Ardabil University of Medical Sciences
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The pulmonary artery‐aorta ratio: Is it related to quality of life in chronic obstructive pulmonary disease
No full textIntroduction
Little is known about the relationship between health status and pulmonary artery diameter in chronic obstructive pulmonary disease (COPD) patients. The aim of this study was to evaluate correlation between pulmonary artery‐aorta ratio (P‐A ratio) and health status of the individuals, using COPD assessment test (CAT).
Materials and Methods
In a cross‐sectional study, 112 COPD patients were recruited. The severity of COPD was determined by global initiative for obstructive lung disease (GOLD). After digital chest CT scan, the P‐A ratio was measured at the level of bifurcation and compared with CAT score, GOLD stage, exacerbation rate and Modified Medical Research Council (MMRC) score.
Results
The average P‐A ratio was 0.89 ± 0.16 and 62.5% of patients had ratio less than one. The P‐A ratio correlates significantly with different GOLD stages, CAT score and MMRC score (P < .001, P < .001, P < .001, respectively). Compared patients with low P‐A ratio (<1), those with high P‐A ratio (≥ 1) showed higher CAT score [11.94 ± 5.94 vs 25.17 ± 5.84] (P < .001). The P‐A ratio was significantly higher in frequent (≥2) comparing low (<2) exacerbations [1.07 ± 0.07 vs 0.77 ± 0.06] (P < .001).
Conclusion
Significant correlations were found between P‐A ratio and GOLD, exacerbation rate and health status, using CAT of patients with COPD. These findings also may suggest the potential role of P‐A ratio, in the management of COPD patients
Comparison of color change of two types of flowable composites after using two different mouthwashes
Get PDFBackground and Aim
By introducing self adhesive composites the clinical steps of composite restorations are facilitated.
The aim of this study was to comparison of color change of two types of flowable composites after using two different mouthwashes.
Materials and methods
The study was performed on 48 composite disks.24 disk of Vertise flow (Kerr/Italy) and 24 disk of Grandio flow(Voco/Germany). The color of base line was measured by spectrophotometer and CIEL*a*b* system. Then samples are divided into 6 groups. they were immersed for 24 hours in chlorhexidine, fluoride and distilled water (control group). Subsequently, the secondary color and E were determined. To analyze the data Kruskal-Wallis and Mann-Whitney Nanoparametric tests were used. The significance level was considered as P = 0.05.
Results
All of the samples had a change of color but none were clinically unacceptable. (E <3.3)
There was no significant difference between the groups. (P = 0.847)
Conclusion
In the study period which was equivalent to two years of daily use of mouthwash for 2 minutes each day, the color change of Vertise flow composite and Grandio flow composite was almost the same as the control group (distilled water) and the result of the present study indicated that composites showed an acceptable color change
Comparative study of EEG changes in neonatal seizure with three months of EEG in neonates referred to Booali hospital in Ardabil in 2016
Get PDFBackground and objective: The prevalence of neonatal seizure in term neonates is 3 per 1000 births, but in preterm newborns is 50 per 1000 births. Babies who have seizures are at high risk of death or neurological disabilities. Seizure is often the first sign of neonatal dysfunction and may be effective in long-term prognosis. EEG is the only available method for the diagnosis of seizures in neonates. Therefore, we compared EEG changes in the first EEG infant seizure with 3 months of age in newborns who referred to the Aristotelian hospital in Bouali Hospital.
Methods: The present study is a cross-sectional descriptive analytical method. In this study, neonates referred to Ardabil Booali Hospital, EEG, were screened for seizure and EEG was monitored 3 months later and the results were evaluated. Finally, all the data were entered into the SPSS-24 statistical analysis program and we analyzed the data according to the type of variables by statistical tests.
Results: In this study, 50 neonates with seizure were enrolled in this study, 70% of which had an average age of 14.92 days. 80% of infants were born at the time of term. The average birth weight was 3.208 kg. 6.2% of infants had abnormal CT scan findings, with an IVH infant and one baby showing brain edema. In this study, only 14% of neonates with abnormal brain strain were observed in the neonatal period and near the seizure. However, after 3 months, 40% of infants experienced abnormal brain stroke findings. Among the changes in EEG with age (P = 0.173), gestational age (P = 0.616), gender (P = 0.176), seizure (P = 0.145), neonatal hypoglycemia (P = 0.594), hypocalcaemia (P = 0.607) no statistic was found.
Conclusion: The results of this study showed that a small percentage of neonates had abnormal EEG in the neonate, but after 3 months of seizure, the larger percentage of them found abnormal EEG
Frequency of β-thalassemia minor in Ardabil province in 2017-2018
Get PDFBackground and Objective. Thalassemia is a genetic condition in which the patient's blood loses a large number of primary red blood cells and can not carry oxygen. Hemoglobin consists of two different chains called alpha and beta. The alpha chain is encoded by the 4 genes in chromosome number 16, and the disturbance in the alpha chain genes causes alpha thalassemia, but because there are 4 alpha genes, so the probability of defective four genes is rare at the same time, therefore, alpha thalassemia Its dangerous type is relatively rare. The other chain of hemoglobin is a beta chain and is encoded by two beta genes that are located on chromosome 11, which, if these genes are defective, cause the beta chain to be low or not at all, and it creates beta thalassemia. At present, the most effective way to prevent thalassemia is to screen for the disease at the population level and then to evaluate the molecularity of individuals. Considering the importance of β-thalassemia minor and its high prevalence in societies, as well as low studies in this regard, in Ardebil and our country We examined the prevalence of β-thalassemia minor and its prevention in Ardabil province during the period of 1939-97
Methods:. This descriptive cross-sectional study was conducted over six months in all of the province for a pre-marriege age of 1396-1396 and for β-thalassemia with ≥ 80, MCH 3.5 In one person or both, they were referred to a blood and oncology specialist after being diagnosed with their β-thalassemia minor, β-thalassemia subjects were enrolled in a census. A questionnaire was prepared to collect the required information including CBC, HbA2, and place of residence information and the subjects completed the relevant questionnaires. After 6 months, the prevalence of β-thalassemia was determined among all the patients referred to the health centers of the province
Result:. Out of the 3962 people referring to the study, 2886 people (72.8%) were resident in Ardabil and 1076 people (27.2%)were resident in other cities. Out of 103 cases of thalassemia, 49 (47.5%) were women and 54 (52.4%) were men. 57 people (55.3%) resident in the provincial capital and 46 (44.6%) residents of the city of Ardebil province were diagnosed with thalassemia.
Conclusion:. The prevalence of β-thalassemia minor during this period was 5.35% in Ardebil, which was 4.06% in capital and 8.79% in other cities. The mean of HbA2 in males was 2.8 and 2.54 in wemen (p = 0.47). Therefore, there was no significant relationship between β-thalassemia prevalence for HbA2 and gender
In vitro Anti Leishmanial Effect of Agrostemma githago Extract on Leishmania Major Promastigotes by Cell Count and MTT Assay
Get PDFBackground and purpose: Treatment of leishmaniasis is getting complicated due to multiple side effects and drug resistance to first-line drugs. Agrostemma githago is a plant with anti-cancer and cytocidal effects, so, this study was conducted to evaluate the anti leishmanial effect of its extract on Leishmania major promastigotes by MTT assay and cell count.
Materials and methods: A total of 2.5×106 Leishmania major promastigotes in their stationary phase were plated to each well of the 96 well culture plates. Cells were then incubated with increasing concentrations of Agrostemma githago extract (0.05 – 2.4 mg/ml) for 48 hours at 25°C. Glucantim was used as standard control. Then, the supernatants were discarded and 50 µl of MTT were added for 3 hours. After centrifuge, the supernatants were replaced by 100 µl of DMSO. The plate was read by ELISA reader at 570 nm. Trypan blue staining was also performed to evaluate the effect of Agrostemma githago extract on Leishmania major promastigotes.
Results: MTT assay showed that increasing concentrations of Agrostemma extract could significantly reduce cell viability of Leishmania major promastigots in a dose dependent manner (p<0.05). IC50 of the Agrostemma and Glucantime were 0.365 and 71.01 mg/ml, respectively.
Conclusion: Aqueous extract of Agrostemma githago was found to have stronger inhibitory effect than Glucantim on Leishmania major promastigots
Klebsiella pneumoniae strain A1-35 New Delhi metallo-beta-lactamase (blaNDM) gene, partial cds
No full textEvaluation of parental parenting characteristics of patients with histrionic personality disorder referring to the psychiatric clinic of Fatemi hospital Ardabil 96-97
Get PDFBackgroun and objective: Child upbringing is a reflection of the kind of relationship that parents shape with their children. Parenting styles affect their lives. The aim of this study was to investigate the parental parenting characteristics of patients with histrionic personality disorder referring to the psychiatric clinic of Fatemi hospital Ardabil 97-96.
Methods: This cross-sectional study was performed on 101 patients with SCID-2 and MCMI tests confirmed by a histrionic personality disorder. After confirmation by the psychiatrist, Yang's parenting questionnaires were used to assess the factors associated with this disorder. The questionnaires were presented to a person by a psychologist. Data were collected through a questionnaire and taken individually. Data were analyzed by SPSS software and analyzed statistically. For data analysis Descriptive statistics such as mean and standard deviation were used. Pearson correlation test and covariance analysis were used to assess the research questions and assumptions.
Results: The most important active schema in histrionic patients was "Emotionally depriving ", "Unrelenting Standards" and "Approval – Seeking" and "Emotional Inhibition." There was a significant relationship between personality disorder and maladaptive schemas. Maternal roots of schemas including "Emotionally depriving", "Unrelenting Standards" and "Approval – Seeking" and the parental roots including "Emotionally depriving", "Unrelenting Standards" and "emotional inhibition" had the highest score. They had the lowest score in the component including Mistrust/Abuse, Abandonment, Defectiveness/Shame, failure, self-sacrifice and insufficient self – control- discipline.
Conclusion: Various early maladaptive schemas create a specific vulnerability to a variety of psychological disturbances and personality pathologies. Addressing early maladaptive schemas in parenting styles leads to improved adolescent mental health and better performance in promoting parental role
Correlation Between Rib Fractures and Prognosis in Multiple Trauma Patients
Get PDFBackground: Thoracic trauma is an important cause of morbidity and mortality in trauma patients and rib fracture due to blunt trauma to the chest wall is the most common etiology.
Objectives: This study analyzed the correlation between rib fractures and prognosis in multiple trauma patients.
Methods: One hundred eighty-four trauma patients suffering from rib fracture due to the blunt trauma were studied. Demographic data, injury characteristics, rib fracture characteristics, the associated injuries, and injury severity score (ISS) were recorded. The rib fracture was classified according to location (left, right, and bilateral) and level (upper [1st - 2nd rib], middle [3rd - 8th rib], and lower [9th - 12th rib]); it also was categorized as lateral and posterolateral.
Results: The rib fractures were posterolateral (69.6%), lateral (30.4%), upper (4.3%), middle (92.4%), and lower (3.3%). Patients with posterolateral fracture had significantly more complications leading to airway intubation and more intensive care support, higher ISS, associated with pelvic and clavicular fracture. Upper rib fractures were associated with more length-of-stay (LOS) while lower rib fractures were associated more with abdominal trauma and lumbar/thoracolumbar vertebral fractures. A significant positive correlation was seen between the number of fractured ribs and ISS, hospital, and ICU LOS. There were no complications during a two-month follow-up.
Conclusions: Upper rib fractures are associated with severe traumas requiring more hospitalization and ICU support due to the greater surgical and medical complications. Morbidity is higher in posterolateral fractures and these patients need more medical care
Bacterial and tissue biomarkers of gastric cancer: new findings and future perspectives: review article
Get PDFGastric cancer (GC) is the second leading cause of cancer-related deaths worldwide. It has been proposed that the specific genotypes of Helicobacter pylori (H. pylori) are the causative agents in the development of gastroduodenal diseases, such as chronic atrophic gastritis, peptic ulcerations, and GC. However, disease progression to GC occurs in only a small proportion of infected patients. Recently, we identified a novel polymorphic site in the 3ʹ-end region of H. pylori vacA gene. The vacA c1 genotype increased the risk of GC. This association was independent of and larger than the associations of the m-, i-, and d-type of vacA or cagA status with GC. Therefore, treatment of H. pylori infection may be an effective way to prevent GC. Expression of cytokines and their associations with inflammatory responses has been shown. Several cytokine polymorphisms, such as IL-1B, IL-8, IL-10, and TNF-α have been considered as risk factors for GC. It has been shown that the interaction of bacterial genotypes and host factors plays an essential role in developing GC. Several altered molecular pathways are involved in the pathogenesis of GC. Micro-RNAs are small, non-coding RNAs of 18-25 nucleotides in length that regulate the expression of target mRNAs. Expression pattern of cancer cells is different compared with the normal cells. Micro-RNAs plays a critical role in apoptosis and classified in two groups: pro- and anti-apoptotic agents. Recent studies have confirmed the oncogenic or tumor suppression role of micro-RNAs in cancer cells. They play a significant role in the GC cell physiology and tumor progression, by translational suppression of target genes. These small RNAs have therefore emerged as a new type of GC biomarker with immeasurable clinical potential. Generally, a variety of micro-RNAs involved in different stages of cancer, including tumorigenesis, angiogenesis, and metastasis. Considering to this issue more than 50% of cancers can be cured, if they were diagnosed in the early stages. Hence, identifying the biomarkers of GC could play an important role in prevention, early diagnosis and rapid treatment of patients. In this review article, we have reviewed the latest findings about bacterial and tissue biomarkers of G
The effect of probiotic yoghurt consumption on oxidative stress and inflammatory factors in young females after exhaustive exercise
Get PDFObjective: To evaluate the effect of probiotic yoghurt consumption on oxidative stress and inflammatory factors in young females after exhaustive exercise.
Method: This study included 27 healthy participants with an age range of 18-25. For two weeks, 450 grams of probiotic yoghurt and 450 grams of ordinary yoghurt were given to the supplement and control groups, respectively. Fasting blood samples were taken at baseline and at the end of study. At the end of the intervention, the participants were given one exhaustive exercise and then fasting blood samples were taken to test for blood antioxidant enzymes, inflammatory markers, and oxidative markers. Data were analyzed using descriptive statistics as well as paired and independent samples t-test.
Results: In supplement group, the glutathione peroxidise (GPX) blood levels and serum levels of total antioxidant capacity (TAC) significantly increased at the end of two weeks of intervention (p<0.05). After intense physical activity, the blood levels of superoxide dismutase (SOD), GPX and serum levels of TAC significantly increased, whereas the serum level of tumour necrosis factor alpha (TNF-?), matrix metalloproteinase 2 (MMP2), matrix metalloproteinase 9 (MMP9), and malondialdehyde (MDA) significantly decreased in the supplement group compared to the control group (p<0.05). Besides, there were no significant changes in other biochemical factors.
Conclusion: Regular probiotic yoghurt consumption significantly modulated MMP2, MMP9 and some inflammatory factors, and thus guarded against exhaustive exercise-inducing oxidative injury in young healthy females