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"Lacticaseibacillus rhamnosus" GG improves behavior, immune functions, and biological age markers in female mice with premature aging
No full textThis work was supported by the Research Group UCM (910379) and FIS (PI15/01787) of the Health Institute Carlos III – Regional Developing Aid European Funds (ISCIII-FEDER), PID2022-136874OB-C31 and PID2022-136874OB-C32 (MICIU/AEI/10.13039/501100011033), and CDTI (INDEKA IDI-20190077 and SyBARIOTA IDI-20210293).Background. Prematurely aged mice (PAM), characterized by an inadequate stress response, exhibit early immunosenescence and reduced lifespan compared with exceptional non-PAM (E-NPAM) of the same age. Lacticaseibacillus rhamnosus GG (LGG) has been proposed as a beneficial probiotic in healthy aging. This study aimed to evaluate the effects of LGG consumption over 2 and 4 weeks on behavioral parameters, peritoneal leukocyte function, and lifespan in adult female PAM. Results. Female ICR-CD1 mice were classified as either PAM or E-NPAM and divided into three groups: (1) PAM control (PAMC), (2) PAM receiving LGG (PAMLGG), and (3) E-NPAM control (E-NPAMC). The PAMLGG group consumed a lyophilized LGG suspension in skim milk for 4 weeks, while the PAMC and E-NPAMC groups received a skim milk solution. Behavioral tests were conducted after 2 weeks, and leukocyte function was analyzed after 2 and 4 weeks. The results showed that the PAMLGG group exhibited improved behavioral responses and enhanced immune functions, which was reflected in a lower biological age and in a longer longevity compared with the PAMC. Conclusion.
LGG supplementation positively influenced behavior, immune function, and biological age markers in female PAM, leading to increased longevity. These findings indicate that LGG administration could be a good nutritional strategy for slowing down the aging process, allowing a healthy longevity to be achieved. © 2025 Society of Chemical Industry.Universidad Complutense de MadridInstituto de Salud Carlos III (España)European CommissionMinisterio de Ciencia, Innovación y Universidades (España)Centro para el Desarrollo Tecnológico Industrial (España)Depto. de Genética, Fisiología y MicrobiologíaFac. de Ciencias BiológicasTRUEpu
Ocupació, família i permisos parentals a Espanya: Una anàlisi longitudinal i interseccional
No full textLa forma de conciliar empleo y familia varía significativamente dentro del colectivo de madres, así como también su acceso a las políticas de permisos. Desde una perspectiva longitudinal e interseccional, este artículo analiza por primera vez la conciliación de las trayectorias laborales y familiares en España. Para ello, a partir de los datos retrospectivos de la Encuesta de Fecundidad de 2018, se lleva a cabo un análisis de secuencias multicanal para las madres de 18 a 55 años, según el nivel de educación y el país de nacimiento. Los resulta-dos muestran que las desigualdades en cuanto a la penalización laboral por maternidad son notables entre los diferentes grupos interseccionales y se perpetúan con menor intensidad para las cohortes más jóvenes. Si bien la trayectoria laboral prematernidad resulta clave para mantener una pauta de conciliación continua, hay un grupo importante de madres que se incorpora al empleo después de largas interrupciones, cuando los menores crecen. El acceso al permiso por maternidad es considerable, pero no el de la reducción de jornada.How mothers reconcile work and family life varies significantly between individuals, as does their access to policies on maternity leave. This article takes a longitudinal and intersectional approach to analyse for the first-time the reconciliation of careers and family life in Spain. It uses retrospective data from the 2018 Fertility Survey to undertake a multichannel sequence analysis for mothers aged 18-55, according to level of education and country of birth. The results show that inequalities in the “motherhood penalty” are striking across different intersectional groups and are perpetuated to a lesser extent among younger cohorts. While pre-maternity career trajectory is key to maintaining a continuous pattern of work-life balance, there is a large group of mothers who enter employment after long breaks, when their children are older. Access to maternity leave is widespread, but access to reduced working hours is not.La manera de conciliar ocupació i família varia significativament dins del col·lectiu de mares, així com també el seu accés a les polítiques de permisos. Des d’una perspectiva longitudinal i interseccional, aquest article analitza per primera vegada la conciliació de les trajectòries laborals i familiars a Espanya. Per fer-ho, a partir de les dades retrospectives de l’Enquesta de Fecunditat de 2018, es du a terme una anàlisi de seqüències multicanal per a les mares de 18 a 55 anys, segons el nivell d’educació i el país de naixement. Els resultats mostren que les desigualtats quant a la penalització laboral per maternitat són notables entre els diferents grups interseccionals i es perpetuen amb menor intensitat per a les cohorts més joves. Si bé la trajectòria laboral prematernitat resulta clau per mantenir una pauta de conciliació contínua, hi ha un grup important de mares que s’incorpora a l’ocupació després de llargues interrupcions, quan els menors creixen. L’accés al permís per maternitat és considerable, però no pas el de la reducció de jornadaDepto. de Sociología AplicadaFac. de Ciencias Políticas y SociologíaTRUEpu
Influencers y vacuna covid-19 : análisis y efectos de mensajes pro y antivacunas. Un estudio cuantitativo, cualitativo y de neurociencia
No full textTesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias de la Información, leída el 22-01-2025La percepción de las vacunas como instrumentos sanitarios inseguros se acentúa particularmente en el continente europeo, donde una fracción de la población las considera no solo irrelevantes, sino también no seguras ni eficaces (Larson et al., 2016). A este panorama se suma la crisis de salud pública derivada de la COVID-19 y el intenso debate en torno a la vacunación en plataformas de redes sociales, lo que genera una proliferación de mensajes a favor y en contra de las vacunas, incluyendo la participación de influencers. Investigaciones previas han evidenciado que este debate contribuye a la propagación de desinformación (Cuesta et al., 2021), por lo que analizar la actividad de estos influencers y su audiencia resulta crucial para comprender el discurso en las redes sociales en el ámbito de la salud pública y poder contrarrestar los temores y mitos con estrategias efectivas para combatir la desinformación...The perception of vaccines as unsafe health tools is particularly accentuated in the European region, where a fraction of the population considers them not only irrelevant but also unsafe and ineffective (Larson et al., 2016). To this landscape, the public health crisis derived from COVID-19 and the intense debate surrounding vaccination on social media platforms add, generating a proliferation of pro and anti-vaccine messages, including the participation of influencers. Previous research has shown that this debate contributes to the spread of misinformation (Cuesta et al., 2021), making it crucial to analyze the activity of these influencers and their audience to understand discourse on social media in this realm of public health and counter fears and myths with more effective strategies to combat misinformation...Fac. de Ciencias de la InformaciónTRUEunpu
Ecology and Evolutionary Biology as Frameworks to Study Wine Fermentations
No full textWe thank members of Sanchez, Petrov and Microbial Interactions and Ecology Lab for helpful discussion. Recent research by Ignacio Belda's laboratory has been supported by grants PID2019-105834GA-I00 (acronym Wineteractions) and PID2022-138343NB-I00 (acronym INDUSYNCON) funded by the Spanish State Research Agency/Science and Research Ministry (https://doi.org/10.13039/501100011033) and by ERDF/EU. Belen Benítez-Dominguez acknowledges her predoctoral grant PRE2022-103063 funded by ICIU/AEI/10.13039/501100011033 and by ESF+. Sergio Izquierdo-Gea acknowledges his predoctoral grant FPU21/06830 funded by the Spanish Ministry of Science, Innovation and Universities. JCC Vila was partially funded by a Center for Computational (CEHG), and Evolutionary and Human Genomics postdoctoral fellowship at Stanford.Winemaking has leveraged microbiology to enhance wine quality, typically by engineering and inoculating individual yeast strains with desirable traits. However, yeast strains do not grow alone during wine fermentation, rather they are embedded in diverse and evolving microbial communities exhibiting complex ecological dynamics. Understanding and predicting the interplay between the yeast community over the course of the species succession and the chemical matrix of wine can benefit from recognising that wine, like all microbial ecosystems, is subject to general ecological and evolutionary rules. In this piece, we outline how conceptual and methodological frameworks from community ecology and evolutionary biology can assist wine yeast researchers in improving wine fermentation processes by understanding the mechanisms governing population dynamics, predicting and engineering these important microcosms, and unlocking the genetic potential for wine strain development.Ministerio de Ciencia, Innovación y Universidades (España)Center for Computational, and Evolutionary and Human Genomics, University of Stanford (United States)Depto. de Genética, Fisiología y MicrobiologíaDepto. de Química AnalíticaFac. de Ciencias BiológicasFac. de Ciencias QuímicasTRUEpu
Understanding Interfacial Ice Premelting: Structure, Adhesion, and Nucleation
No full textThe interface of ice with solids plays an exceptionally important role on a wide variety of natural phenomena, such as the melting of permafrost, sliding of glaciers or frost heaving, as well as on many important technological applications such as windmills, car tires, or aircrafts. In this work, we perform a systematic computer simulation study of ice premelting and explore the thickness and structure of quasi-liquid layers formed at the interface of ice with substrates of different hydrophilicities. Our study shows that interfacial premelting occurs systematically on neutral substrates of whatever hydrophilicity, forming films of limited thickness for substrates with contact angles larger than ca. 50° but exhibiting complete interfacial premelting at smaller contact angles. Contrary to most experimental studies, we focus not only on the premelting behavior with temperature, but also with pressure, which is a matter of relevance in important situations such as ice friction. Our study is cast within a rigorous framework of surface thermodynamics, which allows us to show that the premelting film structure is a function of a single thermodynamic variable. By this token we are able to relate properties measured along an isobar, with premelting films at arbitrary temperature and pressure. Our results are also exploited to study ice adhesion, with a view to the understanding of icephobicity. We find that adhesion strength in atomically smooth surfaces is 1 to 2 orders of magnitude larger than those found in experiments, and conjecture that the reason is substrate roughness and the presence of organic adsorbents. Our theoretical framework also allows us to exploit our results on interfacial premelting in order to gain insight into heterogeneous ice nucleation. Our results show that apolar smooth substrates of whatever hydrophilicity are unlikely nucleators, and that too large hydrophilicity conspires also against ice nucleation. Furthermore, we exploit our statistical-thermodynamic framework to shed light on the nature of the surface intermolecular forces promoting interfacial premelting, and provide a model to predict quasi-liquid layer thickness as a function of the substrate’s hydrophilicity with great potential applications in fields ranging from earth sciences to aircraft engineering.Ministerio de Ciencia, Innovación y Universidades (MCIN)Polish National Agency for Academic ExchangeAcademic Supercomputer Center (CI TASK) in Gdansk.Depto. de Química FísicaFac. de Ciencias QuímicasTRUEpu
Optimización del aprendizaje mediante la utilización de una plataforma de evaluación virtual y interactiva
No full textDepto. de Inmunología, Oftalmología y ORLFac. de MedicinaFALSEsubmitte
Baliero y Córdova en Madrid. La estética de lo necesario y el Fondo Javier Feduchi
No full textComunidad de MadridEdiciones ComplutenseEdiciones ComplutenseTRUEpu
Association among clinical severity indicators, psychological health status and elastic properties of neck muscles in patients with chronic mechanical neck pain.
No full textAPC financiada por la UCM: para los acuerdos transformativos de la CRUE.Background: Since objective stifness measures are not consistent with the patients' perception and its correlation with the clinical severity of neck pain is not clear, novel studies assessing the clinical relevance of muscle stiffness are needed.
Objectives: To analyze the correlation among psychological factors, clinical severity indicators, and muscle stiffness in neck muscles in patients with chronic mechanical neck pain, and compare these factors with asymptomatic controls.
Methods: A cross-sectional observational study was conducted. Participants included cases with chronic neck pain and asymptomatic controls, assessed for muscle stiffness using shear wave elastography, psychological health (anxiety and kinesiophobia), and clinical severity. Data analysis involved correlation matrices and comparison between groups.
Results: Although no significant differences in levator scapulae stiffness were observed between groups (p > 0.05), patients exhibited significantly increased stiffness in the anterior scalene and cervical multifidus muscles (p = 0.009 and p = 0.040, respectively). STAI scores were significantly higher in patients for both subscales (STAI-S p = 0.002 and STAI-T p 0.05). Significant correlations between pain chronicity, intensity, disability, and psychological factors were confirmed. Notably, the levator scapulae stiffness was positively associated with disability, anxiety, and kinesiophobia (all p < 0.01). However, the anterior scalene and cervical multifidus stiffness, even if significantly associated with demographic factors (p < 0.05), were not associated with clinical or psychological outcomes.
Conclusion: The findings underscore the intertwined nature of psychological factors and muscle stiffness in chronic neck pain, suggesting the need for integrated approaches in treatment that consider both physical and psychological dimensions.Sección Deptal. de Radiología, Rehabilitación y Fisioterapia (Enfermería)Fac. de Enfermería, Fisioterapia y PodologíaTRUEpu
Santa María de Gradefes. En torno a los orígenes del archivo y datos para su reconstitución: un privilegio de 1172
No full textThe task of reconstituting an archive, through the incorporation of those documents that have disappeared, but that have somehow come down to us, is a historiographically useful, archivally convenient, and culturally valuable task. The objective of this article is to reconstruct a royal privilege of Fernando II addressed to the monastery of Santa María la Real de Gradefes in 1172. We have news of the missing document through the Tumbo of the monastery and a transfer of it in a fourteenth-century romance issued by the episcopal chancellery of León. The diploma deals with the recognition of the town of Gradefes and the granting of a monastic reserve on its limits. The diplomatic analysis of the monastery's documentary collection, the privileges of the Fernandina chancery and the transfer preserved in the Royal Chancery of Valladolid allow us to propose the incorporation of a new document to the monastic archive of Gradefes, increasing its collection.La tarea de reconstitución de un archivo, mediante la incorporación de aquellos documentos desaparecidos, pero que de alguna manera han llegado a nosotros, es una tarea, historiográficamente útil, archivísticamente conveniente y culturalmente de gran valor. El presente artículo tiene por objetivo reconstruir un privilegio regio de Fernando II dirigido al monasterio de Santa María la Real de Gradefes en 1172. Del documento desaparecido tenemos noticia a través del Tumbo del monasterio y de un traslado de este en romance del siglo XIV, emitido por la cancillería episcopal de León. El diploma versa sobre el reconocimiento de la villa de Gradefes y la concesión de coto monástico sobre sus límites.
El análisis diplomático de la colección documental del monasterio, de los privilegios de cancillería fernandina y del traslado conservado en la Real Chancillería de Valladolid nos permiten proponer la incorporación de un nuevo documento al archivo monástico de Gradefes aumentando su fondo.Depto. de Historia de América y Medieval y Ciencias HistoriográficasFac. de Ciencias de la DocumentaciónTRUEpu
Julio Mangas Manjarrés. Opera electa
No full textJulio Mangas Manjarrés, nacido el 3 de diciembre de 1940 en Alaejos-Valladolid y fallecido el 21 de octubre de 2022 en Salamanca, fue uno de los más destacados historiadores de la Antigüedad. Su dedicación e intensa labor a la universidad española abarca más de medio siglo, dejándonos una amplia lista de publicaciones, especialmente desde la Historia Social, introduciendo líneas de investigación muy novedosas, por los temas elegidos y la metodología aplicada. Entre sus múltiples aportaciones, muy centradas en la Hispania antigua, sobresalen sus reflexiones sobre la esclavitud y las poblaciones dependientes, la religión a partir del sacerdocio o el ritual mágico, la civitas y la organización político-administrativa romana, o sus lecturas de materiales epigráficos. Gran parte de estos trabajos mantienen su actualidad y no siempre son fáciles de encontrar; de ahí la publicación de esta Opera electa, que incluye algunos de sus estudios más relevantes y aún muy útiles para sus colegas, personas discípulas o jóvenes investigadoras. Quizás el profesor Mangas de la Universidad Complutense de Madrid hubiese optado por otra selección de sus obras, pero las editoras consideramos que las elegidas reflejan bien las inquietudes intelectuales y las aportaciones de quien vivió con pasión el estudio de las sociedades de la Antigüedad.Universidad de OviedoEdiciones ComplutenseDepto. de Prehistoria, Historia Antigua y ArqueologíaEdiciones ComplutenseTRUEpu