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Study of the Impact of Introducing a Multimedia Learning Tool in Podiatric Medical Courses
No full textAssociation Between Psychotic and Dissociative Symptoms: Further Investigation Using Network Analysis
No full textImmunity and Protective Efficacy of a Plant-Based Tobacco Mosaic Virus-Like Nanoparticle Vaccine Against Influenza a Virus in Mice
No full textComparative Dermatology—Pavement Paws: Frictional Dermatosis in Puppies Analogous to Pool Toes
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Evaluation of Impact of Blood Pressure on the Measurement of Intra Ocular Pressure: Falck Multifunctional Device vs Goldmann Applanation Tonometry
No full textPurpose : This study was designed to compare intraocular pressure (IOP) measurements taken using Goldmann Applanation Tonometry (GAT) with those obtained by the Falck Multifunctional Device (FMD, Falck Medical, CT, USA), to evaluate their respective accuracy and reliability.
Methods : For the GAT measurement, IOP was assessed three times at intervals of 30 seconds (Average IOP GAT) in each eye. Subsequently, Central Corneal Thickness (CCT) was measured using a pachymeter (Pachmate 2, DGH Technology, Exton, PA, USA). Following this, IOP measurements were taken serially with the FMD in each eye. The device calculated an average IOP for each eye (IOP FMD), which was accepted for analysis only if the calculated variability was less than 10%. Additionally, Ocular Pulse Amplitude (OPA), which is the difference in IOP between systolic and diastolic phases, was recorded. Notably, GAT measures IOP predominantly during diastole. Therefore, to correct for systolic contributions, half of the OPA value was subtracted from the IOP FMD (Corrected IOP FMD).
Results : The study included a total of 40 eyes from 21 patients, with a gender distribution of 57% male and 43% female. The participants had a mean age of 63.7 years. The mean Average IOP GAT was 15.2 mm Hg, with a mean CCT of 561.4 µm. In contrast, the mean Corrected IOP FMD was found to be 16.3 mm Hg. This resulted in a significant difference of 1.1 mm Hg, with the Corrected IOP FMD being higher (p-value = .029). When corrected for CCT variations, the Mean Average IOP GAT adjusted to 14.4 mm Hg, leading to a discrepancy of 1.9 mm Hg (p = 0.01).
Conclusions : The study reveals that GAT, which operates on the premise of measuring IOP on a very thin and elastic membrane during diastole, inherently harbors sources of variability. It fails to take into account factors such as capillary forces affecting the moist corneal surface and the elasticity of corneal tissue. Consequently, GAT consistently underestimates IOP when compared to FMD measurements. This underestimation persists even after adjustments for corneal thickness and the systolic portion of the cardiac cycle are accounted for. The FMD, on the other hand, includes an algorithm that compensates for corneal wetness, tissue elasticity, and systolic variation during the cardiac cycle, thus potentially offering a more accurate and reliable method for IOP measurement
Heart Failure and Impaired Cognitive Function: Findings From the National Health and Nutrition Examination Survey
No full textThe relationship between heart failure and cognitive impairment has not been clearly delineated. The primary objective of this analysis was to determine whether patients with heart failure have greater cognitive impairment compared with those without heart failure, using the National Health and Nutrition Examination Survey continuous dataset (n=111,797) from 1999 to 2021
Haemophilus Influenzae Epididymo-Orchitis and Bacteraemia in an Immunocompetent Patient
No full textBackground: Epididymitis is a common cause of scrotal pain in adults, with coliform bacteria being the most common isolated organisms in patients older than 35. Case presentation: A 51-year-old healthy patient presented with scrotal pain and swelling, and was found to have epididymo-orchitis and bacteraemia caused by Haemophilus influenzae, which has not previously been reported as a cause of epididymo-orchitis and bacteraemia in immunocompetent patients. Discussion: Diagnostic studies can help confirm the diagnosis and detect the causative pathogen. In all suspected cases, a urinalysis, urine culture and a urine or urethral swab for nucleic acid amplification tests (NAATs) for Neisseria gonorrhoeae and Chlamydia trachomatis should be performed. Colour Doppler ultrasonography often shows an enlarged thickened epididymis with increased Doppler wave pulsation in epididymitis. H. influenzae are pleomorphic gram-negative rods that commonly colonise the human respiratory tract and are associated with a number of clinical conditions. H. influenzae has been reported as a cause of epididymo-orchitis in prepubertal boys, and in few cases were associated with positive blood cultures. In adults, H. influenzae has been isolated before from urine samples or urethral swabs in patients with epididymitis or epididymo-orchitis. Conclusion: This case highlights the possibility of H. influenzae causing epididymo-orchitis and bacteraemia in immunocompetent patients. Healthcare providers should consider H. influenzae in the differential diagnosis of epididymitis and epididymo-orchitis in both immunocompetent and immunocompromised patients