Ardabil University of Medical Sciences
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Anthology: The philosophy of architecture in the structure and organization of modern health information systems
No full textSuccessful Ostial Stenting in a Patient with a Single Coronary Artery from the Right Sinus of Valsalva: A Case Report
Get PDFAbstract: Single coronary arteries (SCAs) constitute a rare coronary anomaly which is usually asymptomatic. However, SCAs may become symptomatic and even cause myocardial ischemia and infarction and as such necessitate proper intervention whether percutaneous or surgical. We describe an 89-year-old woman with an SCA from the right sinus of Valsalva presenting with chest pain and acute myocardial infarction. We succeeded in performing percutaneous coronary intervention and stenting on the ostial lesion of the SCA, and there were no further complications. The patient was discharged 2 days later with no adverse complications
Evaluation the success rate of extra corporal shock wave lithotripsy (ESWL) in patients with urinary stones
Get PDFBackground: Urinary stones are one of the most common and earliest known human diseases. Extracorporeal shock wave lithotripsy (ESWL) is known as the most common method for treating urinary stones less than 20-25 mm. The aim of this study was to evaluation the success rate of ESWL in patients with urinary stones.
Methods: In this cross-sectional descriptive study 200 patients with urinary stones between 7-25 mm which were candidates for lithotripsy, enrolled in the study. Patients with coagulation disorders, urinary or other organ transplantation, pregnant women, uncontrolled blood pressure patients, and those who are contraindicated for drug use have been excluded from the study. The process was carried out by an operator and by the Dornier Compact Delta II lithotriptor. Two weeks later, the patients were re-visited, and ultrasound was performed, and the success rate of stones was measured and recorded and classified in three groups complete response, partial response and failure in treatment. Collected data analysed by statistical methods in SPSS version 19.
Results: Efficacy of Arian 101 lithotriptor in removing of renal stones, were found to be 74% complete response, 25.5% partial response while 0.5% of subjects had no response. There was significant positive correlation between the size of stones before and after lithotripsy (r=0.49, p=0.001). In stones upper than 10 mm, the upper calices stones had 100% complete response. Also, in stones lower than 10 mm, the upper calices stones had 100% complete response.
Conclusions: The results showed that Dornier Compact Delta II lithotriptor has more efficacy in treatment of stones. In stones below 10 mm, the success rate of treatment was generally higher, especially in the upper calices stones and pelvic. In stones larger than 10 mm, the success rate was slightly lower, but in the case of upper calices stones, the complete response was 100%
Factors Affecting Medical Trip from the Perspective of Azerbaijani Tourists, Iran 2016
Get PDFBackground & aim: Health tourism is an organized travel to maintain, improve and re-access physical and mental health. Health tourism helps to sustainable development and economic motivation of the country. The aim of this study was to investigate the affecting factors to choose Iran as a destination to receive medical services from the viewpoint of Azerbaijani tourists Methods: Semi-structured interviews were conducted on ten Azerbaijani tourists in a combined study with qualitative sections. The collected data were analyzed using content analysis to identify and classify the effective variables on tourists' attraction. Based on the results of the qualitative step and reviewing the literature, a questionnaire was designed using the Lickert scale. The questionnaires were completed by 213 tourists and the affecting factors were ranked based on their impact coefficient. Data were analyzed by descriptive statistics including frequency, average, and standard deviation, using SPSS v.20 software.
Results: Most of the respondents were male (63.4%) aged between 20-40 years (43.2%). The highest frequencies of diseases were related to internal diseases (10.3%), infections (9.4%), surgeries (8.5%), and urology (8%), respectively. Quality of the medical services and cost of treatment, with averages and standard deviations of 3.08 ±0.05 and 3.05±0.35, were respectively the most important factors in traveling to Iran. Medical equipment and political-security took the next places with averages and standard deviations of 2.98±0.04 and 2.98±0.07. Finally, waiting time for receiving (2.84±0.09) had the least effect in traveling to Iran from the tourists' view point.
Conclusion: Results indicated that quality of health services, the cost of treatment, medical equipment, and political- security factors were positively affected the tourists' motivation in traveling to Iran for their medicinal purposes. Waiting time, therapeutic diversity, sociological factors, and tourism attractiveness did not have much importance. Therefore, we suggest that advertising and marketing programs should focus on the top five factors affecting health tourism
Elevated plasma levels of hTERT mRNA and DNA in patients with gastric cancer in Northwest of Iran
Get PDFBackground: Gastric cancer (GC) as the fourth common cancer over the world and responsible for the second cause of cancer-related deaths, has high incidence rate in Iran and especially in its North-Western province, Ardabil. In this study, the circulating hTERT mRNA and DNA were studied in patients affected with GC in Ardabil.
Methods: Using conventional PCR and RT-PCR, Q-PCR and Q-RT-PCR, evaluating the circulating hTERT nucleic acids in the plasma samples of the 100 GC cases and the same number of sex-, age-, and residence place adjusted healthy volunteers, as the control group has been done.
Results: The circulating hTERT mRNA level in patients was higher (40X) than the controls. In the case of circulating DNA, cases had higher difference (65X). These findings have been evaluated as significant difference. There were no significant relationships between hTERT level and age groups or adenocarcinoma type among cases.
Conclusions: The elevated hTERT mRNA/ DNA plasma level among patients indicates the accuracy of the proposed subjects. However, performing cohort studies on circulating hTERT mRNA is advised
Investigating Prevalence of Mycoplasma hominis Infection in Pregnant Women with Premature preterm rupture of membrane (PPROM) and it’s neonatal effect
Get PDFBackground and Objective: Preterm prelabor rupture of membranes (PPROM),is defined as rupture of thefetal membranes with before the onset of regular uterine contractions before completed weeks 37 of gestation, and represents aserious perinatal problem. The purpose of this study was to evaluate the prevalence of cervical colonization by Mycoplasma hominis in patients with preterm premature rupture of the membranes (PPROM).
methods: We studied 160 women between 25 and 37 weeks of gestation with PPROM. Cervical swabs were obtained for genital mycoplasmas and assessed by PCR. In the control group were 160 women with a normal pregnancy without preterm labor.
Results: Mycoplasma hominis was detected in 17.5 % (28/160) of the patients with PPROM. In the control group Mycoplasma hominis was detected in 6.3 % (10/160) pregnant women.
The results of the odds ratio test showed that the odds ratio of Mycoplasma hominis infection in patients with PPROM was 3.18 times more than of pregnant women without PPROM, and the chance of developing RDS in infant In mothers with PPROM, was 3.71 times more than of pregnant women who have no PPROM.
Conclusion: Our results provide evidence of an association between cervical colonization with genital mycoplasmas and preterm premature rupture of the membranes
Comparsion effect of Parastamol and Pethidine for reducing women's labor pain in Ardabil Alavi Hosiptial
Get PDFBackground and Objective: The use of pain-relieving drugs during labor is now part of standard care in many countries throughout the world. Each method has its own risks and benefits, with variations in effectiveness, availability and acceptability. To assess the efficacy and safety of pethidine versus paracetamol as an analgesic during labor in Ardabil Alavi hospital in 2017.
Methods: In this clinical trial study, 100 women expected to have a natural childbirth were observed. The subjects were randomly allocated in two groups with using paracetamol and pethidine for pain relief. Regarding the intensity of labor pain experienced by the subjects and the outcome of delivery were collected by means of questionnaires.
Results: There was a significant difference between the average pain score in paracetamol and pethidine groups in 30 minutes after intervention, but there was not a significant difference between the severity of the pain in two groups before intervention and 10 and 60 min after intervention. No significant differences were seen regarding duration and interval of uterine contractions , neonatal complications, first minute apgar score and side effects of investigated drugs between the two studied groups. There was a significant difference between the average of fifth minute apgar score and mother SBP after intervention and mother RR after intervention.
Conclusions: Use of paracetamol has more beneficial effects for many parturient women compared to pethidine
Evaluation of the toxicity effects of silk fibroin on human lymphocytes and monocytes
No full textSilk fibroin nanoparticles (SFNPs) as a natural polymer have been utilized in biomedical applications such as suture, tissue engineering-based scaffolds, and drug delivery carriers. Since there is little data regarding the toxicity effects on different cells and tissues, we aimed to determine the toxicity mechanisms of SFNPs on human lymphocytes and monocytes based on reliable methods. Our results showed that SFNPs (0.5, 1, and 2 mg/mL) induced oxidative stress via increasing reactive oxygen species production, mitochondrial membrane potential (∆Ψ) collapse, which was correlated to cytochrome c release and Adenosine diphosphate (ADP)/Adenosine tri phosphate (ATP) ratio increase as well as lysosomal as another toxicity mechanism, which led to cytosolic release of lysosomal digestive proteases, phosphor lipases, and apoptosis signaling. Taken together, these data suggested that SFNPs toxicity was associated with mutual mitochondrial/lysosomal cross-talk and oxidative stress on human lymphocytes and monocytes with activated apoptosis signaling
2- Tumor Suppression or Oncogenic Role of miR-100 in Cancer; Implications for Esophageal Cancer
Get PDFEsophageal cancer (EC) is one of the deadliest malignancies worldwide. Esophageal squamous cell carcinoma (ESCC) constitutes the most common type of EC in Asian countries. Despite advanced surgical techniques, 5-year survival of the affected patients is very low. Therefore, identification of genetic factors and cellular regulatory pathways, including microRNAs (miRNAs), in esophageal carcinogenesis is necessary for early detection. MiRNAs are a class of small non-coding RNA about 18-24 nucleotides in length that negatively regulate gene expression. Deregulation of miRNAs was shown to have a crucial role in the pathways underlying tumorigenesis and tumor progression. Evidence indicates that aberrant expression pattern of miR-100 is associated with pathogenesis of ESCC. The function and expression pattern of miR-100 in ESCC are controversial and its effects in tumor progression has not been fully elucidated. A better understanding of molecular procedures mediated by miR-100 in carcinogenesis, may lead to the opportunity of exploring potential miR-100 based therapeutic applications. In this review, we provide an overview of miR-100, including its important regulation pathways and target genes involved in the development of cancers, emphasizing on its potential role in ESCC
Synthesis of New Derivatives of 1,2,3‐Triazole‐Linked Phthalazine‐1,4‐dione in Water: Experimental Aspects and Molecular Docking Calculations
No full textA new series of phthalazine‐based 1,2,3‐triazole derivatives are synthesized by the reaction of 2‐methyl‐3‐(prop‐2‐yn‐1‐yl)‐2,3‐dihydro‐phthalazine‐1,4‐dione or 2,3‐bis(prop‐2‐yn‐1‐yl)‐2,3‐dihydrophthalaz‐ine‐1,4‐dione with aromatic azides via copper‐catalyzed azide‐alkyne cycloaddition reactions in the presence of metformine as a ligand. These reaction procedures have the advantages of high‐to‐excellent yields, short reaction times, mild experimental conditions, and operational simplicity. All the synthesized compounds are screened in vitro for their anti‐bacterial activities against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis. Furthermore, the results of anti‐bacterial activity of the synthesized compounds was investigated using molecular docking calculations