Ardabil University of Medical Sciences
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Effect of Ceratonia siliqua L. extract on DNA Fragmentation of Sperm in Adult Male Mice Treated with Cyclophosphamide
No full textThis study was conducted to determine the effects of Ceratonia siliqua L. (CS) extract on sperm parameters and DNA damage in adult male mice treated with cyclophosphamide (CP). Based on an initial dose response experiment on Ceratonia siliqua L. extract, five treatment groups were set up: control, sham (normal saline: 0.2 ml per day, IP), CP (15 mg kg-1 per week; IP), Ceratonia siliqua L. (100mg l-1 per day; IP), and group of Ceratonia siliqua L. along with CP for 35 days. After euthanizing the animals, sperms from caudal part of epididymis were collected, and their parameters, Malone Di-Aldehyde (MDA) level, and DNA fragmentation were analyzed. In the mice exposed to cyclophosphamide, reduction in the sperm count and viability and increase in the abnormal sperm and MDA levels were detected (p < .05). In addition, an increase in sperms with damaged DNA was detected in CP group, while the use of Ceratonia siliqua L. Extract significantly recovered these disturbances in the treatment group (p < .05). This study suggested the competence of Ceratonia siliqua L. extract in the improvement of sperm parameters and DNA fragmentation in animals treated with CP
Comparison effect of Entonox and Dexamethasone versus Remifentanil and Dexamethasone on the control of painless delivery
No full textBackground: Labor pain is often severe. Unrelieved labor pain can have an adverse effect on the physiologic status of women. Pain during labor is accompanied by fear, which is related to slower progress of labor. Accurate measurement and appropriate management of pain is a significant problem for attendant medical and nursing personnel. There are choices to be made during labor about options available for pain relief in labor; each method has its own risks and benefits, with variations in effectiveness, availability and acceptability.
AIM: The purpose of this study was to Comparison effect of Entonox and Dexamethasone versus Remifentanil and Dexamethasone on the control of painless delivery in the delivery room of Alavi Hospital in Ardebil
Materials and Methods: In this clinical trial study, 100 women with term pregnancy were observed. In all of the cases, labor pains started spontaneously and had fetal and maternal indication for normal vaginal delivery. They were divided into two groups randomly. The A group received Entonox and Dexamethasone and the B group received the Remifentanil and Dexamethasone. Data of labor pain and outcome of delivery collected by means of questionnaires.
Results: Pain severity according to VAS score was significantly lower in patient received remifentanil and dexamethasone after 30, 60, 120 and 180 min after intervention VS subjects with Entonox and Dexamethasone. There is no significantly different regard to duration of labor's active phase, the number of uterine contractions, apgar score and fetal heart rate between two groups. Concerning maternal complications between the two groups, dry mouth which was lower in the remifentanil and dexamethasone group than in the entonox and dexamethasone group. The rest of the cases showed no statistically significant differences between the two groups. There is no significant difference about mean diastolic blood pressure and maternal respiratory rate between the two treatment groups.
Conclusions: Concomitant use of remifentanil and dexamethasone is recommended compared with Entonox and Dexamethasone because it is safe for the mother and child and provides more favorable analgesia during labo
Investigation of the impact pattern of maxillary third molars in Ardabil population
No full textPurpose: The aim of present investigation was to evaluate frequency of different angles, numbers of roots, depth of impaction in maxillary third molarsand their damages to nearby structuresby analyzing panoramic radiography.
Materials and Methods: This study was conducted by analyzing panoramic radiography
382 (124 men & 258 women) patients who referred to baser radiography center, rad radiography
center and Ardabil dental school between year 2014 to 2015.
Results:The most frequent angle of impacted teeth in maxillary third molar in both genders was
vertical (48/9%), and the most frequent depth was class C according Winter Classification System
(46/8%), in approximately 85% of cases No space between teeth and sinus was observed and according to numbers of roots 54% of teeth had 2 roots, 22% 3 roots and 8% had only one root. The
most important damage to nearby structures was angular periodontal lesions which were demonstrated in radiography (52%), making caries on second molars (100%), root resorption on second
molars (6%) and in 18% no harmful lesions on molar 2 or radiographic lesions were detected.
Conclusions: Within the limitations of this study, most of third impacted maxillary molars
had enough space to maxillary sinus and most of them were vertically, thus extraction of these
impacted teeth seems simple and possible
In silico design of peptide inhibitors of tubulin: amyloid-β as a lead compound
No full textMicrotubule is one of the most studied targets in cancer research. Stabilizing and destabilizing of the
microtubule by targeting its building block tubulin are common mechanisms of microtubule targeting
agents. Cancer associates inversely with Alzheimer’s disease (AD). So the rate of developing AD is significantly slower in patients with cancer and vice versa. Amyloid-b (Ab) peptide inhibits tubulin polymerization and induces apoptotic death of cancer cells. We studied the interactions of Ab with tubulin using
protein-protein docking and MD simulation. Ab bond to the vicinity of the vinblastine binding site and
interacted with the H6-H7 loop. Interaction of Ab with H6-H7 loop blocked nucleotide exchange and
may be attributed as a possible reason for blocking of tubulin polymerization. We designed new Abbased peptidic inhibitors of tubulin using visual inspection and alanine scanning method. P1
(FRHYHHFFELV) and P9 (HYHHF) bound efficiently to tubulin and also interacted with the H6-H7 loop.
Obtained results indicated that proposed peptides could potentially inhibit nucleotide exchange as Ab
Factors Affecting on Establishment of Health System Reform Plan in Ardabil Province
Get PDFBackground & objectives: In today's world, health has wider prospect and special attention has been paid to non-medical expectations. The health care reform plan aims to improve community health, reduce treatment costs and increase the satisfaction of patients. The aim of this paper was to identify the factors influencing the development of health system in Ardabil province.
Methods: This mixed-methods study was performed in two stages. In the first stage, comprehensive literature review was carried out and important factors in establishment of health system reform in the world were discovered. In the second stage and using the first stage findings, the questionnaires were completed by 185 experts and administrators of health development plan in Ardabil province who were selected by non-random purposeful sampling and local factors affecting the establishment of the plan in the province hospitals were obtained. Lisrel software was used for factor analysis .
Results: The most important indicators of development of health care system were as follows: political support, providing and promoting community participation, management and resource assurance, satisfaction guarantee for paramedics, commitment of senior executives, commitment of interested physicians, continuous monitoring and evaluating and providing the feedback to project executives, existence of infrastructure and project steering committee. The results of structural equation modeling showed the relationship between independent and dependent variables.
Conclusion: The study modeling indicators showed that, the proposed model is in good agreement. It seems that paying attention to regional indicators and variables is very important in the formulation and implementation of strategic plans and has a decisive role in achieving the goals
Assessment of the developmental status of 3 to 5-year-old children with congenital hypothyroidism treated with levothyroxine in Ardabil city
Get PDFBackground: Congenital hypothyroidism (CH) is one of the most common preventative evolutionary disorders in newborns and children, which, if not treated promptly, leads to mental retardation and developmental disorders.
Objective: The purpose of this study was to assess the developmental status of 3 to 5-year-old children with congenital hypothyroidism treated with levothyroxine in Ardabil city in Northwest Iran.
Methods: In a descriptive cross-sectional study, 78 infants (44 boys and 34 girls) with congenital hypothyroidism under treatment with levothyroxine who referred to Ardabil city health centers during 2013-2018 were evaluated by an Ages and Stages Questionnaire (ASQ) for their developmental status.
Results: In total, 32 (41%) were impaired and 46 (59%) were healthy according to the ASQ. Of those, 11 children (14.1%) had temporary congenital hypothyroidism. There was no significant difference in terms of height, weight, birth weight, maternal age, number of tests performed each year, average TSH (Thyroid-stimulating Hormone) in the first year of treatment, gender, place of residence, education and parental relationship between two impaired and healthy children. There was a significant relation between number of visits by doctor (p=0.02), age at diagnosis (p=0.001) and age at treatment time (p=0.003), initial dose of levothyroxine (p=0.02) with developmental status of children based on ASQ results.
Conclusion: According to the findings of this study, it can be concluded that neonatal screening is one of the most successful health-system programs in the country, and the detection and initiation of hypothyroidism in neonates as soon as possible leads to a reduction in developmental disorder in them
Synthesis and cytotoxic effect of a few N-heteroaryl enamino amides and dihydropyrimidinethiones on AGS and MCF-7 human cancer cell lines
Get PDFBackground and purpose: Cancer prevalence has increased in the last century posing psychological, social,
and economic consequences. Chemotherapy uses chemical molecules to control cancer. New studies have
shown that dihydropyrimidinethione (DHPMT) derivatives have the potential of being developed into
anticancer agents.
Experimental approach: New derivatives of DHPMTs and a few acyclic bioisosters were synthesized via
Biginelli reaction and assessed for their toxicity against gastric (AGS) and breast cancer (MCF-7) cell lines
through MTT method.
Findings / Results: Chemical structures of all synthesized N-heteroaryl enamino amides and DHPMTs
were confirmed by spectroscopic methods. Result of biological assessment exhibited that none of the
tested agents was more cytotoxic than cis-platin against AGS and MCF-7 cell lines and compound 2b
was the most cytotoxic agent against AGS (IC50 41.10 µM) and MCF-7 (IC50 75.69 µM). Cytotoxic data were
mostly correlated with the number of H-bond donors within gastric and breast cancer cells.
Conclusion and implications: It was realized that DHPMTs were able to inhibit the growth of cancer cells
much better than acyclic enamino amides and moreover; N-(4-methylbenzothiazol-2-yl) DHPMT derivative
(2b) supposed possible interaction with a poor electron site of target due to the lipophilic nature of
benzothiazole ring and also less electron rich nature than isoxazole. Similar scenario was observed with acyclic
enamino amides in which incorporation of sulfur and nitrogen containing heterocycles doubled the cytotoxic
effects. Results of the present contribution might assist in extending the scope of DHPMTs as privileged
medicinal scaffolds
Shigella flexneri strain arums98 O-antigen polymerase (rcf) gene, partial cds
Get PDFRcf gene sequence from Shigella flexneri arums98 strai
Using social network rates among Ardabil city women over 25 years old
Get PDFIntroduction: The role of women in the structure of society and family is very important. Unfortunately, due to the
lack of proper planning to fill leisure time among people and especially women, overuse of social networks had a
huge impact on their daily lives and in addition to the benefits, sometimes it has some problems. Method: This
cross-sectional descriptive study has been done on 150 women over 25 years who selected randomly from Ardabil
city in the 2018. Required information were collected using a research based questionnaire containing
demographic and specialized questions about the rate of using social networks and their reasons. Collected data
were analysed using descriptive and analytical statistical methods in SPSS version 21. Results: The mean age of
women was 34 ± 9 years. Of all women, 72% were married, 69% had graduated education, 27% were
housewives, 44% were employees and 63% had a median income. Of all women, 94.7% were registered as
members of social networks. Of them, 66% were registered on telegram. The most common reason for using
Telegram, was chat and reading news. The maximum time spent with more than 5 hours for the social network
was Telegram. Conclusion: Results showed that, most of the studied women have been used social networks
and of them telegram and Instagram are more popular networks among Ardabil’s wome