Ardabil University of Medical Sciences
ArUMS Digital Repository (سامانه اطلاعات زیست پزشکی و سلامت)Not a member yet
7752 research outputs found
Sort by
Clozapine-induced Toxicity via Induction of Oxidative Stress and Mitochondrial Dysfunction in Human Blood Lymphocytes and Protecting role of L-Carnitine
No full textClozapine is a useful antipsychotic drug but with serious, life threatening toxicity effects. The aim of this study is to assess the direct cytotoxicity effect of clozapine (CLZ) on human blood lymphocytes and investigate the protective effect of L‐carnitine (LC) against clozapine‐induced cytotoxicity. Clozapine at 70 μM concentration induced cytotoxicity following 12 h. The Clozapine induced cytotoxicity was associated with intracellular reactive oxygen species (ROS) generation, mitochondrial membrane potential (MMP) collapse, lysosomal membrane injury, lipid peroxidation, and depletion of glutathione (GSH) and raising of oxidized glutathione (GSSG). We showed that LC (1 mM) has a beneficial cytoprotective effect against clozapineinduced toxicity. Summery, clozapine causes organelles damages and triggers oxidative stress in lymphocytes. These data suggest that using of L‐carnitine could be useful for prevention and treatment of clozapine toxicity. Finally, it could be concluded that LC exerts a beneficial antioxidant and mitochondrial protective effects against oxidative stress induced by CLZ
Prospective evaluation of the effect of mandibular implant overdenture on Peri-implant Tissues
Get PDFIntroduction: Implant-supported over-dentures (IODs) are an accepted and predictable form of treatment for the edentulous jaw. The purpose of this prospective clinical study was to evaluate the effect of mandibular implant overdenture on Peri-implant Tissues
Materials and Methods: A prospective study was carried out with 24 edentulous patients (n = 24; mean age 67.13 years). In all patients, two dental implants were placed in the interforaminal region of the mandible and after a 3-month healing period overdentures were fabricated .Clinical and radiographic parameters were evaluated 6 and 12 month after completion of the prosthetic treatment . Implant loss, bleeding on probing , gingival recession , Attachment level and probing depth were assessed as clinical parameters. Peri-implant bone loss was assessed on dental radiographs taken with a paralleling technique . Peri-implant tissue health was assessed, and the presence of mucositis and peri-implantitis was recorded
Results: 24 patients who received 48 implants were evaluated. The average marginal bone loss of patients was 0.33mm after 6 month of evaluation and 0.63mm after one years . the mean probing depth was 1.89mm and 2.19mm respectively after 6 and 12 month of evaluation . No implants were lost and no peri implantitis occurred. the survival rate was 100% after one year of function.
Conclusion: Considering the limitations of this short term clinical study, two implants to retain mandibular overdentures seems to be a feasible treatment option with a high survival rate for patients with insufficient jawbone volume
Evaluation of serum levels of Decoy Receptor 3 and IL-6 in COPD patients
Get PDFBackground & Objective: The serum decoy receptor 3 (DcR3) level increases in chronic inflammatory diseases. The present study aimed to examine serum DcR3 and IL-6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) and the correlation of this markers with airflow limitation.
Methods: We measured serum DcR3 and IL-6 levels in 60 COPD patients (30 stable COPD (SCOPD), and 30 acute exacerbation of COPD (AECOPD)), and 30 control subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, peripheral O2 saturation (SpO2), and COPD Assessment Test (CAT) score. We also tested the association of serum DcR3 level with COPD patients’ clinical parameters.
Results: Both serum DcR3 and IL-6 levels increased with increasing severity of airflow limitation in SCOPD and AECOPD groups (P < 0.01 to P < 0.001, respectively). It also increased in patients with AECOPD group compared with SCOPD group in GOLD stages III-IV (P < 0.05 to P < 0.001, respectively). In addition, there was a significant positive correlation between serum DcR3 level and IL-6, CAT score and Smoking history (per year).
Conclusion: The study showed that serum DcR3 level increased with an increasing severity of airflow limitation in COPD patients, markedly in acute exacerbation phase. This increase was associated with a reduced quality of life and increased severity of hypoxia. These results suggest that DcR3 in COPD patients may be participate with its pathophysiology
Aesthetic outcome of the implant crowns of anterior maxillary teeth in immediate and delayed method
Get PDFIntroduction: in the modern and advanced today dentistry,implant teratment is one of the best replacement method of the missing tooth. specially implants of anterior maxillary edentulus site that have high influence to esthetic and self confidence of patients.
Materials and Methods: In this study 34 patients from one office taht have intrusion criteria and need to replacement anterior one tooth including one of the superior canine to canine by one implant, was selected. patient are divided to 2 groups .first group are treated by immediate loading implant, second group by delayed loading implant. 12 month after replacment of crowns , WES scores was recorded for checking of esthetic outcome. this index was compered to standard clinical photos and evaluated by two prosthodontics. finally, after collection information by questionare was analysed in the spss 19 with independen T test and and man vitni u test (P value 0/05).
Results: results show that esthetic oute come (WES) of maxillary anterior implant crowns , in the delayed loading (6.59±0.795) and in the immediate loading (6.94±0.827) was acceptable to standards.(p>0.05).but no significant difference was observed in the esthetic oute come (WES) anterior maxillary implant crowns in the immediate and delayed loading. so that color , general tooth form, outline and volume of clinical crown, surface texture, translucency of anterior maxillary implant crowns in the immediate and delayed loading was not significant difference (p>0.05).
Conclusion: According to proper esthetic out come of anterior maxillary teeth in the immediate and delayed loading method , confirmation in this study , previous studies, use of this method for esthetic of implant was offered
Clinical evalution of metal-ceramic crowns and fixed partial denture made by dental students at the dental faculty of Ardabil university of medical sciences in 2016-2018
Get PDFIntroduction: The complications of fixed partial dentures and single crowns have a great importance to be evaluated. The objectives of this study were to determine the prevalence of complications associated with crowns and bridges and the effect of service duration on the prevalence of complications among a Population Presenting for Treatment to a Dental School in Ardebil. A total of 40 patients were selected. Qualities of the present fixed partial dentures were clinically and radiographically assessed. Clinical examinationwas performed. The results of this study showed that the percentage of the failures were Periodontal disease (53.8%), Open contact (25.6%), porcelain fracture (20.5%), open margins (10.3%), Occlusal problem (7.7%), Poor esthetics (7.7%) ,prostheses loose (5.1%) and endodontic complications (0%). The duration of service was found to influence most of the assessed complications especially periodontal disease and open contact. With limitation of this study, the periodontal disease and gingival bleeding are the most frequent complications responsible for failure of fixed partial denture and single crowns that recommend an effective method to control dental diseases and to improve dental awareness.
Method and Materials: A total of 40 patients (age range of 20-60 years, 15 of the participants were females and 25 males) were selected randomly from the dental clinic at Ardebil Medical College, Dentistry Program. A sample questionnaire will prepared in order to collect the relevant data. All prostheses will be performed by several general dental practitioners with a minimum of one year service duration. Patients will informed and written consents will be obtained. Age, gender and the time of prostheses placement will be recorded. Complete clinical and radiographic examinations will be conducted. Statistical analysis was done using a Statistical Package for Social Science (SPSS, version 22). Descriptive statistics, including means and standard deviations were calculated for continuous variables, frequency and percentage for categorical variables, were calculated
Results: With limitation of this study, the periodontal disease and open contact are the most frequent complications responsible for failure of fixed partial denture and single crowns
Investigating of the relationship between blood type and Rh with obstructive and non obstructive coronary disease
No full textBackground and abjective: Considering the high prevalence and the mortality and morbidity of CVD and the various the importance of etiologic studies, and there are some reports of blood group and Rh in the incidence of diseases including CVD, to investigate the relationship between blood groups and Rh obstructive and nonobstructive coronary disease and other risk factors, this study was conducted in patients hospitalized in Imam Khomeini
Methods: This case-control study was performed in Imam Khomeini Hospital, Ardabil, Iran, from December 2018 to August 2019. The target population included the case and control groups. Inclusion criteria in the case group included patients with coronary artery obstruction diagnosed by angiography more than 50% and the control group included patients with normal angiography, all age groups were of both sexes. All patient information through checklists including blood group variables, Rh, age, sex, fasting blood sugar, cholesterol, triglycerides, LDL, HDL, blood pressure and location Residence was recorded. Finally, all the data from the checklists were entered into SPSS 23 program and analyzed.
Results: In this study, 462 patients undergoing coronary angiography were studied. 231 patients with coronary artery occlusion in the case group and 231 patients without coronary artery occlusion in the control group. There was a significant relationship between blood groups and coronary artery disease in the case and control groups, but there was no significant relationship between Rh and coronary artery disease in the case and control groups. In both case and control groups, there was a significant relationship between blood and Rh groups with hyperlipidemia and also in the control group between Rh and diabetes. But no significant relationship was found between blood and Rh groups with hypertension and diabetes in case and control groups
Conclusion: There was a significant relationship between the blood groups and the incidence of coronary artery disease. blood group O had a protective role against coronary artery disease, but blood group AB had a significant risk factor for coronary artery disease. No association was found between Rh and obstructive and non-obstructive coronary artery diseas
Pediatric Immunology
No full textPeriodic fever aphthous stomatitis pharyngitis adenitis (PFAPA), also known as Marshall syndrome, is the most commonly identified periodic fever syndrome
Treatment of PFAPA is a matter of debate. NSAIDs may provide symptomatic relief and shorten the duration of an episode, but decrease the length of the symptom-free interva
Effectivness of Intravenous Acetaminophen and Ondansetron in Prevention of Post Appendectomy Shivering In General Anesthesia Method
Get PDFBackground and Objective: Postoperative shivering is characterized by involuntary movements of one or more muscle groups in the early stages of recovery after a general anesthesia. This complication can lead to many problems for patients. In this study, we evaluated the efficacy of intravenous Acetaminophen and Ondansetron in preventing of shivering in patients undergoing general anesthesia with appendicitis diagnosis and compared the efficacy of each.
Methods: This study is a triple blind clinical trial. It was conducted on 150 patients with ASA class I and II undergoing appendectomy with general anesthesia in Fatemi Hospital affiliated by ARUMS during 2017-18. These patients were randomly divided into three groups of Acetaminophen and Ondansetron and placebo. Patients were unaware of the type of drug received. Half an hour before surgery, drugs were injected in groups, then the endotracheal tube was removed and the patients were transferred to the recovery room and shivering was measured up to half an hour after the operation.
Results: Survey of demographic data showed that there was no significant difference between sexes, mean age, weight average and ASA distribution in study groups in three groups(p>0.05). Incidence and severity of shivering in recovery room in Ondansetron group were significantly lower than Acetaminophen group and placebo group (p<0/05). Evaluation of the incidence of nausea and vomiting in the recovery room in the group receiving ondansetron was significantly lower than the other two groups (p<0/05). VAS-based pain assessment was indicated at recovery room, where pain score in ondansetron group was significantly higher than other groups and acetaminophen had the greatest effect on pain relief (p<0/05).
coclusion: This study showed that ondansetron is a suitable and effective option in the prevention of postoperative shivering. According to the results, decreasing nausea and vomiting in the ondansetron group could also be another advantage of ondansetron
Particulate matters and bioaerosols during Middle East dust storms events in Ilam, Iran
No full textParticulate matters can be transferred distances from their sources. Due to different chemical and microbial characteristics, they can potentially impact on public health and ecosystems. Therefore, in this study we aimed to study the concentrations of particulate matters (PM2.5 and PM10) and types of bacteria in the ambient air of Ilam city during dusty (PM10 ≥ 150 µg/m3) and non-dusty days from February 2012 to February 2013. Totally, there existed more dust storm events during warm and dry months. The Mann-Whitney test confirmed a significant relationship between dusty and non-dusty days (P < 0.05). Totally, by increasing the PM concentrations, the number of bacterial colonies increased. Kruskal-Wallis test showed that there was a significant relationship between the number of bacterial colonies and season. The mostly observed bacterial colonies were Staphylococcus, Cryptococcus, Corynebacterium, Bacillus, Actinosynnema, Nocardioides, Arthrobacter, Flavimonas, Paenibacillus, Pseudomonas, Microbacterium, Planococcus, Streptomyces, Kurthia, Neisseria Agrococcus, Curtobacterium, Duganella, Ancylobacter, Paracoccus, Propionibacterium, Pseudomonas, Rhizobium and Enterococci. The predominant direction of dust plumes in Ilam city was from the west of Ilam from neighboring countries. The higher number of microbial colonies during dusty days in this city obviously showed the important role of these events on microbial characteristics