Ardabil University of Medical Sciences
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Redefining and comparing family structure in different theories
Get PDFIn the divine system, by addressing family authenticity in future manuscripts and explaining it in a space devoid of negative affectors, a long-term view of the family structure not only in the world but in the spaces ahead is one of the places to consider. By explaining the structure of the family in the best position in the Qur'an, God has made it clear in the Qur'an that the pattern of the family can be continued in various situations, including worldly life and the stages ahead. In this article, in addition to addressing family issues in order to continue and redefine the family structure in various theories, we will analyze this structure in the Qur'an
Evaluation of the expression of miR-296-5p and miR-512-5p genes in breast cancer patients in Ardabil province and their relationship with hTERT gene expression and telomerase activity
No full textBackground and Purpose: Brest cancer is an abnormal growth of abnormal cells that occurs in different breast tissues. Telomerase is in charge of telomere extending. It is triggered in about 90% of cancer cells. hTERT is the controlling subunit of telomerase and plays a critical role in the activation of telomerase. miRNAs are the novel regulator of gene silencing and can target hTERT by binding the 3’ UTR of its mRNA, and regulate gene expression.This study was designed to investigate the expression level of mir-296-5p and mir-512-5p in breast cancer patients in Ardabil province and their relationship with hTERT gene expression and telomerase activity.
Materials and Methods: Samples were taken from women with breast cancer.Thirty sampels of cancerous tissue were collected along with marginal samples from patients.after microRNA extraction,cDNA synthesis was performed.after primer design for microRNAs Real time reaction was performed.a qualitative TRAP assay was also used to measure telomerase activity.
Results: Real-time data analysis revealed that the expression levels of mir-296-5p and mir-512-5p in the cancer sample were significantly reduced compared to the control samples,also,decreased expression of these two microRNAs increased telomerase activity.
Conclusion: Based on the results,mir-296-5p and mir-512-5p can target telomerase activity in breast cancer. In our study ,decereased expression of these two microRNAs had an adverse effect on telomerase activity and increased telomerase activity.Therefore,it can be concluded that targeting these two microRNAs can be a good therapeutic tool for the treatment of breast cancer
The effectiveness of home-use photobiomodulation toothbrush for treating dentin hypersensitivity A pilot study
No full textBackground and Aims: Dentin hypersensitivity is a frequent oral condition among patients suffering
from gingival recession. Recent studies have suggested that photobiomodulation has the potential to reduce inflammation and relieve pain.
Materials and Methods: Thirty patients with gingival recession and dentin hypersensitivity were selected and randomly assigned to three groups of equal size: fluoride varnish, photobiomodulation, and the combination. Dentin pain and hypersensitivity were measured using visual analog scale (VAS) by two
distinct tests: the contact test with a periodontal probe and the air blast test on the areas of gingival recession and denuded root; once at baseline and again one month after the initial application of treatments.
Results: A significant reduction in dentin pain and hypersensitivity was observed in all three groups.
However, the reduction was significantly greater in the combination group.
Conclusion: At-home treatment of dentin hypersensitivity with photobiomodulation toothbrush is a convenient, safe, and effective method for the management of dentin hypersensitivity.
Key words: Dentin hypersensitivity • photobiomodulation • fluoride varnis
Nurses-Nurses Professional Collaboration Status from the Nurses' Viewpoints in Critical Care Units of Ardabil Educational Hospitals, 2017
Get PDFBackground & Aim: Collaboration and teamwork are essential elements of nursing. Increased collaboration among nurses is critical for maintaining an effective and safe therapeutic environment. Therefore, checking the status of nurse-nurse collaboration is very important. The purpose of this study was to determine the status of nurse-nurse professional collaboration from nurses’ viewpoint in critical care units of Ardabil educational hospitals in 2017.
Methods: This was a cross-sectional descriptive study. The statistical population consisted of all nurses working in intensive care units of Ardabil educational centers (216 persons). Of them, 171 nurses were selected by total sampling method, considering exlusion and inclusion criteria. Data collection tools included a demographic form and a 35-item nurse-nurse collaboration scale. Data were analyzed using descriptive (frequency, mean and standard deviation) and inferential statistics (independent t-test, one-way ANOVA, and Pearson test) using SPSS 20 software.
Results: Mean of nurses’ collaboration was 95.36±6.93. Among the cooperation sub-scales, the highest levels were related to the three dimensions of professionalism (3.12), coordination (2.89) and collaborative processes (2.69) and the lowest to the dimensions of conflict management (2.51) and interaction (2.50). There were significant and positive relationships between nursing work experience (r=0.194, p=0.011), work experience in intensive care units (r=0.165, p=0.031), age (r=0.284, p<0.001), hospital workplace (F=2.83, p=0.026), workplace unit (F=5.044, p<0.001) and work shift (t=2.25, p=0.024) with nurses’ professional collaboration.
Conclusions: Due to the low scores of conflict management and interaction dimensions among nurses, holding workshops on how to improve communication, training the conflict resolution skills, teamwork practice in student time, organizational support and quality improvement of nursing work environments can be effective steps in increasing nurse-nurse collaboration
Investigating the effect of UV radiation on the bacterial and fungal bioaerosols in operating and isolated rooms air (Case study: Imam Khomeini Hospital in Khalkhal)
Get PDFIntroduction: Contact with bio-aerosols is associated with a wide range of health effects, including communicable diseases, acute toxic effects, allergies, and cancer. Also, the release of bioaerosols into the air of different parts of the hospital plays an important role in causing nosocomial infections. Currently, UVC radiation is used in hospitals to eliminate the microorganisms and to reduce health hazards in operating rooms and protective environment room. The purpose of this study was to investigate the effect of UVC radiation on bacterial and fungal bio-aerosols in operating room and Protective Environment Room.
Material and methods: This experimental study was performed in four operating rooms(ORs) and four Protective Environment Rooms (PERs) in Imam Khomeini Hospital, khalkhal. Bacterial and fungal bio-aerosols were evaluated according to NIOSH standard No. 0800 standard. For bacterial sampling, tryptic acid agar plus Cyclohexamide antibiotic was used and for subcutaneous fungal sampling, Saber Dexteres agar with chloramphenicol antibiotic was used. After ambient air sampling, UVC radiation was performed at two time intervals of 20 min and 8 h; after each radiation, sampling and culture of the samples were repeated. By 3 times repetition of sampling at three points of each room, a total of 432 samples were obtained. Plates were transferred to the laboratory under sterile conditions and after incubation, the plates were examined for bacterial and fungal bio-aerosols.
Results: The difference between the mean concentration of bacterial and fungal bio-aerosols in the UVC radiation at two intervals of 20 min and 8 h was significant (P < 0.05), which indicates a decrease in the concentration of bacterial and fungal bio-aerosols by UVC radiation. Besides, the greater the removal efficiency was observed for lower initial concentration of bacterial and fungal bio-aerosols. In this study, multiple regression test showed no significant relationship between environmental factors (temperature and humidity) and bacterial and fungal density in operating rooms and isolates at all three sampling times (before UV irradiation, After 20 minutes of irradiation and after 8 hours of irradiation) (P-value˃0.05).
Conclusion: The concentration of bacterial and fungal bio-aerosols in pre-irradiated ORs and PERs were significantly different from those recommended by WHO, which could be due to inadequate environmental disinfection, inefficiency of ventilation system. , Lack of control over traffic, type of surgery performed or type of disease. UVC radiation can have a significant impact on reducing bacterial and fungal bio-aerosols in ORs and PERs. Periodic monitoring of bacterial and fungal bio-aerosols and evaluation of bio-aerosols in hospital environments, medical education centers and medical laboratories can be utilized through integrated management such as proper use of disinfectants prior to UV radiation. Proper UV exposure (depending on the concentration of bio-aerosols) reduced the bacterial and fungal bio-aerosols, thereby reducing the costs and control of nosocomial infections
Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials
No full textObesity is a medical situation in which excess body fat has gathered because of imbalance between energy intake and energy expenditure. In spite of the fact that the variety of studies are available for obesity treatment and management, its "globesity" still remains a big challenge all over the world. The current systematic review and meta-analysis aimed to evaluate the efficacy, safety, and mechanisms of effective herbal medicines in the management and treatment of obesity and metabolic syndrome in human. We systematically searched all relevant clinical trials via Web of Science, Scopus, PubMed, and the Cochrane database to assess the effects of raw or refined products derived from plants or parts of plants on obesity and metabolic syndrome in overweight and obesity adult subjects. All studies conducted by the end of May 2019 were considered in the systematic review. Data were extracted independently by two experts. The quality assessment was assessed using Consolidated Standards of Reporting Trials checklist. The main outcomes were anthropometric indices and metabolic syndrome components. Pooled effect of herbal medicines on obesity and metabolic syndrome were presented as standardized mean difference (SMD) and 95% confidence interval (CI). A total of 279 relevant clinical trials were included. Herbals containing green tea, Phaseolus vulgaris, Garcinia cambogia, Nigella sativa, puerh tea, Irvingia gabonensis, and Caralluma fimbriata and their active ingredients were found to be effective in the management of obesity and metabolic syndrome. In addition, C. fimbriata, flaxseed, spinach, and fenugreek were able to reduce appetite. Meta-analysis showed that intake of green tea resulted in a significant improvement in weight ([SMD]: -0.75 [-1.18, -0.319]), body mass index ([SMD]: -1.2 [-1.82, -0.57]), waist circumference ([SMD]: -1.71 [-2.66, -0.77]), hip circumference ([SMD]: -0.42 [-1.02, -0.19]), and total cholesterol, ([SMD]: -0.43 [-0.77, -0.09]). In addition, the intake of P. vulgaris and N. sativa resulted in a significant improvement in weight ([SMD]: -0.88, 95 % CI: [-1.13, -0.63]) and triglyceride ([SMD]: -1.67, 95 % CI: [-2.54, -0.79]), respectively. High quality trials are still needed to firmly establish the clinical efficacy of the plants in obesity and metabolic syndrome
Comparison of antimicrobial effect of bioceramic and epoxy resin endodntic sealers against Enterococcus faecalis
Get PDFIntroduction: Enterococcus faecalis is the most common specie cultured from teeth with infection or failed root canal treatment. Chemo-mechanical preparation of root canal is not able to completely eliminate bacteria from root canal system. It is important to use endodontic sealers with antibacterial effect to remove remaining bacteria in root canal. The purpose of this study is to compare antibacterial effect of epoxy resin sealers with bioceramic sealers against Enterococcus faecalis at In-vitro conditions.
Method and material: Antimicrobial effect of two epoxy resin sealers - AH Plus and AD Seal,Meta - and two bioceramic sealers - MTA Fillapex,Angelus and Sure Seal Root – against Enterococcus faecalis (ATCC 29212) were assayed using both agar diffusion and direct contact tests. In agar diffusion teset, 0.5 McFarland suspension was added to plates containing TSB medium (Tryptic Soy Broth). Blank discs dipped in each sealer were placed on plates and incubated for 24 hours at .then inhibitory zones for each sealer were measured in millimeters. In direct contact test, microtubes containing same amounts of each sealer with TSB were incubated for 24 hours at . The cultures were diluted and the number of bacteria enumerated in CFU/ml. Data were statistically analyzed using ANOVA .
Results: In both tests, MTA Fillapex and AH Plus had significantly more antibacterial effect than Sure Seal and AD Seal, whereas the difference between MTA Fillapex and AH Plus and also between AD Seal and Sure Seal was not remarkable. In both tests MTA Fillapex had the most antibacterial activity. Sure Seal and AD Seal had no effect in agar diffusion test while in direct contact test they had very low effects.
Conclusion: MTA Fillapex and AH Plus have the most antibacterial activity (respectively) while Sure Seal and AD Seal have very low effects
Comparison of the Effect of Rivaroxaban and Enoxaparin on Deep vein thrombosis (DVT) prophylaxis in Pelvic Surgeries - Systematic Review and Meta-Analysis
Get PDFBackground and objective: Prophylactic anticoagulant therapy after total hip arthroplasty is a recommended procedure after surgery. Since the prophylactic anticoagulant effects of enoxaparin and rivaroxaban after hip arthroplasty have been evaluated in various studies, we decided to systematically review and compare the effect of rivaroxaban with enoxaparin on CVT after arthroplasty.
Methods: This study was a systematic review and meta-analysis study that conducted a search strategy based on PubMed, SCOPUS and Science Direct databases using keywords such as rivaroxaban, enoxaparin, DVT, THA and thromboembolism. The studies were limited to Farsi and English, and the search was conducted in the period 2000–2018. Consoart checklist was used to check the quality of articles. Variables such as blindness, randomness were considered. Data were analyzed in Revman 5 software. I2 and chi2 were used to determine heterogeneity.
Results: Overall, 499 articles were found. There were 388 articles left after repeated articles were deleted. After reviewing the inclusion criteria, finally 10 articles with meta-analysis inclusion criteria were included.I2, which indicates the heterogeneity of the study was 66%, indicating low heterogeneity of the study, and reflects the obtained stimates with high result. The results showed that Enoxaparin recipients were significantly more likely to develop DVT than patients receiving rivaroxaban. The results showed that enoxaparin recipients were significantly more likely to develop DVT than patients receiving rivaroxaban
Conclusion: Since rivaroxaban has been identified as a more effective drug, it is recommended to use it because of its more protective effect in pelvic surgery discussion
Evaluation of serum levels of visfatin and sirtuin-1 in COPD (exacerbation) patients and compared with control groups
Get PDFBackground and Objective: Disturbance in the balance of inflammatory and anti-inflammatory factors are evident in the development of chronic obstructive pulmonary disease (COPD). The present study aimed to investigate serum visfatin and sirtuin-1 levels in patients with stable and acute exacerbation of COPD.
Methods: We measured serum visfatin and sirtuin-1 levels in 30 patients with stable COPD (SCOPD), 30 patients with acute exacerbation of COPD (AECOPD), and 30 control subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, peripheral O2 saturation (SpO2), and COPD Assessment Test (CAT) score. We also tested the association of serum visfatin and sirtuin-1 levels with COPD patients’ clinical parameters.
Results: Serum visfatin levesl increased in SCOPD and AECOPD groups compared with control group (P < 0.05 and P < 0.001, respectively). Moreover, visfatin levels increased in AECOPD patients compared with SCOPD group in GOLD stages III-IV (P < 0.05). On the other hand, serum sirtuin-1 levels significantly decreased in COPD patients compared with healthy subjects (P < 0.05). There was a significant negative correlation between serum visfatin and sirtuin-1 levels.
Conclusion: Elevated visfatin levels demonstrated its proinflammatory effects in patients with COPD, especially in AECOPD patients. In addition, there was negative association between serum visfatin and sirtuin-1 levels suggest that may be their pathophysiologic and therapeutic roles in COPD patients
Epidemiological Study of Oral Lesions Referred to the Pathological Laboratory of Ardabil in 2016-2018
Get PDFBackground and Aim
The prevalence of oral mucosal lesions is varied in different countries or even in different geographical regions of each country. The epidemiologic data on the oral lesions in the north-west of Iran namely Ardabil remain unknown. In this regard, this study assessed epidemiologic data of oral lesions referred to Oral Pathology laboratories of Ardabil city during 2016-2017.
Materials and Methods
In this descriptive and retrospective trial, 102 cases of oral lesions from patients with biopsied oral lesions in the pathology laboratories and hospitals of Ardabil city during 2016-2018 were selected. The data of patients' records were transferred to a form. The incidence of the oral lesions were reported regarding their types including red oral lesions, pigmented oral lesions, vesicolobullose lesions, benign lesions, malignant lesions, intra-bony oral lesions, oral cysts and other types of oral lesions. The data were subjected to chi-square test regarding their age and gender.
Results
Oral cysts (27, 27.6%) was the most prevalent oral lesions in the studied patients. Furthermore, benign tumors (26, 26.5%), intra-bony oral lesions (20, 20.4%), malignant oral lesions (12, 12.2%), other lesions (11, 11.2%), vesicolubollosa lesions (3, 3.1%), pigmented oral lesions (2, 2.0%) and red oral lesions (1, 1.0%) ranked in the next order.
Significant differences existed regarding the incidence of malignant tumors in terms of age (p=0.012) so that the frequency of malignant tumors in the age group of higher than 60 years old was higher than others (with the incidence of 11.1%, 5.9%, 14.3%, 9.5% and 42.9 % in the age groups of 11-20, 21-30, 31-40, 41-50 and over 60 years old respectively).
The incidence of intra-bony oral lesions in females (29.8%) was significantly higher than males (11.8%) (p=0.027). Furtheremore, significant differences were found regarding the incidence of intra-bony oral lesions in the different age groups (p=0.047) with the frequency of 22.2%, 22.2%, 14.3%, 23.8%, 50.0% and 14.3% in the age groups of 1-10, 11-20, 31-40, 41-50, 51-60 and over 60 years old respectively.
No other significant differences were found regarding the incidence of different oral lesions in terms of age and gender.
Conclusion
Therfore, oral cysts was the most prevalent lesions in the biopsies of the oral lesions in Ardabil city while red, pigmented and vesicolubullose lesions showed lower frequencies. In most lesions, the age and gender was not differently reported