Ardabil University of Medical Sciences
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Aleukemic Leukemia presenting with polyarthritis and pathological fractures: A Case Report
No full textIntroduction:
About %30 of patients with leukemia initially present with musculoskeletal signs and symptoms as medullary involvement including limping , bone or joint pain and fractures.
Case presentation:
The patient was a 10 year old boy that present with polyarthritis and pathological fracture of his wrist and vertebral body bones. Peripheral blood test revealed no abnormal cells, bone biopsy at the fracture
site only showed small aggregates of unremarkable lymphocytes. A bone marrow study couldn't provide a definitive diagnosis of acute leukemia on morphology and immunohistochemistry. A diagnosis of precursor B-cell ALL was unequivocally confirmed by bone marrow biopsy.
Conclusion:
ALL is the commonest childhood cancer, accounting for up to one third of all pediatric malignancies. Common presentations include; fever, bleeding and lymphadenopathy, while about 30presented of patients with bone or joint pain. However, musculoskeletal symptoms can be the only presenting feature of ALL, causing a delay in diagnosis
Alterations in the behavior, cognitive function, and BDNF level in adult male rats following neonatal blockade of GABA-A receptors
No full textGamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the mature brain. At an early developmental period, it acts in an excitatory manner that influences many processes of proliferation, migration, and differentiation of the neurons. Previous evidence indicated that manipulation of the GABAergic system function by activation or blockade of its receptors during developmental periods leads to behavioral and cognitive abnormality in adulthood. Therefore, we examined the effects of neonatal blockade of GABA-A receptors by bicuculline on behavior, cognitive function, and hippocampal and prefrontal cortex (PFC) brain-derived neurotrophic factors level (BDNF) in adulthood. As a result, neonatal rats were treated with either bicuculline (75,150, and 300 μg/kg) or DMSO on postnatal days 7,9, and 11. These groups underwent the behavioral (open field, elevated plus maze, and hot plate) and learning and memory (passive avoidance learning and memory) tests in postnatal days (PNDs) 61−70. After the ending of the behavioral tests, the rats were sacrificed under deep anesthesia and the hippocampi and prefrontal cortex (PFC) of the brain were removed for assessing the BDNF mRNA expression. Our results indicated that neonatal administration of bicuculline at the highest dose increased passive avoidance memory and hippocampal BDNF level. Meanwhile, this drug at a low dose impaired this type of memory and increased PFC BDNF level. Besides, treatment with bicuculline during postnatal days increased anxiety and pain sensitivity in a dose-dependent manner. Taken together, these findings confirmed the notion that GABA-A receptors during the developmental period are important for programming neurobehavioral phenotypes in adult life
Health risk assessment of heavy metals in dust particles precipitated on the screen of computer monitors
No full textDust is an important factor to indoor pollution that contains suspended particles and heavy metals. Since today, use of computer has become an essential part of human life. Therefore, this study aimed to compare the amount of heavy metals deposited on CRTs and LCDs and their risk assessment. Ten dust samples for each type ofmonitor were collected fromCRT and LCD screens in accordance with the standard OSHA ID-125 and ID-206, wet filter wipe method. Concentrations of Pb, Hg, Cd, Cr, and Cu were measured by inductively coupled plasma–optical emission spectrometer. Exposure and risk assessment of these elements were estimated using USEPA’s exposure parameters. The average concentrations of heavy metals in the dust on CRTs (0.82 mg/kg) were higher than LCD screens (0.69 mg/kg). Cr with 62.824% and Hg with 0.849% had the highest and lowest average concentration in both types of monitors. The non-carcinogenic risk and carcinogenicity indexes of CRT monitors were 0.0009, and 3.94 × 10−11 and for LCD monitors were 0.0008 and 2.94 × 10−11. In both monitors, ingestion is the main route to exposure with heavy metals. The average concentration of heavy metals in CRT dust. HI values for studied metals in dust of CRTs and LCDs were less than safe limit of 1. Because RI < 10−4, cancer risk of studied elements in dust can be ignored
Acute Generalized Exanthematous Pustulosis (AGEP): A Case Report
No full textIntroduction:
Acute generalized exanthematous pustulosis ( AGEP ) is an uncommon drug eruption characterized by superficial pustules. Predisposing factors include medications, biting and viral illness.
Case Presentation:
A 10 year old boy admitted with severe pruritic papulopustular lesions. The lesions were appeared firstly on neck and face, then were spread across the body especially trunk and extremities. The pustular stage was more brief and subsequently erythematous papular rash appeared that suggesting AGEP. He had not got fever, mucosal and internal organs involvement. Treatment was commenced with topical mometasone, but the response was not good, so systemic prednisolone was commenced as 1 mg/kg/day. The lesions became less colored in the few days and subsequently desquamation was appeared.
Conclusion:
AGEP is a rare condition and the skin conditions such as toxic epidermal necrosis, drug hypersensitivity syndrome and generalized pustular psoriasis may be mistaken with AGEP
The relationship between moral sensitivity, ethical climate, and job strain with patient privacy from viewpoint of operating room staffs
No full textBackground: The privacy of patients in the operating room is in particular importance. The results of previous studies have shown that various factors are affecting in this context. The aim of this study is to evaluate the relationship between moral sensitivity, ethical climate and job strain with respect to patients' privacy in operating rooms.
Materials and methods: All of operating rooms nurses of teaching hospitals affiliated to Ardabil University of Medical Sciences were entered into this descriptive-analytical study with census sampling method in 2019. To collect data, standard surveys of moral sensitivity, ethical climate, job strain and privacy were used. Data were analysed by SPSS15 software using descriptive and analytical statistics methods (independent t-test, ANOVA, pearson correlation and regression analysis).
Results: There was a positive significant relationship between moral sensitivity and privacy (r=0.56, p<0.001) and ethical climate and privacy (r=0.60, p<0.001), too. But, There was an inverse and significant correlation between Job strain and privacy (r=-0.69, p<0.001). The results also showed that moral sensitivity is the best predictor of patients’ privacy.
Conclusions: Despite the predictability of all variables, results showed that moral sensitivity is the most important component in patients' privacy. In this regard, by increasing the moral sensitivity of nurses, the privacy of patients can be improved
Structural Optimization of Flavonoids, Carotenoids, Alkaloids and Saponins as Antileishmanial Agents by molecular modeling methods
No full textIntroduction: Leishmaniasis is a parasitic disease caused by Leishmania parasites which transmission to humans is facilitated by the bite of a sandfly. The disease can cause different symptoms, from self-healing cutaneous Leishmaniasis to potentially fatal kala-azar or visceral Leishmaniasis. Approximately one billion people live in areas endemic for Leishmaniasis and an estimated 30000 new cases of Visceral Leishmaniasis and more than 1 million new cases of Cutaneous Leishmaniasis occur annually. The important issue in the chemotherapy of Leishmaniasis include availability of very few drugs, the emergence of resistance to the existing drugs, their toxicity and also lack of cost-effectiveness. Therefore, it is of utmost importance to search for and develop new effective drugs and drug targets for the treatment of Leishmaniasis. Natural products are already used in the men’s daily diet; thus, they could be considered as suitable source for exploration of safe therapeutic goals.
Materials and methods: Present study aimed at proposing effective and safe antileishmanial compounds among natural products, using molecular docking methods. For this purpose, 67 flavonoids and 45 alkaloids were subjected to molecular docking process in order to obtain potential Leishmanial target-binding agents. AutoDock 4.2 was used for molecular docking simulations and PLIP webserver was also applied to analyze the complex interaction results. Top-ranked molecules were subjected to intermolecular binding interaction analysis via density functional method by Gaussian 03 software.
Results and Discussions: Candidate ligands were docked into active sites of 10 validated Leishmanial targets and then ranked with regard to obtained binding affinities (ΔGb). Subsequently, on the basis of structure binding relationship studies, top-ranked ligands were evaluated and probable antileishmanial pharmacophores were proposed. It was found that mostly alkaloids and flavonoids exhibited high binding affinities to the validated leishmanial targets in comparison to crystallographic ligands. The tightest binding belonged to acerosin-uracil DNA glycolase (UDG) complex (ΔGb -10.24 kcal/mol) and tithonine exerted multitarget binding potential. Hydrogen bond, vdw contacts and π-π stacking were found to be determinant binding interactions within flavonoids structures while alkaloids were associated with vdw contacts and salt bridge.
Conclusion and Suggestions: In general flavonoids exhibited better binding affinity into active site of validated leishmanial targets in comparison to alkaloids. On the basis of obtained results, UDG can be considered as a potential target for upcoming antileishmanial purposes due to the association with superior binding affinities toward flavonoids which are appropriate chemical scaffolds to be developed as antileishmanial agents
Production of application of nursing process and patient education in common diseases of old age for better care in the elderly
No full textThe Status of Ageism in Caring for Elderly Patients From Nurses’ Perspective
No full textBackground: As the number of elderly people referred to hospitals increases, so does the number of discrimination reports in the care of the elderly, compared with younger people. This study aimed to investigate the status of ageism in caring for elderly patients from nurses’ perspective.
Methods: It was a descriptive cross-sectional study that was conducted in three selected hospitals of Ardabil province, Iran, in 2019. A total of 482 nurses were recruited by convenience sampling. The data were collected using a demographics questionnaire and the Ageism Scale in Hospital Care and analyzed using descriptive (frequency, percentage, mean, and standard deviation) and inferential statistics (the Pearson correlation coefficient, independent t-test, one-way ANOVA, and Scheffe post hoc test) in SPSS V. 20.
Results: The mean age of the participants was 33 years. Most nurses showed moderate ageism when providing care to older adults. The level of ageism was significantly associated with age (P=0.002), gender (P=0.001), work experience (P=0.032), and the ward in which the nurses worked (P=0.001)
Conclusion: The findings revealed that the study hospitals suffered ageism. Also, the level of ageism was associated with the age, gender, admission ward, and work experience of the nurses. Thus, it is suggested to consider appropriate interventions to prevent ageism, when designing and planning care for older adults.
Keywords: Ageism, Discrimination, Prejudice, Caring, Ira
The Role of Impulsivity and Cognitive Emotion Regulation in the Tendency Toward Addiction in Male Students
No full textBackground: Addiction is one of the most important issues today that has affected all institutions, including the family and the society, and the close connection between this issue and the correct methods of raising children in the family is undeniable. Objective: This study aimed to investigate the role of impulsivity and cognitive emotion regulation in the tendency toward addiction in students of Ardabil universities. Methods: The methodology applied in this research was descriptive correlation. A total of 520 male students who study at Ardabil universities were selected by 2-stage random sampling. To measure the variables, the Barratt Impulsivity Scale, the Cognitive Emotion Regulation Questionnaire (CERQ-P), and the Addiction Preparation Scale of Weed and Butcher were used. Results: To analyze the findings, the Pearson correlation coefficient and multiple regressions were used. The obtained results show that there is a positive correlation between impulsivity and tendency to addiction (P<0.01). Also, there is a correlation among all components of impulsivity and tendency to addiction (P<0.01). Statistically, there is a positive correlation between cognitive emotion regulation and tendency to addiction (P<0.01). The results of multivariate regression showed that motor impulsivity, cognitive impulsivity, nonplanning, self-blame, acceptance, rumination, and putting into perspective were significantly able to predict the tendency to addiction. Conclusions: Noting that the variables of impulsivity and cognitive emotion regulation can properly predict the tendency to addiction, university counseling centers can, through workshops, teach the students different ways of controlling these variables in a variety of situations and so they will be able to prevent the tendency toward drug use
Fulminant Myocarditis a Serious Complication of Coronavirus: A Case Report
No full textIntroduction:
Coronavirus cause a multisystem disease and can effect the heart and cause myocarditis. The symptoms are hypotension, altered mental status and eventually death.
Case Presentation:
The case was 2 years old girl with the symptoms of fever, malaise that has began 2 days ago and the symptoms aggravated at the night before admission. She had unconsciousness, mottling, hypotension, tachypnea, cyanosis and huge hepatomegaly. Arterial blood gas analysis demonstrated "PH=7.24, PCO2=25 .2, PO2=55.8, HCO3=11". Inflammatory biomarkers was at low level. Echocardiography showed cardiomegaly, biventricular dysfunction. The patient deteriorated rapidly, so she was intubated, volume expander and ionotropic agent was commenced, but in spite of these management and finally resuscitation she died. COVID-19 RT-PCR was reported positive next day.
Conclusion:
COVID-19 can cause fulminant myocarditis that can lead to rapidly progressive cardiogenic shock, biventricular dysfunction and death soon after beginning of symptoms