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ADVANCEMENTS IN MICROARRAY MANUFACTURING ENABLE EMERGING TECHNOLOGIES
No full textSignificant advances in manufacturing technologies have enabled the production of new DNA microarrays for use in emergent technology. Photolithography, wafer scale manufacturing, and improvements in synthesis chemistry and design enable high-throughput production of extremely high-quality arrays. These new arrays offer extremely high oligonucleotide densities, in the range of tens of thousands of oligonucleotides per square micron. They also offer smaller features sizes, with millions of features per square centimeter. Furthermore, they can be manufactured with the DNA tethered at either end to the surface, leaving either the 5’ or 3’ end free and available for use in enzymatic reactions; and they can be manufactured on new surfaces, such as hydrogels, which are biocompatible with enzymatic reactions. Here, we discuss the use of these new arrays for pathogen detection, viral genotyping, and high-resolution spatial transcriptomics
A Computational Method for Detecting Compound Promiscuity in Early-Stage Pharmaceutical Discovery
No full textModern drug discovery and chemical biology research relies heavily on analyzing bioassay data. One of the many challenges in bioassay data analysis is identifying false trails, i.e., chemical compounds which initially appear to have desirable activity but are found to be problematic upon further investigation. Badapple (the BioAssay-Data Associative Promiscuity Pattern Learning Engine) was created over ten years ago to help researchers identify promiscuous compounds and thus avoid a common source of these false trails. Through an effort involving software engineering, cheminformatics, and biomedical data science we have developed Badapple 2.0, which incorporates updated assay records and expanded data semantics. The expanded semantics offer additional insights into Badapple’s predictions and have supported novel, in-depth analyses which demonstrate the comprehensiveness of its data. Badapple 2.0 was developed as part of an ongoing anti-alphaviral discovery effort, and has high potential for improving the efficiency of other early-stage drug discovery projects
Secured Through Stone: The Power, Monuments, and Memory of Thyra Danmarkarbót and the Jelling Dynasty
No full textSometime in the mid-tenth century on the Jutland peninsula of Denmark, the Viking Age Queen Thyra (d. ca. 958/9) passed away and the epithet Danmarkarbót—Denmark’s Adornment—was skillfully carved onto her memorial runestone. Yet Thyra’s story has been clouded by few and unreliable textual sources, by differing assessments of her familial background that have emerged from those sources, and by misrepresentations of the material culture relating to her. This thesis explores Thyra and her place within the Viking Age Jelling dynasty through textual and material evidence and considers how the construction of both medieval and modern memory work and memorialization and commemorative practice influence our understanding of her and the life she may have led
Understanding the Metallic and Oxide Phases in Platinum-based Bimetallic Heterogeneous Catalysts after High-Temperature Oxidation
No full textPlatinum (Pt) and palladium (Pd) are critical components in diesel emission control systems, enabling the conversion of harmful pollutants under demanding conditions. However, Pt’s effectiveness is hindered by sintering under high-temperature oxidizing environments. This dissertation investigates how Pt and Pd evolve under oxidizing conditions at 800°C, highlighting their distinct thermodynamic behaviors and interactions. Using TEM, EDS, EELS, XRF, XRD, and EXAFS, we show that Pd suppresses Pt sintering by reducing the volatility of PtO₂, leading to the formation of stable particles. Both Pt and Pd are present in metallic and oxide states, forming biphasic \u27Janus\u27 particles with conjoined metal and oxide regions. We demonstrate that Pt moderates Pd oxidation, altering its mechanism and stabilizing the formation of these Janus structures. These particles enable continuous redistribution of mobile species, supporting self-healing behavior and sustained catalytic performance after prolonged aging. This work provides insight into metal–oxide phase stability in Pt-alloy systems and offers a pathway to design catalysts that meet Department of Energy targets—ultimately supporting cleaner air and improved public health
Phase Nanoscopy with Correlated Frequency Combs
No full textIn this dissertation a sensing method applying to any physical quantity that modifies optical phase is developed. Two pulses are produced inside a synchronously pumped Optical Parametric Oscillator, generating two identical, undistinguishable frequency combs. The physical quantity to be measured applies a small phase shift/round trip to one of the pulses, resulting in a frequency shift of the corresponding comb. The latter frequency is measured as a beat by interfering the two combs on a detector. A world record resolution, close to the quantum limit, of 0.033 nanoradian (corresponding to 0.006 fm in displacement) is achieved. A detailed analysis of the parameters affecting the signal to noise is presented. It leads to further methods of enhancing the sensitivity through miniaturization on a chip, and coupling the OPO to a microresonator will bring the displacement sensitivity beyond that of LIGO. The research opens pathways to applications in fundamental
What can we learn from the high school math reform efforts in California, Georgia, and Oregon? A policy analysis
No full textUsing publicly available data sources, this policy analysis examined how three states—California, Georgia, and Oregon—approached high school mathematics reforms to address questions regarding what prompted these states to revise their high school math standards and course pathways; how their approaches to reform were similar or different; and what other states could learn from their methods.
Individual state cases were developed, focusing on content standards, course pathways, and graduation requirements. A cross-case study was created to compare reforms from the three states.
While all states aimed to reform high school mathematics to address equity issues and offer options aligned with students’ college and career aspirations, they approached the process in various ways. This variation stemmed from each state’s policy revision structures, political climates, and community feedback. Other states engaged in reform efforts should examine the approaches of states with similar structures and consider adopting their strategies
Optimization and Acceleration of PUF Design through Reduced Order Standard Cell Modeling
No full textApplication Specific Integrated Circuit (ASIC) designs continue to scale with ever increasing complexity and device counts in the billions. Demand for scalable high-fidelity simulations of these systems drives the need for the development of novel modeling capabilities. This research formulates a non-intrusive model order reduc-tion (MOR) framework, called PUF-ROMS, to accelerate and optimize the design and analysis of physical unclonable functions (PUFs) on ASICs. The primary goals of PUF-ROMS are to estimate entropy and temperature-voltage noise (TV-noise) of circuit structures used in the design in an accelerated evaluation environment to enable designers to explore architecture options with the goal of maximizing entropy and minimizing the adverse impact of TV-noise on accessing this entropy. PUF-ROMS starts with the development of reduced order models (ROMs) for the logic cell primitives used in the PUF circuit structure. The cell primitive ROMs are then used in SPICE system-level Monte Carlo (MC) simulations to enable efficient exploration of the PUF design space, including improvements in both utility and performance
PARTNER Collective Impact Survey FINAL EVALUATION REPORT
No full textThe Healthy Here coalition, based in Bernalillo and Santa Fe Counties, brings together over 30 organizations working across four key areas: healthy eating, active living, family healthy weight, and vaccinations. In summer 2025, the coalition conducted a PARTNER Collective Impact Survey to evaluate its network structure, contributions, and effectiveness. The survey, completed by 29 organizations (87.9% response rate), provided insights into how member organizations collaborate, the resources they contribute, and how trust and value are perceived across the network.
Findings show that coalition members most frequently contributed community connections, content expertise, and information sharing, with Presbyterian Community Health and the Bernalillo County Health Equity Council most often recognized as lead organizations. Overall, trust scores averaged 3.30 and value scores averaged 2.82, reflecting moderate confidence in reliability, mission alignment, and resource contributions. Nearly 90% of respondents rated Healthy Here as successful or very successful in reaching its goals, citing strengths in diverse stakeholder engagement, collective decision-making, and a shared mission.
Key challenges included funding instability, organizational capacity limitations, inconsistent participation, and competing priorities, along with a need for more Spanish-language resources and direct community engagement. Respondents identified additional funding, clearer expectations, consistent communication, and strategic planning as priorities for strengthening coalition impact.
The survey results suggest that Healthy Here is a strong, collaborative coalition with opportunities to enhance sustainability, clarify shared goals, and deepen community engagement. These findings provide a foundation for guiding future action to increase collective impact on health equity and chronic disease prevention in New Mexico
