University of Szeged
SZTE Doktori Értekezések Repozitórium (SZTE Repository of Dissertations)Not a member yet
7511 research outputs found
Sort by
Targeting Tigers and Flies: A Policy Analysis of Xi Jinping’s Anticorruption Efforts in China
Get PDF
The role of syndecans in pathological protein aggregation
Get PDFNeurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are marked by the pathological aggregation and prion-like spreading of misfolded proteins,including amyloid-beta (Aβ), tau, and alpha-synuclein (α-syn). These proteins undergo structural transitions that lead to oligomer formation, fibrillation, and ultimately neuronal damage. Recent studies suggest that heparan sulfate proteoglycans (HSPGs), particularly transmembrane syndecans (SDCs), are key mediators in the internalization and propagation of these aggregates. However, the isoform-specific roles of syndecans in neurodegeneration remain incompletely characterized. In this thesis, we systematically investigated the contribution of syndecan isoforms SDC1–4 to the cellular uptake, fibrillation, and intracellular trafficking of Aβ1–42, α-syn, and tau. Using syndecan-overexpressing K562 and SH-SY5Y cells, we employed flow cytometry, confocal microscopy, Thioflavin T assays, scanning electron microscopy, and co-immunoprecipitation techniques. We found that syndecan-3 (SDC3), a neuron-specific isoform, markedly enhanced the uptake and fibrillation of these pathological proteins via a lipid raft-dependent pathway. The heparan sulfate chains of SDCs were critical in mediating this interaction. Furthermore, we explored the interplay between syndecans and apolipoprotein E (ApoE) isoforms, showing that ApoE2 facilitated, while ApoE4 impaired, SDC-mediated Aβ uptake. Co-localization and biochemical assays confirmed isoform-specific binding between ApoEs and SDCs. SDC3 expression was elevated in human neuronal models and transgenic AD mouse brains, supporting its potential as an early biomarker. Our findings reveal that syndecans—particularly SDC3—play a central role in the endocytic uptake and seeding of misfolded proteins, contributing to neurodegenerative disease progression. These results highlight the potential of targeting syndecan-mediated pathways for early diagnosis and therapeutic intervention in AD and related disorders
Innovative Approaches in Laryngotracheal Surgery and Medical Education : Surgical Techniques, 3D Modeling, and Educational Applications in Head and Neck Surgery
Get PDFThe assessment of neuropathic dysfunction in Type 1 diabetic patients: the role of metabolic and molecular/inflammatory mechanisms
No full textChristopher Dresser életművének első két szakasza (1857-1873), avagy vitalizmus, botanika és művészet kapcsolódási pontjai
No full textThe conclusions of my dissertation demonstrate that the concept of force in Christopher Dresser's (1834-1904) oeuvre’s ornamental theory has a vitalist background, with components related to the period around 1800 – namely the Romantic sciences of the search for unity, moreover to the Goethean idealistic botanical morphology of Naturphilosophie, id est the search for an archetype, as a side-branch of the Jenaean constellation.
According to my thesis an important component of Dresser's artistic botany is his knowledge of Goethean metamorphosis theory, which also represents a transmission of the influences of the years around the 1800s to the ornamentation, or art of the mid-19th century. The consequence of all this, in Dresser's case, is a unique, purely ideal that is to say an abstract ornamentation, which in this sense is an important pre-modern predecessor of the turn-of-the-century art.
Therefore, as a result of the above, the implications of the links to the period around 1800 are thus reflected in Dresser's artistic botanical writings and ornamental theory
Pedagógusok és tanárszakos hallgatók adathasználattal kapcsolatos vélekedéseinek és hatékonyságérzetének vizsgálata
Get PDFIn-service teachers’ everyday work includes using student data to enhance both instruction and learning. Student data originates from various sources (national competence assessments, oral exams, tests etc.), including demographic characteristics and absenteeism. Accessing, analyzing, interpreting, and appropriately utilizing data is challenging for teachers. International research has shown that data use for improving instruction and learning is greatly influenced by teachers' self-efficacy. There has been limited attention to investigating teachers' data use in Hungary. Therefore, the aim of our study is to understand in-service teachers' and pre-service teachers' beliefs and sense of efficacy regarding data use. Using the method of data triangulation, we conducted two studies, each preceded by pilots. Data were collected using self-developed instruments for data use, assessment, and background information, as well as two adapted instruments: the Data-Driven Decision-Making Efficacy and Anxiety Inventory (3D-MEA, Dunn et al., 2013) and the Data Use Practices survey (Reeves et al., 2016).The large-scale surveys yielded Nteachers=275 and Nstudent teachers=250 responses.
The results indicate that a high ratio of in-service teachers have high self-efficacy in accessing, interpreting, and utilizing information and assessment results from external sources in their teaching, albeit with high levels of anxiety associated with these activities. Student data is primarily used to support students, with only a small proportion being incorporated into instructional activities. In contrast, pre-service teachers vary in their self-efficacy of using student data, and many experience low anxiety about data or express greater reliance on data in the teaching-learning process. Furthermore, the findings suggest that data use courses in teacher education have a significant impact on both in-service teachers' and pre-service teachers’ self-efficacy beliefs regarding data use. It also became evident which courses significantly impact specific dimensions and the number of courses necessary to increase self-efficacy in a particular dimension.
This research highlights the importance of improving the use of commonly available student data for instructional purposes starting from teacher education programs. Data use courses significantly impact self-efficacy in this respect, which is an indicator of data-driven decision making and thus of increased student performance (cf. Dunn et al., 2013). Based on the results, the author believes that this research serves as a good starting point for future studies examining classroom data use from various perspectives and laying the groundwork for international comparative studies
Bridging the gap between experimental and human sepsis: Porcine models for sepsis research with improved clinical relevance
Get PDF
