1997 research outputs found
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N-linked Glycosylation of the Bone Morphogenetic Protein Receptor Type 2 (BMPR2) Enhances Ligand Binding
Get PDFThe bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate downstream transcription factors. It is well established that a single BMP receptor may bind multiple BMP ligands with varying affinity, and this has been largely attributed to conformation at the amino acid level. However, all three type 2 BMP receptors (BMPR2, ACVR2A/B) contain consensus N-glycosylation sites in their extracellular domains (ECDs), which could play a role in modulating interaction with ligand. Here, we show a differential pattern of N-glycosylation between BMPR2 and ACVR2A/B. Site-directed mutagenesis reveals that BMPR2 is uniquely glycosylated near its ligand binding domain and at a position that is mutated in patients with heritable pulmonary arterial hypertension. We further demonstrate using a cell-free pulldown assay that N-glycosylation of the BMPR2-ECD enhances its ability to bind BMP2 ligand but has no impact on binding by the closely-related ACVR2B. Our results illuminate a novel aspect of BMP signaling pathway mechanics and demonstrate a functional difference resulting from post-translational modification of type 2 BMP receptors. Additionally, since BMPR2 is required for several aspects of normal development and defects in its function are strongly implicated in human disease, our findings are likely to be relevant in several biological contexts in normal and abnormal human physiology
Sr. Ruthann Boyle
Get PDFIn this two part interview, Sr. Ruthann Boyle discusses her calling in high school to the Sisters of Saint Francis by way of encouragement from her family and numerous religious sisters in Beech Grove, Indiana. Her first duty as a sister was to work as a teacher in places such as Cincinnati, Indianapolis, and Montana with the Crow Indians, the latter experience becoming important preparation for her work as a second grade teacher in Papua New Guinea. Sr. Boyle also recalls her time in Papua New Guinea, fulfilling what was once her mother’s dream, working as a Christian missionary helping others in a unique land and culture. She describes how she taught both genders in a society that had significant gender inequality and her job as a curriculum advisor, working with the Huli people to “open their world so they could learn more about God.” In the second segment, Sr. Boyle discusses how she aided in redesigning the sisters’ veils, wrote booklets for postulants, and created new Christian communities through the recruitment of new sisters in Papua New Guinea.https://mushare.marian.edu/wrp/1024/thumbnail.jp
Sr. Kathryn (Kate) Holohan
Get PDFIn this interview Sr. Kathryn Holohan reflects on her desire to become a missionary at a very early age and the opportunity to do so in Papua New Guinea. One of the first four Sisters of St. Francis to contribute to a functional education system in the Southern Highlands, Sr. Kate discusses the travel to PNG as well as the lack of resources. She also highlights the success of their collaborative mission work with other Sisters from different parts of the world, not only in contributing to the education of the native people, but also founding a system to accommodate native vocation among the women of PNG.https://mushare.marian.edu/wrp/1015/thumbnail.jp
Sr. Lorraine Geis
Get PDFIn her oral history, Sister Lorraine Geis reflects on her time as a Sister of Saint Francis both in the United States and Papua New Guinea. Sister Geis grew up in a farming family, which would set the foundation for her love of teaching agriculture to high school students later in life. As a novice, she taught second graders in Bridgetown, Cincinnati. She was invested in 1952 and her final profession was in 1956, after which she went to Riverview Gardens in Saint Louis and taught for seven years. It was in 1961, however, when her life would change dramatically. Praying to the Holy Spirit for guidance, she was given an answer to her request for direction in the call to go to Papua New Guinea, a mission begun in 1955 by Capuchin priests of Pittsburgh by Pope Pius XII. Sister Geis describes her time in Papua New Guinea teaching agriculture and math to the students while having students care for their own land. She also explains topics such as subsistence farming, gender inequality, clothing differences, food types, and educational discrepancies between those from the highlands and the coast of Papua New Guinea.https://mushare.marian.edu/wrp/1028/thumbnail.jp
A Thomistic Appraisal of Human Enhancement Technologies
No full textDebate concerning human enhancement often revolves around the question of whether there is a common “nature” that all human beings share and which is unwarrantedly violated by enhancing one’s capabilities beyond the “species-typical” norm. I explicate Thomas Aquinas’s influential theory of human nature, noting certain key traits commonly shared among human beings that define each as a “person” who possesses inviolable moral status. Understanding the specific qualities that define the nature of human persons, which includes self-conscious awareness, capacity for intellective thought, and volitional autonomy, informs the ethical assessment of various forms of enhancement. Some forms of cognitive and physical enhancement may be desirable from the perspective of what constitutes the “flourishing” of human persons in our fundamental nature; while other forms of enhancement, such as emotive or so-called “moral” enhancement, run the risk of detracting from human flourishing when evaluated from the virtue-theoretic perspective Aquinas promotes
The Redemptive Inversions of Jeremiah in Romans 9-11
No full textThis article presents seven points of focused dissonance between Jeremiah and Romans, by identifying how Romans 9–11 inverts the judgment language of Jeremiah 1–20 against Judah. Without claiming that the inversions in Romans 9–11 are intentional, the article argues that the inversions of this section of Jeremiah are similar to the inversions that Deutero-Isaiah performs on this same section of Jeremiah, identified by B. Sommer. The inversions of Jeremiah that occur in Romans 9–11 highlight these chapters\u27 positive stance toward corporeal, ethnic Israel, and provide another argument against interpreting \u27all Israel\u27 in Rom 11,26 as the church
Sr. Martine Mayborg
Get PDFIn this interview Sr. Martine Mayborg highlights Mother Cephas\u27s Motherhouse Message for the call to mission work in Papua New Guinea and her overall experience of traveling and teaching there. Sr. Martine was one of the first four Sisters of St. Francis (Oldenburg) to be sent there for their mission work, teaching various subjects disciplines to elementary school children. Sr. Martine describes the unlikely circumstances for the Sisters\u27 undertaking of the mission work, as well as the conditions experienced there. In particular, she describes cultural experiences relating to the gender and social status, food, and language of the native people, as well as the gradual development toward independence gained 1975.https://mushare.marian.edu/wrp/1010/thumbnail.jp