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Machine Perfusion for Recovery of Brain Death Donor Hearts From Extended Distances
No full textThe emerging ex vivo machine perfusion (MP) enables the extension of ex situ intervals, potentially expanding the heart transplant (OHT) donor pool. From October 18, 2018, to June 30, 2023, isolated OHT using donation after brain death (DBD) from extended distances (\u3e500 miles) were identified in the United Network for Organ Sharing database, and categorized into cold storage (non-MP, N = 1,212) and MP group (N = 152). The MP utilization rate for DBD hearts from extended distances surged from 0% in 2018 to 27.7% in 2023. Recipient characteristics including listing status were similar except for history of cardiac surgery (non-MP, 32% vs. MP, 41%, p = 0.019). The travel distance was longer in MP group (696 vs. 894 miles, p \u3c 0.001), as was donor organ preservation time (4.42 vs. 6.27 hours, p \u3c 0.001). One-year survival was similar between groups (non-MP, 93.0 ± 0.8% vs. MP, 90.5 ± 2.9%, p = 0.23). In multivariable Cox hazards models, MP was not associated with mortality (hazard ratio, 1.19; p = 0.60). Among MP cohort, survival was comparable between hearts transported between 500-999 miles (N = 112) and those over 1,000 miles (N = 40). The utilization of MP for DBD heart recovery allows for safe DBD recovery from extended distance with comparable survival to cold storage
Kir5.1 Regulates Kir4.2 Expression and Is a Key Component of the 50-Ps Inwardly Rectifying Potassium Channel in Basolateral Membrane of Mouse Proximal Tubules
No full textKir5.1 encoded by Kcnj16 is an inwardly rectifying Kþ channel subunit, and it possibly interacts with Kir4.2 subunit encoded by Kcnj15 for assembling a Kir4.2/Kir5.1 heterotetramer in the basolateral membrane of mouse proximal tubule.We now used patch clamp technique to examine basolateral Kþ channels of mouse proximal tubule (PT) and an immunoblotting/immunofluorescence (IF) staining microscope to examine Kir4.2 expression in wild-type and Kir5.1-knockout mice.IF staining shows that Kir4.2 was exclusively expressed in the proximal tubule, whereas Kir5.1 was expressed in the proximal tubule and distal nephrons including distal convoluted tubule.Immunoblotting showed that the expression of Kir4.2 monomer was lower in Kir5.1-knockout mice than that in the wild-type mice.In contrast, Kir4.1 monomer expression was increased in Kir5.1 knockout mice.IF images further demonstrated that the basolateral membrane staining of Kir4.2 was significantly decreased in Kir5.1 knockout mice.This is in sharp contrast to Kir4.1, which also interacts with Kir5.1 in the distal nephron, and IF images show that Kir4.1 membrane expression was still visible and unchanged in Kir5.1 knockout mice.The single channel recording detected a 50-pS inwardly rectifying Kþ channel, presumably a Kir4.2/Kir5.1 heterotetramer, in the basolateral membrane of the proximal tubule of Kir5.1 wild-type mice.However, this 50-pS Kþ channel was completely absent in the basolateral membrane of the proximal tubule of Kir5.1 knockout mice.Moreover, the membrane potential of the proximal tubule was less negative in Kir5.1 knockout mice than wild-type mice.We conclude that Kir5.1 is essential for assembling basolateral 50-pS Kþ channel in proximal tubule and that deletion of Kir5.1 decreased Kir4.2 expression in the proximal tubule thereby decreasing the basolateral Kþ conductance and the membrane potentials
Treatment of Androgenetic Alopecia With Low-Dose Oral Minoxidil Monotherapy Compared With Combination Therapy With Dutasteride or Finasteride
No full textGlucagon-Like Peptide-1 Receptor Agonist Use Is Not Associated With Increased Complications After Total Hip Arthroplasty in Patients Who Have Type 2 Diabetes
No full textBackground: Glucagon-like peptide-1 (GLP-1) agonists have emerged as a powerful diabetic treatment adjunct; however, their effects on outcomes following total hip arthroplasty (THA) are not well known. This study aimed to compare the risk of complications in patients who had type 2 diabetes mellitus (DM) who were on GLP-1 agonists with those who were not on these medications. Methods: In total, 14,065 patients who had type 2 DM undergoing primary THA between 2016 and 2021 were retrospectively reviewed using a national database. Propensity score matching was employed at a 1:4 ratio to match patients who used GLP-1 agonists (n = 812) to those who did not (n = 3,248). Patients were matched on age, sex, insulin status, presence of other diabetic medications, comorbidities, and smoking status. Multivariable logistic regressions were performed to examine 90-day and 1-year THA outcomes between groups. Results: Patients who were not on GLP-1 agonists exhibited increased rates of extended hospital stays (≥3 days) (odds ratio 1.25, P = 0.01). Patients who were on GLP-1 agonists exhibited no significant differences in surgical or medical complication rates at 90 days compared to those not on GLP-1 agonists. There were also no significant differences in rates of all-cause revision THA, aseptic revision THA, or periprosthetic joint infection during the 1-year postoperative period. Conclusions: This study demonstrated that GLP-1 agonists were not associated with increased risks for medical or surgical complications in patients who had DM undergoing THA and were associated with lower rates of extended hospital stays after surgery. This study provides additional evidence regarding the association of GLP-1 agonist use before THA with postoperative outcomes. Given the potential for increased glycemic control and weight loss, more data are needed to delineate the role of GLP-1 agonists in the optimization of patients who have DM before THA to minimize postoperative complications. Level of Evidence: Level III, retrospective cohort
Primary Treatment of Eyelid Conjunctival Melanoma With Immunotherapy: A Case Report
No full textConjunctival melanoma is a rare, life-and sight-Threatening ocular malignancy sharing molecular features with cutaneous and mucosal melanoma. Despite current clinical approaches, high recurrence rates and frequent metastases pose significant challenges in management. Immune checkpoint inhibitors such as ipilimumab and nivolumab have revolutionized cutaneous melanoma treatment, but their efficacy in conjunctival melanoma remains largely unexplored. Herein, the authors present the case of metastatic palpebral conjunctival melanoma in a 59-year-old male successfully treated with a first-line combination of ipilimumab and nivolumab without adjuvant therapies or local surgeries. Local disease resolution was achieved after only 7 months of treatment, and the immune checkpoint inhibitor regimen was well-Tolerated with limited systemic adverse effects and no ocular side effects
COVID-19 Communication Messaging and Culture: A Survey of Latino and Non-Latino Americans
No full textThe Question of Textbooks in Academic Libraries: To Purchase or Not? A Scoping Review
No full textObjectives: Textbook costs have escalated for students and the library. The objective of this scoping review is to assist libraries in developing a collection policy for course-required textbooks informed by themes and outcomes recognized in the existing body of research.
Methods: The scoping review was conducted using Arksey and O’Malley’s framework and the JBI Manual for Evidence Synthesis. The team did an environmental scan, constructed a comprehensive search strategy in six databases, and conducted hand and cited-reference searching. Included papers were quantitative or qualitative studies with outcomes described and mapped to prevailing themes.
Results: Nine hundred twenty-three records were identified via database and cited reference searching. After deduplication, 760 records were screened, and 675 records were excluded. 85 full-text records were retrieved and after review, 29 records were further excluded. Fifty-six studies were included for review, most of which were case studies. Thirteen recurring themes were identified and grouped.
Conclusions: Libraries are increasingly enlisted in wider academic strategies to make education more affordable for students. Course reserves programs are often initiated or expanded at the request of student groups, sometimes motivating financial support from administration. Published studies have focused primarily on undergraduate settings. The scoping review provides recommendations for the development and management of textbook collections
InTouch Week of October 20, 2025
No full textNew Obstetrics and Gynecology Residency Program Established Building Bridges for Better Health Fire Safety Training Events for Students, Faculty, and Staff TCDM Prepares Dental Professionals to Meet New Mexico’s Evolving Needs In the Community-NYMC Advances Children’s Environmental Health Initiatives Across New York State Alumni Spotlight: Deena Casiero, M.D. \u2706, Advancing the Game of College Sports Medicinehttps://touroscholar.touro.edu/in_touch/1377/thumbnail.jp
InTouch Week of December 8, 2025
No full texthttps://touroscholar.touro.edu/in_touch/1383/thumbnail.jp
Under the Ocean to Ocean Bridge: California in the Distance
No full texthttps://touroscholar.touro.edu/quill_and_scope_images/1230/thumbnail.jp