1997 research outputs found
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Best Practices for Online and Blended Learning: Introducing the R2D2 and TEC-VARIETY Models
Get PDFThere are dozens of new technologies emerging each year and endless ways in which they can be used for teaching and learning. So many in fact, that most instructors are simply overwhelmed. Curt Bonk offers two simple yet powerful frameworks that can be used to organize and understand what is available. Based on two decades of research, he will reveal dozens of practical examples using his widely acclaimed R2D2 (Read, Reflect, Display, and Do) framework for instructional design with technology. He will also showcase his TEC-VARIETY model for enhanced student motivation with Web technologies, where each letter stands for a well-known motivational principle. While detailing best practices he has seen around the globe, he will discuss how these two models can be expanded or altered to fit one’s particular preferences and needs. Those attending this session will walk away with many practical strategies that can be incorporated directly into face-to-face, blended, and virtual classes, events, or programs
Queer People in Brazil and The United States: Bridging The Gap
Get PDFThe LGBT+ community is generally grouped into one big group with all the same needs by media, organizations, and people. However, LGBT+ people have different concerns and needs based on age, race, ability, and so many other identities to which they can also fall under. Additionally, gender and sexual diversity greatly differ in needs within the community. This research focuses on the history of social movements for, and politics concerning primarily cisgender women of a sexual minority (lesbian, bisexual, etc.) in America and Brazil. Traditional research methods were primarily used to discover the reality of queer people in America, such as availability to resources and mental health. However, my research of the reality of the community in Brazil is primarily based on participant observation by interviews, question and answer sessions with politicians, as well as daily conversations (or lack thereof). With this research, commonalities along with differences were found between the two countries regarding history, politics, struggles, and victories for LGBT+ women, which ultimately lead to my conclusion of proposed solutions for the betterment of women in the queer community
Putting Gender on the Agenda: A Feminist Approach to Study Abroad
Get PDFA presentation at the 2017 Higher Education Partnership: Internationalization in the Americas conference in San Miguel de Allende, Mexico (sponsored by the Partners of the Americas organization). This presentation outlines the Women’s Rights and Women’s Empowerment in the Western Hemisphere study abroad initiative at Marian University
Nutrient Sensing by Tas1R Proteins is Required for Normal Bone Resorption
Get PDFCurrent therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations and/or negatively impact patient compliance with therapy. Developing improved therapies requires diversifying our understanding of the mechanisms underlying postnatal bone remodeling by examining lesser-known signaling pathways. One such pathway is the taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors, which participates in monitoring energy and nutrient status. Previous work reported that global deletion of TAS1R member 3 (TAS1R3), which is a bi-functional protein that recognizes amino acids or sweet molecules when dimerized with TAS1R member 1 (TAS1R1) or TAS1R member 2 (TAS1R2), respectively, leads to increased cortical bone mass. Here, we corroborate the increased thickness of cortical bone in Tas1R3 knockout mice and confirm that Tas1R3 is expressed in the bone environment. Quantification of serum bone turnover markers indicate that this phenotype is likely due to uncoupled bone remodeling, with levels of the bone resorption marker CTx being reduced greater than 60% in Tas1R3 mutant mice; no changes were observed in levels of the bone formation marker PINP. Consistent with this, Tas1R3 and its putative signaling partner Tas1R2 are expressed in primary osteoclasts and RAW264.7 cells following RANKL-mediated differentiation. These findings suggest that osteoclast function and/or differentiation may be altered in the absence of Tas1R3 expression. To test this, we quantified bone-specific expression of Rankl and determined the Rankl:Opg ratio; no differences were observed between control and Tas1R3 knockout mice in these analyses. In vitro studies examining further downstream effectors of TAS1R2:3 in response to saccharin and receptor antagonist gurmarin are currently underway. Collectively, our findings provide the first demonstration that nutrient monitoring by TAS1R3 is essential for normal bone resorption in vivo
Examining LRP4’s Capacity to Participate in Inhibitory WNT Signaling in Bone Cells
No full textContext: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteoclasts, and osteocytes. WNT signaling through low-density lipoprotein receptor related protein 5/6 (LRP5/LRP6) is one of the central signaling pathways that aids in controlling bone homeostasis. A prominent antagonist of the WNT signaling pathway is sclerostin. Low-density lipoprotein receptor related protein 4 (LRP4) is required to facilitate sclerostin-mediated inhibition of LRP5/LRP6. Clinically, mutations in LRP4 (R1170W and W1186S) which diminish its ability to bind sclerostin result in bone overgrowth. The mechanism by which LRP4 participates in this process is unknown. In vitro experiments suggest that LRP4 physically binds sclerostin and presents it directly to nearby LRP5/LRP6.
Objective: Delineating the mechanistic function(s) of LRP4 is important because if LRP4 directly provides sclerostin to LRP5/LRP6 then interfering with this process represents a potential therapeutic intervention for promoting anabolic bone formation.
Design: Genetic cloning is currently underway to fluorescently tag LPR5, LRP6, LRP4 and the LRP4 missense mutation (R1170W) for FRET/FLIM microscopy experiments. FRET/FLIM microscopy will be used to examine the live in vitro signaling dynamics of LRP4.
Results: We expect to determine if LRP4 co-localizes with LRP5 or LRP6 in living bone cells, whether this co-localization is sclerostin dependent, and whether the LRP4 missense mutation affects this interaction. Our results will characterize the novel role LRP4 plays in sclerostin-mediated WNT inhibition and capacity to effect bone mass
Teaching through Problem-Based Learning to Increase Student Engagement and Understanding
Get PDFProblem-based learning (PBL) is a learner-centered instructional model that empowers students to take ownership of their learning. This presentation will highlight the benefits of PBL and provide tips on how to incorporate mini-PBL units into courses for adult learners
Terms of Engagement
Get PDFA common challenge for many professors today is achieving persistent, high-quality student participation. This highly interactive session will begin with identifying challenges you face engaging students. Then, using a dynamic 5-component model for understanding what \u27student engagement\u27 means, we will draw from research and good practice literature as well as presenter and participant experience to identify strategies for promoting each component. The session’s closing activity will be to identify solutions to the specific challenges participants identified in the opening activity. Participants will leave with a repertoire of practical strategies for conducting a course that fosters sustained attention and elicits students’ best work in today’s varied teaching and learning contexts
Identification of Gene Signature Associated with Elevated Bone Formation Rate in Aging Mice
Get PDFOsteoporosis is a disease of low bone mass resulting from bone resorption exceeding bone formation that places individuals at enhanced risk for fracture, disability, and death. There is an urgent and unmet need for novel targets in treating osteoporosis, requiring a better understanding of the endogenous mechanisms regulating bone formation. Recent work indicates that deletion of the Bmpr2 gene in skeletal progenitor cells of mice using Prx1-Cre leads to substantially elevated bone mass in young adulthood due to increased bone formation rate. Additionally, unpublished work suggests that the age-related decline in bone mass of female Bmpr2 mutant mice is reduced approximately two-fold compared to control mice and quantification of serum bone turnover markers reveals this is associated with a sustained increase in bone formation to at least 35 weeks of age (but not 55 weeks of age) with no alteration in bone resorption. Collectively, these data raise the possibility that Bmpr2 mutant mice may serve as a novel model for elucidating mechanisms that regulate osteoblast activity in aging mice.
We sought to identify the gene signature associated with elevated osteoblast activity using genome-wide transcriptome profiling of marrow-free humerii from control and Bmpr2 mutant mice. Applying stringent criteria comparing individual transcripts to eight well-accepted housekeeping genes (Ppib, Gapdh, Hprt, Tbp, Ppia, GusB, Prkg1, and Ywhaz), and contrasting the results at 35 weeks of age to the transcriptome profile at 55 weeks of age, we constructed a Venn diagram sorting the genes into 15 distinct zones. Bioinformatic analyses on this refined gene set indicates that elevated bone formation rate in Bmpr2 mutant mice correlates with enrichment for genes containing binding sites for transcription factors associated with skeletal homeostasis. Further, several genes corresponding with osteoblast differentiation and activity are up-regulated in Bmpr2 mutant mice at 35 weeks of age