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SARS-CoV-2-related Multisystem Inflammatory Syndrome in Adults
Get PDFAdults infected with SARS-CoV-2 may develop a multisystem inflammatory syndrome (MIS-A) characterized by elevated inflammatory markers and multisystem organ involvement. We report the case of a patient who presented with fever and vomiting at hospital admission. He tested positive for SARS-CoV-2 infection and blood tests showed elevated inflammatory markers. The patient developed acute cardiac dysfunction and shock in less than 24 hours and the echocardiogram revealed an LVEF of 30%. He was discharged 3 weeks later fully recovered. MIS-A should be considered if a compatible syndrome is observed in patients with evidence of SARS-CoV-2 infection by PCR test or serology
Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach
Get PDFWe report a case of ceftriaxone-induced encephalopathy correlated with a high concentration of the drug in cerebrospinal fluid (CSF). Cephalosporin neurotoxicity is increasingly reported, especially in association with fourth-generation cephalosporins. The factors influencing CSF concentration are plasma concentration, liposolubility, ionization, molecular weight, protein binding and efflux. In our patient, high levels of ceftriaxone (27.9 mg/l) were found in CSF. β-Lactam-associated neurotoxicity is mainly due to similarities between GABA and the β-lactam ring. Because of differences in CSF/plasma ratios and blood–brain barrier efflux among patients, plasma drug monitoring cannot be used to estimate CSF concentration. As far as we know, this is the first reported case of ceftriaxone-induced encephalopathy associated with a high CSF concentration
La bioetica come professione e l'expertise in materia bioetica: riflessioni pedagogiche sullo sviluppo di un curriculum di Master di secondo livello in bioetica e scienze sociali in ambito anglosassone
Get PDFIn questo saggio delineo alcune riflessioni sul bioeticista di professione: chi è, cosa fa, e con quali competenze. Nella prima parte del saggio vado a delineare le ragioni
che hanno spinto alla creazione del Master di II livello in Bioetica e Società al King's College a Londra nel 2013, e le riflessioni pedagogiche che hanno informato le decisioni curriculari. Nella seconda parte di questo saggio mi occupo
di specificare le competenze relazionali e contributive che vanno a contraddistinguere l'expertise in materia bioetica, per poi andare a concludere discutendo delle competenze aggiuntive richieste in ambito di expertise in materia di
etica clinica e di etica della ricerca clinica. Le tesi contenute in questo articolo combinano le mie riflessioni personali basate sulla mia esperienza pluridecennale come
professore e direttore di un programma di Master di secondo livello al King's College London, con la letteratura anglosassone sul tema dell'expertise e delle competenze
in ambito di bioetica. Concludo con pro e contro nel formalizzare le competenze dell'esperto di bioetica. Nonostante difficoltà oggettive nella formalizzazione delle competenze in maniera retrospettiva, i pro appaiono maggiori dei contro e appare necessario procedere a una formalizzazione prospettiva per assicurare che si ragioni bene in una materia così essenziale alla salute pubblica
Human Granulocytic Anaplasmosis as a COVID-19 Mimicker
Get PDFIntroduction: Human granulocytic anaplasmosis (HGA) is a tick-borne illness caused by the bacterium Anaplasma phagocytophilum. HGA has a widely variable clinical presentation and can be life-threatening.Case description: A 77-year-old man was transferred from an outside facility with altered mental status, a fever of up to 40.5°C, and shortness of breath. Laboratory analysis revealed a progressively worsening pro-inflammatory state and abnormalities in the patient’s coagulation studies. With clinical and laboratory evidence concerning for potential COVID-19 infection, the patient was placed in isolation as a precaution. The results of two COVID-19 tests, given approximately 24 hours apart, were negative. The patient’s spouse confirmed a bug bite to his upper extremity while working outdoors. His symptoms resolved completely after a 10-day course of empiric doxycycline.Discussion: The diverse clinical presentations of HGA necessitate a broad differential diagnosis, including viral, bacterial and non-infectious aetiologies. In severe cases, a cytokine-mediated immune cascade can occur (namely, cytokine storm) leading to devastating downstream effects. This cytokine storm can be seen in many other diseases, but most recently it has been demonstrated in the novel coronavirus disease 2019 (COVID-19). Conclusion: Here we present a case of HGA in which diagnosis was delayed due to mimicry of COVID-19 infection. This case highlights the importance of taking clinical and social histories, seasonality and geography into account during diagnosis, and maintaining a broad differential with non-specific symptoms. Despite the current COVID-19 pandemic, we recommend that HGA remains in the differential diagnosis of a pro-inflammatory state with an atypical respiratory presentation
Comprendere la scienza è importante, proteggerla essenziale
No full textL'invito a “Comprendere la scienza per superare l'emergenza COVID-19” fatto dalla Dichiarazione è assolutamente appropriato e con- divisibile. La realizzabilità di tale visione, tuttavia, è direttamente osta- colata da fenomeni nuovi e problemi più profondi di quelli accennati dalla
Dichiarazione, che minacciano direttamente il futuro dell'etica e del progresso scientifico
Recensioni: Pandemia e Generatività. Bambini e adolescenti ai tempi del Covid
Get PDFL'anno scorso, la Consulta Scientifica del Cortile dei Gentili – l'ente del Pontificio Consiglio della Cultura deputato al dialogo fra credenti non credenti – pubblicava il volume Pandemia e Resilienza. Persona comunità e modelli di sviluppo dopo la Covid-19 (Edizioni CNR, 2020), un
volume collettaneo open access scaricato dal sito istituzionale del Consiglio Nazionale delle Ricerche da
circa 95.000 lettori. Tale documento recensito sulle pagine di questa rivi- sta dal Cardinale Gianfranco Ravasi,
otteneva un successo notevole, al punto che il Presidente della Consulta Scientifica, Giuliano Amato, riteneva opportuno dare un seguito a tale lavoro. Così è nato Pandemia e Generativà. Bambini e adolescenti ai tempi del Covid (Edizioni CNR, 2021)
Progetto INNO.M.A.M.: Il network delle stazioni agrometeorologiche
Get PDFThe aim of this technical report is to present the network of agro-meteorological stations set up on farms within the INNO.M.A.M. project and located mainly in the northern part of the Sicilian coast. The stations acquire data useful for studying the phenomena associated with mango cultivation in Sicily. In addition to the geographical coordinates, the configuration chosen for all the stations, the characteristics of the sensors of the quantities measured and the parameters derived from them are described here
Rome: NE slopes of the Palatine hill. Archaeology of architecture and ancient masonries deep analysis, in Caravale A. (ed.), Archaeological Computing: Selected Papers from the 2020 IMEKO TC-4 MetroArchaeo International Conference
Get PDFThe NE slopes of the Palatine hill and the Colosseum valley area have a long archaeological research history. Here the continuous urban development has produced the overlap of architectural complexes distributed over time. The huge amount of archaeological documents produced by the research is managed within a GIS environment. For the analysis of ancient walls we introduced the use of image-based-modelling photogrammetry in order to create a very detailed 3D documentation linked to a DBMS dedicated to ancient structural features. Through this methodology we can evaluate specific aspects of ancient construction yards for each period. We can also refine the chronological sequences of the architectural structures and verify the contextual relationships of the surrounding buildings in order to formulate wide-ranging reconstructive hypotheses
Computed tomography and handcrafting processes of an ancient musical instrument: the aulos from Poseidonia
Get PDFThis paper aims to explore how digital imaging and computed tomography (CT) can provide us with significant results and valuable information otherwise unavailable in the study of ancient instruments. Whilst its methods provide great potential in terms of the diagnostics and preservation of ancient musical instruments, radiology has been underused in this field of application. As an improved method for the visualisation and analysis of the material density of instruments and of their surfaces and volumes, CT allows for a useful evaluation of the handcrafting process of instruments as well as the visualisation of invisible fracture lines and lesions in their structures, showing possible modifications, damages and repairs
Archaeological Computing and the MetroArchaeo International Conference Award: an introduction, in n Caravale A. (ed.), Archaeological Computing: Selected Papers from the 2020 IMEKO TC-4 MetroArchaeo International Conference
Get PDFIntroduction to the section ARCHAEOLOGICAL COMPUTING: SELECTED PAPERS FROM THE 2020 IMEKO TC-4 METROARCHAEO INTERNATIONAL CONFERENC