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Increasing Student Engagement to Impact Achievement
Get PDFThis presentation will cover two different strategies for engaging students in course content with the intent of improving academic achievement. One example will discuss the use of video to explain assignments prior to the due date in graduate coursework. The second will promote using online assessment to engage students in required course readings at any level
Facilitating Dialogue in the Classroom
Get PDFPolitics and gender, race and religion, healthcare and war – our country is divided over many important issues. Dialogue is a way of talking and listening to create shared understanding, and in the classroom, we need it now more than ever. Dialogue invites equal participation, withholding judgment, and exploring assumptions in a spirit of mutual inquiry. This workshop provides practical resources for facilitating dialogue about divisive issues
Epidermal Loss of Gag Confers a Migratory and Differentiation Defect in Keratinocytes
Get PDFG-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two members of the G protein family, Gaq and Ga-11, activate one of the main GPCR pathways and function as oncogenes by integrating mitogen-stimulated signaling cascades that are active under malignant conditions. Recently, it has been shown that targeted deletion of Ga-11 and Gaq from endothelial cells impairs the Rho -mediated formation of focal adherens junctions, suggesting that Gai vg signaling may also play a significant role in cytoskeletal-mediated cellular responses in epithelial cells. Indeed, combined deletion of Ga-11 and Gaq confers a significant migratory defect in keratinocytes that delays cutaneous wound healing in an in vivo setting. This delay can be attributed to a defect during the reepithelialization phase due to significantly attenuated migratory capacity of Gaq-null keratinocytes under combined Ga-11 deficiency. In fact, cells lacking Gaivg demonstrate a severely reduced ability to respond to mitogenic and migratory signals in the microenvironment, leading to inappropriate and premature terminal differentiation. These results suggest that Gaivg signaling pathways may be critical for integrating mitogenic signals and cytoskeletal function to achieve normal physiological responses. Emergence of a malignant phenotype may therefore arise from both under- and overexpression of Gai vg signaling, implicating its upstream regulation as a potential therapeutic target in a host of pathologic conditions
You Can Do Both: Teach Students How to Write While Teaching Your Content
Get PDFFaculty today often struggle with students\u27 poor writing skills, failing to get the quality of written work that they imagine students can do. The traditional assignment of a research paper inadequately addresses the disciplinary and process issues of getting students to write well in classes. This session will address two related elements of these challenges: Teaching students how to write effectively as part of course content and using writing strategies to teach content. Participants will examine a sample writing integration plan in a sociology course, discuss ways to adapt it to their own disciplines, and then examine writing-to-learn strategies meant to help students remember content and/or generate critical perspectives. The sample plan, a list of activities, and a reference sheet will be provided to each participant
The Experiential Classroom: Challenges of Addressing the Millennial Generation as they Prepare for the Modern Day Workforce
Get PDFExperiential learning, the key feature of the re-designed curriculum of the Byrum School of Business, begins early in the students’ experience and continues throughout their academic career. This enables graduates to be versed and proficient with the 21st century skills needed upon arrival and ready to contribute in an effective and efficient way. This presentation will explain the who, what, how, and outcomes of the curriculum redesign. Questions and discussion will be encouraged
Outcomes in Blunt Cerebrovascular Injury Following the Use of an Evidence-Based Treatment Protocol
No full textBlunt cerebrovascular injury (BCVI) is rare but has been identified in trauma victims with increasing frequency in recent years due to improvements in imaging techniques and screening protocols. The incidence of BCVI is believed to be about 1% in blunt trauma victims. Multiple different criteria have been established for BCVI screening. BCVI is graded according to severity of vessel injury1. Treatment varies by institution, ranging from observation to the use of antiplatelet or anticoagulant agents. Due to the rarity of these injuries, optimal treatment is not yet known and most treatment strategies are based on retrospective reviews with poor patient follow up for outcome measures. Goodman Campbell Brain and Spine (GCBS) has developed an evidence-based treatment protocol for managing BCVI. In this study, the authors present data regarding outcomes for BCVI patients managed at a level I trauma center using this treatment algorithm
Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation.
No full textTargeting early steps in amyloid-beta production: Alzheimer\u27s disease (AD) has a long history as the “amyloid deposit” disorder. Many disorders are now known to be caused by protein β-sheet misfolding and aggregation (e.g., Parkinson\u27s disease: α-synuclein; Huntington\u27s disease: Huntingtin; spongiform encephalopathy: prion protein) (Rambaran and Serpell, 2008). Commonly, the family of amyloid mental disorders often have multiple aggregating proteins with most having one or two highlighted. For example in AD, amyloid beta (Aβ) extracellular aggregates in senile plaques (SP) are the most obvious postmortem observation along with intracellular tau tangles. However, AD patients often have accumulation of TDP43 and α-synuclein (in Lewy bodies) (Josephs et al., 2014). While reducing Aβ remains the main AD target, there has been a recent shift from targeting the late forming amyloid plaques, to earlier steps in production of Aβ. Recent work has suggested that small oligomers of Aβ could be the neurotoxic compounds with structures on the order of Aβ octomers forming pores in neuronal membranes causing cell death (Arbor et al., 2016). Under this paradigm, the larger extracellular amyloid plaques could actually be neuroprotective via a mechanism of sequestering the more deleterious Aβ monomers. In addition to not being neurotoxic (wrong marker physically) the amyloid plaques present late in disease after neuronal death has occurred (wrong marker temporally). While the field continues to target the already existing Aβ in AD patients, the effort to target even the production of Aβ has been reinvigorated. Possible targets include the initial production of amyloid precursor protein (APP), APP insertion in membrane lipid rafts, APP shuttling to early endosome compartments, and processing of APP. The molecular pathways causing this shift away from targeting amyloid plaques as well as therapeutics will be the content of this perspective
On the Emerging Role of the Taste Receptor Type 1 (T1R) Family of Nutrient-Sensors in the Musculoskeletal System.
Get PDFThe special sense of taste guides and guards food intake and is essential for body maintenance. Salty and sour tastes are sensed via ion channels or gated ion channels while G protein-coupled receptors (GPCRs) of the taste receptor type 1 (T1R) family sense sweet and umami tastes and GPCRs of the taste receptor type 2 (T2R) family sense bitter tastes. T1R and T2R receptors share similar downstream signaling pathways that result in the stimulation of phospholipase-C-β2. The T1R family includes three members that form heterodimeric complexes to recognize either amino acids or sweet molecules such as glucose. Although these functions were originally described in gustatory tissue, T1R family members are expressed in numerous non-gustatory tissues and are now viewed as nutrient sensors that play important roles in monitoring global glucose and amino acid status. Here, we highlight emerging evidence detailing the function of T1R family members in the musculoskeletal system and review these findings in the context of the musculoskeletal diseases sarcopenia and osteoporosis, which are major public health problems among the elderly that affect locomotion, activities of daily living, and quality of life. These studies raise the possibility that T1R family member function may be modulated for therapeutic benefit
