Ardabil University of Medical Sciences
ArUMS Digital Repository (سامانه اطلاعات زیست پزشکی و سلامت)Not a member yet
7752 research outputs found
Sort by
The concern of today’s families: computer games for children and adolescents are Useful or harmful
Get PDFAssessing quality of life of asthma patients over 12 years old under the supervision of Asthma and Allergy Clinic of Ardabil University of Medical Sciences
Get PDFBackground: Asthma is one of the most common chronic diseases that has a significant prevalence and incidence and in recent years due to the presence of various stressors has increased and despite advances in science, this disease is still a problem in the medical world. Reporting patient health status and assessing patients' quality of life increases clinical data, and integrating it with clinical practice can dramatically improve care outcomes. Therefore, quality of life assessment can be a useful tool for standardizing communication between physicians and patients that potentially improves clinical and functional outcomes.
Aim: To determine the quality of life criteria in asthmatic patients over 12 years old under the supervision of Asthma and Allergy Clinic.
Matherials and Methods: The statistical population was people over 12 years of age with asthma referred to the Asthma and Allergy Clinic of Ardabil University of Medical Sciences. The sampling method was counting or census and the sample size was proportional to the number of referrals and according to similar studies was 200 people. Data collection time was from July to August 2020 and the questionnaire used was SF36 Quality of Life Questionnaire.
Result: 200 patients were included in the study. The mean age of patients was 29.64 years. The highest age group was 15 to 25 years. 103 patients (51.5%) were male and 97 patients (48.5%) were female. Regarding patients' residences, the highest number of residences was related to Ardabil and the lowest number was related to Nir. Regarding the monthly income of patients, the average income of study participants was 3.47 million Tomans per month. The average cost of treatment among study participants was 230.10 thousand tomans. . 105 patients (52.5%) had an allergic type, 47 patients (23.5%) had a non-allergic type and 48 patients (24%) belonged to the samter phenotype. The control level of most patients was good. Statistical analysis showed that the majority of patients were in the fourth stage of treatment. And the economic burden of the disease is heavy in the eyes of the majority of patients. In our study, it was found that patients with allergic phenotype have a better quality of life than other patients, and also the better the level of asthma control, the better the quality of life of patients. Patients with treatment costs less than 250 thousand tomans have a better quality of life than patients with higher treatment costs. Also, patients under 25 have a better quality of life than patients over 35. It was found that the quality of life in steps 1, 2 and 3 is better than higher treatment steps. Gender and place of residence have no effect on patients' quality of life
Conclusion: Quality of life of asthmatic patients is related to asthma phenotype, asthma control status, average cost of treatment, and age and step therapy of the patient
Evaluation of clinical, laboratory and radiographic characteristics of Patients With Alkaptonuria ochronosis in Ardabil Province
Get PDFBackground: Alkaptonuria is a rare recessive autosomal metabolic disease that occurs due to a deficiency of the homogenetic acid oxidase hepatic enzyme. Symptoms usually appear as discoloration of the tissues and degenerative joint disease usually after 1 to 2 years of age.
Aim: evaluate the clinical manifestations and radiographic and laboratory findings of patients with Alkaptonuric Akronosis in Ardabil province.
Patient and methods: In this cross-sectional, descriptive-analytical study, all patients with Alkaptonuronic Acronosis in Ardabil province who referred to rheumatology clinic after obtaining informed consent were enrolled. A questionnaire including demographic information, height, weight, history of smoking and alcohol, educational level, occupation, clinical presentation, laboratory and radiographic findings were completed for each patient. The data were recorded in the relevant checklists and the results were statistically evaluated.
Results: In this study, 28 patients were eligible for inclusion, 7 of whom were in alkaline phase and the rest had clinical symptoms. The mean age of patients was 49.82 ± 17.2 years and mean age of onset was 42.13 ± 11.51 years. The mean age of patients with clinical symptoms was 57.10 ± 10.21 years and mean age of onset of clinical symptoms was 42.05 ± 11.43 years. The minimum age of onset of clinical symptoms was 20 and maximum 68 years.
The average duration of clinical symptoms to admission was 9/45 ± 6/60 years. Of the 27 patients studied, 12 were male and 16 were female. The most common symptoms in symptomatic patients were back pain and skin symptoms, cartilage involvement (pigmentation and discoloration of the ear), ocular symptoms, pelvic, nail and shoulder involvement respectively. In terms of radiographic findings in patients with clinical symptoms, the most common findings were wafer sign in thoracic and lumbar vertebrae, cervical spine and knee joint involvement, which was observed in 90% of patients.
Conclusion: Investigation of clinical manifestations and radiographic and laboratory findings of patients with Alkaptonuric Akronosis in Ardabil showed that back pain is the most common complaint in these patients and it is necessary to obtain more detailed history and examination in case of low back pain
Determining prevalence of C-shaped canals in mandibular first and second molars using CBCT
Get PDFIntroduction & Objective: C-shaped canal is formed when a fusion or adhesion occurs on the buccal or lingual side of a tooth between its mesial and distal roots. The aim of this study was to investigate the prevalence of C-shaped canals in the first and second mandibular molars using CBCT.
Materials and Methods: This research was a descriptive analytical cross-sectional study. The statistical population of this study consisted of all CBCT stereotypes of Dr. Baser and Rad Radiology Center in Ardabil, which are available in the archives of the mentioned centers from 2017 to 2019, which were selected using random sampling method and sample units. Evaluation of the C-shaped canal in the first and second molar of the mandible was performed based on the classification of Fan.
Results: Finally, 369 patients were studied, of which 199 (53.9%) were male and 170 (46.1%) were female. 36.3% had the highest frequency between 31-40 years and 3.5% had the lowest frequency over 60 years. Of the 182 people who had the first molar, 11 had a C-Shaped canal, all of which had the shape of a C2 canal. Of the 330 patients with second molars, 18 (20 teeth) were C-Shaped, with 4 out of every 4 types, with C2, C3, C1, and C4 being the most common with 9, 6, 3, and 2, respectively. The frequency of C-shaped canals was significantly higher in men and in the first molar (P <0.05).
Conclusion: The results of this study showed that more C-shaped canals were seen in the first molar than the second molar. Also, only C2 was seen in the first molar, but in the second molar there were all 4 types of canals. It was also observed that the frequency of C-shaped canals was significantly higher in men than in women
Frequency of deaths and physical disabilities caused by recorded accidents in student community in Ardabil between 2011 and 2017
Get PDFBackground: Student incidents are incidents that occur in the school environment. Student incidents can include incidents such as traffic accidents, falls, collisions, burns, electric shocks, and conflicts. However, due to the sensitivity of the matter, accurate statistics of student incidents in the city of Ardabil are not available, so examining the frequency of incidents that have caused death and handicap in the student community of Ardabil, can pave the way for providing solutions to reduce these incidents and handicaps and other complications related to incidents in this city.
Aim: To determine the frequency of deaths and physical handicaps caused by incidents registered in the student community of Ardabil between 2011 and 2017.
Materials and Methods: In this retrospective cross-sectional descriptive cross-sectional study, data related to the incidents of 7 to 18 year old students in Ardabil during the years 2011 to 2017 were collected from 750 students who had an incident. The collected data from Teacher Insurance and Fatemi Hospital in Ardabil were analyzed by SPSS25 software and chi-square tests and ANOVA analysis of variance
Results: The total number of incidents registered in the student community between 2011 and 2017 was 750 cases that 475 cases (63.33%) included quarrels and falls, 236 cases (31.47%) included accidents and 39 cases (5.2%) included burns. The mean age of the injured children was 13.04± 3.17. The rate of death and handicap caused by incidents included 22 cases (2.93%) deaths and 18 cases (2.4%) handicaps. Traffic accidents with 13 cases (59.0%) deaths and 6 cases (33.33%) handicap; Conflict and fall were associated with 8 cases (36.4%) death and 4 cases (22.22%) handicap and finally burns with 1 case (4.6%) death and 8 cases (44.44%) handicap . The mortality rate and handicap of children were not significantly related to their age; However, the incidence of accidents and burns increased with age (P <0.05).
Conclusion: According to the results, it seems that male students are more prone to accidents than female students. Involvement and conflict compared to other factors can play a role in the occurrence of accidents. Finally, traffic accidents can play the largest role in student death, but conflicts and falls, and burn incidents can play the largest role in student handicap
The situation of domestic violence in married women with addicted and non-addicted spouses in Urmia
Get PDFDomestic violence The physical abuse perpetrated by a family member against another member or members, often perpetrated by men against women. Although violence against women is banned in many countries of the world and people are prevented from committing it, the reality is that violence against women is hidden behind rituals, cultural customs, social norms and beliefs. Addiction is one of the problems that not only endangers the lives of millions of people today, but also makes their families face many problems. In this descriptive and comparative study, 300 women were abused, 39 of whom had an addicted spouse.
Materials and Methods: The required information was collected using a questionnaire containing demographic characteristics by face-to-face interview. The questionnaire also contained information on physical, sexual, economic, and psychological-verbal violence.
Results: 39 women (13%) had an addicted husband. The rate of physical, sexual and economic violence in women who had addicted husbands was 92.3% (36 women), 79.5% (31 women) and 76.9% (30 women), respectively, and in women who did not have addicted husbands. They were 88.9 (232 women), 71.6% (187 women) and 88.9 (232 women), respectively. It was found that the difference between the overall mean scores of addicted and non-addicted spouses in violence experienced and also its sub-tests is significant. This study also showed that physical violence (P = 0.042) and economic violence (P = 0.036) against women with addicted husbands are significantly higher. However, there was no significant relationship between husband addiction and sexual violence (P = 0.35).
Discussion and Conclusion: Due to the high level of violence experienced in the spouses of addicted people, it is necessary to try to prevent addiction in married people, including accuracy in premarital tests and eliminating the causes of addiction, including poverty and unemployment. Other effective interventions for reducing addiction, including training and supportive and intervention counseling, are recommended
Assessment of soft and hard tissue around Single-implants based on gingival biotype in the posterior region of the mouth
Get PDFDue to the growing acceptance of patients for the use of dental implants, today the use of dental implants to replace missing natural teeth is a standard treatment option with well-developed components. Achieving beauty in an implant depends on three factors: the proper position of the implant, the amount of bone on the buccal surface of the implant, and the condition of the soft tissue around the implant. Today's knowledge states that maintaining the health of soft tissue in the maintenance and long-term success of implants is as important as osteointegration and the presence of sufficient bone around the implant. Based on gingival biotypes.
Materials & Methods: In this study, 48 single-unit implants from a private office center, one year after implant placement, were selected for this study, and then the gingival biotype status was evaluated using the Transplant Probe Transplantation (TRAN) method. If the probe was seen from beyond the gums, the patient's biotype was considered Thin, and if the probe was not observed, the patient's gingival biotype was considered Thick. Then we divided the patients into two groups of patients with Thin gingival type and patients with Thick gingival biotype. After classifying the patients, the periodontal status around the posterior dental implants was evaluated for BOP, PPD, GI in each of the Thin and Thick gingival biotype groups, and then the extent of bone resorption around the implant (Bone Loss) using radiography. Parallel PA, we measured the rate of bone resorption from the implant platform to the site of the first implant-bone contact by using Remexis radiology software and We examined hard tissue, soft tissue and periodontal tissue of patients in both groups by using T-test and Chi-Square test.
Results: In terms of statistical comparison, the relationship between gingival biotype and bone loss (Bone Loss), BOP, PPD, GI was significant, while the relationship between gingival biotype and PI was not significant.
Conclusion:Hard tissue condition, soft tissue around implants with Thick biotype is better than Thin
The protective effect of cinnamon and ginger hydro‐alcoholic extract on carbon tetrachloride‐induced testicular damage in rats
Get PDFSexual dysfunction of men is one of the most serious problems in human society. This study aimed to evaluate the protective effect of cinnamon and ginger extract on testicular damages induced by carbon tetrachloride (CCl4). Thirty‐six male Wistar rats were randomly divided into 6 groups (n = 6): 1. Normal control; 2. Carbon tetrachloride (CCl4); 3. CCl4 + Cinnamon; 4. CCl4 + Ginger; 5. CCl4 + Cinnamon and Ginger; and 6. Cinnamon + Ginger. CCl4 (1 ml/kg) was injected intraperitoneally on the 14th day, and cinnamon (50 mg/kg, orally) and ginger (250 mg/kg, orally) were administered daily for 14 days. Fifty hours after the CCl4 injection, the testicles and epididymis were separated and examined as to histological alterations and oxidative stress markers. CCl4 significantly increased malondialdehyde level and decreased total antioxidant capacity when compared to the normal control group (p < .05). In addition, degenerative alterations in the testicular and epididymal tissue were observed in CCl4 group. The pre‐treatment with ginger and cinnamon extract significantly improved these parameters when compared to the CCl4 group (p < .05). The results of this study indicated that co‐treatment of ginger and cinnamon reduces the damages induced by CCl4 in testicular tissue by increasing antioxidant capacity and reducing lipid peroxidation
Preparation and physicochemical characterization of chitosan-coated Solid lipid nanoparticles (SLN) system for oral drug delivery of tacrolimus
Get PDFIntroduction
Tacrolimus is a potent immune system inhibitor used to prevent organ rejection after organ transplantation. Oral administration of tacrolimus is due to the fact that the oral method is used because of its convenience and better acceptance for patients who need this drug frequently. This procedure has a number of limitations, such as small and variable bioavailability, the effect of the first hepatic transit, the narrow treatment window, large changes in pharmacokinetic properties in the patient's body, and low solubility. One of the best ways to overcome these limitations is to use nanoparticles for tacrolimus drug delivery. Our aim in this study was to use solid lipid nanoparticles with chitosanic coating to improve the oral drug delivery of tacrolimus and to investigate its effects.
Methods
To determine the amount of tacrolimus using dilution, different concentrations of the drug were prepared and their absorption was measured by using uv-vis spectrophotometer at 245 nm. The ultraviolet absorption calibration diagram of the drug was prepared and then this graph was used to determine the amount of unknown samples. Solid lipid nanoparticles containing tacrolimus were then prepared using a solvent diffusion method. Finally, the uptake of the samples was measured using a uv-vis spectrophotometer at a wavelength of 245 nm. Then, SLNs were used to evaluate solid lipid nanoparticles, to calculate drug loading indices in nanoparticles, tacrolimus release pattern from SLNs, FTIR (Fourier Transform Infrared Spectrometer), to measure the size, shape, morphological characteristics of particles and SLNs thermal analysis.
Results
According to the present study, the nanoparticles were produced with an average size of 50-100 nm and were spherical in shape. The drug entrapment efficiency was 97.29% and the drug loading in SLNs was 13.33%. The results of electron microscopy confirm the spherical and nanoparticle nature of the carrier. Evaluation of nanoparticles obtained by FTIR and TGA analysis indicates no chemical interaction between the carrier used and the drug used. In addition, the coating structure of chitosan on the surface of SLN nanoparticles and the formation of amide bond between chitosan and stearic acid are confirmed by these analyzes. The drug release pattern was biphasic, and the coated SLNs with chitosan had a slower and more controlled release.
Conclusion
According to the results of this study, coated SLNs with chitosan had a slower and more controlled release. Based on the results of this study, solid lipid nanoparticles composed of stearic acid lipid are suitable carriers for tacrolimus
Relation between transcranial doppler findings, neuroimaging and functional state in the first days of acute cerebrovascular accidents- hemorrhagic and ischemic in patients admitted to the Ardabil city hospital during 2015-2016
Get PDFBackground: Cerebrovascular accident (CVA) is the third leading cause of death in the United States. Considering the diagnostic and clinical value of sonography of extra cranial vessels of the brain, identifying findings obtained from patients suspected of having CVA and Transient Ischemic Attack (TIA) and their prevalence is of great importance. The aim of this study was to investigate the relation between TCD finding, neuroimaging and functional state of ischemic and hemorrhagic CVA patients.
Methods: This was a cross-sectional study that has been done on 100 stroke patients admitted to Ardabil city hospital from March 2015 to March 2016. Patients underwent to CT-scan, doppler sonography, and TCD. The obtained data were analyzed by statistical methods in SPSS version 21.
Results: The mean age of the patients was 66.3±11 years and 53% were women. High blood pressure, history of heart disease, smoking, and diabetes were the major risk factors in the present study. Fifty eight percent of the patients had moderate to severe disability in their functional status. Atheroma plaques, intima-media thickening, and the change of speed in the external carotid artery were most frequent in doppler sonography investigations. There was no significant correlation between the obtained results from TCD and the functional status of the patients.
Conclusions: Considering the non-significant correlation between TCD results and the functional state of the patients in this study, for exactly study of this topic, study the TCD of patients on several different days and after starting treatment is essential