Ardabil University of Medical Sciences
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The Effect of Aspirin in Prevention of Catheter Thrombosis and Increased internal Jugular Venous Catheter permanence
Get PDFBackground and Objective: Chronic renal failure is associated with irreversible loss of renal function. If disease was reached this stage needs dialysis. Central cardiac dialysis patients often work due to the formation of clots in the lumen or in the veins, with the prevalence of this disorder reaching 63%. cause of the formation of a clot in the catheter pathway is not well known, and in limited cases, a specific cause for the formation of a clot in the catheter can be found. Recent studies have also shown that aspirin acts not only as an anti-clot drug but also reduces oxidative stress and inflammation. While many studies suggest that platelet function impairs renal failure, several studies have shown that platelet aggregation increases during dialysis. Due to the relatively high prevalence of catheter failure due to thrombosis and the cost of replacing the catheter in these systems, we decided to study the effect of aspirin on prevention of Jugular vein catheter thrombosis and prolonged shelf-life Catheter.
Methods: This interventional study was performed on 114 patients. 114 patients were randomly divided into two groups of 57. Background information such as age, sex, cause of renal failure, concomitant diseases such as diabetes or hypertension, history of cardiovascular and stroke, peripheral vascular diseases, history of statin use or anti-clot drugs were obtained from patients in order to determine their possible effect on the two groups of intervention and control. Catheter size was 14 in all patients. A group of 57 patients was treated with 80 mg daily aspirin regimen. The control group was also treated with placebo. The number of catheter functioning days as well as demographic characteristics of the patients were obtained through a questionnaire and file information.
Results: The mean age of patients was 66.5 years and the standard deviation was 11.04. The mean age of the intervention group was 68.78 and the standard deviation was 9/80 and the mean age of the control group was 22/64 with a standard deviation of 11/80. Statistical analysis showed a significant relationship between the use of aspirin and the prevention of catheter thrombosis. This is more true in diabetics and male sex.
Conclusion:. Aspirin is recommended in patients with a permanent cathete
Comparison of Salivary Catalase and Superoxide Dismutase Levels in Women With Gestational Diabetes Mellitus and Non-diabetic Pregnant Women in Patients Referring to Boali Hospital in Ardabil in 2018- 2019
Get PDFIntroduction: Pregnancy is considered a stressful event, results in higher levels of oxidative stress and considerable changes in physiological and metabolic functions such as gestational diabetes mellitus (GDM). Due to the cumulative effect of antioxidants and considering the controversies in this area, this study was undertaken to investigate the catalase and superoxide dismotase of saliva in pregnant women whit gestational diabetes in comparison to nondiabetic pregnant women.
Method and Materials: In this cross-sectional study, unstimulated saliva of 29 patients with gestational diabetes and 56 non-diabetic pregnant patients were collected and amounts of salivary catalase and superoxide dismotase were assessed separately in these individuals. Data obtained from the study was statistically analyzed using descriptive statistics methods and Mann-Whitney test.
Results: P<0.05 was considered as significant in all tests. The mean value of salivary catalase level was 0.25±0.42 in women with gestational diabetes and 0.22 ±0.14 in non-diabetic pregnant women. The mean value of superoxide dismotase level in the saliva was 0.95±0.63 in women with gestational diabetes and 0.44 ±0.83 in non-diabetic pregnant women. According to the data obtained from this study, it could be stated that in women with gestational diabetes the level of catalase and superoxide dismotase are increased ,compared with nondiabetic pregnant women, but none of these changes are significant
Sleep quality and related factors in the elderly
Get PDFBackground and objective: environmental factors are efficiency in the hospital patient sleep. Increase stimulation and Inappropriate the environmental conditions lead to disturbing sleep of patients. The aim of the study was to evaluate sleep quality and related factors in elderly hospitalized imam Khomeini Ardabil.
Materials and Methods: This a cross sectional study was performed by method probability sampling Available in 200 elderly patients of Internal Medicine and Surgery parts in the year 2019. The data Was analyzed by SPSS version 21 software, descriptive statistics and tests Pearson correlation test and T test at the significant level P<0/ 05.
findinds: In this study Of total the participants, were 150 patients (75%) male. The average age of the study population was 7.99 ± 70.96 years. The average score of sleep quality was in older women 2.85 ± 22.64 and in older man 3.1 ± 22.36 . moderate sleep quality were in elderly participants More at better in elderly women . The sleep quality in elderly people complained from the light, cold, heat, personnel, together patients and crew sound and the unpleasant smell Was lower than that of other the elderly. the sleep quality scores was a significant relationship with hypertension ( p=0/02) , History of fracture (p =0.001), and sound personnel (p =0.006). was not statistically significant Gender, environmental factors (cold, heat, light, sound, smell undesirable companions and inappropriate bed) and field diseases (diabetes, history of stroke or heart disease, incontinence and respiratory diseases and pain) associated with sleep quality scores (p> 0/05).
Conclusions: Improving the environmental factors of the basic elements that can affect the sleep process. Considering the fact that older people have sleep disorders than other groups to consider these factors is more important for this group.
Key words: quality sleep, elderly, related factor
MEFV gene and Kawasaki disease, Is there any association between MEFV gene mutations and Kawasaki disease?
No full textBackground and objective: Kawasaki disease (KD) is an acute febrile, self-limiting, and systemic vasculitis of unknown etiology. MEFV gene has a major role in autoinflammatory disorders and innate immune reactions. Several reports revealed that MEFV gene mutations are associated with systemic vasculitis. The aim of this study was to determine the association between KD and MEFV gene mutations.
Methods: The peripheral blood of 30 patients who were diagnosed with KD based on ACC criteria were collected and the samples screened for the 12 common pathogenic variants according to manufacturer’s instructions.
Results: The mean age of patients (13 females and 17 males) was 7.7 years. Ten percent of patients showed a mutation, that was meaningfully (p<0.05%) lower than that of healthy controls (25%). E148Q was shown in two patients and compound heterozygous (E148Q-M680I) was detected in one of them with lack of FMF presentations. No significant and meaningful associations were detected between the MEFV gene variant alleles and KD.
Conclusion:Unlike in other types of pediatric vasculitis, this study did not reveal any significant association between the MEFV gene mutations and KD, moreover, because of the lower frequency of mutations in these patients, it seems that this gene has a modifier and/or protective role in KD
Age estimation based on pulp chamber volume by CBCT
Get PDFIntroduction:Identify age in anthropology, forensic and verify the growth of children and adolescents is important. Age estimation method using teeth, is particularly valuable. This study sought to assess the accuracy of age estimation by the Kvaal’s method using cone beam computed tomography (CBCT) scans of mandibular canine teeth in an Iranian population.
Materials and Methods: In this cross-validation study, information of 180 sample (95 Female and 85 Man) was collected from the files of patients presenting to RAD oral and maxillofacial radiology clinic. The parameters used in the Kvaal’s method were measured in the mandibular canine teeth on CBCT scans of the patients.First, the regression formula suggested by Kvaal et al, was used for age estimation. Then we designed our own formula for age estimation in our Iranian population and the fitness of statistical model was assessed.
Results: The results showed that there was no significant relationship between estimated age of men using Kvaal's method and biological age. Also, the variables of root pulp length and root width in the middle region of the root are good predictors of age in men, and the variables of tooth length, root width in the CEJ region, root width in the midpoint between A and C, root width in the middle region of the root are good predictors of age in women.
Conclusion: The Kvaal’s formula was not suitable for use in our Iranian population. We did not obtain suitable results with the use of our own designed regression formula either
Evaluation of professionalism indicators by physicians working in educational hospitals in Ardabil in 2018
Get PDFBackground and Objective: Professionalism is one of the central pillars of the medical profession because of its close relationship with the improvement of physician-patient relationships, patient satisfaction, employee satisfaction in the healthcare delivery profession, and even health care outcomes. Studying professional evaluation is important as one of the most important competencies in the medical profession and since promoting professionalism is one of the goals of any medical school, it will be an essential element in evaluating professional behavior.
Methods: The sample size was 100 persons. PSCOM professional questionnaire (including:Accounatability, Altrurism, Duty, Enrichment, Honor & Integrity,Respect) was used as data gathering tool after determining its face and content validity. Data were collected in three ways: 1(through department heads, who reviewed their group members through a research instrument; 2) through hospital educational deputies, who presented their views during the research instrument; 3) medical students in the position of residency and intern were evaluate their professors by research tools. In this evaluation, 100 questionnaires were completed by students for 100 physicians and sixty-nine questionnaires were completed by ten heads of departments and three educational assistants. SPSS 25 software was used for data analysis. T-test and one-way anova were used to analyze the relationship between gender, group, and hospital variables with professionalism indices.
Results: In this study, 21 female physicians and 79 male physicians were studied for compliance with professional standards by 100 students and 69 physicians by hospital department heads and teaching assistant. The index of “Doctors coverage is respectful of others” scored 4.89 out of 5”. Students scored the highest score (4.97 out of 5) on the index of “It behaves in a way that indicates a commitment to privacy” and the lowest score (4.26) on the index of “striving for welfare and partner development” (Table 4-2).
Conclusion: The results of this study showed that the use of professionalism indices among specialist physicians working in hospitals was good and regarded in evaluating both hospital managers and educational deputies and students' evaluation
Ecological Niche Modeling of West Nile Virus Vector in Northwest of Iran
Get PDFObjectives: West Nile virus (WNV ) is a microorganism and the leading cause of the
spread of fatal diseases in horses, birds, and humans. The etiologic agent of West Nile
fever belongs to the genus Flavivirus that is transmitted by Culex mosquitoes in Iran
and throughout the world. We aimed to evaluate the distribution of WNV vectors in
northwest of Iran ecological niche modeling. Methods: This cross-sectional study was
conducted in Ardabil province in one year, from January to December with the samples
captured from May to November 2017. Forty-five locations from all 10 counties of the
province were selected randomly to determine the seasonal activity of mosquitoes. Larval
collection was carried out twice a month. MaxEnt version 3.3, ArcMap 10.3 software,
jackknife, and crew methods were used to determine the impact of climatic change and
environmental factors on the distribution of mosquito species. Results: A total of 2000
larva were collected, 1789 (89.5%) of which were Culex larvae. Seven species of Culex
genus were identified, including Culex pipiens, Cx. modestus, Cx. theileri, Cx. hortensis,
Cx. perexiguus, Cx. tritaeniorhynchus, and Cx. mimeticus. Two important ecological niche
areas were identified in the north and south of the province. The annual temperature and
rainfall in the cold seasons were the most important factors affecting the distribution
of Culex species larva. Cx. pipiens was identified as the main vector of WNV vectors
with high frequency in Ardabil province. Conclusions: Two large areas were found
as the ecological niches of larvae of these species. It is recommended that additional
investigations be carried out on infection in adult female Cx. pipiens and its hosts in
these areas
Causes of conflict between clinical and administrative staff in hospitals
No full textBACKGROUND: Providing the high-quality services in hospitals depends on to minimize conflict between all members within a health team. This study aimed to identify the causes of conflicts experienced by clinical and administrative staff in hospitals.
METHODS: A cross-sectional study was carried out in 2018. The sample included 320 clinical and administrative staff from six hospitals affiliated to Ardabil University of Medical Sciences that were selected using two-step clustering sampling method. Data collection was accomplished by self-administered questionnaires. Descriptive statistics, t-test, and ANOVA were used for data analysis.
RESULTS: Total conflict score revealed that clinical staff had higher levels of perceived conflict than administrative staff. In terms of organizational position, the study results showed a significant difference in the reported conflict between nurse groups and other groups (physicians and paramedical, administrative, financial, and logistic staff). The most important causes of conflict in the viewpoint of clinical staff were organizational and job characteristics (3.54 ± 1.28), poor management (3.51 ± 1.12), and inefficient communication system (3.42 ± 1.33). For administrative staff, on the other hand, poor management (3.18 ± 1.33), inefficient communication system (3.17 ± 1.36), and attitudes and perceptions (3.06 ± 1.41) were shown to be paramount factors.
CONCLUSION: Clinical and administrative staff of hospitals are like parts of a train track. The irrational relationship between them will result in distortion and lower quality of services. Therefore, effective strategies to decrease staffs' experience of conflict need to be developed. This might create a healthier and more productive work environment which positively affects the care quality
Evaluation of the cytotoxic effects and cell cycle analysis of dihydropyrimidinone and 2,4,5-tri aryl imidazole derivatives on AGS, HEPG2 and MCF-7 human cancer cell lines.
Get PDFBackground: Cancer is the most prevalent disease in the word and one of the leading causes of increased mortality that Gastric cancer, liver cancer, and breast cancer have the highest mortality rates. Dihydropyrimidinones (DHPMs) and imidazoles are heterocyclic compounds. A review on previous studies revealed that DHPM and imidazole derivatives possess several medicinal properties including antitumor activity. In this study we examined the cytotoxic effects and cell cycle analysis of DHPM and 2,4,5-triaryl imidazole derivatives on human cancer cell lines.
Methods: AGS, MCF-7, and HEPG2 cancer cell lines were treated by compounds and incubated for 24 hours. Cytotoxicity was examined by MTT assay and the IC50 values for each compound were determined. For Top-ranked compounds EB/AO staining was used for apoptotic cell detection and DAPI staining method was used to analysis of cell cycle by flow cytometry.
Results: Top-ranked compounds were identified by MTT assay. 2(IC50=12.43±0.8uM), 4(IC50=0.45±0.03uM) and 1(IC50=3.7±0.2uM) were the most active compounds in AGS, MCF-7 and HEPG2 cells, respectively. These compounds also showed increase in apoptotic cells .The cell cycle analysis indicated the arrest of the cell cycle at G1 phase in AGS and HEPG2 cell lines, whereas compound 4 had no effect on cell cycle profile of MCF-7 cells.
Conclusion: Results indicated that DHPM derivatives containing phenyl substituent on carboxamide group were the most effective compounds on AGS and HEPG2 cell lines and thiazole ring in this position enhanced cytotoxicity against HEPG2 cell line. Between imidazole derivatives, 3-bromophenyl moiety on C2 position of imidazole ring elevated the cytotoxicity especially on MCF-7 cell line
Comparison of awareness, attitude and Function of healthy and patient Persons from risk factors of depression disorder in 2019
Get PDFBackground and objective: The high prevalence of depression in Iranian society has sounded the alarm. Understanding the symptoms of depression is an important part of self-care knowledge. A person's appropriate attitude toward the disease can help to promote positive interventions and enhance their performance against risk factors. Therefore, the present study compared the awareness, attitude and Function of healthy and patient Persons from risk factors of depression disorder in 2019.
Method: The research method is descriptive and field-based. The statistical population was all patients with depression referring to Dr. Fatemi Ardebil Medical Center in 1398 and all healthy individuals referring to Ardabil Public Libraries. The statistical sample included 180 people (90 depressed and 90 healthy) who were selected by non-randomized and available method. Questionnaires were used to collect data. The content and face validity of the research questionnaires were confirmed by supervisors and advisors and its reliability was confirmed by Cronbach's alpha method. The data were analyzed by SPSS 15 software.
Results: The status of healthy people regarding knowledge and practice against risk factors for depressive disorder is not appropriate but in view of risk factors for depression disorder is not appropriate. Depression status was related to awareness of risk factors for depression but it was not appropriate for attitude and performance against risk factors for depression. There was a significant difference between healthy and ill people regarding the risk factors of depression disorder and function in relation to risk factors of depression disorder, while there was no significant difference in attitude towards risk factors of depression disorder. For Depressed People to Know the Risk Factors for Depression Disorder by Marital Status and Occupation, Attitude to Risk Factors for Depression Disorder by Age and Marital Status, and Functioning Against Risk Factors for Depression Disorder by Age, Gender, and Education The difference is significant.
Conclusion: Regarding the inadequate knowledge, attitude and practice of depressed and healthy individuals about risk factors of depression, it is suggested that regular training courses be organized for these strata to prevent the consequences and consequences of depression