Ardabil University of Medical Sciences
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The Effect Mucilages of Plantago ovata and Salvia macrosiphon as a Replacement of Fat on Sensory, Microbial and Durability of Low-Fat Stirred Yoghurt Probiotics
Get PDFBackground & objectives: The aim of this study was the effect of mucilages of Salvia macrosiphon and Plantago ovata as a prebiotic instead of fat and its effect on the sensory, microbial and survival properties of low-fat stirred yogurt probiotic.
Methods: In this study, mucilages of Salvia macrosiphon and Plantago ovata were added to the low-fat stirred yogurt in concentrations and various ratios of 0.01%, 0.04% and 0.07%, after the extraction. The effects of adding mucilage on the properties of low-fat stirred yogurt probiotic containing bifidobacterium bifidum stored at refrigerated temperature (0 to +4 °C), such as sensory, durability assessment and total probiotic bacterial count were investigated for 3 weeks. The results were analyzed using ANOVA test.
Results: The results showed that the yoghurt containing of 0.04% Salvia macrosiphon mucilage and 0.04% Plantago ovate mucilage had the highest scent, taste and sensory rating. The combination of salvia macrosiphon and Plantago ovate mucilages had a significant effect on sensory properties (p<0.05). A significant decrease was observed in the color score of yogurt samples, with increasing the percentage of the Salvia macrosiphon and Plantago ovate mucilages (p<0.05). The probiotic bacterial life of Bifidobacterium bifidum increased until the seventh day with the addition of mucilages to yogurt, and then decreased. The sample containing 0.07% mucilage of Salvia macrosiphon showed the highest amount of probiotic bacteria, but live bacterial count significantly increased with increasing of these two hydrocolloids compared to the control group (p<0.05).
Conclusion: The results of this study showed that the some doses mucilages of Plantago ovata and Salvia macrosiphon as a replacement of fat could play a significant role in keeping up the sensory properties of low fat yogurt during storage. Thses additives can improve the negative effects of reduced yogurt fat with increasing the amount of probiotic bacteria and improving oral sensation
Exposure and risk assessment of PAHs in indoor air of waterpipe cafés in Ardebil, Iran
No full textThe aim of this study was to determine the concentrations of polycyclic aromatic hydrocarbons (PAHs) bound to particulate matter (PM) in the indoor air of waterpipe cafés of Ardebil city, and to further assess the health risk due to exposure to PAHs. 50 out of 236 cafés were selected using systematic random sampling method and air samples were taken from standing breathing zone of smokers and employees, ∼150 cm above the ground level. The concentrations of PAHs were determined using GC-MS. The results showed that the mean indoor concentration of PAHs in the cafés was 5522.1 ± 594.8 ng/m3. It was 5915.2 ± 650.5, 2404 ± 271.4, and 7304.9 ± 846.0 ng/m3 for cafés with fruit flavored tobacco, regular tobacco, and the both, respectively. The means of the hazard quotient (HQ) for PAHs in different age groups, including 11 to <16, 16 to <21, 21 and older, and the cafés employees were 0.35, 0.75, 3.65, and 18, respectively. Also, the mean of estimated cancer risk for PAHs in the aforementioned age groups and employees were 0.65 (10−5), 1.31(10−5), 6.43 (10−5) and 31.3 (10−5), respectively. The results indicated the increased health risk levels related to the inhalation of tobacco smoke due to PAHs concentrations in the waterpipe cafés
The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats
No full textThe purpose of this study was to investigate the effect of clomiphene citrate and human chorionic gonadotropin (HCG) on the structural changes, as well as the evaluation of the expression of cation channel sperm‐associated protein 1 (CatSper1), cation channel sperm‐associated protein 2 (CatSper2), luteinizing hormone/choriogonadotropin receptor (LHCGR), and steroidogenic factor 1 (SF1) genes in testicular tissue of rats. All rats divided into five groups as follows; G1 as the control group that received normal saline, G2 received olive oil, G3 received 100 IU/kg HCG, G4 received 5 mg/kg clomiphene citrate, and G5 received 5 mg/kg clomiphene citrate and 100 IU/kg HCG. At the end of the experiment period, Day 56, blood samples were taken and the serum was isolated. Then, histomorphometric analysis, hormonal assess, and real‐time polymerase chain reaction to measure the expression of CatSper1, CatSper2, LHCGR, and SF1 genes were performed. The results showed that the concentrations of testosterone, follicle‐stimulating hormone, and luteinizing hormone were decreased in the G4 group, whereas these parameters were increased in the G3 group. A comparison of the sperm quality indicated a significant reduction in the quality of sperm cells in the G4 group compared with other groups. The quality of sperm was significantly enhanced in the G3 and G5 groups in comparison with the G1 group. Also, our findings demonstrated that the expression of CatSper1, CatSper2, LHCGR, and SF1 genes were significantly elevated in the G3 group when compared with other experimental groups. According to the obtained results, it seems that clomiphene citrate reduces the process of spermatogenesis and the detrimental impacts of this compound would be neutralized by the administration of HCG
Diabetes distress and its clinical determinants in patients with type II diabetes
No full textAim: The present study aimed to determine the status of diabetes distress and its clinical determinants
in type II diabetes patients.
Methods: This descriptive-analytical study was performed on 220 patients with t diabetes referred to Diabetes Clinic of Imam Khomeini Hospital in Ardabil, Iran. The samples were selected using convenience sampling method. Data collection tools included demographic and disease form and Diabetes Mellitus Scale (DDS). Data analysis was performed using SPSS software version 22 via descriptive (frequency, mean, standard deviation) and inferential statistics (compare means, Pearson correlation coefficient and stepwise multiple regression). Results: The average duration of diabetes was 7.64 (SD ¼ 4.68) years. 63.7% of the patients had moderate to severe diabetes-related distress. Emotional burden dimension had the highest score among the subscales of diabetes distress. In addition, there was a correlation between positive family history (p ¼ 0.017), duration of diabetes (p ¼ 0.028) and type of treatment (p ¼ 0.47) and diabetes distress. Hemoglobin A1C levels, body mass index and triglyceride were the major predictors of diabetes distress.
Conclusions: Considering the high prevalence of diabetes distress in patients with type II diabetes, it seems that paying attention to clinical predictors of distress and screening of patients with diabetes is a reasonable and accessible method for health care providers and patients to improve their disease management
evaluation of laparatomy in patients with multiple trauma confirmed by FAST technique from september 2016 to september 2019 infatemi hospital in ardabil
Get PDFDiagnostic value of Ultrasonography in the detection of Bone Erosions in patients with Rheumatoid Arthritis: a comparison with Conventional Radiography
Get PDFObjective: Rheumatoid arthritis (AR) is the most common systemic infammatory disease of joints, with prevalence of 1% worldwide. Bone erosion (BE) is a central feature of rheumatoid arthritis and is associated with disease severity and poor functional outcome. Conventional Radiography (CR) and Ultrasonography (US) play an important role in the diagnosis of RA. The aim of this study was to
compare the value of two methods in the detection of BE in AR patients. Methods: In this cross-sec- tional study, 111 patients with confrmed RA have been randomly selected and were studied. A checklist which includes demographic information such as age, gender, place of residence, history
of smoking, education level and history of rheumatologic disease was completed for all patients, and then radiography and high-resolution US of dominant hands and wrists of metacarpophalangeal (MCP) joint were performed. Collected data was analysed by statistical methods in SPSS version 22. Results: The results of this study showed that there is no signifcant diference between these two
methods in detection of BE. In age groups < 44 years old, US with 98% had more sensitivity than CR with 89%. Conclusion: Results showed that there is no signifcant diference in diagnostic value of US in bone erosion in patients with rheumatoid arthritis, in comparison with CR in terms of gender and diagnosis for the existence of erosions; however, in determining the amount of BE in age groups < 44 years old, US has better performance than CR
The Relationship between Systemic Filling Pressures with Central Venous Pressure of the Body during Cardiac Surgery.
Get PDFEvaluation of root canal anatomy of the mandibular central and lateral incisors, by using CBCT archive in Ardabil population
Get PDFBackground & Objective: Awareness of dental anatomy and morphological canal variations is essential for successful root canal treatment. The pulpal tissue of human teeth has many forms. Determining the internal anatomical connections prior to root canal treatment is crucial so that insufficient awareness will lead to an undesirable outcome of root canal treatment and may require root canal treatment or surgical intervention. CBCT images allow us to investigate three-dimensional root canal morphology and identify additional canals and roots. Since there are differences in root canal morphology in different populations and the results are very widely depending on the method, we decided to investigate the root anatomy of mandibular central and lateral teeth with CBCT archive in Ardabil.
Methods: In this descriptive study, CBCT images of 358 patients who have the inclusion criteria were evaluated. In this study, 358 radiographies were selected and systematically randomly sampled from CBCT images taken at the Oral and Maxillofacial Radiology Clinic by Panomeca promax 3D mid, using Romexis software,were studied. The data were analyzed in SPSS.24 software.
Results: All mandibular centrals and laterals were single-rooted and 58% of centrals and 54.6% of laterals had one canal. The root of 50.55% of mandibular centrals was straight and for common curvature in the indirect roots in the right mandibular centrals is in the mesial direction and in the left centrals is in the distal direction. The root of 58.15% of right mandibular laterals was straight, whereas the root of most left mandibular laterals was curved. Common curvature in the indirect roots in the right mandibular laterals and in the left mandibular laterals is in the distal direction.
58% of mandibular centrals are classified as Vertucci Type I. After that, the most common type was Type III and the least prevalent was Type V. 50.55% of the mandibular laterals are Vertucci type I. After that, the most common type was Type III. The lowest incidence of right mandibular laterals was of type VI and the lowest incidence of left mandibular laterals was in association with Type V and VII.
Conclusion: The morphology and root canal system are different in different populations, and CBCT imaging is a useful and effective tool in detecting root canal anatomy. In the present study in Ardabil population, all incisors examined had one root and 42% of centrals and 49.45% of laterals had two root canals. Finally, the results show that the root canal morphology in Ardabil population is different compared to similar studies with respect to population and ethnicity, sample size and method used
Outcome of Surgery as Sole Treatment of Eosinophilic Granuloma of Jaws
Get PDFLangerhans cell histiocytosis (LCH) is characterized by the congregation of proliferating langerhans cells (LC). Langerhans cells are a part of dendritic cell system of primary immune response that is responsible for presenting antigen to lymphocytes. Being a rare disease, the total incidence of LCH is reported to be 1 in 2 million people. LCH mainly affects children and young adults, with a slight male predilection. LCH is clinically divided into three groups namely Letter-Siwe disease (multiple multi organ affecting LCH at very young age), Hand-Schuler-Christian disease (LCH of bone involvement exophthalmos and diabetes insipidus), and Eosinophilic granuloma (LCH of bone, solitary or multiple). The extent of involvement influences the treatment planning. In this retrospective study, we survey five patients with eosinophilic granuloma in jaws (bony LCH). The diagnosis was confirmed by tissue biopsy and histopathologic examination. Surgery and curettage of the lesions were carried out under general or local anesthesia. After surgery, the patients were examined clinically every 6 month in the first year and then once in a year. The overall outcome was excellent. According to the results, it can be concluded that surgical curettage of localized eosinophilic granuloma is an appropriate and sufficient treatment
Thiamine pyrophosphate improved vascular complications of diabetes in rats with type 2 diabetes by reducing glycation, oxidative stress, and inflammation markers
Get PDFBackground: Thiamine deficiency contributes to hyperglycemia and diabetes complications. Thus, in this study, the effect of thiamine pyrophosphate (TPP) on the in vivo and in vitro formation of glycation, oxidative stress, and inflammatory markers (the main contributors of vascular diabetes complications) was examined in type 2 diabetes rat model.
Methods: Type 2 diabetes was induced in rats with a combination of streptozotocin and nicotinamide (55+200 mg/kg). Two groups of rats, healthy and diabetic, were treated with 0.1% TPP in drinking water daily for 3 months and the 2 others received water only. The glucose, insulin, early to end glycation products, the activity of glyoxalase system, lipid profile, LDL oxidation markers, inflammatory markers, creatinine in the serum, and proteinuria in the urine of all rats were determined. Moreover, albumin and LDL were incubated with glucose in the presence and absence of TPP, and the samples were investigated for glycation and oxidation products. Different variables in all 4 groups were compared with multiple analysis of variance (MANOVA-Tukey) test using SPSS version 16. Significance level was set at p<0.05.
Results: TPP decreased the formation of diverse glycation and oxidation products in both in vivo (glycated LDL= 144.50±3.48 and oxidized LDL= 54.08±2.67 μmol/l) and in vitro (glycated LDL= 107.00±2.82 and oxidized LDL= 50.83±1.22 μmol/l). In addition, the vitamin reduced fasting blood sugar (9.23±0.29), insulin resistance (9.10±0.50), tumor necrosis factor-α (285.43±15.97), interleukin-6 (257.65±13.06), and improved the lipid profile, the activity of Glo system (Glo-I= 31.65±1.06 and Glo-II= 27.01±0.90 U/mL) and renal function in the diabetic rat (p<0.001).
Conclusion: TPP decreased the major risk factors for diabetic complications and corrected the alternations of glucose and lipid metabolism in type 2 diabetic rats; thus, it is recommended for diabetes treatment