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Videos of eMouseAtlas Models: Theiler Stage 19 (11-12.25 dpc)
No full textA number of videos for each of the eMouseAtlas 3D mouse embryo models to show the overall form and in some cases selected anatomy. Each video is identified by the unique EMA ID with annotation if required. The videos labelled as "watermovies" are captured using the OPT system with the embryo spun on a longitudinal axis with no tissue clearing
Data from: Time-of-day of infection: impact on liver stage malaria parasites in untreated and drug treated hosts
No full textBackground: Circadian clocks are thought to have evolved due to the benefits of anticipating daily environmental rhythms. Daily environmental rhythms that impact on fitness include interactions between organisms, such as host-pathogen interactions. For example, host susceptibility to infection for taxonomically diverse hosts and pathogens varies across the circadian cycle. We previously revealed that mosquito vectors are less susceptible to malaria (Plasmodium) infection during their active phase (night time) and here, we test whether a similar pattern occurs for infection of the mammalian host.
Methods: We used Plasmodium berghei-infected Anopheles stephensi mosquitoes to infect mice during their rest or active phase, both in untreated and pyrimethamine-treated mice. We assessed the parasites’ success in establishing at the first site of replication (in the liver) by quantifying parasite burdens using qPCR, adjusted for sporozoite inocula. By independently manipulating the photoschedules of vectors and hosts, we standardise the time-of-day for parasites and mosquitoes used to initiate infections and thus directly test the impact of host time-of-day on the parasites’ ability to establish an infection.
Results: The three experiments we conducted showed that pyrimethamine treatment reduced parasite liver burdens, but not in a biologically significant manner dependent on host time-of-day (active/rest phase). Furthermore, host time-of-day did not affect parasite liver burdens in untreated hosts.
Conclusions: Understanding the roles of host, parasite and vector rhythms on malaria transmission is important given that mosquitoes are altering the time-of-day they bite. That rhythms per se do not affect vector to host transmission suggests that at the impacts of time-of-day on components of vectorial capacity are more epidemiologically influential than host rhythms
Voices of Experience 2016-2024 Conversations
No full textFull verbatim transcriptions, audio-record and image of intergenerational conversations facilitated by Voices of Experience (VoE). Conversations take place between an older person who has made a longstanding professional contribution to the built environment, paired with an individual at the outset of their career. The pairings have not met before. They share a common work theme or project and each conversation takes place in a setting connected with the participants' work. The emphasis is on female and minority experience. Conversations register an exchange of experience, a place to listen and respond; space for new connections, including immaterial, social and personal aspects of professional work. VoE is a collaborative project led by Suzanne Ewing (University of Edinburgh), Jude Barber (Collective Architecture) and Nicola McLachlan (Collective Architecture).Voices of Experience Conversation 1 [2016] - Margaret Richards and Nicola McLachlan; Voices of Experience Conversation 2 [2016] - Fiona Sinclair and Mairi Laverty; Voices of Experience Conversation 3 [2016] - Dorothy Bell and Emma Fairhurst; Voices of Experience Conversation 4 [2016] - Anne Duff and Cathy Houston; Voices of Experience Conversation 5 [2017] - Kirsteen Borland and Heather Claridge; Voices of Experience Conversation 6 [2017] - Jocelyn Cunliffe and Melanie Hay; Voices of Experience Conversation 7 [2017] - Denise Bennetts and Grace Mark; Voices of Experience Conversation 8 [2017] - Kate Macintosh and Elaine Keenan; Voices of Experience Conversation 9 [2019] - Joyce Deans and Ruta Turcinaviciute; Voices of Experience Conversation 10 [2019] - Adele Patrick and Akiko Kobayashi; Voices of Experience Conversation 11 [2023] - Joyce Deans and Christina Gaiger; Voices of Experience Conversation 12 [2023] - Margaret Stewart and Freya Purcell; Voices of Experience Conversation 13 [2023] - Annie Pollock and Giulia Morrone; Voices of Experience Conversation 14 [2024] - Dorothy Nicoll and Sophie Irvine; Voices of Experience Conversation 15 [2024] - Anna Stuart and Ruth Rodger; Voices of Experience Conversation 16 [2024] - Jim Johnson and Scott McAuley. For each conversation: audio .mp3 file + transcription .pdf file + image .jpe
Videos of eMouseAtlas Models: Theiler Stage 7 (4.5-6 dpc)
No full textA number of videos for each of the eMouseAtlas 3D mouse embryo models to show the overall form and in some cases selected anatomy. Each video is identified by the unique EMA ID with annotation if required. The videos labelled as "watermovies" are captured using the OPT system with the embryo spun on a longitudinal axis with no tissue clearing
Targeted ligand design using a combined computational and experimental approach to unlock new metal separations
No full textAs societal demand for metals grows, sustainable routes to their efficient recovery from primary ores and secondary waste streams have become increasingly important. In this regard, understanding the chemical detail of metal separations is implicit to designing more efficient and environmentally benign processes. Herein, we report a combined computational and experimental approach to targeted ligand design by modification of a simple diamide (L), previously reported as a selective precipitant for Au. This afforded three new reagents through the addition of electron-donating (LOMe) and withdrawing (LCl) groups, and the inversion of the amide linkage (Linv). Computational studies confirmed the expected trends in protonation of the amide and subsequent metal uptake experiments showed all ligands act as selective precipitants for Au at low acid concentrations in the presence of an excess of ligand. Significantly however, the use of stoichiometric amounts of LOMe and LCl resulted in a switch in selectivity from square-planar (AuCl4-) to tetrahedral metalates (GaCl4- and FeCl4-), with precipitation suppressed for Linv. Computational modelling rationalised this reversal in metalate selectivity with LOMe and LCl on thermodynamic grounds, while Hirshfeld surfaces, NCI plots and QTAIM analyses highlighted halogen bonding as the most important structure directing interaction. Importantly, preliminary studies with LOMe suggested a viable pathway to the separation of Ga and Fe from industrially generated waste streams, which could be exploited in the recycling of zinc residues and end-of-life GaN light-emitting diodes
Demographic, burnout, job experience, and job satisfaction of UK MND nurses and allied health professionals
No full textThe 5 datasets are comprised of demographic, burnout scores, job satisfaction and wellbeing of the UK motor neuron disease nurses and allied health professionals workforce. This is a cross-sectional data that was captured in the inaugural meeting on November 16th, 2023
Berlin (East)
No full textBerlin in the 1980s was in a state of suspension, with the physical trappings of the Cold War still omnipresent but subtly in decay. This collection of images, mostly dating from 1982, gives a vivid snapshot of the city’s multi-liminal character in those years, focusing mainly on the everyday trappings of division, including not only well-known setpieces of ‘The Wall’, such as Potsdamer Platz or Bernauer Strasse, but also lesser-known quirks such as border-straddling transport infrastructure (such as the extraordinary Wollankstrasse S-Bahn station, accessible only through a ‘hole in the wall’, as well as the better-known Friedrichstrasse) or anomalies such as the Steinstücken ‘exclave’. More generally, the S-Bahn network within West Berlin, latterly a quasi-extra-territorial DDR operation widely boycotted by West Berliners, is documented in its final state of truncation and rampant decay, seen most spectacularly in the images of the wildly overgrown Gesundbrunnen station – together with an early 21st-century image (from exactly the same viewpoint) of the latter’s rebuilt state as a bustling, modern national transportation hub. These historic photographs, which are made available in partnership with DOCOMOMO-International - the global network for documentation and conservation of the modern movement - are available as an open-access library of images, free of copyright restrictions. These files, which are divided into West Berlin and East Berlin sites, may be copied, edited and shared on condition that the appropriate citation is used, as per the terms of the attached Creative Commons Attribution licence
Ferrara – 2025 images
No full text### DOCOMOMO INTERNATIONAL MASS HOUSING ARCHIVE ### The provision of healthy modern housing for all was one of the foremost ideals of the Modern Movement, and inspired a vast wave of planning and building across the world during the 20th century. In the last quarter of the century, even as the foundational programmes of Europe and America lost their impetus, the baton was passed on to other countries, especially in eastern Asia, where the narrative of Modern mass housing was reinvigorated for the next century - a unique example of a key Modernist project that actually continues and thrives today, and which thus forms a principal focus of interest for DOCOMOMO – the leading international organisation promoting the documentation and conservation of buildings, sites and neighbourhoods of the Modern Movement. As heritage, the built legacies of this diverse and multi-generational adventure are almost always too controversial to qualify for conservation strategies. Instead, therefore, recording and inventorisation must dominate the heritage interest in this field. In the recognition of that fact, DOCOMOMO’s International Specialist Committee on Urbanism and Landscape, in partnership with the Scottish Centre for Conservation Studies at the University of Edinburgh, has launched the International Mass Housing Archive, whose aim is to provide an open-access library of images of significant housing projects in each working-group territory, free of copyright restrictions. These files may be copied, edited and shared on condition the appropriate citation is used, as per the terms of the attached Creative Commons Attribution licence. ### Structure ### The International Mass Housing Archive is subdivided under geographical headings corresponding to the constituent working groups of DOCOMOMO, and the individual housing projects are searchable under city and project name. Initially, the Image Archive will be managed and augmented centrally by DOCOMOMO and the SCCS, in partnership with University of Edinburgh Information Services, commencing with pilot city surveys sourced from our own photographic records in the first instance. The archive is related to several existing mass housing documentation initiatives. These include one concerning Britain, namely the online version of the 1994 book, Tower Block: http://towerblock.org/TowerBlock.pd
Outcome Tables
No full textObjective assessment and monitoring of physical performance in soccer players are mandated features of practice in English soccer academies. Based on these approaches, our interest was to investigate and compare the longitudinal physical performance profiles of those players that had eventually been successful and unsuccessful at the two highest levels, becoming male professional English Premier League and Championship level soccer players. The specific research objective was to investigate the between player variability and predictive validity of physical assessment measures against eventual playing outcome. A total of 297 male youth participants (born between 1999 to 2006) affiliated to three category one academies were tracked for eight years across six objective physical tests. Data were analysed by a series of mixed method ANOVAs, comparing outcome with age. Canonical Discriminant Function Coefficients and the TRIPOD Statement were applied for transparent reporting of prediction efficacy. Results suggest that physical characteristics offer little or no discriminatory power. We conclude by offering guidance for academies’ interpretation and usage of physical data
Videos of eMouseAtlas Models: Theiler Stage 9 (6.25-7.25 dpc)
No full textA number of videos for each of the eMouseAtlas 3D mouse embryo models to show the overall form and in some cases selected anatomy. Each video is identified by the unique EMA ID with annotation if required. The videos labelled as "watermovies" are captured using the OPT system with the embryo spun on a longitudinal axis with no tissue clearing