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Spontaneous Intra-Cerebral Haemorrhage Presenting with Chest Pain in a Healthy Young Man
Get PDFSpontaneous, non-traumatic intra-cerebral haemorrhage is the second most common type of stroke and is associated with significant morbidity and mortality. It is defined as the presence of blood within the cerebral parenchyma without prior injury or surgery. The purpose of this work is to describe an atypical presentation of spontaneous intra-cerebral haemorrhage in a healthy young adult. A literature review was also carried out
Mondor's Disease in SARS-CoV-2 Infection: A Case of Superficial Vein Thrombosis in the Era of COVID-19
Get PDFSARS-CoV-2 causes blood hypercoagulability and severe inflammation resulting in an increased risk of thrombosis. Consequently, COVID-19 patients with cardiovascular disease seem to be at higher risk of adverse events. Mondor’s disease is a rare, generally self-limiting, thrombosis of the penis. The pathogenesis of Mondor’s disease is unknown, and it is usually diagnosed through clinical signs and with Doppler ultrasound evaluation. We describe the case of a young man with COVID-19 infection who manifested Mondor’s disease
Thyroid Storm Associated with Testicular Choriocarcinoma
Get PDFThyroid storm is a rare, life-threatening condition that can be caused by various pathologies including serious conditions associated with human chorionic gonadotropin (hCG)-producing tumours. We present the case of a 17-year-old male patient with a 1-month history of dyspnoea and a 3-day history of palpitations and fever. General examination revealed a left testicular mass. Blood tests revealed β-hCG >225,000 mIU/ml, thyroid-stimulating hormone (TSH) 0.02 IU/ml, and thyroxine (T4) 19.07 μg/dl. He was admitted with thyroid storm. Treatment with antithyroid drugs and chemotherapy was started, but the patient died on the third day of admission.This case highlights a rare occurrence of thyroid storm linked to testicular choriocarcinoma, and provides a necessary reminder that, in some instances, hCG at very high levels can exert a thyrotropic effect due to its molecular structure, which is similar to that of TSH
Masquerading Hypervascular Exophytic Liver Nodule
Get PDFPatients with liver cirrhosis are at increased risk of developing hepatocellular carcinoma (HCC) and are placed on routine surveillance for HCC. Diagnosis algorithms are in place to guide clinicians in the evaluation of liver lesions detected during surveillance. Radiological assessments are critical with diagnostic criteria based on identification of typical hallmarks of HCCs on multiphasic computed tomography (CT) and dynamic contrast-enhanced magnetic resonance imaging (MRI). We report a patient with a hypervascular exophytic lesion indeterminate for HCC on CT imaging. While the detection of an exophytic arterially-enhancing lesion in an at-risk patient on CT imaging may prompt clinicians to treat the lesion as HCC without further evaluation, the patient underwent contrast-enhanced MRI with the lesion being eventually diagnosed as an exophytic haemangioma. Thus, no further action was necessary and the patient was continued on routine HCC surveillance
La suggestione nella testimonianza
Get PDFLa prova testimoniale è caratterizzata da una struttura complessa. Infatti, per la valutazione di una testimonianza occorre esaminare, da un lato, la narrazione di un fatto, e, da un altro lato, l’attendibilità del testimone, che può essere influenzata, in vario modo, dalle dinamiche dell’attività psichica in rapporto alla percezione ed al ricordo dei fatti, e dalle sue alterazioni a causa dell’età, del sesso, delle emozioni e passioni, del temperamento, delle illusioni e allucinazioni, delle involuzioni e malattie mentali specialmente in relazione all’attenzione e alla memoria.
Al fine di evitare l’inquinamento del ricordo è fondamentale utilizzare determinate tecniche di intervista. Il presente lavoro si propone di illustrare la metodologia denominata “intervista cognitiva”, che è stata elaborata con il preciso scopo di ridurre al minimo il rischio di suggestione
Perché le norme editoriali?
Get PDFPartendo da alcuni esempi, il lavoro intende proporre una
riflessione sulle norme editoriali relative a pubblicazioni
scientifiche, in particolare sulla loro coerenza interna e sulla loro utilità nella trasmissione dei testi
Pedofilia: la scienza a confronto
Get PDFDare una definizione di tipo psicopatologico di soggetti con comportamenti sessuali devianti non ha trovato terreno fertile e fondamenta salde e pertanto questi comportamenti vengono classificati come inusuali e in contrasto con la morale collettiva; viene anche stilata una classifica in base al livello di pericolosità nei confronti della vittima oltre che del soggetto stesso. In cima a tale lista troviamo la pedofilia ed il sadismo e a seguire tutte quelle scelte sessuali che prevedono fantasie e atti di esibizionismo, travestimento, voyeurismo o masochismo. Pur essendo conosciute e ritenute conseguenza di un disturbo di natura psichica, non sono annoverate all’interno dell’ambito del sistema medico-scientifico ma sono principalmente trattate in sistemi quasi esclusivamente di tipo giuridico. Il presente contributo intende pertanto analizzare il tema sia da un punto di vista descrittivo quanto da una prospettiva più scientifico-trattamentale
Tilted and standard ring solitons in shallow water
Get PDFThe propagation of nonlinear multiring soliton structures in a shallow water is theoretically investigated. To study this problem, we have derived a cylindrical (or concentric) Korteweg-deVries equation (cKdVE) for an incompressible,
inviscid, and irrotational fluid. The cKdVE has been solved analytically and numerically to describe, respectively, the localized multiring structures with tilted and standard boundary conditions
The role of geological origin of smectites and of their physico-chemical properties on aflatoxin adsorption
Get PDFSince 2013, bentonite in the form of dioctahedral smectite is an additive authorised in the EU as a substance for the reduction of the contamination of feed by aflatoxins. Several studies indicate a big difference in the effectiveness of smectites in sequestering aflatoxins. A clear correlation between mineralogical and physico-chemical properties of smectites and aflatoxin adsorption has not been well established. In the effort to identify the most critical mineralogical, chemical, and physical properties that affect aflatoxin adsorption by smectites, 29 samples of bentonites obtained from different sources around the world were evaluated. “As received” samples were divided into two main groups, i.e. hydrothermal (n=14) and sedimentary (n=15) bentonites depending on their geological origin. The characterization studies showed that all samples contained dioctahedral smectite as major mineral; a moderate CEC value (60-116 cmol/kg); the presence of iron; a small organic matter content; a near-neutral pH; and a fine and uniform particle size (<45μm). They differed substantially in their sodium, calcium and magnesium contents, and in the swelling properties depending on the geological origin. Several in vitro adsorption studies showed that they also differed in a significant manner in adsorbing aflatoxin B1 (AFB1). A correlation between geological origin and AFB1 adsorption capacity was found (p<0.001), being sedimentary smectites significantly more effective than hydrothermal ones in adsorbing the toxin at different pH values. The extent of AFB1 adsorption by all samples was negatively and linearly correlated to the extent of desorption, and sedimentary smectites were significantly more effective than hydrothermal smectites in keeping bound the adsorbed fraction of the toxin (p < 0.001). In addition, correlation studies using the Pearson statistical method showed a significant relationship among some physico-chemical properties of smectites and the amounts of adsorbed toxin. In particular, AFB1 adsorption by smectites correlated positively with sodium content and swell index, but negatively with d001-value, magnesium and calcium contents. In conclusion, it seems that the geological origin of smectite is a useful guide for the selection of bentonites for AFB1 detoxification. Sedimentary bentonites containing sodium/swelling-smectite should be preferred to hydrothermal samples as potential aflatoxin binders. Taking into account the geographical origin of our samples, this approach should be applicable to bentonites worldwide
Manuale del RUP : prontuario operativo del Responsabile Unico del Procedimento
No full textQuesto Manuale operativo è rivolto al Professionista che necessita di una guida
pratica e veloce per destreggiarsi senza incertezze nel variegato sistema normativo
e procedurale che disciplina le attività del RUP.
Si procede attraverso il censimento e la riorganizzazione di tutti i disposti normativi
facenti riferimento al RUP - sia di carattere generale che specifici delle varie fasi
procedurali - e successivamente ricostruendo minuziosamente l’iter dei diversi subprocedimenti, per consentire una consultazione rapida e funzionale degli argomenti.
Lo schema espositivo è volutamente semplice e lineare, si avvale di innumerevoli
tabelle sinottiche e diagrammi di flusso e consente in qualsiasi punto l’immediata
verifica della fonte normativa di provenienza - riportata per esteso nell’appendice
normativa di ogni capitolo - per favorire un preciso riscontro delle varie prescrizioni.
Ciascun capitolo è inoltre dotato di una “Scheda normo-cronologica”, che per ogni
fase ricapitola gli adempimenti, elencandoli secondo l’ordine sequenziale di
svolgimento. L’accurato indice analitico introdotto in questa terza edizione facilita
inoltre il reperimento dei tanti argomenti oggetto di trattazione.
L’Opera, curata con pazienza e precisione, risulta pertanto un prezioso ed
insostituibile strumento di lavoro e di semplificazione - unico nel suo genere - che
coadiuva il RUP nella prioritaria esigenza di attuare le procedure in tempi brevi,
verificandone al contempo la correttezza e senza rischiare di incorrere in errori o
dimenticanze