Ardabil University of Medical Sciences
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Identification and introduction of COX-2 novel inhibitors based on Curcumin structure using receptor based virtual screening
No full textBackground and purpose
Inflammation is the body's defense mechanism against pathogens, which can lead to many diseases. Cyclooxygenase 2 enzyme is one of the main enzymes involved in the inflammatory process and its inhibition reduces and eliminates inflammation. In this study, To Achieve compounds with the potential for anti-inflammatory effects and restriction of pathological conditions connected to inflammation , chemical compounds with a structural scaffold similar to the curcumin compound, wich showed inhibitory effects on cyclooxygenase 2, were investigated.
Materials and Methods
In the present project, 2063 chemical compounds based on 70% structural similarity with curcumin obtained from the PubChem database and then they was saved. Then, the various steps and filters of the virtual screening process was performed by the servers of Molinspiration, SwissADME, admetSAR and PASS. Finally, the energy and interactions of the selected compounds were investigated using Autodock 4.2 software.
Results
Compounds CID_54676038, CID_337736, CID_628942 and CID_337738 with free binding energies of -10.49, -10.34, -9.65 and -9.40 kcal /mol, respectively showed the highest free binding energy among all selected compounds. These four compounds formed hydrogen and hydrophobic interactions with key amino acids of cyclooxygenase 2 enzyme active site. According to molecular docking results, amino acids Gln178, Phe504, Ser339, Ile503, Ala502, Val509, Trp373, Met508 and Ala513 may be important in maintaining the stability of compounds in cyclooxygenase 2 active site.
Conclusion
In recent study to identify and introduce new cyclooxygenase 2 inhibitors, it was observed that a number of important amino acids establish hydrogen and hydrophobic interactions with 4 selected compounds, curcumin and Celecoxib on cyclooxygenase 2 active site. Also, in studies to investigate the specific effects of these compounds on cyclooxygenase 2, it was observed that one of the main selected compounds has a greater affinity to form a complex and bind to cyclooxygenase 2 than cyclooxygenase 1
Urinary Tract Bleeding as a Rare Manifestation of Uterine Artery Pseudoaneurysm
No full textPseudoaneurysm of the uterine artery is a rare condition, which usually occurs after a traumatic birth, cesarean section, dilatation and curettage, and hysterectomy. This case is a 28-year-old female patient that presented with the chief complaint of severe urinary tract bleeding and hypovolemic shock. This patient underwent cesarean section 2 months before the first presentation. After the primary examination, the patient was sent to the hybrid operation room with the primary diagnosis of uterine artery pseudoaneurysm and coil embolization was done for treating the pseudoaneurysm. Considering continued bleeding, open surgery was performed and the internal iliac artery was ligated
Frequency of under 18 years marriages in Ardabil city and the factors affecting it in 2009-2019
No full textBackground: The exact rate of under 18 marriage is not known in Iran. Despite all the many studies on the causes and roots of increasing the age of marriage, less attention has been paid to the issue of underage marriage. Due to social and cultural consequences of child marriage and health system policies based on women's physical and mental health; the present study examines the frequency of under 18 marriage of girls in Ardabil city and its related factors during 2009-2019.
Aim: To determine the frequency of under 18 marriage of girls in Ardabil city and related factors during 2009-2019.
Methods and material: The statistical population of the study was marriages registered during the years 2009 to 2019 from the marriage counseling center and laboratory of Ardabil city. Of all marriages registered during this period, marriages under the age of 18 were registered to determine the frequency. To do this, we went to the above centers and extracted information about the number of marriages under the age of 18 during the last 10 years from the centers' system. In the second step of the research, a researcher-made questionnaire was validated by 10 professors in the relevant field and its reliability was assessed using a retest method to examine the factors related to marriage under 18 years. This questionnaire contained 27 questions and 221 people entered the study.
Results: The highest rate of marriage under 18 years in Ardabil in 2009 with 3886 cases (15.68%) and the lowest rate in 2011 with 1148 cases (4.63%). The rate of marriages under 18 years of age decreased significantly during the 10 years of 2009 to 2019. Over time and over the years, the number of marriages under the age of 18 in under 14 and 15 to 18 age groups has decreased significantly.
Conclusion: The number of marriages in girls under 18 years of age has decreased from 2009 to 2019. In total, the three components of faith and good characteristics of the husband, love and affection to the husband and emotions such as wearing a wedding dress and buying a wedding, respectively, formed the ranks of one to three effective components in marriage under 18 years old girls in Ardabil
Tranexamic acid effect on glioblastoma and endothelia cell migration in co-culture environment
No full textBACKGROUND AND OBJECTIVE: High infiltration of glioma cells into the surrounding brain tissue is the cause of treatment failure in glioblastoma. Glioblastoma interactions with endothelial cells increase the migration of cancer cells. Co- culture systems try’s to prepare a situation similar to physiology of body. The aim of this study was to investigate the effect of tranexamic acid (TXA) on reducing the migration of glioblastoma and endothelial cells and the levels of metalloproteinases-2 and -9 (MMP-2/9) in co-culture conditions.
METHODS: In this experimental study, cells prepared from Pasteur Institute were treated with different concentrations of TXA in mono-culture and co-culture. Cell survival was determined by MTT assay. The rate of migration was assessed by making grooves in the culture dishes and comparing the groove area at different time intervals in the control and treated groups with 6 and 24 mM TXA. The levels of MMP-2/9 enzymes in the control group and cells treated with 6 mM TXA were assessed by zymography.
FINDINGS: Decreased survival of T98G and HUVECs cells was observed in mono- and co-culture from 60 mM TXA and above. Groove area in HUVECs group treated with TXA was significant more than control group. No difference in groove size after 36 hours of threatment was observed in T98G cells. TXA significantly reduced the levels of MMP-2 and MMP-9 in co-culture conditions and the reduction level in MMP-2 is more than MMP9.
CONCLUSION: The results showed that TXA could reduce the migration of glioblastoma and endothelial cells as well as the levels of MMP-2/9 in co-culture condition
Concurrent chronic lymphocytic leukemia and COVID-19: A comprehensive review of epidemiological, diagnostic, and therapeutic challenges
No full textA comprehensive review of the literature on chronic lymphocytic leukemia (CLL) patients and recommendations regarding the evaluation and treatment of these patients was conducted. The overall prevalence of CLL and COVID-19 concurrence was found to be 0.6% (95%CI: 0.5% to 0.7%). Diagnostic interaction between CLL and COVID-19 remains a major challenge. Also, CLL patients have a lower rate of anti-SARS-CoV-2 IgG development. Evidences show the unacceptable therapeutic outcome in these patients. Although the CLL-COVID-19 occurrence is associated with adverse clinical consequences, no general and standard agreement has yet been presented for the management and treatment of this disease
Comparison of color stability of bulk fill and conventional composite resins following exposure to mouthrinse
No full textIntroduction: Comparison of color stability of bulk elephant and conventional composites against mouthwashes Abstract Introduction: Color change of composite restorations is the main factor in replacing these restorations. This study aims to compare the color stability of composite elephant bulk composites against mouthwashes.
Materials & Methods: In this laboratory study, 40 samples of composite (tetric n ceram) A2 with a diameter of 4 mm and a thickness of 4 mm were divided into four groups: a- in the presence of non-alcoholic MissWake mouthwash, in the presence of chlorhexidine mouthwash C- In the presence of alcohol-based Listerine mouthwash, In the presence of distilled water mouthwash and 40 samples of tetric n ceram bulk composite (A2) with a diameter of 4 mm and a thickness of 4 mm (10 samples) in the four groups mentioned The samples were then washed using SiC-400 grit paper and OptiDisc, then washed thoroughly with water for 10 seconds to remove debris and then at 100 ° C and 245 ° C for 24 hours. The primary dye (L, a, b) was measured in an incubator using an Easyshade spectrophotometer and the CIELab system. Data were analyzed by two-way ANOVA at a significance level of 0.05.
Results: The color change of the composite (tetric n ceram (AE) (967/32±1/1) is less than the composite tetric n ceram bulk fill (837/56±2/1) (P <0.05). In both conventional composite and elephant bulk, the lowest amount of color change (AE) in distilled water, respectively; Non-alcoholic fluoride; Listerine mouthwash and alcohol-containing and chlorhexidine mouthwash were observed.
Conclusion: None of the common composites and elephant pulp in distilled water; Non-alcoholic fluoride; Listerine mouthwash and alcohol-based co-mit did not cause clinically perceptible discoloration in the composites; But in chlorhexidine mouthwash in both composites discoloration was clinically unacceptable. Keywords: dye, resin composite, mouthwash
Prevalence of oral mucosal lesions in patients with type 2 diabetes mellitus in Ardabil in 2020
No full textIntroduction: public health emergencies of the century, affecting more than 400 million people worldwide. Diabetes is associated with complications, mortality, and high socioeconomic costs. It can seriously affect the quality of life of patients. In some studies, diabetes has been shown to be associated with oral mucosal lesions, but the exact relationship between diabetes and oral mucosal lesions remains unclear and there is still considerable debate about this. Whether oral mucosal lesions in diabetic patients are more than non-diabetic patients or not. Therefore, we decided to investigate the prevalence of oral mucosal lesions in diabetic patients.
Methods: This study was a case-control study. 115 people with diabetes as a case group and 115 healthy people as a control group were chosen. Demographic information, medical and dental history of the study participants were collected through a questionnaire that includes: age, sex Smoking status, use of dentures, duration of diabetes, fasting blood sugar level, HbA1c level, type of drug used. During this examination, the condition of patients in terms of oral mucosal lesions such as oral candidiasis, other white and red lesions, pigmented lesions, exophytic masses, recurrent aphthous stomatitis, traumatic ulcers, geographical tongue, grooved tongue was determined and were recorded in a questionnaire.
Results: The results showed that the overall prevalence of oral mucosal lesions in diabetic patients (58.26%) was not significantly different from healthy individuals (34.78%). In diabetic patients, the duration of the disease and the mean fasting blood sugar and mean HbA1c were significantly higher in those with oral lesions than in those without oral lesions.
Conclusion: The prevalence of oral mucosal lesions in people with type 2 diabetes mellitus in Ardabil is higher than non-diabetic people. The findings of the present study, in addition to providing a preliminary picture of the prevalence and pattern of oral mucosal lesions in people with type 2 diabetes mellitus, can also be used to treatment plan policies to take
Determination of extent and severity of Periodontal disease in patients with obstructive coronary artery disease, evaluated by angiography
No full textIntroduction: Periodontal disease is a local inflammatory process that leads to alveolar bone resorption and if left untreated and the disease progresses, it can lead to the loss of a dental unit. Numerous studies have supported this hypothesis that; Inflammatory factors related to periodontal disease enter the bloodstream and lead to systemic inflammation as a risk factor for coronary heart disease.
The aim of this study was to determine the extent and severity of periodontal disease in patients with obstructive CHD and to compare them in patients with one-vessel, two-vessel and three-vessel involved.
Methods and Materials: The present study is a cross-sectional descriptive analytical study on 96 patients who underwent coronary angiography and obstructive coronary heart disease; Based on the angiographic result, patients were classified into three categories: one involved vessel, two involved vessels and three involved vessels. Then, periodontal indices Plaque Index, Bleeding On Probing, Periodontal Pocket Depth and Clinical Attachment Loss were measured in these three groups and together Were compared.
Results: In this study, a comparison of periodontal indices between the three groups showed that only the Plaque Index increases with increasing number of vessels involved and this relationship is statistically significant(P<0.05), but the indices of Bleeding On probing, Periodontal Pocket Depth and Clinical Attachment Loss was not statistically significant between the three groups.
Conclusion: According to the results of the present study and due to the strong relationship between poor oral hygiene and the degree of coronary artery occlusion; The need to improve oral care has become more apparent among patients with cardiovascular disease, and physicians and dentists should pay special attention to oral health care in these patient
Students' Nutrition Literacy and the Existence of Health Care Providers in Iranian Schools
Get PDFBackground: The objective of this study was to investigate the relationship between Students' nutrition literacy and the existence of health care providers in Iranian schools.
Study design: A cross-sectional study.
Methods: This study was conducted on 504 students in Ardebil City, northwestern Iran from Oct 2017 to Jan 2018. The FLINT questionnaire was used to assessment the food and nutrition literacy. Socio-demographic characteristics and the existence of health care providers were collected using demographic questionnaire.
Results: Nearly 75% of students had not a health care provider. Most students had a low FNLIT (62% males and 58.1% females). The probability of low FNLIT was lower in students with health care providers than those without them (OR=0.46, CI 95%; 0.10, 0.91).
Conclusion: One of the reasons for the low nutritional literacy of students may be due to the lack of health care providers in schools. Health educational administrators employ specialized health care providers in Iranian schools
Evaluation of defense mechanisms, strength and level of development of Ego in patients with obsessive-compulsive disorder in patients referred to the psychiatric clinic of Fatemi Hospital in Ardebil
No full textBackground: Obsessive-compulsive disorder is defined by repetitive and persistent thoughts, desires, or mental images that the individual considers unwanted and disturbing. Decreased quality of life in patients with OCD is severely affected by signs and symptoms.
Objective: This study is performed in order to determine the defense mechanisms, strength and level of development of Ego in obsessive-compulsive disorder patients referred to the psychiatric clinic of Fatemi Hospital in Ardebil
Methods and meterials: Information in this study was extracted using Demographic Questionnaire, Yale-Brown Questionnaire and Igo Power Questionnaire and Ego Transformation Level Questionnaire, Ego Defense Mechanism Questionnaire. This questionnaire was self-report and was given to the patient before completing the training. This questionnaire has a validity above 80% and is standard. The evaluations were performed by psychiatrists working in the clinic. The severity of obsessive-compulsive disorder was reported by Yale-Brown.
Results: In this study, 46 people entered the study according to the entry criteria. Their average age was 35.9 14 9.14 years. 25 (54.3%) were men and 21 (45.7%) were women. The results of the study showed that people's gender does not affect the rate of obsessive-compulsive disorder. (P<0.05). 27 people (58.7) of the subjects studied with an average of 37.03 have obsessive-compulsive disorder. While 19 people (41.3%) of the studied people with an average score of 22.47 are healthy in terms of obsessive thoughts. In the study of EGO defense mechanisms in people with obsessive-compulsive disorder, some defense mechanisms were significantly associated with people's EGO (P <0.05). In our statistical study, the relationship between EGO power and obsessive-compulsive disorder was statistically significant. (P<0.05). The results of statistical analysis of the level of EGO evolution in the studied individuals showed that the level of EGO evolution was not much different in people with obsessive-compulsive disorder and non-infected people. Also, the association of EGO evolution level with significant obsessive-compulsive disorder was not significant (P <0.05).
Conclusion: Our findings showed that obsessive-compulsive disorder was associated with EGO strength and EGO defense mechanisms, and this relationship was statistically significant. The disorder was not associated with gender or EGO level