Ardabil University of Medical Sciences
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In silico design of peptide inhibitors of tubulin: amyloid-β as a lead compound
No full textMicrotubule is one of the most studied targets in cancer research. Stabilizing and destabilizing of the
microtubule by targeting its building block tubulin are common mechanisms of microtubule targeting
agents. Cancer associates inversely with Alzheimer’s disease (AD). So the rate of developing AD is significantly slower in patients with cancer and vice versa. Amyloid-b (Ab) peptide inhibits tubulin polymerization and induces apoptotic death of cancer cells. We studied the interactions of Ab with tubulin using
protein-protein docking and MD simulation. Ab bond to the vicinity of the vinblastine binding site and
interacted with the H6-H7 loop. Interaction of Ab with H6-H7 loop blocked nucleotide exchange and
may be attributed as a possible reason for blocking of tubulin polymerization. We designed new Abbased peptidic inhibitors of tubulin using visual inspection and alanine scanning method. P1
(FRHYHHFFELV) and P9 (HYHHF) bound efficiently to tubulin and also interacted with the H6-H7 loop.
Obtained results indicated that proposed peptides could potentially inhibit nucleotide exchange as Ab
Factors Affecting on Establishment of Health System Reform Plan in Ardabil Province
Full text linkBackground & objectives: In today's world, health has wider prospect and special attention has been paid to non-medical expectations. The health care reform plan aims to improve community health, reduce treatment costs and increase the satisfaction of patients. The aim of this paper was to identify the factors influencing the development of health system in Ardabil province.
Methods: This mixed-methods study was performed in two stages. In the first stage, comprehensive literature review was carried out and important factors in establishment of health system reform in the world were discovered. In the second stage and using the first stage findings, the questionnaires were completed by 185 experts and administrators of health development plan in Ardabil province who were selected by non-random purposeful sampling and local factors affecting the establishment of the plan in the province hospitals were obtained. Lisrel software was used for factor analysis .
Results: The most important indicators of development of health care system were as follows: political support, providing and promoting community participation, management and resource assurance, satisfaction guarantee for paramedics, commitment of senior executives, commitment of interested physicians, continuous monitoring and evaluating and providing the feedback to project executives, existence of infrastructure and project steering committee. The results of structural equation modeling showed the relationship between independent and dependent variables.
Conclusion: The study modeling indicators showed that, the proposed model is in good agreement. It seems that paying attention to regional indicators and variables is very important in the formulation and implementation of strategic plans and has a decisive role in achieving the goals
Assessment of the developmental status of 3 to 5-year-old children with congenital hypothyroidism treated with levothyroxine in Ardabil city
Full text linkBackground: Congenital hypothyroidism (CH) is one of the most common preventative evolutionary disorders in newborns and children, which, if not treated promptly, leads to mental retardation and developmental disorders.
Objective: The purpose of this study was to assess the developmental status of 3 to 5-year-old children with congenital hypothyroidism treated with levothyroxine in Ardabil city in Northwest Iran.
Methods: In a descriptive cross-sectional study, 78 infants (44 boys and 34 girls) with congenital hypothyroidism under treatment with levothyroxine who referred to Ardabil city health centers during 2013-2018 were evaluated by an Ages and Stages Questionnaire (ASQ) for their developmental status.
Results: In total, 32 (41%) were impaired and 46 (59%) were healthy according to the ASQ. Of those, 11 children (14.1%) had temporary congenital hypothyroidism. There was no significant difference in terms of height, weight, birth weight, maternal age, number of tests performed each year, average TSH (Thyroid-stimulating Hormone) in the first year of treatment, gender, place of residence, education and parental relationship between two impaired and healthy children. There was a significant relation between number of visits by doctor (p=0.02), age at diagnosis (p=0.001) and age at treatment time (p=0.003), initial dose of levothyroxine (p=0.02) with developmental status of children based on ASQ results.
Conclusion: According to the findings of this study, it can be concluded that neonatal screening is one of the most successful health-system programs in the country, and the detection and initiation of hypothyroidism in neonates as soon as possible leads to a reduction in developmental disorder in them
Synthesis and cytotoxic effect of a few N-heteroaryl enamino amides and dihydropyrimidinethiones on AGS and MCF-7 human cancer cell lines
Full text linkBackground and purpose: Cancer prevalence has increased in the last century posing psychological, social,
and economic consequences. Chemotherapy uses chemical molecules to control cancer. New studies have
shown that dihydropyrimidinethione (DHPMT) derivatives have the potential of being developed into
anticancer agents.
Experimental approach: New derivatives of DHPMTs and a few acyclic bioisosters were synthesized via
Biginelli reaction and assessed for their toxicity against gastric (AGS) and breast cancer (MCF-7) cell lines
through MTT method.
Findings / Results: Chemical structures of all synthesized N-heteroaryl enamino amides and DHPMTs
were confirmed by spectroscopic methods. Result of biological assessment exhibited that none of the
tested agents was more cytotoxic than cis-platin against AGS and MCF-7 cell lines and compound 2b
was the most cytotoxic agent against AGS (IC50 41.10 µM) and MCF-7 (IC50 75.69 µM). Cytotoxic data were
mostly correlated with the number of H-bond donors within gastric and breast cancer cells.
Conclusion and implications: It was realized that DHPMTs were able to inhibit the growth of cancer cells
much better than acyclic enamino amides and moreover; N-(4-methylbenzothiazol-2-yl) DHPMT derivative
(2b) supposed possible interaction with a poor electron site of target due to the lipophilic nature of
benzothiazole ring and also less electron rich nature than isoxazole. Similar scenario was observed with acyclic
enamino amides in which incorporation of sulfur and nitrogen containing heterocycles doubled the cytotoxic
effects. Results of the present contribution might assist in extending the scope of DHPMTs as privileged
medicinal scaffolds
Shigella flexneri strain arums98 O-antigen polymerase (rcf) gene, partial cds
Full text linkRcf gene sequence from Shigella flexneri arums98 strai
Using social network rates among Ardabil city women over 25 years old
Full text linkIntroduction: The role of women in the structure of society and family is very important. Unfortunately, due to the
lack of proper planning to fill leisure time among people and especially women, overuse of social networks had a
huge impact on their daily lives and in addition to the benefits, sometimes it has some problems. Method: This
cross-sectional descriptive study has been done on 150 women over 25 years who selected randomly from Ardabil
city in the 2018. Required information were collected using a research based questionnaire containing
demographic and specialized questions about the rate of using social networks and their reasons. Collected data
were analysed using descriptive and analytical statistical methods in SPSS version 21. Results: The mean age of
women was 34 ± 9 years. Of all women, 72% were married, 69% had graduated education, 27% were
housewives, 44% were employees and 63% had a median income. Of all women, 94.7% were registered as
members of social networks. Of them, 66% were registered on telegram. The most common reason for using
Telegram, was chat and reading news. The maximum time spent with more than 5 hours for the social network
was Telegram. Conclusion: Results showed that, most of the studied women have been used social networks
and of them telegram and Instagram are more popular networks among Ardabil’s wome
Evaluation of Iatrogenic Errors and the quality of Root canal treatments of Maxillary Premolar and molar teeth in Ardebil by the aid of CBCT-2017-2018
No full textIntroduction: Errors during root canal therapy are inevitable in some cases, but at the same time efforts that are being made to reduce their frequency and thus improve the prognosis of endodontic therapy; This study was conducted by CBCT images in 1397 with the aim of investigating the prevalence of errors during operation and the quality of root canal therapy of premolar and molar maxillary teeth in Ardabil.
Materials & Methods: In this cross-sectional and retrospective study, To investigate the iatrogenic errors the therapy and the quality of the trerapy performed from 327 endo CBCT images of the teeth of 1 and 2 molars and premolars were used in people over 15 years of age. The existing teeth in these images (CBCT) was investigated in three dimensions Axial, Coronal, Sagital in terms of tooth filling length, number of undetected channels and perforation occurred during treatment, by a dental student under the supervision of a radiologist and an endodontics specialist. Then, the information obtained from the study was described using descriptive - statistical methods (frequency and percentage) and using SPSS statistical software version 20 using chi-square test at 5% error level.
Results: The results showed that the frequency of under channel length (24.46%), undetected channel (13.46), OVER channel length (6.12%), root analysis (1.75%), apical perforation (2. 45%), broken device in the channel (2.45%), root fracture during work (0.92%) and no error was observed in the strip perforation.
Conclusion: According to the results obtained by modifying and upgrading the teaching methods, the amount of undesirable treatments such as iatrogenic errors of inappropriate filling length and undetected canal can be reduced
Investigation of infectious abortion and its complications in pregnant women admitted in Alavi hospital in Ardebil during 1390-1397
No full textBackground and Objective: Infection is one of the most common causes of maternal mortality. And mortality from miscarriage is actually caused by infection. A 1990 study of abortion deaths in the United States found that 62 percent of deaths were due to illegal abortions and 51 percent were due to infections. Infectious abortion is an abortion associated with infection with fever, endometritis, and parametritis. It is one of the most serious threats to women's health around the world. Infectious abortions and deaths from infectious abortions are rare in countries where abortion is legal, but are more common in many developing countries where it is illegal or inaccessible.
Methods: In this study, information about pregnant women admitted to Alavi Hospital in Ardabil city during the years 1390-97, who had an infectious abortion, was extracted from the women's hospital file and analyzed using statistical methods. The case of women who had an abortion in the first or second trimester of pregnancy and had at least two of the following were studied:
Results: The rate of infectious abortion in this study was 40 people per 50,000 live births, which was equivalent to 8 cases per 10,000 live births. The mean age of the women studied was 32.58±5.35 years. In most studies, the highest number of women in the gestational age group was over 13 weeks (50%), followed by 30% of pregnant women at 9-12 weeks of gestation, and finally the lowest number of women aged 8-4 weeks. they had. Most women admitted to pregnancy had more than three pregnancies due to an abortion. Among them, 5 (12.5%) of them had a first pregnancy and 7 (17.5%) had a previous pregnancy. About 80% of women had a fever, with the highest rates of clinical manifestations after fever, including vaginal bleeding, tachycardia, abdominal pain, vaginal discharge, body aches, and urinary incontinence, respectively. 52.5% of women had an open cervix at the time of referral, and 35% of women had a closed cervix. 45% of the women surveyed were hospitalized for less than 4 days and the remaining 55% were hospitalized for more than 4 days. Complications of infectious abortion included peritonitis, uterine rupture, septic shock, and DIC. Twenty-five percent of women had a miscarriage when they went to the doctor, and 35 percent had a miscarriage with a midwife using tools such as curettage and less.
Conclusion: Referral due to infectious abortion due to manipulation and its complications can be due to the use of induction drugs and safe methods for abortion, and it is not possible to judge the reduction of general induction statistics
The Effectiveness of Acceptance and Commitment Therapy on Posttraumatic Cognitions and Psychological Inflexibility among Students with Trauma Exposure
Full text linkBackground: Posttraumatic stress disorder has a negative impact on the individual, family, and community due to disturbance in social
functioning, increased stress, and life‑threatening health status. Therefore, effective and useful therapeutic interventions in this area are very
important. This study aimed at examining the effectiveness of acceptance and commitment therapy (ACT) on the posttraumatic cognitions
of students with trauma exposure. Methods: In this quasi‑experimental study, population included all students of Islamic Azad University in
Roudehen, Tehran, Iran, during the academic year of 2018–2019. After administering trauma questionnaire, the second version of acceptance
and action questionnaire (AAQ‑II), and posttraumatic cognitions inventory (PTCI) to 500 people, 113 people who experienced trauma and
had high scores in PTCI and low scores in AAQ‑II were identified. Of whom 40 people were selected randomly. After the clinical interview,
the subjects were randomly placed in the experimental group (who received ACT, n = 20) and placebo group (n = 20). Both groups were
pre‑ and posttested using the PTCI and AAQ‑II. Then, the obtained data were analyzed using covariance analysis. Results: The results showed
that there was a significant difference in posttraumatic cognitions (negative cognitions about self, negative cognitions about the world, and
self‑blame) between the two groups. In addition, the results of posttest related to ACT had a significant impact on psychological inflexibility.
In other words, ACT reduced posttraumatic cognitions and increased psychological flexibility of these students. Conclusion: The findings of
the present study reveal that despite posttraumatic cognitions of students with trauma exposure, ACT increases value‑based behaviors through
increasing psychological flexibility and decreasing experiential avoidance
Correlation of serum fatty acid binding protein-4 and interleukin-6 with airflow limitation and quality of life in stable and acute exacerbation of COPD
Full text linkBackground/aim: The serum fatty acid binding protein 4 (FABP-4) level increases in chronic inflammatory diseases. The present study aimed to examine serum FABP-4 and interleukin (IL)-6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) and the correlation of these markers with airflow limitation.
Materials and methods: We measured serum FABP-4 and IL-6 levels in 60 COPD patients [30 stable COPD (SCOPD), and 30 acute exacerbation of COPD (AECOPD)], and 30 healthy subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, peripheral O2 saturation (SpO2), and COPD Assessment Test (CAT) score. We also tested the association between serum FABP-4 levels and some characteristics of study parameters.
Results: Both serum FABP-4 and IL-6 levels increased with increasing severity of GOLD grades in SCOPD (P < 0.01 for both) and AECOPD groups (P < 0.001 and P < 0.01, respectively). It also increased in patients with AECOPD group compared with SCOPD group in GOLD grades I-II (P < 0.01) and GOLD grades III-IV (P < 0.05). In addition, there was a significant positive correlation between serum FABP-4 level with IL-6, CAT score, and smoking history and inversely with FEV1 and SpO2.
Conclusion: The study revealed that serum FABP-4 level was elevated with increasing GOLD grades in COPD patients, markedly in acute exacerbation phase. The increase was associated with elevated serum levels of IL-6 and severity of hypoxia. Thus, it seems that FABP-4 may be involved in the pathogenesis of COPD