Ardabil University of Medical Sciences
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Effects of French maritime pine bark extract (Oligopin®) supplementation on bone remodeling markers in postmenopausal osteopenic women: A randomized clinical trial
No full textFrench maritime pine bark extract (FMPBE; Oligopin®), a dietary supplement, is rich in procyanidin. The objective of this study was to determine the effects of FMPBE on bone remodeling in postmenopausal osteopenic women. This randomized, double-blinded, placebo-controlled clinical trial was conducted on 40 postmenopausal osteopenic women. Individuals were randomly assigned to either FMPBE (250 mg/day, n = 21) or placebo (250-mg starch/day, n = 19) for 12 weeks. Biochemical indices, including bone remodeling marker, were assessed before and after the intervention. After the 12-week intervention, that is, FMPBE supplementation, a significant increase in bone alkaline phosphatase (BAP), procollagen type 1 amino-terminal propeptide (P1NP) levels and a significant decrease in C-terminal telopeptide of type I collagen (CTx1) were observed. Compared with the control group, FMPBE supplementation resulted in a significant increase in P1NP (0.015), BAP levels (0.001), and BAP/CTx1 ratio (p = 0.001) and a significant decrease in CTx1 levels (0.006). FMPBE supplementation for 12 weeks in postmenopausal osteopenic women produced favorable effects on bone markers. Meanwhile, further research is needed to determine whether FMPBE supplements can be used as a preventive strategy for bone loss in postmenopausal osteopenic women.
Keywords: French maritime pine bark extract; Oligopin; bone remodeling; osteopenic; postmenopausal
The relationship between local systemic filling pressures with central venous pressure body
No full textBackground and Objective: Measurement of local systemic filling pressure in the bed causes to determine other hemodynamic parameters such as venous return, and the stressed volume. The aim of the present study was to evaluate the relationship between local systemic filling pressures with body central venous pressure.
Methods: In this study the patients were candidates to cardiac surgery in Ardebil Imam Khomeini hospital in the first half of 1397, with the consent of the patients, entered to the study. Then, from the distal of upper extremity an arterial line were kept, and a tourniquet was closed to the same arm, and the pressure of them were measured. Concurrently, the CVP of patient was measured. At the end of study the other parameters were gained from patients files, and the data was recorded separately.
Results: The 43 patients (71.7%) were man and 17 (28.3%) were women. The Mean CVP, Psf, CO, and CI were 8.3±4.5 mmHG, 17.0±6.1, 3.27±1.1, and 1.89±0.7, respectively. The 10 patients (16.7%) had mild heart failure, 42 patients (70%) had moderate heart failure, and 8 patients (13.3%) had severe heart failure. There were positive and significant relation between CVP and PSF (r=0.478: p=0.001). The EF status has no significant effects on CVP with SBP, DBP, MAP, CO and CI. There was significant and reverse correlation between PSF value with CO, and CI in severe heart failure (p<0.05).
Conclusion: The obtained results of study indicated that the PSF evaluation in comparison to CVP especially in sever heart failure patients had higher valu
Effect of Caparis Spinosa Alcoholic Extract on the Isolated Rat Pancreatic Islets
No full textObjective: From ancient time, plants were used to cure human diseases. Capparis spinosa L. belongs to the
Capparaceae family and was reported to have some biological activities such as cytotoxic, anti-inflammatory,
antimutagenic, antioxidant and anti-diabetic effect. It has very active chemical groups such as alkaloids, phenolic,
flavonoids, tannins, and many other minerals. Phenol compounds have antioxidant activity and can scavenge free
radicals so that plants containing these compounds have promissing effects for human health. Moreover, flower bud
pickles of C.spinosa are traditionally used as a food supplement for treatment of diabetes. The aim of this study was
to evaluate the effect of C.spinosa alcoholic extract on cellular viability and oxidative stress in rat pancreatic islets.
Material and Method: In this experimental set up, the male rats were anesthetized and their pancreas were removed,
then the islets of Langerhans were isolated and incubated in vitro for 24 hours. The islets were incubated with plant
extract for 24 hours after which cellular viability and production of reactive oxygen species were measured.
Results: The C.spinosa bud alcoholic extract markedly increased survival of the islet cells. This effect increased by
increasing the doses of extract and greatest effects were observed in 103 and 104 μgmL-1 (p <0.001). Also, at
mentioned concentrations, ROS production was reduced up to 37% (p <0.01) and 72 % (p <0.001) of control,
respectively.
Conclusion: Based on these results, we suggest that C.spinosa can be a promising candidate for prophylaxis and
treatment in therapeutic strategies of diabetes
Effect of low-level laser on controlling pain after clinical lengthening of tooth crown surgery
Get PDFBackground and objective: the effect of low-level laser on reducing pain after oral surgeries such as clinical tooth crown lengthening surgery has not yet been confirmed, and it is a controversial issue discussed in the studies. The aim of this study was to investigate the effect of low-level laser on reducing pain after clinical tooth crown lengthening surgery. Materials and Methods: The study is a clinical trial and the size of the samples consists of 30 patients undergone clinical tooth crown lengthening surgery. 15 patients were treated with laser radiation immediately after surgery, and the rest were treated with placebo laser irradiation. After that, the pain was assessed on the same day of laser radiation, the third day, and the seventh day following the surgery. After collecting data, they were analyzed by SPSS statistical software using t- test. P-values less than 0.05 were considered as statistically significant. Findings: The mean pain score in samples treated with laser therapy after surgery was less than those who were treated with placebo laser radiation, and this difference was statistically significant. (p <0.05). Conclusion: The results of this study indicate that low-level laser can reduce the severity of pain in clinical tooth crown lengthening surgery
Assessment of the Relationship Between Facial and Dental Midlines with Anatomical Landmarks of the Face and Oral Cavity
Get PDFObjective: The purpose of the present study was to determine the facial anatomical landmarks, in order of accuracy, closest to the midline of the face, as well as oral cavity midline, and to specify which intraoral anatomical landmarks are closer to the dental midline.
Methods: Three commonly used anatomical landmarks including nasion, nose, and philtrum tips were marked clinically in 108 subjects. A frontal full-face digital image was used for midline analysis in accordance with the esthetic frame. Deviations from the facial and oral midlines were measured for the three clinical landmarks. Dental midline was considered as the fourth landmark. Alginate impressions were taken, and casts were analyzed under standardized conditions. The labial frenum and incisive papilla were marked. Cast images were taken and analyzed.
Results: Data showed difference between the mean ratios of the selected anatomical landmarks and the facial and oral midlines (p≤0/05). The anatomical landmark hierarchies, in proximity to the facial midline, are commissural midlines, nasion, philtrum tip, nose tip, and dental midline, respectively. The anatomical landmark hierarchies, in proximity to the commissural midline, include dental midline, philtrum tip, nose tip, and nasion. The labial frenum was less deviated from the dental midline than the incisive papilla.
Conclusion: With respect to shortcomings, the results showed that all of the anatomical landmarks were deviated from the facial and oral midlines. The order of proximity of the anatomical landmarks to the facial midline was as follows: commissural midline, nasion, philtrum, and dental midline
Study complications and follow-up outcomes of preterm infants hospitalized in Ardabil city hospital in 2016
Get PDFBackground: Preterm birth is one of the leading and direct causes of newborn mortality. The aim of this was to study complications and follow-up outcomes of preterm infants hospitalized in Ardabil city hospital in 2016. Methodology: This cross-sectional study was conducted on 73 preterm babies at Ardabil city hospital in 2016. The research-based checklist included demographics, and the outcome data were completed through the infant�s examination and by studying hospital files. Collected data were analyzed by statistical methods in statistical package for the social sciences v.19. Results: The rate of mortality was 21.2%, and the rate of developmental disorders (DD) was 26.2%. The main preterm infant�s problems were respiratory distress syndrome (RDS) and ICTER, respectively. There was a significant inverse relation between gestational age (GA) and birth weight with the rate of mortality and developmental disorders. The relationship between sex and mortality rate was not significant. There was a significant relation between DD with RDS, age of infants, weight and round head of infants in 6 months. Conclusion: Results showed that preterm infants are at risk for DD and mortality in comparison with full-term infants. Hence, specialized care for them is essential in the future
Preparation and Characterization of Sustained Release Scaffold Containing Tetracycline in Periodontal Infections
No full textIntroduction
Periodontitis is a chronic inflammatory disease that affects the integrity of the supporting tissues of the tooth, including the gingiva, periodontal ligament and alveolar bone, which are generally known as the periodontium. The local delivery of antibiotics offers the potential for reaching and maintaining the therapeutic concentration at the site of the infection; since in this method drug is directly applied to the site, the concentration of the drug can be significantly
higher than the systemic ones. Several degradable and non- degradable devices were developed for the delivery of
antimicrobial agents into the periodontal pocket. In recent years, functional biomaterial research has been directed
towards the development of improved scaffolds and novel drug delivery systems. The aim of this study was to develop
a local delivery device, Sodium Alginate/CMCNa/ Adipic acid dihydrazide (NaAlg/CMCNa/ADH) scaffold, which
allows the sustained release of tetracycline to effectively control local infection in periodontitis.
Methods
In the present work, NaAlg/CMCNa/ADH scaffold synthesized by freeze-drying 2.5% polymer solution. Adipic acid
dihydrazide (ADH) was added as crosslinker and N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
(EDC) and 1-Hydroxybenzotriazole hydrate (HOBt) were added as Carboxyl group activator. Then dialysis was
performed for 3 days against distilled water. In order to drying, the gel was poured into plates and lyophilized at -45 ° C for 24 hours. Then Samples were immersed in tetracycline solution vials for 48 hours in dark condition. The scaffolds were then dried by freeze-drying method for 24 hours. Finally, the scaffolds were evaluated by SEM, FTIR,
1H NMR, Swelling test, and TG/DTA. The amount of tetracycline released from the scaffolds was analyzed by
spectrophotometry in PBS solution. Triplicate experiments were performed for each sample and expressed as means±
standard deviation.
Results
The synthesized scaffolds had porous structure according to SEM images and in the scaffolds containing tetracycline
the porous macrostructure was intact. In the FTIR spectra of NaAlg/CMCNa/ADH scaffold, the shoulder was seen at
1645 cm-1 Which indicates the formation of amide bond. The average water uptake of scaffolds was 93.216% ± 4.419.
Scaffolds loaded by tetracycline showed sustained release pattern and were able to release 68% of drug up to 72 hours
(figure1).
Conclusion
The NaAlg/CMCNa/ADH scaffolds could be beneficial in the management of periodontal infections and were suitable
as a slow‐release device for tetracycline
The Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Women in IRAN: A review study
No full textBackground: Human Papillomavirus (HPV) was initially recognized in patient with cervical cancer and is one of the most important sexually transmitted viruses in the world. There are over 200 unique HPV genotypes that have been confirmed, of which 30 to 40 are categorized on the basis of their oncogenic potential as high- risk and low- risk leading to cervical neoplasia and miled dysplasia. HPV vaccination is currently not included in the national vaccination program in Iran. Regional data on the distribution of HPV types in women are important as they can predict the impact of currently available vaccines and help health policy makers to consider all the possibilities with regard to HPV vaccination. In this review study we sought to determine the prevalence and Genotype distribution of HPV in Iranian women.
Materials and Methods: This study was a simple review and prevalence rate of HPV in Iran was investigated from 2008-2018 using several databases including Cochrane, Scopus, Medline, Web of Science, Embase, Google Scholar, Iran medex, and Scientific Information Database with keywords: Human Papillomavirus, HPV Genotypes, HPV Prevalence. 16 articles were selected based on the research criteria.
Results: Result showed that among the HR and LR types, HPV-6 was the major genotype 64.8%. Type 16 and 18 were the most frequent HR-HPV types (presented in 26% of the patient). Multiple HPV infections were presented in 40.7% of the positive genotyping specimens.
Conclusion: The results of the present study underscore the need for further enforcement of STD control strategies in Iran. Higher frequency of HPV among the collected isolates and also the higher prevalence of HPV types 6, 16, 18. It seems that HPV vaccination as well as an organized prevention program can be safe and efficient to reduce HPV types.
Keywords: Human Papillomavirus, HPV Genotypes, HPV Prevalence
Transvaginal ultrasound compared with serum β-hCG level for diagnosis of ectopic pregnancy in symptomatic patients
Get PDFBackground: Ultrasonography (US) is the most important imaging modality in detecting both intrauterine and ectopic pregnancies. The aim of this study was to comparison transvaginal ultrasound with serum β-hCG level for diagnosis of ectopic pregnancy (Ep) in referred women to Ardabil city hospital.
Methods: In this cross-sectional study, a total of 207 women with diagnosis of Ep were enrolled during 2018. All women underwent transvaginal US in the first 24 hours and US done by an expert radiologist. Serum levels of β-hCG at first 24 hours and the time gap between US examination and last menstrual period (LMP) were compared between women with positive and negative US findings. Data collected by a checklist and analyzed by statistical method in SPSS version 21.
Results: The primary US were positive in 174 women (84.1%) and negative in 33 women (15.9%). The mean of time gap between US and LMP in women with diagnosed EP was significantly higher than other women (median, 42 days versus 45 days, p=0.042). Also, the mean of serum level of β-hCG had significant difference between two groups. In logistic regression analysis results showed that the time gap between US and LMP hadn’t significant impact on EP diagnosis. The best discriminative zone was set at a serum β-hCG level of 105.65 mIU/ml with a sensitivity and specificity of 82% and 27%, respectively and the under-ROC area was 58%.
Conclusions: According to our findings, the median serum level of β-hCG in women with undiagnosed Ep were significantly lower than women with correct diagnosis of Ep but the mean and median of time gap between US and LMP in women with diagnosed EP was more than women without Ep. Also, the proposed discriminative zone for serum level of β-hCG in our study is different from the previous studies
The Effect of Vitamin D on the Treatment of Patients with Chronic Musculoskeletal Pain with Serum Vitamin D Deficiency
No full textBackground and objective: Vitamin D deficiency is a major health problem and has been addressed in many parts of the world and is not limited to areas with low sunlight and even in areas with high sunlight. Vitamin D deficiency is a widespread and serious problem worldwide, and is unexpectedly high in sunny countries such as the Middle East. Therefore, the main purpose of this study was to evaluate the effect of vitamin D in the treatment of patients with chronic musculoskeletal pain with serum vitamin D deficiency.
Method: This research is a quasi-experimental study (pre-test-post-test). The statistical population of the study is patients with chronic musculoskeletal pain in the age range of 15-45 years referred to orthopedic clinic of Fatemi hospital in 2019. The sample consisted of 40 patients that according to the orthopedic expert and the results of the tests, their vitamin D level was less than 30 ng/ml. The study sample received intervention for ten weeks. Patients with a serum vitamin D deficiency below 10ng/ml (deficient) received a 300,000 unit dose of vitamin D every two weeks (6) and a 50,000 unit dose of vitamin D tablet each week, and patients with a vitamin D level between 10 to 30 (Insufficient) Every two weeks they received 300,000 units of vitamin D (3 Ampoules) and 50,000 units of vitamin D tablets each week. Data were collected during pre-test and post-test using demographic questionnaire and NRS pain numeric rating scale.
Results: The results of the study showed that the level of pain in patients with chronic musculoskeletal pain before vitamin D administration was above average level and after intervention it was lower than average level. Also, serum levels of vitamin D in patients with chronic musculoskeletal pain after vitamin D administration were higher than the average level and also, serum levels of vitamin D before and after the intervention were significantly different. Finally, the findings showed that the level of pain in patients with chronic musculoskeletal pain before and after vitamin D administration was significantly different.
Conclusion: After administration of vitamin D, serum levels of vitamin D are increased in patients with chronic musculoskeletal pain. also, with increasing serum vitamin D levels, patients' pain levels decrease. Therefore, it can be said that the level of pain in patients with chronic musculoskeletal pain after vitamin D administration is significantly reduced and therefore dietary enrichment with vitamin D is suggested