Ardabil University of Medical Sciences
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Evaluation of PH and Apgar score of neonates born by cesarean section due to fetal distress recorded in NST in pregnant women referring to Alavi hospital in Ardabil in 1397
Get PDFBackground and objectives: Cesarian section is a form of surgical childbirth in which neonate and placenta gets excisioned by an insision of abdominal and uteral wall. The prevalence of C-sections has been increased in the past decades. According to WHO a 15% rate for this surgical operation is accepted. NST is a method which monitors the fetal health and provides data on the proper time for ending the pregnancy in emergent situations, however its not very accurate in diagnosing hypoxia sometimes and may cause unnecessary C-sections.
Methods: The current study was a cross-sectional analytical and descriptive survey in which, 139 neonates with an impaired Non-stress Test were enrolled. Demographic data of mothers and neonates were gathered as well as other information such as 1st and 5th minute APGAR scores and umbilical cord pH. Finally, the gathered information were analysed using SPSSv22.
Results: The mean age of mothers was 26.17±5.18 years. The mean birth weight of the neonates was 3281±361.22 grams. 252 forms of impaired NST pattern were found in the evaluated sample of neonates. Bradycardia and late decelerations had a significant relationship with acidosis (P<0.05) . Also, late decelerations were associated with lower APGAR scores (P<0.05). umbilical artery pH was significantly correlated with 1st (r=0.34; p<0.001) and 5th minute APGAR scores (r=0.32; p<0.001) . Positive predictive value of NST was 48.9.
Conclusions: NST has a medicore positive predictive value in diagnosing fetal acidosis. This medicore positive predictive value of NST can be a significant predictor of unnecessary
C-sections in low risk pregnancies. In some cases such as tachycardia, lengthening of the NST time may reduce the rate of unnecessary C-sections, but some forms of impaired NST such as bradycardia and late decelerations, should be considered more important and may need more emergent surgical reactions
Explaining the lived experience of people with spinal cord injury: A Hermeneutic Phenomenological Study
Get PDFBackground and Objective: One of the chronic conditions that may occur for any individual is the spinal cord injury (SCI). The spinal cord injury can cause paralysis of the limbs and co-morbidities associated with it. This study aimed to explain the lived experience of people with spinal cord injury.
Materials and Methods: This study was a hermeneutic phenomenological design conducted with the participation of 15 clients with SCI, during 2019 in the city the Ardebil. Participants included 4 women and 11 men who participated in semi-structured individual interviews. The length of the interviews were varied between 30 to 100 minutes. The interviews were transcribed and analyzed using the method introduced by Van Manen.
Results: Lived experiences of the participnts were condensed into six main themes: spinal cord injury as a major change, challenges and concerns, psychological reactions, coping mechanisms, living in the society, living with family and relatives.
Conclusion: Based on the results of this study, it can be concluded that clients with spinal cord injury are faced with multiple challenges and experiences that should be considered in their care plan
Comparison of IgG vzv level in patients with zona and the control group
No full textBackground & Objective : Chickenpox and herpes zoster diagnoses are often made by history and examination. In most cases the clinical presentation and being limited to a dermatome makes it easy to diagnose zona. But in some cases the lesion's morphology are not classic or there are no rashes at all. In these circumstances the only signs are pain in the involved dermatome and a rise in varicella zoster antibody. We designed this study to set diagnostic criteria based on vzv IgG to make diagnosis of these patients easier.
Methods: In this case-control study , Patients with zona in dermatology and infectious clinics in Ardabil are selected as case group and patients with same age and gender from those clinics without zona defined as control groups.Participants vzv IgG level was measured.
Results: ROC curve was used to define a cutoff point between the two groups. Area under the curve was 0.989 wich is an indicator of a good test for diagnosing zona(P value was less than 0.001). Cutoff point of 803.00 had a specificity of 97 percent and a sensitivity of 87 percent.
Conclusion: Based on the results of ROC curve , diagnosing zona via vzv IgG is both sensitive and specific. Because of high sensitivity this test can be used to rule out the diagnosis of zona and based on high specificity it can confirm the diagnosis
The Incidence of Minor β-thalassemia Among Individuals Participated in Premarital Screening Program in Ardabil Province: North-west of Iran
Get PDFIntroduction: The most effective way to prevent
thalassemia is to screen for the disease at the
population level and then to evaluate the molecularity of individuals. Considering the importance
of minor β-thalassemia and its high prevalence in
societies. Aim: to investigate the incidence of minor
β-thalassemia among Individuals participated in
Premarital Screening Program in Ardabil province:
North-west of Iran. Methods: This descriptive crosssectional study was conducted on 39620 individuals participated in the national screening program
for Minor β-Thalassemia. Of them 1925 cases had
mean corpuscular volume (MCV) < 80 in one person
or couple which referred to HbA2 concentration
check. Results: Of all 1925 cases, 95 cases (4.93%)
had HbA2>3.5 and defined as Minor β-Thalassemia.
The total incidence of minor β-thalassemia among
all participated people was 2.4%. Of thalassemia
cases 48.4% were women and 51.6% were men.
Of all β-thalassemia cases, 49.5% live in Ardabil
city and rest of them live in other cities. Conclusion: Results showed that the prevalence of minor
β-thalassemia in Ardabil province was lower than
country average rate and a study should be done in
future for exact estimation of the disease
Relationship of Formaldehyde Concentration in Ambient Air with CO, NO2, O3, Temperature and Humidity: Modeling by Response Surface Model
Get PDFBackground & Aims of the Study: Exposure to formaldehyde in ambient air has attracted a great attention, due to harmful health effects. This study was aimed to determine formaldehyde concentration in winter and spring seasons, in Azadi square region, Tehran, and the relation of variations of CO, NO2, O3, temperature and humidity with formaldehyde concentration was modeled based on Response Surface Methodology.
Materials & Methods: This cross-sectional study was conducted in 2014–2015 in Tehran. For measuring the formaldehyde concentration, NIOSH3500 method was employed. The concentration of formaldehyde was detected at 580 nm wavelengths by PerkinElmer LAMBDA spectrophotometer model of 25UV/Vis. Data of CO, NO2 and O3 concentration were attained from Tehran Air Quality Control Company. SPSS 16 and Design Expert (version 7) were used for analyzing data.
Results: Results showed the concentration of formaldehyde in the spring was on average 4.7 ppb more compared to winter season. The Model fitted for the prediction of formaldehyde showed a significant p-value (<0.001). Moreover, the R2 and Adj-R2 values were obtained about 0.8237 and 0.7607. In this model, it is observed the parameters of CO, NO2, O3 and temperature has a direct relation with the variations of formaldehyde, and humidity has an indirect relation.
Conclusions: Results indicated formaldehyde concentration in spring season is on overage higher than winter spring. The fitted model showed the CO, NO2, O3 and temperature is in a direct correlation with formaldehyde changes in ambient air, and humidity is in an indirect correlation
Adjuvant chemotherapy withmelatoninfortargeting human cancers:Areview
No full textdifferentially influence tumors from normal cells. In this review, the roles of melatonin adjuvant therapy in human cancer are discussed. Combination of melatonin with chemotherapy could provide synergistic antitumoral outcomes and resolve drug resistance in affected patients. This combination reduces the dosage for chemotherapeutic agents with the subsequent attenuation of side effects related to these drugs on normal cells around tumor and on healthy organs. The combination therapy increases the rate of survival and improves the quality of life in affected patients. Cancer cell viability is reduced after application of the combinational melatonin therapy. Melatonin does all these functions by adjusting the signals involved in cancer progression, re‐establishing the dark/light circadian rhythm, and disrupting the redox system for cancer cells. To achieve effective therapeutic outcomes, melatonin concentration along with the time of incubation for this indoleamine needs to be adjusted. Importantly, a special focus is required to be made on choosing an appropriate chemotherapy agent for using in combination with melatonin. Because of different sensitivities of cancer cells for melatonin combination therapy, cancer‐specific targeted therapy is also needed to be considered. For this review, the PubMed database was searched for relevant articles based on the quality of journals, the novelty of articles published by the journals, and the number of citations per year focusing only on human cancers
Evaluation of linalool effects on serum lipid profile on carbon tetrachloride damaged rats
Get PDFBackground and Objective: Linalool is a linear organic compound and monoterpene alcohol, which is found in several herbs such as coriander, Thymus, Hyssop and lavender. It seems to be effective in preventing and reducing damage caused by oxidants. Therefore, the s tudy is arranged out to evaluate the effects of linalool on lipid profiles in carbon tetrachloride (CCl4) induced oxidative damages in rats. Materials and methods: In this s tudy, 36 male Wis tar rats were divided into six groups (n=6), respectively, normal control, linalool control, injury control, pre-treatment with linalool, pretreatment with silymarin and pos t-treatment with linalool. For fourteen days, Groups I and III received dis tilled water, Groups II and IV received Linalool and finally Group V received silymarin. All the groups except groups I and III, were also intoxicated with 1.5 ml CCl4 (i.p, in a 1:1 dilution with olive oil) on the 14th day. Normal control and Linalool control groups received only olive oil. Group V was pos t-treatment group and received Linalool at 2, 6, 24 and 48h after CCl4 injection. At the end, blood serum samples were used for biochemical tes ts. Results: CCl4 significantly (p<0.05) increased triglyceride, choles terol, LDL levels and reduced HDL level when compared to the control group. The adminis tration of Linalool significantly (p<0.05) improved these alterations near to control rats. Conclusion: Linalool has protective effects agains t lipid profile alterations in carbon tetrachloride intoxicated rats
Evaluation of the Paraquat Effect on Leishmania major Promastigotes and HUVECs Viability under in vitro Condition
Get PDFBackground & objectives: Pentavalent antimonials are the first-line drugs for treatment of leishmaniasis, which have multiple side effects such as drug toxicity. Moreover, parasite resistance to these drugs is rising around the world. Second-line drugs, including Amphotericin B and pantamidine have also side effects and expensive for patients. According to the cytotoxic effects of paraquat, this study was conducted to evaluate the effect of paraquat on Leishmania major promastigotes and HUVECs viability.
Methods: A number of 2.5×106 of Leishmania major promastigotes were treated in each well of 96 well plates with different concentrations of paraquat. Cells were incubated for 48 hours in 24 °C. MTT test was performed for evaluating paraquat impact on promastigotes. The absorbance was measured using a microplate reader at 570 nm. The trypan blue staining assay was performed to evaluate the number of viable Leishmania major promastigotes following paraquat treatment. Furthermore, the effect of paraquat concentrations on HUVECs viability was evaluated under the cell culture condition.
Results: The results of the MTT test showed that increasing concentrations of paraquat could significantly reduce the viability and the number of Leishmania major promastigotes in comparison to control group (p<0.05). In this study, the IC50 for Leishmania major promastigotes was calculated as 272.46 µg/ml. Trypan blue results were in line with the finding of MTT assay. Moreover, we found that HUVECs were susceptible to paraquat (IC50=188.99 µg/ml).
Conclusion: Paraquat has a strong inhibitory effect on Leishmania major promastigotes and human endothelial cells. Although more comprehensive studies on the effects of the topical use of paraquat on Leishmania major lesions in animal model and its side effects are necessary
