Ardabil University of Medical Sciences
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Plants of the Genus Heracleum as a Source of Coumarin and Furanocoumarin
Get PDFHeracleum is one of the greatest genera of the Umbelliferae family that has more than 120 species. This genus is represented by 109 species in Asia. Common names for the genus or its species include hogweed and cow parsnip. This paper discusses the phytochemistry, ethnopharmacological use and pharmaceutics of Heracleum species. Many kinds of metabolites have been isolated and identified, that furanocoumarins are among the significant ones. Modern pharmacological studies demonstrated that Heracleum and its active compounds have extensive biological activity, particularly in anticonvulsant, anti-inflammatory, antifungal, anticancer, anti-psoriatric, anti-vitiligo and antioxidant activities. In clinical test, Heracleum has successfully been utilized to treat psoriasis, vitiligo, carminative, stomachs, pain killer and anticonvulsant
The Relationship between Emotional Intelligence with Posttraumatic Growth in Hemodialysis Patients
Get PDFBackground & objectives: Despite numerous physical, psychological and social problems in hemodialysis patients, these patients also experience some positive psychological changes, called "posttraumatic growth". Posttraumatic growth is a complex concept associated with many factors, such as the characteristics of individual emotional intelligence. The purpose of this study was to determine the relationship between emotional intelligence and posttraumatic growth in hemodialysis patients in Ardabil province.
Methods: This descriptive-correlational study was conducted on all hemodialysis patients referred to hospitals in Ardabil Province in 2017. The Instruments used was included demographic characteristics form, Short form of Emotional Intelligence and Posttraumatic Growth Inventory. Data analysis was performed using descriptive and inferential statistics in SPSS version 15.
Results: Most of the patients were male (55%), married (88.8%) and illiterate (45%). The mean and standard deviation of posttraumatic growth and emotional intelligence were 69.94±12.78 and 140.88±19.47, respectively. Also, emotional intelligence was associated with posttraumatic growth (r=0.617, p<0.001).
Conclusion: The results of the study showed that emotional intelligence had a direct correlation with post-traumatic growth. So, it can be suggested that education and promotion of emotional intelligence in hemodialysis patients can promote the development of post-traumatic growth
Aging and its impact on civilian centers in outpatient referrals Social Security Organization
Get PDFDrug Resistance Patterns and Genotyping of Acinetobacter baumannii Strains Isolated from Patients Admitted to Shahrekord Teaching Hospitals Using REP-PCR
Get PDFBackground & objectives: In recent years, Acinetobacter baumannii has been shown to be
associated with several nosocomial infections, including pneumonia, bacteraemia, urinary
tract infections, wound infection and meningitis. This organism can survive in the hospital
environment and rapidly develops resistance to many antibiotics. The molecular genotyping
can increase our knowledge about the spread of A. baumannii strains from one hospital to
another and their drug resistance. Therefore, this study aimed to determine the prevalence of
antibiotic resistance profile as well as phylogenetic relationships of A. baumannii strains in
Shahrekord teaching hospitals.
Methods: In this study, antibacterial susceptibility patterns of A. baumannii strains isolated
from different clinical specimens (urine, blood, sputum) to amikacin, ampicillin/sulbactam,
aztreonam, cefepime, ceftazidime, ciprofloxacin, gentamycin, imipenem, meropenem,
norfloxacin, ofloxacin, piperacillin/tazobactam, tobramycin were tested using disk diffusion
(Kirby-Bauer) method. Finally, genotyping of A. baumannii strains was performed using
REP-PCR method. Results: During this study, 50 samples of patients were identified as A. baumannii (71%), and
their drug resistance rates were assessed. All A. baumannii strains were resistant to
ceftazidime and cefepime and also a high rate of resistance to aztreonam, norfloxacin,
ciprofloxacin, amikacin, imipenem, gentamycin, and ampicillin-sulbactam were observed. On
the other hand, our results demonstrated nine genotype groups among A. baumannii strains
based on REP-PCR method.
Conclusion: Due to the high prevalence of antibiotic resistance among isolated A. baumannii
strains, similarities between different genotypes and the dispersion of these genotypes in
different parts of Shahrekord hospitals, the implementation of infection control programs in
different parts of the hospital is necessar
Allicin prevents the formation of Proteus-induced urinary crystals and the blockage of catheter in a bladder model in vitro
No full textStone formation and catheter blockage are major complications of Proteus UTIs. In this study, we investigated the ability of allicin to inhibit P. mirabilis-induced struvite crystallization and catheter blockage using a synthetic bladder model. Struvite crystallization inhibition study was carried out using P. mirabilis lysate as urease enzyme source in synthetic urine (SU). Struvite productions were monitored by phase contrast light microscopy and measurements of pH, Mg2+ and Ca2+ precipitation and turbidity. A catheter blockage study was performed in a synthetic bladder model mimicking natural UTI in the presence of allicin at sub-MIC concentrations
(MIC=64 μg/ml). The results of crystallization study showed that allicin inhibited pH rise and consequently
turbidity and precipitation of ions in a dose-dependent manner. The results of catheter blockage study showed
that allicin at sub-MIC concentrations (2, 4, 8 μg/ml) significantly increased the time for catheter blockage to
occur to 61, 74 and 92 h respectively compared to allicin-free control (48 h). In a similar way, the results showed
that allicin delayed the increase of SU pH level in bladder model in a dose-dependent manner compared to allicin-free control. The results also showed that following the increase of allicin concentration, Mg2+ and Ca2+ deposition in catheters were much lower compared to allicin-free control, further confirmed by direct observation of the catheters’ eyehole and cross sections. We conclude that allicin prevents the formation of Proteusinduced urinary crystals and the blockage of catheters by delaying pH increase and lowering Mg2+ and Ca2+ deposition in a dose-dependent manner
Evaluation of awareness of the importance of prenatal care in reproductive ages in Abbibeiglu city 2014
Get PDFInvestigation of the TERRA and Telomere length changes in placenta specimens of pregnancies complicated with pre eclampsia and normal pregnancies
Get PDFBackground and objective: Pre-eclampsia is one of the major gestational health issues. Pre-eclampsia is a pregnancy-specific syndrome that can affect virtually every organ system. This diagnosis is made in women whose blood pressures reach 140/90 mm Hg or greater for the first time after midpregnancy. The purpose of the present study was to evaluate of expression level LNCRNA TERRA and Telomere length and their association with Pre-eclampsia.
Methods: In this case-control study, 25 mothers with Pre-eclampsia who referred to Ardabil Alavi Hospital and diagnosed with Pre-eclampsia were fetched for them after obtaining consent and completing the designed questionnaire, Placenta specimens were taken and analyzed by LNCRNA TERRA and Telomere length. The mothers of the control group were selected from mothers with Normal Pregnancy and tests for the control group were also performed in their placenta specimens. The relationship between LNCRNA TERRA and Telomere length and Pre-eclampsia was investigated in both case and control groups, and then the statistical analysis software was analyzed.
Results: In this study, the mean for expression level of LNCRNA TERRA in the case group was 7. 87 ± 1. 9 and in the control group was 9. 8 ± 2. 8. The results showed that there was a significant difference between the two groups in terms of expression level of LNCRNA TERRA. The mean for Telomere length in the case group was 4. 35 ± 1. 9 and in the control group was 6. 2 ± 1. 54. The results showed that there was a significant difference between the two groups in terms of Telomere length,too. The mean of gestational age in this study was 37. 3 ± 2. 1 weeks and the mean BMI of the subjects was 24. 1 ± 3. 8. There was no statistically significant difference in expression level of LNCRNA TERRA and Telomere length between the sexes of newborns in the patients group.
Conclusions: Our data identified LNCRNA TERRA and Telomere length signature involvement in Pre-eclampsia
Mitochondrial protective and antioxidant agents protect toxicity induced by depleted uranium in isolated human lymphocytes
No full textDepleted uranium (DU) is a by-product of the enrichment procedure of natural uranium. During production and usage, uranium may be released into the environment due to failure to follow standard procedures, thus causing environmental pollution. In this study, toxicity effects of uranium (VI) and protective role of mitochondrial permeability transition pore sealing and antioxidant agents studied by isolated human lymphocytes. Human lymphocytes were exposed to different concentrations (0.1, 0.5, 1, 2 and 5 mM) of DU for 6 h and cytotoxicity was measured by trypan blue assay. The mechanistic parameters were assessed after 1, 2 and 3 h of lymphocyte treatment with 1/2 IC506h (0.3 mM), IC506h (0.8 mM) and 2 IC506h (1.6 mM) of DU. The reactive oxygen species (ROS), lysosomal membrane destabilization, mitochondrial membrane potential (MMP), lipid peroxidation, GSH and GSSG levels on human lymphocytes exposed to UA, were measured. The results indicate that toxicity of U (VI) was concentration dependent on human lymphocytes. Also, U (VI) induced ROS production, MMP reduction, lysosomal membrane destabilization and lipid peroxidation in human lymphocytes. In U (VI) treated lymphocytes, decrease in intracellular GSH and raise in extracellular GSSG levels were observed. We report that mitochondrial permeability transition (MPT) pore sealing and antioxidant agents, have the capacity significantly to prevents, mitochondrial toxicity. Thus, the inhibition of mitochondrial oxidative stress and mitochondrial dysfunction by MPT pore sealing and antioxidant agents is associated with the inhibition of DU-induced mitochondrial damages and activation of apoptosis in lymphocytes
Relapsing periodic arthritis, palindromic rheumatism and MEFV gene-related variants alleles in children
Get PDFBackground
Relapsing periodic arthritis is a general term used for a group of diseases with recurring and periodic nature, in which the joints are intermittently involved. The aim of this study is to evaluation of the possible relationship between MEFV gene mutations in intermittent arthritis of children which has recurring and periodic nature.
Methods
In this cross-sectional study we reviewed medical records of all patients with recurrent and periodic arthritis referred to pediatric rheumatology clinic from 2003 to 2019.We excluded all patients with suspicious anamnesis and/or positive history of FMF, JIA, gout, psoriasis, IBD and SLE. The peripheral blood of these patients was screened for the 12 common pathogenic MEFV gene variants (FMF Strip Assay, Vienna lab, Vienna, Austria) according to manufacturer’s instructions.
Results
Among 195 recorded files, 11 patients were identified with idiopathic recurrent and periodic feature. 3 patients suffering from recurrent transient synovitis hip (RSH) and 8 patients were fully compatible with the Pasero and Barbieri modified criteria of palindromic rheumatism (PR). Their mean age at diagnosis was 6.5 and 4.6 years and the average follow-up was 2.6 and 6.6 years in PR and RSH patients, respectively. The most frequently involved joints were knees and ankles in PR patients. The mean duration of attacks was 3.3 days in RSH patients and with various courses in PR. The median number of attacks was 4.75 in PR and 3 in RSH patients per year. In PR group 7 patients showed no mutations and all patients of RSH had these mutations; V726A, R761H, A744S as in heterozygote pattern.
Conclusion
An idiopathic relapsing periodic arthritis in children with exclusively hip involvement is a MEFV gene related arthropathy; whereas with various joint attacks it could be considered as childhood PR
The effects of conjugated linoleic acid supplementation on the serum levels of Interleukin-6 and Sirtuin-1 in COPD patients
Get PDFAbstract
Objective: Chronic obstructive pulmonary disease (COPD) is characterized with systemic inflammation and accelerated inflammaging of the lungs. Some studies have shown that conjugated linoleic acid (CLA) has anti-inflammatory effects. The aim of the present study was to evaluate the effect of CLA supplementation on the serum levels of interleukin (IL)-6 and Sirtuin1 (SIRT1) in patients with COPD.
Method of Study: 82 patients with stable COPD were selected to be studied in a double blind clinical trial. Subjects were randomly assigned to two groups: placebo (n=42) and supplementation (n=40, 3.2 g CLA daily). Forced expiratory volume in one second (FEV1%), BODE index, and the serum levels of IL-6, and SIRT1 were measured at the baseline and also six weeks after the intervention. In addition, the study parameters in the two groups were compared based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.
Results: After supplementation with CLA, the serum levels of IL-6 and BODE index significantly decreased (p<0.05 and p<0.001 respectively). In addition, the serum levels of SIRT1 (p<0.01) and FEV1 (p<0.001) significantly increased in the supplementation group. Based on GOLD criteria, the increase in SIRT1 and the decrease in IL-6 serum levels were found to be statistically significant in stages III-IV in the supplementation group (P<0.05 and P<0.01, respectively)
Conclusions: Supplementation with CLA can modify the inflammatory markers and improve the health status of COPD patients. The results suggest that CLA supplementation in COPD patients can be useful in the management of the disease