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3D modelling from archive and legacy data: preliminary data processing on the Roman shipwreck Grado I, in in Caravale A. (ed.), Archaeological Computing: Selected Papers from the 2020 IMEKO TC-4 MetroArchaeo International Conference
Get PDFCaâ Foscari University is addressing different archaeological issues to enhance knowledge about shipwrecks through digital technologies. In the last few years, the team has applied virtual modelling and digital techniques on archive and legacy data, starting with an innovative museum installation regarding the wreck of the Napoleonic brig Mercurio and cargos of amphoras of the Byzantine shipwreck of Cape Stoba. The potential of digital technologies has allowed us to analyse and elaborate different kinds of documentation, including archives, to obtain 3D models that could be studied and visualized with innovative technological solutions. The paper presents an original proposal to create a 3D virtual model of an ancient shipwreck based on archival and heterogeneous data. Regarding the Grado I Roman shipwreck, we processed perspective drawings of the hull and the amphoras, measurements during the excavations, digitalization of analogical images and of a survey of the cardboard scale model to obtain a complete virtual 3D model of the shipwreck. Legacy data represent a precious source for bringing to life obsolete representations of cultural heritage
Soffredi del Grazia: la voce antica di Pistoia nella civiltà della traduzione medioevale
Get PDFThe essay focuses one of the three “vertical” volgarizzamenti written in Pistoia
between the end of the 13th and the first half of the 14th century: the one fulfilled
in France by Soffredi del Grazia in 1275 and copied in the MS. Forteguerriano A 53 by Lanfranco di ser Iacopo del Bene in 1278 (the so-called Albertano
pistoiese). Following some information about Soffredi and a brief status quaestionis,
the paper substantiates the lexicographic relevance of this ancient text,
which deserves a new critical edition – now in progress – and the inclusion into
the textual database that allows to publish the Tesoro della Lingua Italiana
delle Origini (tlio)
A Case of Fatal Intestinal Infarct Preceded by Recurrent Ischaemic Colitis due to the Enterotoxic Effect of Sodium Polystyrene Sulfonate
Get PDFCase description: A 64-year-old patient with chronic renal failure and persistent hyperkalaemia not corrected by dialysis, was prescribed sodium polystyrene sulfonate (SPS) at a low dose (30 g/day for 2 days a week during the long interdialytic interval). After 3 months of therapy, the patient developed intense abdominal pain with non-specific colitis identified with a colonoscopy. In addition, the biopsy specimens showed rhomboid SPS crystals in the intestinal mucosa. Fourteen months after discontinuing therapy, the patient again presented with colitis and persistent biopsy finding of SPS crystals. The patient died a few months later due to intestinal infarction. Discussion and conclusion: SPS is a cation exchange resin used to treat hyperkalaemia resistant to dialysis, but may cause inflammation and ischaemia of the colon. In our patient, a short 3-month course of low-dose SPS therapy (without sorbitol, which is used to counter iatrogenic constipation caused by SPS) induced relapsing colitis, which was followed by massive intestinal infarction a few months later. In light of frequent reports of its enterotoxic effects, SPS should be replaced with the new potassium chelators (patiromer and sodium zirconium cyclosilicate)
Crohn’s Disease with Atypical Extra-Intestinal Manifestations Developing Under Treatment with Vedolizumab
Get PDFCrohn’s disease is a chronic inflammatory bowel disease that can affect any part of the GI tract, which is frequently associated with extra-intestinal manifestations. Pulmonary parenchymal disease is very uncommon and usually considered to be debilitating and harder to diagnose. Pulmonary granulomas are rarely described in the literature as a complication of Crohn’s disease. Here, we present a patient with Crohn’s disease exacerbation who developed granulomatous lung disease under treatment with vedolizumab. Our case may add evidence to the emerging theory that gut-selective biologic agents could lead to upregulation of some pro-inflammatory factors leading to the evolution of pulmonary disease
Tension Pneumothorax as Initial Manifestation of Granulomatosis with Polyangiitis (GPA)
Get PDFGranulomatosis with polyangiitis (Wegener’s granulomatosis) is a systemic vasculitis that primarily affects small and medium vessels. Its manifestations are usually confined to the upper airway, lower airway and kidney. It can also affect other organs and systems, although this is unusual. We describe the case of a 67-year-old woman who presented with a tension pneumothorax due to rupture of a pulmonary cavity. This pulmonary cavity proved to be secondary to systemic disease which also caused a tumour in her kidney. Biopsy showed non-necrotizing granulomatosis, and even though antineutrophil cytoplasmic antibodies (ANCA) were negative, the diagnosis of granulomatosis with polyangiitis was made
Beware of Drug Interactions Treating Iatrogenic MycobacteriumbovisEndocarditis from Intravesical BCG Instillation
Get PDFWe report a case of mechanical mitral valve endocarditis associated with miliary disseminated bacillus Calmette-Guerin (BCG) infection following intravesical instillations for minimally invasive bladder cancer in a 65-year-old man. The diagnosis was established by echocardiographic evidence of vegetation on the prosthetic mitral valve, miliary lesions in the lungs and evidence of bloodstream infection sustained by Mycobacterium. We successfully treated the patient with the classical regimen of quadruple antituberculous therapy
Severe Complication of Thiopurine Treatment in a Young Woman with Crohn’s Disease
Get PDFCase description: A 28-year old woman receiving thiopurine treatment for Crohn’s disease presented with a systemic primo cytomegalovirus (CMV) infection affecting the gut (colitis), liver (hepatitis), lungs (pneumonitis) and eyes (retinitis). Secondary to this systemic infection, she developed splenomegaly, pancytopenia and lymphadenopathy. Anti-viral treatment resulted in complete resolution of clinical, biochemical and radiological abnormalities within 6 weeks. Conclusion: Early recognition is crucial since CMV infection in a patient receiving thiopurine treatment may result in serious complications
Coronavirus Disease 2019 and Cold Agglutinin Syndrome: An Interesting Case
Get PDFThe coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality worldwide. While patients with COVID-19 most frequently present with pneumonia, respiratory failure and acute respiratory distress syndrome, increasing cases of immune-mediated disorders such as autoimmune thrombocytopenia, haemolytic anaemia and antiphospholipid syndrome have been reported. In this article we describe a rare case of cold agglutinin syndrome (CAS) in a patient with COVID-19. The patient was a 77-year-old man with a history of glucose-6-phosphate dehydrogenase (G6PD) deficiency who presented with COVID-19 infection and acute respiratory failure.
Initially he was started on intravenous steroids, antibiotics and hydroxychloroquine. Laboratory analysis revealed haemolytic anaemia with a positive direct anti-globulin test (DAT) and high titres of cold agglutinins. Hydroxychloroquine was stopped due to suspicion of haemolysis due to G6PD deficiency but the haemolysis persisted. Unfortunately, the respiratory failure progressed and the patient died. In summary, this article describes a rare case of CAS associated with COVID-19. CAS is a heterogenous group of cold autoimmune haemolytic anaemias
occurring secondary to infections or malignancies. No definite treatment for CAS in COVID-19 patients has been approved so far
Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis
Get PDFRheumatoid arthritis (RA) is a chronic inflammatory disease characterized mainly by arthritis, with the possible occurrence of extra-articular manifestations. We report the case of a patient who developed leptomeningitis as the first sign of RA, one year before the diagnosis of RA. Methylprednisolone 1000 mg was given intravenously. Because of the onset of seizures and cognitive impairment, rituximab was started. After three cycles of rituximab (1000 mg on day 0 and 1000 mg on day 15, every 6 months), neurological clinical examination, MRI and electroencephalogram findings were significantly improved