Ardabil University of Medical Sciences
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Evaluation of serum levels of Sirtuin-1 in lung cancer patients
No full textBackground: Sirtuin-1 is a protein from the family of sirtuins that has been implicated in inflammaging and oxidative stress in cancer patients. The aim of this study was to investigate the serum level of Sirtuin-1 and its relation with quality of life in lung cancer.
Methods: Sirtuin-1 levels were measured in 30 male with lung cancer and 50 healthy men. The two groups were matched for age. The difference between the serum levels of Sirtuin-1 between the two groups and its relationship with other clinical parameters were evaluated. Data were analyzed by independent T-test and Spearman correlation and P <0.05 was considered as significant.
Results: Sirtuin-1 levels were significantly lower in the patient group in comparison with healthy group (P <0.001). There was also a significant relationship between serum level of Sirtuin-1 and quality of life according to Karnofsky scale (P = 0.001 r = 0.558), arterial oxygen saturation (P = 0.009 r = 0.470) and smoking history (P=0.003 r = - 0.330). Also, the serum levels of Sirtuin-1 were significantly lower in adenocarcinoma than that in squamous cell carcinoma or small cell lung cancer (p = 0.001).
Conclusion: In this study, serum levels of sirtuin-1 were lower in patients with lung cancer. In addition, there was a positive correlation between serum levels of sirtuin-1 and patients' quality of life (according to Karnofsky scale), hypoxia and smoking history. Therefore, decreased serum sirtuin-1 levels in lung cancer reflect the cell aging process and correlate with poor quality of life
A Review of the Impact of Food Policies on Food Security Status and Healthy/Unhealthy Food Consumption
No full textAbstract: Background: Food insecurity refers to a household’s financial inability to access adequate food. Food subsidy programs are the right strategies that have been undertaken for many years in some countries. Aim:This study aims to summarize and compare the impact of some subsidy programs on food secu-rity as a narrative review. Methods: Community-based studies analyzing the impact of food policies on food security status and healthy/unhealthy food consumption were reviewed.Our search keywords included food tax, healthy/unhealthy food, food security, food subsidy, targeted subsidy, and Iran. ResultsandConclusion:Some subsidy programs aim to improve food security and nutritional status of low-income individuals. Developing countries, for the improvement of food security and hunger, use some food subsidy programs that can improve the food security status. One of the most used pro-grams is a food subsidy program in schools. Unfortunately, the targeted subsidy policy in Iran has affected the nutritional status and food security of households, therefore, it is necessary to implement a food subsidy program for low-income families. Fruits and vegetable subsidies can increase their consumption. Unhealthy food consumption decreasesby implementing food tax programs, especially if the number of tax increases. In general, cash subsidies are more beneficial in improving the nutri-tional status
Effect of Pyridoxal Phosphate on Atherosclerosis and Nephropathy Progression in Atherosclerotic Rats
Get PDFDiabetes vascular complications are the leading cause of death in the world. Therefore, we investigated the effect of pyridoxal phosphate (PLP) on the formation of atheromatous plaque and renal function in atherosclerotic rats.
Materials & Methods: Forty male Wistar rats were randomly divided into four groups of normal, atherosclerotic, and two similar groups under PLP treatment. Atherosclerosis was induced in rats by an atherogenic diet and all groups were treated with 0.18% of PLP in drinking water daily for three months. Hematoxylin and eosin stain was applied to assess the histopathological changes in the aorta of subjects. Insulin resistance index, the activity of the glyoxalase (GLO) system, lipid profile, low-density lipoprotein (LDL) oxidation markers, advanced oxidation protein products, and inflammatory markers, such as high-sensitivity C-reactive protein (hs-CRP) and TGF-β1 were examined in all rats. In addition, serum creatinine levels and urinary protein excretion of all animals were measured.
Results: Atheromatous lesions were not observed in the aorta of PLP-treated atherosclerotic rats. Furthermore, PLP seemed to improve insulin function, lipid profile, kidney function parameters, GLO system activity, and inflammation. We found that PLP treatment decreased the formation of LDL oxidation products both in vitro and in vivo (P<0.001).
Conclusion: According to our findings, PLP imposed a beneficial effect on vascular complications in atherosclerotic rats, which could be attributed to its antioxidant and anti-inflammatory properties. Moreover, PLP has positive impacts on insulin function, dyslipidemia, and GLO system activity
knowledge of dental specialists of Ardabil about civil liability in 2018 and for producing educational content in this regard
Get PDFIntroduction: One of the problems that dentists and physicians face in their profession is patients' complaints against them in the judiciary, so it is necessary that this segment of society be aware of the relevant occupational laws and legal principles governing medical issues. The purpose of this study The study of dentists' awareness of civil liability due to negligence in diagnosis and treatment and ultimately the production of educational content in this field.
Method: In the present study, which is an analytical cross-sectional study, the knowledge of 51 dentists in Ardabil about civil liability due to negligence in diagnosis and treatment was assessed by presenting a questionnaire. Knowledge in terms of age, gender, work experience, local university Education, faculty member and grievance history were reviewed and analyzed. In the final stage, by producing an electronic training file in the form of a compact disc, the concepts related to the subject of civil liability and the pillars of civil liability of dentists were explained by considering the results of the awareness survey and emphasizing the cases where there is less relative awareness.
Results: Using the obtained information and analysis, it was found that the average level of knowledge of all dentists about civil liability is 2.97. In this way, with increasing age, the level of awareness increases (p = 0.001) and with increasing work experience, the level of awareness increases (p = 0.001). Those who had a history of complaints had a higher level of awareness. (p = 0.001) and also the level of awareness of those who were faculty members was higher (p = 0.001) and gender and university of study had no significant effect on the level of awareness of civil liability (p> 0.05).
Conclusion: The level of knowledge of specialist dentists about civil liability due to negligence in diagnosis and treatment is moderate that there is a need to increase lagal knowledge in this group
Plantar Fasciitis Treatment; Efficacy of Extracorporeal Shock Wave Therapy
Get PDFEfficacy of extracorporeal shock wave therapy (ESWT) in the treatment of plantar fasciitis (PF) is under debate in spite of applying in treatment. We aimed to investigate the efficacy of extracorporeal shock wave therapy in decreasing plantar fasciitis heel pain. Methods: Eighty patients fulfilled the inclusion criteria; 77 agreed to participate the study. Patients randomly divided into 2 groups of treating with NSAID alone and NSAID+ESWT and assessed in to periods of 4 and 8 weeks with a focus on ESWT effectiveness. Results: Visual analog score decreased significantly after eight weeks of treatment with ESWT+NSAID in comparison with NSAID group alone. (p<0.05) Conclusion: ESWT reduced pain of PF in our study. So it could be used as treatment options
A case of hydatid cyst in biceps femoris
No full textIntroduction
Hydatid cysts primarily involve the liver and lung, but could be presented in any site of the body including the muscles which is very rare.
Presentation of case
We report a 50-year-old woman with hydatid cyst in biceps femoris presenting as growing painful mass. There was also a small cyst in the liver. The cyst was completely excised and patient was treated with albendazole 15 mg/kg daily before and after surgery. The patient was symptom free during the three months follow-up.
Discussion
Hydatid cyst should be considered as differential diagnosis of any growing mass or cyst in the body in the endemic areas
Evaluation of the causes and therapeutic results of traumatic upper limb amputation in patients referred to Fatemi Hospital in Ardabil in 2018-2019
Get PDFBackground: Injuries are one of the important health problems that are important to control and prevent in epidemiology and public health. Skeletal organs are an important part of the body. Although a defect or loss may not endanger a person's life, it has serious negative effects on his quality of life and can cause problems in his daily work, work and economy.
Aim: To determine the causes and treatment outcomes of traumatic upper limb amputation in patients referred to Fatemi Hospital in Ardabil
Matherials and Methods: The statistical population included all patients referred to Fatemi Hospital in Ardabil with traumatic amputations. The number of samples was 230. All admitted patients due to amputation were extracted from the hospital information system in a total number over a period of two years and each case was studied and entered into the data extraction sheet based on the objectives of the data study. Gradually, the data entered the computer and were analyzed.
Results: The result was that men are significantly more prone to accidents. Most accidents occur in the workplace and during working hours. Sensory disturbance and infection are significantly greater in stump repair. There was no significant difference in motor limitation and deformity. Generally, the complications were less in V-Y plasty method.
Conclusion: Our study preferred to the V-Y plasty method
Investigating the predictive components of the HBM model (health belief model) in performing protective behaviors against Quaid 19 in the patients with breast cancer in Ardabil 2020
Get PDFBackground &Objective: Coronavirus disease 2019, which is currently the most common human infectious disease with a high incidence and mortality rate in the world, has affected various aspects of each person's life. This study aims to investigate the predictability of HBM model components (Health Belief Model) in performing protective behaviors against Covid 19 in patients with breast cancer in Ardabil.
Materials and Methods: This descriptive-analytical study was performed on 92 patients with breast cancer who are part of the list of outpatients and hospitalized in Imam Khomeini Hospital in Ardabil and registered in Ardabil Cancer Registration Center since 1999. 98. Data collection was done with a questionnaire and data analysis was performed using SPSS 24 software.
Results :The mean age of the subjects was 48.34 ±10.082. to do so, the Mann-Whitney test showed significant correlation between the position of the people and the model components of the health belief model.using the variance analysis test to compare the mean of scores of the above variables, the breakdown of marital levels was determined, where scores of scores between the married levels of individuals studied were not statistically significant differences.There were no significant differences between average scores of research units in terms of spouses.The tests conducted by Kruskal-wallis test showed between the average scores of model components according to the treatment type received by patients with a significant correlation of perceived sensitivity (0.01 = p).the effectiveness of effective factors on increasing awareness is television (5 per cent) (6 per cent)and the least effect of advertising signs (4.5 %). Conducting the logistic regression on the effectiveness of model components in carrying protective behaviors showed that self - efficacy perceived self - efficacy is a predictor of behavior.
Conclusion :The results showed that the perceived value of perceived benefits, perceived benefits, self - efficacy, motivation for health and the use of protective methods to carry out protection and perceived sensitivity and perceived obstacles to the working group were superior to each other
Effectiveness of rectal displacement devices in managing prostate motion: a systematic review
No full textPurpose To determine whether rectal displacement devices (RDDs) have a prostate-stabilizing effect during prostate
external beam radiotherapy (EBRT).
Methods A systematic literature search using the PubMed database from January 1, 2000 to December 30th, 2019 was
conducted. The effect of RDDs on inter- and intra-fractional prostate displacements was extracted.
Results From 356 articles identified via the PubMed database and hand search, 21 articles were included in the systematic
review. There was no randomized study. Twelve studies evaluated the role of the endorectal balloon (ERB) in managing
prostate motion. Four studies reported the effect of hydrogel spacer on prostate motion. Four studies examined the effect
of the rectal retractor (RR) on intra-fractional prostate motion, and only one study assessed the impact of ProSpare
(Nottinghamshire, UK) in reducing prostate motion.
Conclusion Using an ERB significantly reduces intra-fractional prostate motion. This prostate-stabilizing effect of the
ERB can translate into reduced planning target volume (PTV) margins and additional rectal dose sparing. Even with an
ERB in place, inter-fractional prostate displacements are seen. As a consequence, ERB application does not obviate daily
verification; however, this is not a crucial topic because pretreatment imaging is always done nowadays. As compared with
ERB, the hydrogel spacer significantly reduces rectal dose and toxicity without influencing prostate immobilization. The
RR can increase prostate and rectal inter- and intra-fractional stability without a clear influence on the reduction of rectal
toxicity. Finally, it is unclear whether ProSpare is a suitable device reducing prostate motion. Further study will be required
to clarify whether the prostate-stabilizing effects of the ERB and RR can result in a safe reduction of PTV margins and
further sparing of organs at risks, especially the rectum
Studying the Relationship of Mental Health and Other Factors with Preference of Delivery Method in Women Referred to Qamar Bani Hashem Hospital, Khoy, Iran
No full textBackground: Childbirth is a fundamental physical and emotional struggle. This study is an attempt to investigate the psychological factors related to the first delivery, and its relationship with the preference of the type of subsequent deliveries in women. Materials and Methods: This is a descriptive-analytical study in which 380 pregnant mothers referred to Qamar Bani Hashem Hospital in Khoy, Iran, who were hospitalized for childbirth, were selected by simple random sampling. Participants were first asked about their preference for the next type of delivery. Afterwards, the Individual and Social Profile Questionnaire, the Edinburgh Depression Questionnaire, the overt and covert anxiety of Spielberger, and the Wake-Forest questionnaire in the interview method were completed. All data were analyzed using SPSS software version 22.0. Results: There was no significant statistical relationship between psychological variables and the preferred type of delivery. Age, spouse's education level, and income were among the predictors of preference for delivery. These factors had a statistically significant relationship with confidence in the physician in participating women. Apart from income, there was a statistically significant relationship between other social factors with preference of the type of delivery. There was also another significant relationship between complications during childbirth and postpartum with a preference for the type of the next delivery (P<0.05). Conclusion: Based on the results, there was a relationship between socio-individual factors and complications during and/or after childbirth with a preference for the next type of delivery in women. Further studies are needed