Ardabil University of Medical Sciences
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Evaluation of Serum selenium levels in acute phase and after improvement of gastroenteritis in children with 3 to 36 months admitted in Bouali hospital of Ardabil from June to December 2019
No full textAbstract: According to the different effects of selenium on diarrhea in children and the questionable role of selenium on the severity and duration of gastroenteritis in children and also due to the fact that diarrhea is one of the most common diseases in the country that causes great damage to the health system Therefore, the aim of this study was to evaluate the serum selenium level in children with acute gastroenteritis and recovery from the disease in Bu Ali Hospital in Ardabil.
Aim: To determine the serum level of selenium in the acute phase and recovery of gastroenteritis in children 3 to 36 months hospitalized in Bu Ali Hospital in Ardabil.
Methods: This study was a case-control study performed on patients aged 6 to 36 months. The case group of children with acute gastroenteritis and the control group also included healthy children who had no history of acute gastroenteritis in the two weeks prior to sampling, who had been referred to the hospital during the study period for reasons other than acute gastroenteritis. After completion of the information form, blood samples were taken from the children and serum was isolated. In the case group, patients returned to the laboratory one week to ten days after the onset of the disease, ie in the recovery phase, for the second time. According to the possible effect of diet on increasing serum selenium levels and dietary changes after diarrhea can increase blood levels of the selenum, to prevent interference with the results of experiments, patients' diets based on the type of diet before the onset of the disease Was considered.
Results: In this study, the mean age of participants in the study was 23.55 8 8.52 months and the mean age of patients was 23.26 8 8.91 months and the mean age of controls was 23.84 23 8.21. They were 3 to 36 months old and 43 cases (56.6%) were male and the rest were female. The number of diarrhea days was 4.68 ± 1.25 days. The mean frequency of diarrhea was 6.53 13 1.13 times. The study of the relationship between selenium levels during the disease and after it with SPEARMAN test showed that there is a statistically significant relationship between these two variables. As the level of primary selenium increases, so does selenium after recovery.
Conclusion: The findings of this study suggest that blood selenium is strongly affected by the severity of diarrhea and factors affecting the severity of diarrhea. It is also concluded that infectious symptoms in patients (such as fever) can reduce serum selenium levels
Contrasting association of Helicobacter pylori oipA genotype with risk of peptic ulceration and gastric cancer
No full textHelicobacter pylori OipA (outer inflammatory protein A) is an outer membrane protein that involves in the binding and colonization of the bacterium in the stomach. The oipA status is associated with the risk of peptic ulcerations (PUs) and gastric cancer (GC) diseases. However, the association trend with PUs compared to GC is often different and highly challenging. We therefore aimed to determine the presence of this genotype in Iranian strains and assess its association with the risk of PUs and GC in a larger number of samples. A total of 319 strains were obtained from 172 patients with non-atrophic gastritis (NAG), 52 with PUs and 95 with GC. The prevalence of the oipA+ vs. oipA− genotype was 67.7% (216/319). The total frequency of the oipA+ vs. oipA− genotypes in NAG, PUs, GC, non-peptic ulceration (including NAG and GC), and non-tumor (including NAG and PUs) groups was 121/172 (70.3%), 50/52 (96.2%), 45/95 (47.4%), 166/267 (62.2%), and 171/224 (76.3%), respectively. In multiple logistic regression analysis, the oipA+ vs. oipA− genotype showed a strong direct association with PUs; the ORadj (95% CI) was 18.751 (4.421–79.531), (p =0.00007). In contrast, it had a significant reverse association with GC; the ORadj (95% CI) was 0.330 (0.179–0.607), (p = 0.00036). In the present study, we interestingly found a contrasting association of the H. pylori oipA genotype with the risk of PUs and GC in Iran. Therefore, the contrasting effect of this genotype may emphasize its independent role in predicting clinical outcomes
AnOptimalModel forEducationalLeadershipCompetency inClinicalDepartments ofNursing andMidwiferyFaculties
No full textforEducationalLeadershipCompetency inClinicalDepartments ofNursing andMidwiferyFacultiesAsadzadeh MonirF1,SoleimaniT*1,SattariS1,KheirkhahM1,21.Department of Educational Sciences,Ardabil branch,Islamic Azad University,Ardabil, Iran2.Department of Midwifery, Midwifery faculty, Iran University of medical sciences, Tehran,Iran*Corresponding author.Tel: +989148192278,E-mail:[email protected]:Dec 3, 2020Accepted:Dec 20, 2020ABSTRACTBackground&aim:Leadership in medical sciences and nursing education, especially inrelation to clinical learning, is very important, and can significantly predict the effectivenessof clinical education. The aim of this study was to design an optimal model for educationalleadership competency in clinical departments of medical universities.Methods:This research was conducted by a mixed qualitative (qualitative-quantitative)method. To conduct the research, a semi-structured interview was conducted with 15 deputiesand group managers in some universities in the northwest of the country. It was evaluated bycontent analysis method and, in the qualitative stage, approved by fuzzy Delphi method andapplication of structural equations.Results:The competency variable of educational leaders from the perspective of educationaladministrators and deputies in the qualitative stage and category analysis included 50competencies in five categories of leadership competencies in clinical education, self-assessment and evaluation of educational performance, development of student clinical skillsand individual competence, human resources.The designed model was evaluated in aquantitative step with the structural equation technique.Conclusion:Considering the importance of educational organizations as well as thecompetencies of managers in medical sciences for clinical success, this model can be used bydecision makers and consultants in order to select clinical education leaders in universitiesandto guide managers
Prevalence of Tartrazine Dye Use in Grilled Chicken Production Centers: A Case Study of Ardabil Province
No full textBackground & objectives: Sometimes artificial dyes are used instead of saffron as a fraud to improve the color of grilled chicken. Due to the adverse effects of some industrial colors such as tartrazine on human health, this study was conducted to determine the prevalence of using this color instead of saffron in the preparation of grilled chicken.
Methods: In a cross-sectional analytical study, 550 samples of colored grilled chicken were collected in a simple random sampling method in the cities of Ardabil province, 2016. Thin layer chromatography was used to extract the dye in the collected samples and the results were compared with the National Standard of Iran No. 2634. Data were analyzed by descriptive statistical tests.
Results: The results showed that of the total samples of grilled chicken prepared for consumption in Ardabil province, about one third (31.81%) of tartrazine dye was used. Although, there was not significant correlation between the colors used in the samples and the sampling site using the Spearman Correlation Coefficients the percentage of using this color was different among different cities of the Ardabil province. The highest percentage of color was found in Sarein city (35.29%) and the lowest was in Kosar city (21.95%).
Conclusion: The present study showed that in all cities of Ardabil province, synthetic tartrazine is used to dye grilled chicken instead of saffron dye. Almost one third of the grilled chicken samples were contaminated with tartrazine synthetic dye
The Predictors of Sexual Satisfaction among Iranian Women with Breast Cancer
No full textBackground: Breast cancer targets women’s sexual organs and deals with patients’ femininity. The low age
of incidence and the late stage of diagnosis of the disease in Iran give rise to sexual dysfunction among patients.
Identifying the severity of the disorder, and its determiners can specify the probable groups to be influenced. Materials
and Methods: In a descriptive cross-sectional study, 144 women with breast cancer who underwent surgical and
complementary therapies were included in the study. Data collection was done through questionnaires: FSFI, SSSW and
the demographic and clinical information questionnaire. Results: The mean age of patients was 42.31 ± 5.18 years. 76
patients (52.8%) underwent partial mastectomy and complementary treatments, and 68 cases (47.2%) underwent total
mastectomy and complementary treatments. All patients had sexual dysfunction in all dimensions. The average score
of sexual satisfaction was 84.3±10 10. The lowest sexual satisfaction score (79.6 ± 9.6) belonged to patients with total
mastectomy (P = 0.013). Regression analysis showed predictability of patients’ sexual satisfaction by type of treatment
and sexual function (P = 0.002 and P = 0.003, respectively). Conclusion: Sexual dysfunction and the low level of sexual
satisfaction in patients with significant predictive effect of treatment type and sexual function denote that the patients
with breast cancer need to be assisted to have proper sexual function and satisfaction leading to higher quality of life
Identification and introduction of nucleoprotein inhibitors as antiviral agents of Crimean Congo fever using virtual screening and computational drug design techniques
No full textIntroduction
Crimean Congo fever is an acute febrile hemorrhagic disease that it is transmitted by mites. There is currently no approved drug for this disease, but ribavirin as an antiviral drug can be useful. According to the lack of approved drugs and the possibility of virus resistance to ribavirin, today extensive research is needed discovery of drugs that are effective on this disease. In this study, compounds with structural similarity to galic acid were collected and docked with Crimean Congo fever nucleoprotein to select best compounds.
Material and Method
In this project, the crystal structure of Crimean Congo fever virus nucleoprotein was obtained from protein data bank. Prior to virtual screening, a library based on 50% structural similarity to galic acid was collected from the PubChem database in SDF format. The 3000 collected compounds crossing of different filters such as PyRx0.8, Rule of 5, ADMET and PASS. Finally, to performed qualitative and quantitative analysis of selected compounds molecular docking simulation was carried out.
Results
Among all compounds of library, thirteen compounds were able to pass successfully all filtrations.Thus, molecular docking of compounds was performed. at Next step, compounds were investigated based on free binding energy and different interactions with amino acids active site. Four compounds with codes of CID_8409, CID_65760, CID_5161 and CID_188481 have been selected with free binding energy of -9.32, -9.10, -8.65 and -8.56 kcal/mol, respectively as the best compounds from the molecular docking stage.
Conclusion
According to the docking results of the compounds and their comparison with ribavirin, gallic acid and previous articles, the amino acids Ile304, Lys462, Gln457, Lys411, Gln303, His456, Ala469 and Ala302 seemed to be important and necessary for interaction with compounds in the active site. According to evaluation, optimum hydrogen bonds, hydrophobic and π-cation seemed to be important and necessary
The Interaction between LncRNAase and epigenetic factors in gastric cancer progression
Get PDFGastric cancer is one of the most common malignancies in East Asian countries and the second cause of cancer-related death worldwide. Aberrant expression of long non-coding RNAs (lncRNAs) plays a crucial role in the development of GC. These molecules take part in various biological processes such as apoptosis, invasion, cell death markers, reprogramming of pluipotene stem cells, and genomic imprinting, which show that lncRNAs play an essential role in eukaryotic gene expression. LncRNAs interact with epigenetic factors including DNA methylases, histone modifiers, miRNAs, and chromatin remodeling complex, which lead to altered gene expression and cancer progression. Because the symptoms of GC usually develop in advanced stages, it is important to identify factors that are of clinical value for early diagnosis and prognosis of the diseases. Therefore, in this review article, lncRNAs whose expression levels are increased in GC tissue and by interacting with epigenetic factors may be involved in the development of GC are discussed
Study The Protective Effect Of Rosa Canina Against Nsaids Induced Gastric Ulcer In Mice
Get PDFAbstract
Background and Objective: Gastric ulcer induced by nonsteroidal anti-inflammatory drugs (NSAIDs) is a common gastrointestinal disorder affecting many people worldwide. Rosa canina L. is a member of Rosa species that has been widely used as an herbal medicine in many countries. Rosa canina has therapeutic effects against various disorders through its antioxidant, anti-inflammatory and cytoprotective properties. The aim of the present study was to evaluate the potential beneficial effect of Rosa canina in a mouse model of gastric ulcer induced by indomethacin.
Methods: Experiments were performed on male Swiss albino mice. Indomethacin (80 mg/kg, orally) was used to induce gastric ulceration. The extract of Rosa canina fruits (200 and 400 mg/kg/day) was given orally five days before the administration of indomethacin. Normal mice were used as a normal control group.
Results: Macroscopic evaluation of gastric mucosa revealed that indomethacin administration (80 mg/kg) produced apparent gastric mucosal ulcers, while pretreatment with Rosa canina (200 and 400 mg/kg) effectively protected gastric mucosa against indomethacin induced ulcers. Rosa canina significantly increased the level of glutathione (GSH) and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO) in the gastric tissues compared with those in the control group.
Conclusion: oral treatment with the extract of Rosa canina fruits decreased the gastric ulcer induced by indomethacin through antioxidant and anti-inflammatory mechanisms
Prevalence, comorbidity and predictors of anxiety disorders among children and adolescents
Get PDFChildhood anxiety may lead to serious health consequences in later life. The present study provides the
prevalence, comorbidity, and predictors of anxiety disorders among children and adolescents. This was a crosssectional national project that was implemented on 28,698 children and adolescents in Iran. Participants entered
the study by multistage cluster sampling with an equal number of each gender and three age groups (6-9, 10-14,
and 15-18 years) within each cluster. The tools used in this research were the demographic questionnaire and KSADS-PL. To analyze the data logistic regression and chi-square tests were used in SPSS (ver. 16). The
prevalence of anxiety disorder in children and adolescents was 13.2 in boys and 15.1 in girls. Furthermore,
gender, age, place of residence and history of psychiatric hospitalization of parents could predict anxiety
disorders. Anxiety disorders had comorbidity with behavioral disorders, neurodevelopmental disorders, mood
disorders, psychotic disorders, substance abuse disorders, and elimination disorders. According to our findings in
this study, anxiety disorders affect the performance, health and life of children and adolescents, identifying the
childhood anxiety, as well as finding diseases that are associated with anxiety disorders, can help in the
prevention of the disorder
