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Bologna – 2025 images
No full text### DOCOMOMO INTERNATIONAL MASS HOUSING ARCHIVE ### The provision of healthy modern housing for all was one of the foremost ideals of the Modern Movement, and inspired a vast wave of planning and building across the world during the 20th century. In the last quarter of the century, even as the foundational programmes of Europe and America lost their impetus, the baton was passed on to other countries, especially in eastern Asia, where the narrative of Modern mass housing was reinvigorated for the next century - a unique example of a key Modernist project that actually continues and thrives today, and which thus forms a principal focus of interest for DOCOMOMO – the leading international organisation promoting the documentation and conservation of buildings, sites and neighbourhoods of the Modern Movement. As heritage, the built legacies of this diverse and multi-generational adventure are almost always too controversial to qualify for conservation strategies. Instead, therefore, recording and inventorisation must dominate the heritage interest in this field. In the recognition of that fact, DOCOMOMO’s International Specialist Committee on Urbanism and Landscape, in partnership with the Scottish Centre for Conservation Studies at the University of Edinburgh, has launched the International Mass Housing Archive, whose aim is to provide an open-access library of images of significant housing projects in each working-group territory, free of copyright restrictions. These files may be copied, edited and shared on condition the appropriate citation is used, as per the terms of the attached Creative Commons Attribution licence. ### Structure ### The International Mass Housing Archive is subdivided under geographical headings corresponding to the constituent working groups of DOCOMOMO, and the individual housing projects are searchable under city and project name. Initially, the Image Archive will be managed and augmented centrally by DOCOMOMO and the SCCS, in partnership with University of Edinburgh Information Services, commencing with pilot city surveys sourced from our own photographic records in the first instance. The archive is related to several existing mass housing documentation initiatives. These include one concerning Britain, namely the online version of the 1994 book, Tower Block: http://towerblock.org/TowerBlock.pd
EdFoil: an open-source software enabling faster geometrical modelling of composite blades.
No full textSetting up a numerical model is often the most time-consuming stage of any analysis. Preparing the geometry, applying material definitions, and defining boundary conditions can take considerably longer than running the simulation itself. This user guide introduces the \EdFoil framework designed to accelerate the modelling process for composite blades. By automating the generation of airfoils, stations, and laminate sections, the tool aims to reduce setup time and ensure consistency across different models. In addition, it takes advantage of modern computing hardware, allowing engineers and researchers to start modelling full three-dimensional composite blades more efficiently than with traditional two-dimensional workflows. EdFoil is built with Qt, the C++ framework for software development
MND model gene dose proteomics
No full textData Generation: Tandem-mass-tagged mass-spectrometry (TMT-MS/MS) analyses of hippocampal synaptosomes of the Taiwanese mouse model of SMA, generated from n=5 each wildtype (Smn+/+), heterozygous (Smn+/-; SMN2tg/0) and homozygous (Smn-/-; SMN2tg/0) animals, respectively, yielded 6660 raw protein identifications derived from peptide sequences searched against Mus musculus UniProtKB/Swiss-Prot sequences using the MASCOT Search Engine (V2.3.2) through Proteome DiscovererTM software (Version 1.4, Thermo Fisher). Filtering to eliminate protein sequences identified by fewer than 2 or more unique peptides produced 6195 identifications ready for subsequent analysis.
TMT-MS/MS analyses of hippocampal synaptosomes against a novel rat model of ALS 8, generated from n=5 each wildtype (VAPB+/+), heterozygous (VAPB P56S/+) and homozygous (VAPB P56S/P56S), respectively, yielded 7828 raw protein identifications derived from peptide sequences searched against Rattus norvegicus UniProtKB/Swiss-Prot sequences using the MASCOT Search Engine (V2.3.2) through Proteome DiscovererTM software (Version 1.4, Thermo Fisher). Filtering to eliminate protein sequences identified by fewer than 2 or more unique peptides produced 5942 identifications ready for subsequent analysis.
Generation of ratios comparing heterozygous and homozygous expression compared to wildtype of filtered proteins enabled normalised measurement of expression alterations for subsequent analyses. Expression of each protein at wildtype is therefore equivalent to 1 (ie. wildtype: wildtype), while values >1 at heterozygote or homozygote indicate a relative increase in expression, and values <1 indicate a relative decrease in expression.
Application of Markov Clustering algorithm set to a Pearson correlation coefficient of 0.98 to each >2 peptide dataset, inputted as an identifier column of UniProt/Swiss-Prot Accession Number and expression ratio values at wildtype, heterozygous and homozygous in each condition produced discrete clusters based on the sole parameter of similarity in expression profile alteration through genotype. Isolated clusters correlating with levels of full-length Smn expression (SMA model) or mutant VapbP56S expression (ALS 8 model), constituting n=3802 proteins in SMA model and n=3168 in ALS 8 model were mapped to human gene identities in the Ingenuity Knowledge Database (Qiagen).
Ethics: Animals and tissue harvesting
All animals used in this project were treated in accordance with the guidelines outlined by the UK Animal Scientific Procedures Act (1986), adhering to the three principles of Reduction, Refinement and Replacement.
Description of data files:
-Supplementary Table 1_Analysis-Ready_Mapped Clusters_SMA
-Supplementary Table 2_Analysis-Ready_Mapped Clusters_VAPB
Datasets (each in two formats_.xls & .xlsx) contain all biologically relevant alterations identified through expression cluster analysis. 1 for each condition. Alteration of protein expression by >20% in homozygote synapse compared to through colourisation in green (decrease relative to wildtype) or red (increase relative to wildtype). Intensity of colour corresponds to magnitude of change.-Supplementary Table 1_Analysis-Ready_Mapped Clusters_SMA
-Supplementary Table 2_Analysis-Ready_Mapped Clusters_VAPB
Datasets (each in two formats_.xls & .xlsx) contain all biologically relevant alterations identified through expression cluster analysis. 1 for each condition. Alteration of protein expression by >20% in homozygote synapse compared to through colourisation in green (decrease relative to wildtype) or red (increase relative to wildtype). Intensity of colour corresponds to magnitude of change
Attachment-related anxiety and social anxiety: the mediating role of self-esteem
No full textThe dataset includes a unique reference number for each participant. It includes participants' responses to a 'consent to participate' question. It includes participant data, namely: gender, age group, relationship status, and ethnicity.
Participants responded to a shortened version of the Anxiety Subscale of the Experiences in Close Relationships Revised Scale (ECR-R). Reponses to the items of this questionnaire are listed under AA_1 : AA_9. The nine items chosen were those that load most strongly on the Anxiety subscale (see Sibley, Fischer & Liu, 2005).
Participants also responded to the Social Interaction Anxiety Scale. Responses to the items of this questionnaire are listed under SA_1 : SA_20.
Participants also responded to the Rosenberg Self-Esteem Scale. Responses to the items of this questionnaire are listed under SEst_1 : SEst_10
Thin Film Composite Mixed-Matrix Membranes based on Matrimid and Zeolitic Imidazolate Frameworks for CO2/N2 separation performance
No full textMembrane-based gas separation processes are a technology in continuous evolution. Various types of polymer membranes have been developed, many exhibiting high CO2 permeability and selective properties over competing gases such as N2 and CH4. In order to be competitive, membranes must be cheaper, more stable, more efficient and their production must be scalable. One solution is to develop thin film composites with mixed matrix membranes (TFC_MMM) that have the potential to boost productivity while maintaining low costs. In this work, TFC_MMMs containing Matrimid(r) mixed with 12%wt of ZIF-94 were prepared by kiss coating on a porous support. The SEM analysis showed that defect-free membranes with a 3 mm selective layer have been obtained. At 1 bar, the addition of ZIF resulted in the improved the separation performance for the CO2/N2 pair, with CO2 permeance of 4 GPU and CO2/N2 selectivity of 40, surpassing neat TFC-Matrimid (CO2 permeance~3 GPU, CO2/N2 selectivity~29). The use of ZIF-94 also had a stabilising effect on the membranes against CO2 plasticisation at high pressure
Demographic, burnout, job experience, and job satisfaction of UK MND nurses and allied health professionals
No full textThe 5 datasets are comprised of demographic, burnout scores, job satisfaction and wellbeing of the UK motor neuron disease nurses and allied health professionals workforce. This is a cross-sectional data that was captured in the inaugural meeting on November 16th, 2023
Videos of eMouseAtlas Models: Theiler Stage 19 (11-12.25 dpc)
No full textA number of videos for each of the eMouseAtlas 3D mouse embryo models to show the overall form and in some cases selected anatomy. Each video is identified by the unique EMA ID with annotation if required. The videos labelled as "watermovies" are captured using the OPT system with the embryo spun on a longitudinal axis with no tissue clearing
Data from: Time-of-day of infection: impact on liver stage malaria parasites in untreated and drug treated hosts
No full textBackground: Circadian clocks are thought to have evolved due to the benefits of anticipating daily environmental rhythms. Daily environmental rhythms that impact on fitness include interactions between organisms, such as host-pathogen interactions. For example, host susceptibility to infection for taxonomically diverse hosts and pathogens varies across the circadian cycle. We previously revealed that mosquito vectors are less susceptible to malaria (Plasmodium) infection during their active phase (night time) and here, we test whether a similar pattern occurs for infection of the mammalian host.
Methods: We used Plasmodium berghei-infected Anopheles stephensi mosquitoes to infect mice during their rest or active phase, both in untreated and pyrimethamine-treated mice. We assessed the parasites’ success in establishing at the first site of replication (in the liver) by quantifying parasite burdens using qPCR, adjusted for sporozoite inocula. By independently manipulating the photoschedules of vectors and hosts, we standardise the time-of-day for parasites and mosquitoes used to initiate infections and thus directly test the impact of host time-of-day on the parasites’ ability to establish an infection.
Results: The three experiments we conducted showed that pyrimethamine treatment reduced parasite liver burdens, but not in a biologically significant manner dependent on host time-of-day (active/rest phase). Furthermore, host time-of-day did not affect parasite liver burdens in untreated hosts.
Conclusions: Understanding the roles of host, parasite and vector rhythms on malaria transmission is important given that mosquitoes are altering the time-of-day they bite. That rhythms per se do not affect vector to host transmission suggests that at the impacts of time-of-day on components of vectorial capacity are more epidemiologically influential than host rhythms
Voices of Experience 2016-2024 Conversations
No full textFull verbatim transcriptions, audio-record and image of intergenerational conversations facilitated by Voices of Experience (VoE). Conversations take place between an older person who has made a longstanding professional contribution to the built environment, paired with an individual at the outset of their career. The pairings have not met before. They share a common work theme or project and each conversation takes place in a setting connected with the participants' work. The emphasis is on female and minority experience. Conversations register an exchange of experience, a place to listen and respond; space for new connections, including immaterial, social and personal aspects of professional work. VoE is a collaborative project led by Suzanne Ewing (University of Edinburgh), Jude Barber (Collective Architecture) and Nicola McLachlan (Collective Architecture).Voices of Experience Conversation 1 [2016] - Margaret Richards and Nicola McLachlan; Voices of Experience Conversation 2 [2016] - Fiona Sinclair and Mairi Laverty; Voices of Experience Conversation 3 [2016] - Dorothy Bell and Emma Fairhurst; Voices of Experience Conversation 4 [2016] - Anne Duff and Cathy Houston; Voices of Experience Conversation 5 [2017] - Kirsteen Borland and Heather Claridge; Voices of Experience Conversation 6 [2017] - Jocelyn Cunliffe and Melanie Hay; Voices of Experience Conversation 7 [2017] - Denise Bennetts and Grace Mark; Voices of Experience Conversation 8 [2017] - Kate Macintosh and Elaine Keenan; Voices of Experience Conversation 9 [2019] - Joyce Deans and Ruta Turcinaviciute; Voices of Experience Conversation 10 [2019] - Adele Patrick and Akiko Kobayashi; Voices of Experience Conversation 11 [2023] - Joyce Deans and Christina Gaiger; Voices of Experience Conversation 12 [2023] - Margaret Stewart and Freya Purcell; Voices of Experience Conversation 13 [2023] - Annie Pollock and Giulia Morrone; Voices of Experience Conversation 14 [2024] - Dorothy Nicoll and Sophie Irvine; Voices of Experience Conversation 15 [2024] - Anna Stuart and Ruth Rodger; Voices of Experience Conversation 16 [2024] - Jim Johnson and Scott McAuley. For each conversation: audio .mp3 file + transcription .pdf file + image .jpe
Videos of eMouseAtlas Models: Theiler Stage 7 (4.5-6 dpc)
No full textA number of videos for each of the eMouseAtlas 3D mouse embryo models to show the overall form and in some cases selected anatomy. Each video is identified by the unique EMA ID with annotation if required. The videos labelled as "watermovies" are captured using the OPT system with the embryo spun on a longitudinal axis with no tissue clearing