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Pandemia e resilienza. Persona, comunità e modelli di sviluppo dopo la Covid-19
Get PDFIl volume raccoglie un saggio principale a firma della Consulta scientifica del Cortile dei Gentili, con la prefazione del Presidente della Consulta, prof. Giuliano Amato. Seguono 15 brevi saggi di accademici e studiosi quali: Stefano Zamagni, Ugo Amaldi, Francesco D’Agostino, Laura Palazzani, Giacomo Marramao, Emma Fattorini, Leonardo Becchetti, Eugenio Mazzarella, Amedeo Cesta, Antonino Raspanti. I curatori del volume sono Cinzia Caporale e Alberto Pirni. Il volume indaga i profili etico-sociali, economici e di governance della fase post pandemica con la finalità di indicare percorsi virtuosi di rinnovamento culturale
Manuale per la gestione integrata degli stabulari. Principi e indicazioni per la protezione degli animali e la sicurezza dei lavoratori
Get PDFIl volume è l’edizione aggiornata del “Manuale per la gestione integrata degli stabulari” - principi e indicazioni per la protezione degli animali e la sicurezza dei lavoratori – (2012), divenuta necessaria in seguito alla emanazione della Direttiva 2010/63/UE, revisione della Direttiva 86/609, recepita in Italia con il Decreto Legislativo 26/2014 il 4 marzo 2014.
Il Manuale è redatto secondo un approccio integrato che considera contestualmente sia gli aspetti riguardanti la sperimentazione animale sia quelli di sicurezza e salute degli operatori e dei ricercatori
Stress Cardiomyopathy in COVID-19 Disease
Get PDFPatients affected by COVID-19 pneumonia may develop stress cardiomyopathy, also known as Takotsubo syndrome (TTS), at different stages during the disease and with different degrees of left ventricular dysfunction. We describe three cases of TTS in COVID-19-positive patients with different clinical presentations and outcomes. One of them died, while in the other two coronary angiography confirmed the diagnosis but was postponed until after pneumonia resolution because of the risk of virus spread
COVID-19, Chronic Obstructive Pulmonary Disease and Pneumothorax: A Frightening Triad
Get PDFWe describe the case of a male patient admitted to our emergency department during the Italian COVID-19 epidemic, for progressive worsening dyspnoea. A diagnosis of pneumothorax and diffuse interstitial lung involvement was promptly made by lung ultrasound and confirmed by an HRCT scan. A chest CT scan also showed diffuse emphysema, as observed in chronic obstructive pulmonary disease (COPD), and small consolidations in the lower lobes, suggestive for COVID-19 pneumonia. A chest tube was immediately inserted in the emergency room with complete resolution of the dyspnoea. A nasopharyngeal swab for 2019-nCoV was positive. Unfortunately, the patient died from COVID-19-related acute respiratory distress syndrome after 48 days of hospitalization
Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia
Get PDFBackground: In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19). Case description: We describe a patient with rapid worsening of COVID-19 pneumonia and its dramatic improvement under corticosteroids. Discussion: Corticosteroids could be useful in patients with an inflammatory profile, considering that acute respiratory distress syndrome may be the consequence of cytokine storm syndrome
Kikuchi-Fujimoto Syndrome: A Rare Entity to Consider
Get PDFntroduction: Kikuchi-Fujimoto disease (KFD) is a rare, benign, necrotizing lymphadenitis of unknown aetiology with good prognosis. It is characterized by cervical lymphadenopathy, nocturnal diaphoresis and fever. Surgical excision of the adenopathy, histopathological study and immunophenotyping are crucial for diagnosis.Patients and methods: This paper describes five patients with three different histological subtypes of KFD, including an atypical presentation masquerading as pyelonephritis and two other cases where physicians mistakenly started chemotherapy. In one other case cytomegalovirus was identified as the responsible aetiological agent, while in the remaining patient, KFD evolved into an autoimmune condition.Discussion: KFD, although rare, may mimic infectious, autoimmune and neoplastic diseases. It also poses a risk for the subsequent development of an autoimmune disorder
SARS-CoV-2 Infection with Associated Rhabdomyolysis and Probable Myocarditis
Get PDFWe describe a patient with SARS-CoV-2 and severe pneumonia who required mechanical ventilation and developed associated rhabdomyolysis with probable myocardial involvement as evidenced by cardiac enzyme abnormalities and echocardiographic findings. Repeat testing should be done in cases highly suspicious for SARS-CoV-2 as initial molecular tests may be negative, as in our case
Acquired Haemophilia A in Association with Influenza A and Urinary Tract Infection
Get PDFAcquired haemophilia A (AHA) is a rare autoimmune disorder caused by an autoantibody against any circulating coagulation factor, especially factor VIII (FVIII). The lack of awareness of this condition suggests that diagnosis is a challenge and usually delayed, which leads to suboptimal treatment. Consequently, early diagnosis is mandatory to prevent potentially life-threatening bleeding complications. We present the case of an 85-year-old woman admitted to hospital with symptoms of respiratory infection who 12 hours later developed haematuria which required transfusion. Laboratory assays showed an isolated prolonged aPTT, a moderately reduced FVIII and a high inhibitor titre. Influenza A and Escherichia coli were also identified. Antivirals, antibiotics, immunosuppressive drugs and haemostatic agents were started. Two weeks later, the inhibitor was not detected, and bleeding and symptoms of infection had resolved. Immunosuppressive drugs were stopped on day 45 and there has been no recurrence since then. To date, no FVIII inhibitors have been reported in concomitant infection with influenza A and urinary E. coli. The identification of conditions potentially associated with AHA is essential to achieve complete remission
Cardiac Lipoma of the Interventricular Septum
Get PDFCardiac lipomas are rare benign primary neoplasms of the heart, usually found incidentally, that can become symptomatic depending on their size and location. We report the case of a 61-year-old man presenting with chest pain and elevated troponin and a normal EKG and D-dimers. A transthoracic echocardiogram revealed an intracardiac mass attached to the interventricular septum protruding to the left ventricle, later confirmed to be a lipomatous mass consistent with a cardiac lipoma on cardiac magnetic resonance imaging. Due to the mass characteristics and favourable evolution, it was decided not to excise the tumour, and the patient remains asymptomatic after a 4-year follow-up period
Atypical Presenting Symptoms of Acute Onset Acquired Haemophilia with Eosinophilic Fasciitis
Get PDFcquired haemophilia is a bleeding disorder caused by antibodies against coagulation factors. Some cases are associated with autoimmune diseases. However, no cases of acquired haemophilia with eosinophilic fasciitis have been previously reported. Herein we describe the case of a patient with eosinophilic fasciitis associated with acquired haemophilia