the Financial Management Behavior of Generation Z of Ngaban Village, Tanggulangin Subdistrict, Sidoarjo Regency. A total of 100 Generation Z respondents from Ngaban Village, Tanggulangin District, Sidoarjo Regency were sampled using simple random sampling technique. The study used primary data, namely questionnaires via google form. The data analysis technique applied is multiple linear regression analysis assisted by the SPSS 25 program. The results of this study indicate that Financial Technology has a significant effect on Financial Management Behavior, Financial Literacy does not have a significant effect on Financial Management Behavior, Financial Attitude does not have a significant effect on Financial Management Behavior. Simultaneously Financial Technology, Financial Literacy, and Financial Attitude together have a significant effect on Financial Management Behavior
KEBIJAKAN SATU DATA UNTUK MENINGKATKAN KUALITAS PELAYANAN PUBLIK (STUDI TENTANG INTEGRASI NOMOR INDUK KEPENDUDUKAN DAN NOMOR POKOK WAJIB PAJAK)
No full textThe sectoral ego attitude of each agency in sharing data is still a challenge that the government must face. Apart from that, the large number of identity numbers with their own systems adds to the problems surrounding data in Indonesia. In order to support data integration, the government is integrating NIK and NPWP through Undang-Undang Nomor 7 Tahun 2021 concerning Harmonisasi Peraturan Perpajakan Pasal 2 ayat (1a) and Peraturan Menteri Keuangan (PMK) Nomor 136 Tahun 2023 concerning NPWP Bagi Wajib Pajak Orang Pribadi, Wajib Pajak Badan, dan Wajib Pajak Instansi Pemerintah. However, data that is centralized and integrated in one system has an impact on data security, because more data can be accessed from one point of vulnerability. Therefore, it is important to ensure that integrated data is properly protected.
The method in this research is qualitative research with an empirical juridical approach. This research uses public policy theory according to William N. Dunn. Analysis through public policy theory allows systematic and comprehensive analysis of the policy-making process to identify problems, formulate and adopt effective solutions, implement policies well, and carry out evaluations to ensure that the NIK and NPWP integration policy can achieve its goals without compromising the security of people's personal data. .
The results of this research explain that the integration of NIK and NPWP takes into account data security from a regulatory and technological perspective. This integration allows combining NIK-based population data and NPWP-based tax data, so that it has implications for increasing the accuracy of both data and can be used in public services, especially tax services. However, the benefits of this integration have not fully touched various other basic services. Thus, it is necessary to expand valid data access for other basic services in addition to increasing the efficiency of tax service administration, as well as updating the information security management system based on the 2022 version of ISO/IEC 27001
DUKUNGAN SOSIAL DISABILITAS NETRA DALAM MENINGKATKAN KETERAMPILAN MELALUI PELATIHAN MUSIK DI UPT REHABILITASI SOSIAL BINA NETRA MALANG
No full textThis study investigates how social support can help visually impaired people learn skills through music training. The main aim of this research is to find out how participation by blind people can develop skills, such as cooperation, independence and communication, due to support and social interaction from their environment. This research was conducted through a qualitative case study. Data was collected through observations of music training participants and in-depth interviews with instructors, supporters and participants. The role of social support from individuals and groups and its impact on the soft skills studied are considered in the analysis. The research results show that social support provided by the instructor, fellow participants, and the surrounding environment is very important to foster self-confidence, improve communication skills, and encourage participants to actively participate in music activities. In music training, collaborative processes foster technical learning and enhance participants' social and emotional experiences. This study provides new insights into how inclusive music training can significantly improve the soft skills of individuals with visual impairments. The conclusions of this research can help in the development of more efficient training programs that improve their overall quality of life