Ardabil University of Medical Sciences
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67Years old lady ext.mi post mi angina
Get PDFاین کنگره که به شکل case presentation برگزار می گردد و بیشتر به نحوه درمان توسط اینترونشنیست ها می پردازد و در هر case تجربه و آموزش مربوطه توسط مجری توضیح داده می شود و توسط هیئت داوران و شرکت کنندگان نقد و بررسی می شود همچنین caseهای پیچیده کرونری و peripheral در این جلسه مطرح و نحوه بکارگیری وسایل مختلف توسط مجریان و افراد با تجربه در این امر توضیح داده می شود
Evalution of effect of application of two mouthwashes on nickel release from dental alloys.
Get PDFIntroduction: In orthodontic treatment, the various alloys are widely used; these materials are placed in contact with the oral tissues for months or even years. The consumption of some foods and acidic drinks provides good conditions for corrosion of metals, and release elements such as nickel, chromium, copper and silver; therefore, this thesis was conducted to investigating the effect of two types of mouthwashes on the amount of nickel released from dental alloys.
Materials and Methods: In this semi-experimental study, 42 Nickel-chromium metal disks were investigated and Samples were immersed in Listerine and Oral-B mouthwashes for 48 hours, and Immersed solution was examined by inductively coupled plasma (ICP). The results were analyzed by Oneway ANOVA and Tukey post hoc test at 5% alpha level, after measuring the released nickel from dental alloys.
Results: The results of this study showed that, the lowest amount of nickel released; distilled water in the first place and Oral-B mouthwash in the second place and Listerine in the third place. Also the results showed that there is a significant difference in the amount of nickel released from casting dental alloys in Listerine and Oral-B mouthwashes and Oral-B mouthwash with distilled water and Listerine with distilled water.
Conclusion: According to this study, nickel ions released from Oral-B and Listerine mouthwashes, less than the recommended daily intake by the World Health Organization. Therefore, the use of these mouthwashes is recommended
Evaluation of Iatrogenic error in Root Canal Therapy Performed by Students of Ardabil Dental School 2015-2017
Get PDFIntroduction: Root canal therapy such as other dental work is sometimes associated with unwanted and unpredictable conditions, which are referred to as the sum of these events during treatment. Understanding these incidents and its causes for continuing treatment and preventing repeat is necessary. This thesis also aims to Evaluation of Iatrogenic error in Root Canal Therapy Performed by Students of Ardabil Dental School 2015-2017.
Materials & Methods: A random sample of 507 records of root canal therapies performed by 5th – and 6th – year dental students in year 2015 and 2017 was investigated. For each tooth, four periapical radiographs including preoperative, working length, master cone, and obscuration were examined by two staffs of endodontic department using 2× lens magnification. Than the length and density of root fillings, as well as presence of procedural errors including extension of access cavity, ledge, apical perforation, apical zipping, fractured instrument, strip perforation, and missed canal were recorded. Finally the data were gathered and analyzed by SPSS software and Chi- Square test, Mann-Whitney, Kruskal-Wallis, and Fisher’s exact test (α=0.05).
Results: The results of this study showed that 62.1% of teeth had acceptable filling length, In 378 (74.6%) of the teeth, proper fill density and 25.4% of the rest were observed in unsatisfactory filling densities. The results also showed that (12%) of the teeth had technical errors, with the most technical error (4.3%) related to the apical zipping. Also, there was a significant relationship between the lengths of root filling with the student's academic year, but there was no significant correlation between technical error and filling density with the student's academic year. Also, there was a significant relationship between the length of filling with the distribution of teeth in maxilla and mandibles, however, there was no significant correlation between technical error and filling density with the distribution of teeth in maxilla and mandible.
Conclusion: Iatrogenic errors were more often in molar teeth and ledge was the most common one. Also there was a significant difference between 5th – and 6th – year students in the incidence of some of the iatrogenic errors
Mesenchymal Stromal Stem Cell-Derived Microvesicles Enhance Tumor Lysate Pulsed Dendritic Cell Stimulated Autologous T lymphocyte Cytotoxicity
Get PDFBackground: Immunotherapy is one promising therapeutic strategy against glioma, an aggressive form of brain cancer. Previous studies have demonstrated that multiple tumor antigens exist and can be used to induce tumor specific T cell responses. Furthermore, recently it was shown that TLR4-primed mesenchymal stem cells (MSCs), also known as MSC1, mostly elaborate pro-inflammatory mediators. Compared to MSCs, MSC-derived microvesicles (MVs) have
advantageous properties that present them as stable, long lasting effectors with no risk of immune rejection. Therefore, peripheral blood monocyte derived dendritic cells (MoDCs) have been used to load tumor antigens and stimulate T cell mediated responses in the presence of MSC1-derived MVs in vitro. Methods: The B92 tumor cell line was heated to 43°C for 90 min prior to preparation of tumor cell lysates. MVs were purified by differential ultracentrifugation after isolation, stimulation of proliferation and treatment of MSCs. Autologous T cells isolated from non-adherent cells were harvested during the procedure to generate MoDCs and then incubated with heat stressed tumor cell lysate pulsed DCs in the presence of MSC1-derived MVs. T cells were then co-cultured with tumor cells in 96-well plates at a final volume of 200 μl CM at an effector: target ratio of 100:1 to determine their specific cytotoxic activity. Results: Flow cytometric analysis, T cell mediated cytotoxicity showed that heat stressed tumor antigen pulsed MoDCs and MSC1-derived MVs primed T cells elicited non-significantly enhanced cytotoxic activity toward B92 tumor cells (P≥0.05). Conclusion: These findings may offer new insights into tumor antigen presenting technology involving dendritic cells and MSC1-derived MVs. Further exploration of the potential of such nanoscale particles in immunotherapy and in novel cancer vaccine settings appears warranted
The Study of Risk Factors for Coronary Artery Disease in Patients with STEMI and Its Relation to Referral Time
Get PDFBackground and objective: In the last decade, cardiovascular diseases has been recognized as the leading cause of death in the world as a global epidemic and the most common causes of mortality in the country. The aim of this study was to investigate the risk factors of coronary artery disease in patients with STEMI and its relationship with referral time.
Materials and methods: The research method is a cross-sectional and analytical-descriptive study.
The research sample included 188 patients with diagnosis of acute myocardial infarction with ST elevation, which had been referred to the Emergency Department of Imam Khomeini Hospital in Ardabil from the beginning of September 2016 to the end of September 2017. Data collection was done by using the information in the patients 'files, the corresponding Cath lab form and a questionnaire by interviewing themselves and patients' companions and were recorded in the relevant checklist. The data were analyzed using descriptive statistics and correlation tests with SPSSV22 software.
Results: The most common risk factor among patients was smoking (54.7%). The most frequent cases were combined overweight and smoking, followed by high blood pressure and smoking. 6.3% of patients did not have any risk factors for coronary heart disease. Also, there was no significant relationship between coronary risk factors and referral time. There was no significant difference between the subjects in relation to the previous (p = 0.78) and familial (p = 0.49) myocardial history of myocardial infarction and referral time.
Discussion and conclusion: According to the findings, awareness of the risks of smoking and the promotion of healthy lifestyle can reduce the incidence of heart disease
Efficacy of Erythropoietin in treatment of anemia in patients hospitalized in the ICU of Ardabil city hospital
Get PDFBackground: Several studies have shown that approximately 95% of patients who have been admitted to the ICU are anemic. Anemia in acute patients leads to significant transfusion. Transfusion can lead to significant complications. Because of the risks of transfusion an alternative therapy for anemia in patients seems be a necessary need for its. The aim of this study was to investigate the efficacy of Erythropoietin in treatment of anemia in patients hospitalized in the ICU of Ardabil city hospital.
Methods: This study is a clinical trial. In this study after selection of patients based on inclusion and exclusion criteria, their data were entered in a check list. Patients were divided into two groups of 35 persons randomly. For first group, erythropoietin was administrated in addition of iron and in second group only iron was administrated. All patients were administrated 100 mg of iron. Hematological indexes and clinical status of patients was evaluated and results were analyzed by statistical methods in SPSS version 19.
Results: In this study, in cases 65.7% and in controls 71.4% were male. The average age of patients in cases was 61.6±20.8 and controls were 61.02±22.5 years. The mean duration of hospitalization in internal ICU was 37.73 days and in surgical ICU was 21.35 days and was observed that at baseline the hemoglobin levels in internal patients was lower than surgical patients (p=0.023). 80% of patients in case group (5.8 units) and 88.57% of patients in controls (6.3 units) required blood transfusion. The hemoglobin level in erythropoietin receiving group increased significantly compared to the control group.
Conclusions: The results of this study showed that erythropoietin is an effective drug to increase hemoglobin level and can provide a significant increase in hemoglobin level compared to placebo
Determination of Psychometric Properties of Non-Verbal Pain Scale in Patients Receiving Mechanical Ventilation
Get PDFIntroduction: One of the major barriers to pain management is the lack of adequate scale for the assessment and diagnosis of pain in patients with no verbal response under mechanical ventilation in intensive care units. One of the few pain assessment scales in these patients is the Non-Verbal Pain Scale (NVPS).
Objective: This study aimed to determine psychometric properties of Non-Verbal Pain Scale (NVPS) in patients under mechanical ventilation in intensive care units.
Materials and Methods: In this methodological study, 60 patients under mechanical ventilation and admission to trauma, internal, neurological and surgical intensive care units were considered. The pain was assessed using NVPS by two nurses at six different times (before, during and after painful and non-painful procedures). Also, 8-12 hours after the initial test, a retest was performed in 37 out of 60 patients (randomly selected).
Results: The Cronbach's α coefficient for the whole scale was obtained as 0.80 while the correlation between the two raters at different times was 0.89-0.96, and the correlation between test and retest was 0.55-0.86. There was a significant difference in the pain score during painful and non-painful procedures (P=0.001) and a higher pain score in those who confirmed the presence of pain (P<0.001), indicating good discriminant and criterion validity of NVPS.
Conclusion: NVPS has good psychometric properties and can be used as a valid and reliable scale for assessing pain in patients under mechanical ventilation
Evaluation efficacy and side effects of Intravenous ibuprofen and Intravenous acetaminophen in pain control after laparoscopic cholecystectomy
Get PDFBackground and objective: The importance of effective postoperative analgesia is now widely accepted. Systemic opioids administration is the gold standard in reducing the severe pain after surgery but some side effects prevent the use of adequate doses of opioids. The aim of this study was evaluation of adding intravenous acetaminophen and ibuprofen on fentanyl in patient-controlled iv analgesia(PCIA).
Methods: In this randomized clinical trial, 90 patients candidate for elective laparoscopic cholecystectomy (ASA 1-2) randomly allocated in three groups; Control group (n = 30) received saline solution, Acetaminophen group (n = 30) received 1g IV Acetaminophen and Ibuprofen group (n= 30) received 800 mg IV ibuprofen.
All patients received patient-controlled (PCA) fentanyl (60 mg in 100 ml saline solution) analgesia. The drugs administered intravenously after surgery and then every 8 hours, for a total of 3 doses. If VAS>3, meperidine 0/5 mg/kg was administered. Pain score, sedation score, nausea and vomiting, satisfaction, and consumption dose of meperidine and fentanyl was evaluated for 24 hours after surgery.
Results: The demographic characteristics of the three groups did not differ significantly. Pain scores in ibuprofen group (3.02), acetaminophen group (2.89) did not differ significantly but in comparison with control group (5.10) was significantly lower. Severity of shoulder pain, nausea and vomiting, sedation, consumption dose of meperidine and fentanyl were similar in both acetaminophen and ibuprofen groups but in comparison with control group was significantly lower.
Conclusion: Finding of this study shows that use of any of the acetaminophen and ibuprofen in postoperative pain control can reduce the need for consumption of opioids and lead to less complications of nausea and vomiting and sedation.In general, it increases satisfaction of patients. Also acetaminophen can be a good alternative for patients who had limited NSAIDs use to postoperative pain contro
Data on cephalexin removal using powdered activated carbon (PPAC) derived from pomegranate peel
No full textCephalexin is extensively used as an antibiotic for treatment a number of bacterial infections. The data of possible adsorption mechanism and isotherm of Cephalexin on the synthesized adsorbent are depicted in this data article. The data obtained showed that the adsorption trend follows the pseudo-second order kinetic model and that the Langmuir isotherm was suitable for correlation of equilibrium data with the maximum adsorption capacity of 48.78 mg/g. Considering the findings data, powdered activated carbon derived from pomegranate peel as available and a cheap adsorbent, could be considered as promising adsorbent for Cephalexin and probably similar organic pollutants removal from aqueous solutions
Decreasing telomerase activity of adenocarcinoma cancer cell line (AGS) is associated with different concentrations of sodium selenite and cadmium chloride and selenium l methionine
Get PDFBackground: Selenium (Se) has been recognized as an essential element for animals and humans. In the late 1960s, it was first suggested that selenium might have anti-cancer properties. Selenium controls apoptosis in cell cycle. Cadmium (Cd) is a widely used heavy metal that affects human health through occupational and environmental exposure and has been reported as a cause of cancers such as lung, prostate and kidney. The previous studies on Ovarian and breast cancer have shown that cadmium increases telomerase activity and expression level of hTERT. In the present study, we find out the effect of sodium selenite and selenium l methionine and cadmium chloride on telomerase activity in adenocarcinoma cancer cell line (AGS).
Methods: The adenoma carcinoma gastric cancer cells (AGS) were cultured in RPMI1640 supplemented with 10 % fetal bovine serum (FBS) and 1% pen/strep. Concentrations of cadmium chloride, selenium l methionine and sodium selenite were added the adenocarcinoma gastric cancer cells (AGS). Finally, the telomerase activity was measured by telomeric repeat amplification protocol (TRAP) and qRT-TRAP assays.
Results: Average telomerase activity (as threshold cycle (CT)) has been detected for three concentrations (5μM and 10μM and 20 μM) of the noted compounds. The results were 24.82±0.51, 25.31±1 and 25.63±1.32 for Sodium selenite, 24.56±0.25, 25.29±0.98 and 25.60±1.21 for Cadmium chloride and 24.49±0.18, 25.30±0.99 and 25.73±1.32 for Seleniul l methionine, respectively. Representing the signification decreasing telomerase activity at treated samples compared with the controls (p ≤ 0.05).
Conclusions: Decreasing in the telomerase activity which was caused by treating with Cadmium chloride, Selenium l methionine and Sodium selenite is in conflict with some previous findings indicating the increasing in the telomerase activity by treating Cadmium