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Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension
No full textBackground:Pulmonary hypertension (PH) is a progressive and potentially fatal condition if left untreated. Currently, only sildenafil and bosentan have been approved by the FDA for the medical treatment of pediatric patients. The availability of bosentan, in a developing country, such as Indonesia, is a challenge.
Aim: to evaluate the effect of sildenafil and metformin on endothelin (ET)-1 levels in the progression of pulmonary hypertension.
Methods: Forthy eight, 12 weeks old, male Wistar rats, weighing 117-193 gram, were injected by monocrotaline (MCT) (60 mg/kg body weight (BW)) subcutaneously. The rats were then randomly assigned to 4 group (control, sildenafil, metformin, sildenafil plus metformin). One day after MCT injection, sildenafil (5mg/kg BW) and metformin (100mg/kg BW) were administered once daily for 21 days. Right heart catheterization was performed on day 22nd after anesthesia with ketamin 50mg/kg BW and xylazin 5mg/kg BW intramuscularly. Blood was taken intracardially for approximately 3.5 mL, and the rats was euthanized. The serum was stored to -20° refrigerator before ELISA analysis. The lung was harvested and paraffin- blocked for latter histology analysis. Blood serum was analyzed for ET-1, and a section of paraffin-blocked lung was stained with hematoxyline-eosin (HE) and α-smooth muscle actin (α-SMA). Intima media thickness (IMT) of 50–200 µm artery and ratio pulmonary artery smooth muscle cells (PASMCs)/fibroblast were analyzed.
Results: The mean pulmonary artery pressure (mPAP) and ET-1 of the treatment group were significantly lower than those of the control group. Intima media thickness was significantly lower in the sildenafil plus metformin group than in the other groups.
Conclusion: sildenafil and metformin alone or in combination improve mPAP and ET-1 levels. Sildenafil plus metformin prevent artery remodeling in PH model
Green Supply Chain Management Development For Improving The Environmental Concerns Of Business
Get PDFThe green supply chain management (GSCM) is for protection of environmental, and industries can employ it
to decrease side effects of environment and enhance proper application of energy and resources by considering
the future. The purpose of this article is to use a quantitative-qualitative method to identify and develop a
pattern of green supply chains in Indonesian industries and to examine the level of effectiveness and efficiency.
The present study was conducted by examining the information of 21 companies engaged in Indonesian
industries that have implemented GSCM in the last 5 years, during the years 2023-2024. For this purpose,
green supply chain criteria showed that green process design, green innovation, green customers,
environmental management approaches, and human resource management have the greatest impact on
improving environmental performance, managing and optimizing energy consumption and cost of industries.
The results showed that the use of GSCM decrease waste, resources, hence decreases energy consumption and
environmental pollution. The employing of GSCM in industry, improve efficiency and performance. This
article, which is the result of a descriptive-quantitative study, discusses and examines the current status of the
GSCM, the characteristics and components of the green supply chain, and the benefits of establishing a green
supply chain, so that managers can achieve competitive management by using GSCM
Efektivitas Yoga untuk Meningkatkan Kualitas Tidur: Studi Meta-Analisis
Get PDFKualitas tidur berperan penting dalam kesehatan fisik dan psikologis individu dalam jangka panjang. Berdasarkan hal tersebut diketahui bahwa kualitas tidur perlu diperhatikan untuk meminimalisir konsekuensi fisik maupun psikologis yang bisa terjadi. Intervensi yang dapat digunakan untuk meningkatkan kualitas tidur salah satunya adalah yoga. Namun, terdapat temuan yang beragam sehingga menimbulkan inkonsistensi antara beberapa penelitian sehingga dibutuhkan studi meta-analisis untuk melihat besaran efek serta kategorisasinya. Penelitian ini bertujuan untuk melihat efektivitas yoga untuk meningkatkan kualitas tidur individu. Penelitian ini adalah studi meta-analisis menggunakan N, M, dan SD kelompok kontrol dan kelompok eksperimen untuk dianalisis sehingga mendapatkan nilai effect size (g = 0,647, Cl -0,736 – 2,030, efek medium). Hasil penelitian ini menunjukkan bahwa yoga efektif dalam meningkatkan kualitas tidur individu. Oleh karena itu, yoga dapat direkomendasikan sebagai salah satu intervensi non-farmakologis bagi individu yang mengalami gangguan tidur atau ingin meningkatkan kualitas tidur
The effect of cognitive behavioral therapy intervention on reducing social anxiety disorder: A meta-analysis study
Get PDFThis study aims to evaluate the effectiveness of implementing cognitive behavior therapy intervention in reducing the level of social anxiety disorder symptoms. The research uses a meta-analysis method following the PRISMA-P 2020 procedure. There are 14 independent studies involving the use of face-to-face cognitive behavior therapy or Internet-based cognitive behavior therapy to reduce social anxiety disorder. The results of the study indicate that face-to-face cognitive behavior therapy and Internet-based cognitive behavior therapy do not show significant differences in reducing social anxiety disorder symptoms. Additionally, previous indenpendent studies conducted randomized controlled trials using cognitive behavior therapy, which resuluted in a small effect size due to the application of similiar or other behavior therapies as the comparison group
Pengaruh Sudut Pandang Pemotretan dalam Fotografi Olahraga Lari Terhadap Minat Beli di Kota Surabaya
Get PDFPenelitian ini menganalisis pengaruh sudut pandang pemotretan dalam fotografi olahraga lari terhadap minat beli karya foto di Kota Surabaya. Estetika visual menjadi faktor utama yang dikaji, dengan fokus pada elemen sudut pandang pemotretan, komposisi, ekspresi, momen, dan point of interest. Fenomena olahraga lari tidak hanya berfungsi sebagai aktivitas kebugaran, tetapi sebagai sarana ekspresi diri yang sering diabadikan dalam bentuk fotografi, terutama untuk diunggah di media sosial. Hal ini menciptakan hubungan simbiosis antara pelari dan fotografer, di mana pelari membutuhkan dokumentasi yang menarik, sementara fotografer menyediakan jasa pemotretan yang memiliki nilai jual. Penelitian ini menggunakan pendekatan kualitatif dengan analisis visual terhadap karya fotografi. Metode eksperimen diterapkan dengan mengambil foto dari berbagai sudut pemotretan, termasuk high angle, eye level, dan low angle, untuk mengamati respon konsumen terhadap hasil foto. Sebanyak 29 orang pembeli foto pada ajang Surabaya Medic Air Run 2024 dilibatkan guna mengetahui preferensi visual mereka. Hasil penelitian menunjukkan bahwa sudut pemotretan high angle lebih diminati dibandingkan sudut lainnya.
Selain itu, komposisi yang tepat, ekspresi subjek, serta ketepatan momen pemotretan turut berkontribusi dalam meningkatkan daya tarik visual foto
Designing The Marketing Mix through Competitive Profile Matrix and Importance-Performance Analysis Case Study of a Travel Agent in Yogyakarta
Get PDFXY Tour operates as a travel agency in Yogyakarta. The pandemic and its associated travel restrictions affected XY
Tour's operations, including a decline in Yogyakarta tourism. Care must be taken while dealing with post-pandemic
circumstances that boost tourism. This study aims to design an appropriate marketing mix to strengthen XY Tour's
competitive edge. This study employs qualitative and quantitative methods through interviews and surveys. Data from
100 respondents were processed using the Competitive Profile Matrix (CPM) and Importance-Performance Analysis
(IPA). CPM generates six critical success factors from the XY Tour whereas IPA generates six variables in Quadrant I.
According to survey results, this study provides several suggestions, including segmenting customer based on consumer
behavior, targeting new demographic segment, expanding an online and social media presence, and creating unique
backpacker trip package. In terms of the marketing mix, this study suggests a number of recommendations, such as
creating culinary and themed tour packages, introducing cost-based pricing, enhancing social media management and
efficacy, providing customer service training, hiring new staff with social media management expertise, utilizing
Chatbots, and incorporating cultural identity into assets. These recommendations can guide XY Tour to maintain its
operations and boost its competitive edge in the travel sector
Exploring the Shadows: Validation of the Short Dark Tetrad (SD4) in Indonesian
Get PDFThe increasing incidence of crime and violence among university students highlights the importance of understanding dark personality traits within social, educational, and workplace contexts. Dark personality traits including Machiavellianism, Narcissism, Psychopathy, and Sadism—play a significant role in interpersonal dynamics, decision-making, and individual adaptation strategies. This study aims to validate the Indonesian version of The Short Dark Tetrad (SD4) scale. A total of 305 students from various faculties at the University of Surabaya participated in this study, selected through purposive sampling. Data were analyzed using Principal Component Analysis (PCA) to assess structural validity and Cronbach’s Alpha to determine reliability. The results indicate that the Indonesian version of SD4 demonstrates adequate internal structural validity, with reliability coefficients ranging from 0.621 to 0.752. These findings suggest that SD4 is a valid and reliable instrument for identifying dark personality traits among Indonesian university students. The implications of this study support the use of SD4 in both academic and practical settings, particularly for psychological assessment and character development in higher education environments.
Fenomena kejahatan dan kekerasan yang meningkat di kalangan mahasiswa menunjukkan pentingnya pemahaman terhadap aspek-aspek kepribadian gelap (dark personality) dalam konteks sosial, pendidikan, dan lingkungan kerja. Kepribadian gelap, yang mencakup Machiavellianism, Narsistik, Psikopati, dan Sadisme, memiliki peran penting dalam dinamika interpersonal, pengambilan keputusan, serta strategi adaptasi individu. Penelitian ini bertujuan untuk memvalidasi alat ukur The Short Dark Tetrad (SD4) dalam Bahasa Indonesia. Penelitian melibatkan 305 mahasiswa dari berbagai fakultas di Universitas Surabaya yang dipilih melalui metode purposive sampling. Data dianalisis menggunakan Principal Component Analysis (PCA) untuk menguji validitas struktur dan Cronbach’s Alpha untuk menguji reliabilitas. Hasil penelitian menunjukkan bahwa SD4 versi Bahasa Indonesia memiliki validitas struktur internal yang memadai, dengan nilai reliabilitas berkisar antara 0.621 hingga 0.752. Temuan ini menunjukkan bahwa SD4 merupakan alat ukur yang valid dan reliabel untuk mengidentifikasi kepribadian gelap pada populasi mahasiswa Indonesia. Implikasi dari penelitian ini mendukung penggunaan SD4 dalam konteks akademik dan praktis, terutama dalam pengembangan intervensi psikologis dan pemahaman karakter individu di lingkungan pendidikan tinggi
Behavioral Bias, Robo-Advisory, and Trading Decisions on Millennial Investors (Generation and Z) in Surabaya, Indonesia
Get PDFThis study aims to examine the effect of behavioral bias, namely overconfidence, and herding effect on trading
decisions and examine the moderating effect of Robo-advisory on behavioral bias and trading decisions on young
Millennial investors in Surabaya. This research is quantitative with primary data through a survey by distributing
questionnaires to 100 respondents of young Millennial investors in Surabaya. The sampling technique used purposive
sampling. Data does obtain through distributing questionnaires both online and offline—data analysis method using
OLS (Ordinary Least Square) with SPSS application. The results of H1 and H2 are supported, while H3 is rejected.
Overconfidence and the herding effect affect the stock trading decisions of young millennial investors in Surabaya.
Meanwhile, Robo-advisory does not moderate the relationship between behavioral bias and investors' stock trading
decisions
Pola Asuh dan Prestasi Anak Tionghoa dalam Perspektif Psikologi Budaya
Get PDFPenelitian ini mengeksplorasi dampak pola asuh dalam keluarga Tionghoa di Indonesia, dengan fokus khusus pada bagaimana pola asuh tersebut mempengaruhi prestasi akademik anak-anak. Penelitian ini mengkaji hubungan antara pendekatan pengasuhan dan prestasi anak, terutama dalam keluarga Tionghoa Totok (darah murni) dan Peranakan (campuran). Penelitian ini menyelidiki peran komunikasi terbuka, metode disiplin, dan kesadaran diri dalam manajemen waktu sebagai faktor yang berkontribusi pada kesuksesan akademik. Selain itu, penelitian ini mengeksplorasi bagaimana nilai-nilai budaya dalam keluarga Tionghoa membentuk perkembangan kemandirian dan tanggung jawab anak. Penelitian kualitatif deskriptif dipilih untuk memberikan pemahaman yang lebih mendalam. Informan berusia 19 hingga 21 tahun dipilih menggunakan teknik purposive sampling, yang mewakili latar belakang keluarga Tionghoa Totok atau Peranakan. Data dikumpulkan melalui kuesioner mengenai pola asuh yang dipersepsikan (otoritatif, otoriter, permisif) dan wawancara mendalam. Analisis tematik digunakan untuk mengelompokkan dan menganalisis data untuk mengidentifikasi tema utama dan memberikan wawasan lebih dalam mengenai pengaruh pola asuh terhadap prestasi akademik. Temuan penelitian ini menyoroti pentingnya komunikasi demokratis dan peran orang tua dalam mendukung kemandirian dan tanggung jawab anak-anak mereka. Selain itu, penelitian ini menekankan dampak dari metode disiplin non-otoriter terhadap perkembangan emosional dan akademik anak. Penelitian ini menyarankan bahwa pemahaman terhadap dinamika budaya ini dapat meningkatkan dukungan psikologis dan pendidikan bagi anak-anak dalam keluarga Tionghoa