University of Szeged
SZTE Doktori Értekezések Repozitórium (SZTE Repository of Dissertations)Not a member yet
7511 research outputs found
Sort by
The optimal dose of kynurenic acid in improving memory and its antidepressant-like effect in preclinical studies
Full text linkTargeting Tigers and Flies: A Policy Analysis of Xi Jinping’s Anticorruption Efforts in China
Full text link
The role of syndecans in pathological protein aggregation
Full text linkNeurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are marked by the pathological aggregation and prion-like spreading of misfolded proteins,including amyloid-beta (Aβ), tau, and alpha-synuclein (α-syn). These proteins undergo structural transitions that lead to oligomer formation, fibrillation, and ultimately neuronal damage. Recent studies suggest that heparan sulfate proteoglycans (HSPGs), particularly transmembrane syndecans (SDCs), are key mediators in the internalization and propagation of these aggregates. However, the isoform-specific roles of syndecans in neurodegeneration remain incompletely characterized. In this thesis, we systematically investigated the contribution of syndecan isoforms SDC1–4 to the cellular uptake, fibrillation, and intracellular trafficking of Aβ1–42, α-syn, and tau. Using syndecan-overexpressing K562 and SH-SY5Y cells, we employed flow cytometry, confocal microscopy, Thioflavin T assays, scanning electron microscopy, and co-immunoprecipitation techniques. We found that syndecan-3 (SDC3), a neuron-specific isoform, markedly enhanced the uptake and fibrillation of these pathological proteins via a lipid raft-dependent pathway. The heparan sulfate chains of SDCs were critical in mediating this interaction. Furthermore, we explored the interplay between syndecans and apolipoprotein E (ApoE) isoforms, showing that ApoE2 facilitated, while ApoE4 impaired, SDC-mediated Aβ uptake. Co-localization and biochemical assays confirmed isoform-specific binding between ApoEs and SDCs. SDC3 expression was elevated in human neuronal models and transgenic AD mouse brains, supporting its potential as an early biomarker. Our findings reveal that syndecans—particularly SDC3—play a central role in the endocytic uptake and seeding of misfolded proteins, contributing to neurodegenerative disease progression. These results highlight the potential of targeting syndecan-mediated pathways for early diagnosis and therapeutic intervention in AD and related disorders
Innovative Approaches in Laryngotracheal Surgery and Medical Education : Surgical Techniques, 3D Modeling, and Educational Applications in Head and Neck Surgery
Full text linkThe assessment of neuropathic dysfunction in Type 1 diabetic patients: the role of metabolic and molecular/inflammatory mechanisms
No full textChristopher Dresser életművének első két szakasza (1857-1873), avagy vitalizmus, botanika és művészet kapcsolódási pontjai
No full textThe conclusions of my dissertation demonstrate that the concept of force in Christopher Dresser's (1834-1904) oeuvre’s ornamental theory has a vitalist background, with components related to the period around 1800 – namely the Romantic sciences of the search for unity, moreover to the Goethean idealistic botanical morphology of Naturphilosophie, id est the search for an archetype, as a side-branch of the Jenaean constellation.
According to my thesis an important component of Dresser's artistic botany is his knowledge of Goethean metamorphosis theory, which also represents a transmission of the influences of the years around the 1800s to the ornamentation, or art of the mid-19th century. The consequence of all this, in Dresser's case, is a unique, purely ideal that is to say an abstract ornamentation, which in this sense is an important pre-modern predecessor of the turn-of-the-century art.
Therefore, as a result of the above, the implications of the links to the period around 1800 are thus reflected in Dresser's artistic botanical writings and ornamental theory
Perception and production of Chinese vowel finals by Hungarian learners – Some relevant difficulties
Full text linkReports & Diplomatic Correspondence of A Habsburg Diplomat: Anselm Franz von Fleischmann (1711-1716)
Full text linkThis dissertation examines the diplomatic reports and correspondence of Anselm Franz von Fleischmann, a Habsburg diplomat stationed in the Ottoman Empire from 1711 to 1716, during the reign of Sultan Ahmed III. Drawing on fifty-two primary documents from the Austrian State Archives (Österreichisches Haus-, Hof-, und Staatsarchiv - OeStA), supplemented by twenty-four additional sources such as Habsburg frontier commanders' letters and intelligence reports, the study analyzes Ottoman foreign policy and Ottoman-Habsburg relations between 1711 and 1716, during the period of geopolitical turmoil following the Treaty of Karlowitz (1699), through Fleischmann's eyes.
The research focuses on three key events: the Ottoman-Russian War (1711), including the Prut River Campaign and the Treaty of Prut; the Ottoman-Venetian War (1714–1715), encompassing the Montenegrin Uprising, Ottoman military preparations, and the conquest of Morea; and the escalating tensions leading to the Ottoman-Habsburg War (1716), marked by diplomatic failures, Fleischmann's arrest, and Ottoman administrative inefficiencies.
Using archival transcription and comparative analysis with contemporary sources (e.g., the memoirs of Stanisław Poniatowski, Ernst Friedrich von Fabrice, and Aubry de la Motraye, as well as Voltaire's history books, and Ottoman chronicles such as the Târîh-i Râşid and Nusretname), the thesis reveals Fleischmann's perspectives on Ottoman military strategy, domestic politics, and foreign policy maneuvers. It highlights the Habsburgs' efforts to resolve their conflicts with the Sublime Porte through mediation without escalating into conflict, the influence of figures such as the Grand Viziers Baltacı Mehmed Pasha, Damat Ali Pasha, and Tatar Khan Devlet Giray, as well as broader European power shifts involving Russia, Sweden, and Venice.
Ultimately, Fleischmann's records underscore the Ottoman Empire's transitional decline, characterized by corruption, strategic missteps, and territorial ambitions, while affirming the Habsburg Monarchy's rising dominance in Eastern Europe. This study contributes new archival evidence to the historiography of early 18th-century diplomacy, emphasizing the interplay of intelligence gathering, alliances, and warfare in reshaping the balance of power