University of Verona
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Riti di passaggio. Cronaca costituzionale della transizione alla "seconda" Repubblica, 1992-1995
No full textGlossario delle occorrenza costituzionalistich
Così fan tutta, Milano, Teatro alla Scala, novembre 2025
No full textRecensione dello spettacolo, Milano Teatro alla Scala, novembre 202
Reply to the letter to the editor regarding "Insight into the abnormal cardiotocographic patterns following neuraxial analgesia for pain management in labor"
No full textReply to a letter to the Edito
Predicting epilepsy after new onset refractory status epilepticus due to autoimmune encephalitis: The DAME score
Get PDFObjective: This study aimed to identify risk factors and develop a predictive scoring system for autoimmune-associated epilepsy in subjects with autoimmune encephalitis presenting with new onset refractory status epilepticus (NORSE). Methods: This retrospective, multicenter, cohort study included subjects who presented with NORSE at the onset of autoimmune encephalitis and had at least 24 months of follow-up after immunotherapy. The outcome was the development of autoimmune-associated epilepsy, defined as persistent seizures despite adequate immunotherapy and absence of active inflammation. Factors independently associated with the outcome were identified through a backward stepwise selection. Adjusted regression coefficients of each independent predictor were transformed to produce a points-based risk-scoring system. Results: Seventy participants were included (median age = 24.2 years, 38.6% male). During a median follow-up of 53 months, 54.3% of subjects developed autoimmune-associated epilepsy. Status epilepticus duration ≥ 10 days (odds ratio [OR] = 31.14, 95% confidence interval [CI] = 2.12-456.87, p = .012), positivity for antibodies against surface antigens (OR = .12, 95% CI = .02-.85, p = .034), bitemporal magnetic resonance imaging (MRI) abnormalities suggestive of autoimmune encephalitis during acute stage (OR = 49.80, 95% CI = 2.95-841.77, p = .007), and interictal epileptiform discharges during electroencephalographic (EEG) follow-up (OR = 71.32, 95% CI = 6.48-785.32, p < .001) were independently associated with the study outcome. The duration-antibodies-MRI-EEG (DAME) score was developed as an integer-based scoring system predictive of autoimmune-associated epilepsy. With an optimal cutoff of ≥3 points, it yielded a sensitivity of 86.8%, a specificity of 87.5%, and an overall accuracy of 87.1%. Significance: The DAME score could serve as a user-friendly score to predict the risk of autoimmune-associated epilepsy in patients with NORSE due to autoimmune encephalitis
Sostenere i processi di transizione scuola-lavoro. Le Linee di indirizzo emerse dal Tavolo Interistituzionale promosso dall’Ufficio di Ambito Territoriale VIII dell’USR Veneto
No full textPercorso di sviluppo di competenze funzionali all'inserimento lavorativo di studentesse/studenti con disabilita
A Composer’s Progress: Stravinskij a Venezia
No full textRassegna critica della presenza di Igor' Stravinskij in iniziative culturali veneziane legate alla musica, sua ricezione e rapporto con la citta
Optimization of clinical research in Italy: the programmatic instances of the CARE Project
No full textIntroduction and objectives: Clinical research is a strategic priority for the Italian healthcare system, with significant benefits for patients, economy and public health. The Clinical Advancement & Research Excellence (CARE) project identified the main obstacles that limit the full expression of the potential of clinical trials in Italy and proposed concrete solutions. Methods: Starting with an online survey and following a simplified Delphi method, a multidisciplinary panel of experts identified the main barriers to clinical research in Italy and proposed a set of programmatic instances designed to improve the present situation. The final instances were formulated also based on the review by external stakeholders. Results: The following programmatic instances were developed: 1) support the compliance with trial contract signing times; 2) create a national standard for Clinical Trial Sites (CTS) and a dedicated portal; 3) define the role of General Practitioners; 4) promote campaigns to raise awareness on the importance of clinical research. Conclusions: The instances presented offer concrete insights to optimize the effectiveness and efficiency of clinical trials in Italy, ensuring international competitiveness and allowing patients to benefit from innovative therapies
Sequential Customized Phototherapeutic Keratectomy After Meniscus-shaped Stromal Lenticule Addition Keratoplasty in Kerotoconic Eyes
No full textPURPOSE: To assess the safety and effectiveness of sequential customized transepithelial phototherapeutic keratectomy (SCTK) performed after meniscus-shaped stromal lenticule addition keratoplasty (MS-SLAK) in patients with advanced keratoconus, with a focus on higher order aberrations (HOAs), corrected distance visual acuity (CDVA), and corneal biomechanics. METHODS: This prospective interventional study included patients previously treated with MS-SLAK for advanced keratoconus, showing corneal HOAs 3 pm or greater at a 4-mm pupil diameter and at least 200 pm of stromal thickness anterior to the implanted lenticule. All patients underwent SCTK using excimer laser ablation based on the corneal aberrometer, treating HOAs. Two sequential customized SCTK ablations were performed with intraoperative topographic reassessment. Patients were evaluated at baseline and at 3, 6, and 12 months postoperatively. Parameters included CDVA, manifest refraction spherical equivalent, corneal and ocular wavefront, tomographic data, and dynamic corneal response measurements. RESULTS: Six eyes from six patients were analyzed. The procedure resulted in significant visual improvement, with median spectacle CDVA improving from 20/125 to 20/32 at 12 months (P = .0001), and median contact lens CDVA reaching 20/25. HOAs significantly decreased, particularly root mean square (RMS) coma (from 3.3 (1.6) to 1.0 (0.5) pm, P = .02) and ocular RMS HOA (from 4.1 (1.8) to 1.8 (0.4) pm, P = .03). Corneal biomechanics remained stable throughout follow-up, with no signs of ectasia. CONCLUSIONS: SCTK following MS-SLAK seems an effective sequential treatment strategy in advanced keratoconus. Combining biomechanical reinforcement with optical surface regularization enhances visual function and reduces HOAs, and could offer a viable alternative to corneal transplantation in selected cases
Mechanical displacement of retinal arterial embolus during vitrectomy: A simplified surgical approach and literature review
No full textPurpose The management of retinal artery occlusion (RAO) remains controversial and lacks standardized guidelines. We report a case of branch retinal artery occlusion (BRAO) treated with pars plana vitrectomy (PPV) and mechanical embolus displacement 22 h after onset, along with a focused practical review of current surgical strategies.Methods A 50-year-old man with type 2 diabetes and hypertension presented with sudden visual loss and an inferior field defect in the left eye. After unsuccessful digital massage, IOP-lowering therapy, and anterior chamber paracentesis, a 25-G three-port PPV was performed 22 h after symptom onset. Posterior vitreous detachment was induced; intraoperative IOP was set at 8 mmHg; a diamond-dusted membrane scraper was used to gently displace and fragment the embolus distally. A PubMed search for qualitative synthesis identified 20 studies (61 eyes).Results Retinal perfusion was restored intraoperatively. Best-corrected visual acuity improved from counting fingers to 6/9 at 1 week and 6/6 at 1 month, remaining stable at 6 months. OCT showed resolution of inner retinal edema; fluorescein angiography confirmed complete reperfusion without recurrence. Literature analysis compared surgical approaches regarding PPV technique, invasiveness, timing, and visual outcomes versus non-invasive strategies.Conclusions PPV with minimally invasive embolus manipulation may restore retinal perfusion and achieve meaningful visual recovery beyond the conventional 4-6-h therapeutic window. This case in association with the reviewed literature suggest that in selected patients, vitrectomy, controlled IOP and targeted instrumentation is a viable and relatively safe option. Prospective trials are needed to define optimal timing, techniques, and patient selection
Francesco Pellegrini. Medico, storico e umanista veronese
No full textFrancesco Pellegrini nacque a Verona il 4 gennaio 1883, in una delle più nobili famiglie della città, figlio del conte Giuseppe e della marchesa Matilde di Canossa. Si laureò in Medicina e Chirurgia presso l’Università di Padova nel 1906 e, due anni più tardi, iniziò la carriera di ufficiale medico nell’esercito, progredendo fino al grado di tenente generale