Ardabil University of Medical Sciences
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Parkinson’s disease and risk of hip fracture: systematic review and meta-analysis
No full textThe relationship between Parkinson’s disease (PD) and risk of hip fracture yielded inconsistent results. Therefore, we conducted the present systematic review and meta-analysis of published observational studies to assess the association between PD and risk of hip fracture. PubMed, ISI, EMBASE, and Cochrane databases were searched systematically to identify studies assessing the relationship between PD and the risk of hip fracture up to July 01, 2017. In addition, to find related articles, the reference section of retrieved articles was checked. Random-effects model was used for calculation of pooled hazard ratio (HR) and 95% confidence intervals (CI). Thirteen independent studies containing 564,947 participants were included in the meta-analysis. The overall results of included studies showed PD to be associated with the risk of hip fracture (HRoverall = 3.13, 95% CI 2.53–3.87) in women 3.11 (2.51–3.86) and men 2.60 (2.19–3.09). Our meta-analysis showed the direct association between PD and the risk of hip fracture in both men and women. However, due to the limitations of this study, further well-designed studies are required to confirm our findings
The role of gut microbiota and IL-23/IL-17 pathway in ankylosing spondylitis immunopathogenesis: New insights and updates
No full textAnkylosing spondylitis (AS) is a type of arthritis that is referred to a group of chronic immune-mediated inflammatory diseases termed as seronegative spondyloarthropathies or spondyloarthritides. It typically affects the joints of the spinal and axial skeleton and exhibits common clinical features and genetic factors such as human leukocyte antigen class I allele HLA-B27, the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1), and environmental factors such as microbial triggers. Although the precise etiopathogenic mechanisms that implicate the pathogenesis of AS have still remained to be clarified, the IL-23/IL-17 immune axis has been detected as an important factor in the immunopathogenesis of AS. Moreover, therapeutic options targeting this signaling pathway have been demonstrated to be effective in various other inflammatory diseases that share similar genetic etiology and pathogenetic pathways. In mammalian intestinal, there are trillions of commensal microbes that create the intricate symbiotic relationship with host well-known as the microbiota and play the major role in human health and disease. Several publications have appeared in recent years documenting the pivotal role of the gut microbiota and the IL-23/IL-17 pathway in the pathogenesis of spondyloarthritides. In this review, several points are discussed and summarized including recent advances on the role of the IL-17/IL-23 immune pathway in the pathogenesis of AS, HLA-B27, and ERAP 1 and 2 mediated pathogenesis, AS-related microbiota compositions, and new potential therapies for AS
Effect of ketofol in reducing cough caused by fentanyl in patients undergoing general anesthesia
Get PDFBackground and objective: Fentanyl is one of the most commonly intravenous opioids that is used in the operating room for Premedication in patients with a general anesthetic candidate or sedative drugs. Opiate cough induced is a complication that is seen after fentanyl administration. In this study, we measured the effect of co-administration of ketamine and propofol with the title of ketofol (with a 1: 1 ratio of propofol lomg and ketamine 10 mg) to reduce fentanyl-induced cough.
Method:The present study is a randomized, double-blind clinical trial. All patients were aged between 18-60 years old. After obtaining consent from patients for inclusion in the study, 124 patients were selected using convenient sampeling metoth. The first group received ketamine, the second group received propofol, the third group received ketofol, and the fourth group received normal saline. All oral medications were discontinued 8 hours before surgery. To the first group, ketamine 2 cc, to the second group proponol 2 cc (10 mg), to the third group of cetofol 2 cc (propofol 10 mg + ketamine 10 mg 1: 1) and to the fourth group (2 cc normal Saline). Then fentanyl (2 μg / kg) was administered to each of the 4 groups. Coughing, severity and time of onset of it were recorded in time intervals (0-10-5) in each of the four groups. Then, patients underwent general anesthetic with propofol and muscle relaxation. Finally, all the data entered the statistical analysis program and analyzed the data.
Results: In this study, couph rate was 22.6%, 32.3%, 6.5% and 61.3% in ketamine, Propofol, ketofol and control group respectively. The highest cough delay was observed in the recipients of ketofol and propofol, and the highest premature cough was observed in the control group. Also, none of the prescribed drugs did not significantly change the blood pressure, heart rate, and MAP in the control group. It was observed that ketofol, ketamine and propofol significantly reduced the cough rate compared with the control group and ketofol compared to the propofol group.
Conclusion: The results of this study showed that ketoffol had the most fentanyl-induced cough suppressant compared to placebo and propofol, but did not show significant superiority to ketamine
In silico analysis of a few dietary phytochemicals as potential tumor chemo-sensitizers
No full textP-glycoprotein (P-gp) is a membrane ATP-binding cassette (ABC) transporter that extrudes different xenobiotics out of cells.Besides its tissue protection role, overexpression of P-gp on the surface of many neoplastic cells restricts the cell entry of many anti-cancer drugs, the phenomenon which is known as multidrug resistance (MDR). It has been demonstrated thatMDR cells can be sensitized toward anti-cancer agents when treated with P-gp inhibitors/modulators known as chemo-sensitizers. Due to the clinical significance and also considering the fact that many P-gp inhibitors are transported by P-gp, the search for more potent and low toxic non-transported chemo-sensitizers is an active area of research. Regarding this, several naturally occurring compounds were reported as MDR reversal agents, a category which is generally referred to as Bfourth-generation P-gp inhibitors.^ Dietary supplements containing natural products are widely used, and it is possible that they interact with coadministered pharmaceutical substances that are P-gp substrates, leading to altered pharmacokinetic profile. In silico approaches
for quantitative and quantitative prediction of binding mechanism of dietary natural products to P-gp may be regarded as appropriate strategy in the early phase of drug discovery projects since they describe structural features of various phytochemicals for interaction with P-gp and pave the way toward alternative and novel anti-MDR scaffolds. In the present contribution, some phytochemicals of turmeric, black pepper, and green tea as commonly consumed dietary sources were subjected to systematic
combined in silico analysis including molecular docking and amino acid decomposition analysis through B3LYP functional in association with 6-31G basis set. On the basis of major identified drug binding sites within P-gp internal pocket, modeled natural compounds were categorized as substrate, inhibitor, or modulator while structure binding relationship of each category was developed and elucidated
What are the various general issues in the pediatric imaging
Get PDFA diagnostic tool in the pediatric population is x-ray imaging, but it comes with a number of distinct challenges as compared to the adults imaging, because it requires dedicated imaging protocols, sedation or anesthesia, specific training, and most importantly consideration for radiation exposure if ionizing radiation is being used.
One of the challenges for clinical care personnel is to gain the child's trust and co-operation before and throughout the duration of an examination, to acquire quality images and prevent repeat examinations. Even with a quality examination, the accurate interpretation of images requires a thorough knowledge of the intricate and dynamic face of anatomy and special pathological representations in children. This article attempts to draw attention to various challenges of pediatric imaging and the ways to overcome them
Need assessment of adult patients refering to nardabil dental school for dental aesthetic 2017-2018
Get PDFBackground and Aims: The beauty of smile has become one of the main goals of dental treatments. Factors of beauty is different for everyone. The purpose of this research is to be aware of the attitude of the community members about the beauty and the type of need for them in this category and the reasons that prevented the reception of beauty treatments.
Materials and Methods: 384 patients referred to Ardabil Special Dentistry Clinic were surveyed by a questionnaire. data were analyzed using t-test and chi-square tests using spss16 software. P value less than 0.05 was considered as an important statistic.
Results: The significance of the appearance of smile on the overall appearance of social life was higher in women than in men. The gum's shape among the causes of the smile's dissatisfaction was significantly higher in women than in men. Also, people with less aged were expressed less busy teeth as a cause of dissatisfaction, while with increasing age, decay and lack of front teeth were causes of the smile's dissatisfaction. Individuals with Higher education Had chosen Significantly lip form as cause of dissatisfaction from smile while persons with lower education had selected decay of The front tooth for it.
Conclusion: The findings of the study showed that the greatest cause of the discontent of the beauty of the smile was related to the color of the tooth and the shape of the tooth, and most of the subjects wanted beauty treatment, and the factor preventing their treatment was in the first place economic issue
Survey of anthropometric indices among medical university girls in Ardabil, Iran, 2017
Get PDFBackground: Evaluation anthropometric used as a clinical instrument for design and determine the health policy in community. This study aimed to investigate the anthropometric indices in medical university students in Ardabil.
Methods: In this cross-sectional study height, weight, waist circumference and hip circumference were measured. BMI was used to assess the overweight and obesity and WHR was used for central obesity. Data analyzed by statistical methods in SPSS.19.
Results: The mean age of students was 20.4±1.3 years. 28% of students were in age 20. According to BMI, 7% of all students had overweight and 1.5% had obesity. According to the WHR, 78 (39%) had central obesity (WHR >0.8) which were in unhealthy high-risk group.
Conclusions: Results showed that the rate of overweight and obesity in medical university girls in Ardabil was lower than many studies in country. So, programming for rising their knowledge about obesity related factors and increasing their physical activity and modify feeding behavior is essential in future
Frequency of Chlamydia pneumonia & Mycoplasma pneumonia in patients admitted with exacerbation of COPD
Get PDFObjective:
Infections are the major cause of the acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The etiology of acute exacerbation of COPD is heterogeneous and still under discussion. Serological studies have suggested that mycoplasma pneumonia and Chlamydia pneumonia may play a role in acute exacerbation of COPD.
Material-Methods:
200 serum samples from 100 AECOPD patients were studied by ELISA method for detection humoral response of mycoplasma pneumonia and Chlamydia pneumoniae.100 samples obtained during recent hospitalization for the measurement of IgM , 4 weeks after 100 samples obtained again for the evaluation of IgG.
Results:
A total of 100 AECOPD patients, 73(73%) males and 27(27%) females were included in this study. The mean age of the patients was 74.37±8.50. The incidence of M.pneumoniae and C.pneumoniae infections were found as 13% and 14%.Combined infections were also detected in 7% patients. The mean FEV1%perdicted was 46.633 ±11.10729 and in stage 2 COPD was 40 cases, stage 3 55cases and stage 4 5cases. The incidence M.pneumoniae in 3 difference stages were 5%, 16.4% and 40% with respect to the order, moreover, for the mentioned stages 12.5%, 14.5% and 20% of incidence were observed in the case of the C.pneumoniae infections.
Conclusion:
The findings suggest that atypical infections seem to have substantial frequency in acute exacerbation of COPD. Moreover, age of patients seemed to have no significant correlation with infection of M.pneumoniae and C.pneumoniae whereas reduction of FEV1 influences on the infection noticeably
Correlation between Keratinized Tissue width and Periodontal Indices around Implant supported Fixed Prosthesis
Get PDFBackground: The role of KM on peri-implant tissue health was undetermined and it was discussed controversially in literature. The width of KM which result in long term implant success was insecure. The aim of this cross-sectional study is to determine whether a correlation exists between The width of Keratinized Mucosa and the health of implant supporting tissue.
Materials and Methods: 73 functional dental implants which support fixed prosthesis were examined and Periodontal parameters include plaque index, gingival Index, bleeding on probing, probing pocket depth, marginal recession, width of keratinized mucosa and radiographic marginal bone level were evaluated and measured.All data were collected and analyzed by SPSS statistical software.
Results: The mean Gingival Index score, Plaque Index score and Marginal Recession were higher for implants which have less than 2 millimeters of keratinized mucosa, but this difference were not statistically significant. (P > 0.05) There were no significant difference in Periodontal Pocket Depth and Marginal Bone Level between implants with wider than 2 millimeters of keratinized mucosa and implants with less than 2 millimeters of keratinized mucosa. Thus, we did not find any correlation between KM and measured parameters.
Conclusion: Even though the present results suggest that there is no correlation between width of keratinized mucosa and implant-supporting tissue health, longitudinal randomized studies are necessary
Identification of COX-2 inhibitors via structure-based virtual screening and molecular dynamics simulation
No full textIn an attempt to identify potential COX-2 inhibitors, a multi-step virtual screening strategy was performed on a series of compounds. For this purpose, ZINC database was screened on the basis of 50% structural similarity with celecoxib and indomethacin as the representative of COX-2 and COX-1/COX-2 inhibitors, respectively. Selected molecules were subjected to various filters such as Lipinski's rule of five and also several ADME parameters. Toxicity risk of molecules was approximated via in silico methods. Moreover, COX-2 inhibitory activities of the selected compounds were predicted using PASS program. Molecular docking was performed to improve the accuracy of screening and also to find the details of the interactions of the hit compounds with the active site. Finally, MD simulations on top-ranked structures ZINC_1130464, ZINC_3181760, ZINC_33402495 and celecoxib were carried out with COX-2. Furthermore, RMSD, RMSF, hydrogen binds, Rg and energy analysis during MD simulation certainly indicated the stable binding of selected compounds with COX-2 structure. Moreover, docking and MD results revealed that hydrophobic contacts and optimum hydrogen bonds were determinant factors in the interactions of in silico hits and COX-2