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Rasburicase vs. Allopurinol: Mortality in Hematological Malignancies Post Anti-Hyperuricemic Therapy - Real-World Study
No full textPurpose: This retrospective, real-world (RW) study utilizing propensity score matching investigated tumor lysis syndrome (TLS)-related mortalities following anti-hyperuricemic (HU) monotherapy (allopurinol vs. rasburicase) in hematological malignancies. The study aim was to determine if a significant difference exists in the proportion of TLS-associated mortalities in hematological malignancy patients who received either rasburicase or allopurinol. Methods: Following random selection of patient cases of rasburicase or allopurinol monotherapy, 141 in each group were PS-matched for TLS risk using 11 predictive covariates. Results: Rasburicase-treated patients had significantly lower TLS-associated mortality (2.1% (n = 3) vs. 7.1% (n = 10) (p = 0.047)). Conclusions: Following successful PS matching of TLS-risk factors, this study suggests rasburicase statistically significantly reduces TLS-associated mortalities compared to allopurinol
Social Processes and Engagement Along the HIV Care Continuum: A Mixed Methods Exploratory Study With Diverse African American/Black and Latine Emerging Adults Living With HIV
No full textBackground: Racial/ethnic and age-related disparities in HIV care continuum engagement are serious in the US. American/Black and Latine (AABL) young/emerging adults living with HIV have the lowest rates of engagement, but aspects of their experiences and some subpopulations are understudied. The present study is grounded in social action theory and uses a sequential explanatory mixed methods design to explore social interaction processes (e.g., social networks, trust), and their relationships to HIV management, in a diverse cohort including those with non-suppressed HIV viral load. Methods: Participants engaged in baseline assessments (N = 271). A subset (N = 62) was purposively sampled for maximum variability for qualitative interviews. Quantitative data were analyzed with descriptive statistics and logistic regression. The primary outcomes were engagement in HIV care and viral suppression. Quantitative results were used to develop qualitative research questions, and qualitative data were analyzed with directed content analysis. Joint display methods were used to integrate results. Results: On average, participants were 25 years old (SD = 2). The majority (59%) were Latine/Hispanic, 41% were African American/Black. Nearly all were male (96%) and sexual minorities (93%). Nearly half (49.1%) were born outside the US/Puerto Rico. Most were well-engaged in care (72%) and virally suppressed (81%). The proportion of network members who used illicit drugs reduced the odds of being well-engaged in HIV care (OR = 0.38; p = 0.014) and suppression (OR = 0.32; p = 0.009) at the bivariate level. Satisfaction with HIV care (OR = 1.18; p = 0.016) and trust in providers (OR = 1.04; p = 0.045) increased the odds of viral suppression. In qualitative results we found social networks were vital to well-being, but, like participants, located in strained socioeconomic circumstances. In this context, we organized results into five themes: (1) social losses were disruptive to HIV management; (2) service settings and care providers were important network members; (3) family disapproval of sexual/gender minority status had negative effects; (4) immigrant participants were highly reliant on service settings; and (5) networks influenced participants’ drug use and their drug use also reduced the size and changed the composition of networks. Conclusions: The present study advances knowledge on social interaction processes among diverse AABL young/emerging adults living with HIV, and highlights points of intervention
InTouch Week of June 16, 2025
Get PDFJonathan Sheindlin, M.D. \u2793, and John Morningstar to be Honored at NYMC’s Annual Golf Tournament 15th Annual Paul K. Woolf, M.D., Pediatric Trainee Research Day Spotlights Outstanding Research NYMC Researchers Identify Novel Strain of Syphilis Bacterium TCDM Alumni Reunion Celebrates the Class of 2020 and Showcases Innovation in Digital Dentistry Alumni Spotlight: 2025 Student Commencement Speakers Reflection on NYMC and What Comes Next Alumni Spotlight: The Cooper’s Lifelong Bond with NYMChttps://touroscholar.touro.edu/in_touch/1367/thumbnail.jp
Translation Into Russian of Poems by the American Poet Neeli Cherkovski (1945-2024): “Portrait at 76,” “The Stone Served Us Well,” “Pick,” “For the Barbarians,” “This Poem a Sonnet for Kit Robinson”
No full textUsing Multi-Tiered Systems of Support (MTSS) to Address Activities of Daily Living, Rest and Sleep
No full textExploring the Barriers and Facilitators of Pre-Exposure Prophylaxis (PrEP) Utilization Among Heterosexual Men
No full textPre-Exposure Prophylaxis (PrEP) is a highly effective intervention for preventing HIV infection, yet research has primarily focused on populations such as men who have sex with men (MSM) and cisgender women, leaving heterosexual men (MSW) underrepresented in HIV prevention studies. This study investigates heterosexual men’s awareness of PrEP and their intention to use it, identifying key factors that influence PrEP consideration. A cross-sectional online survey was created and disseminated to heterosexual men across the United States aged 18-45 years, reaching a sample size of 277 respondents, using Qualtrics for recruitment and data collection. Logistic regression was used to assess how variables such as HIV worry and stigma influenced PrEP intention. The findings revealed that concern about contracting HIV (OR=9.52, p=0.00) was a significant predictor of PrEP intention, with men who expressed higher levels of concern were ten times likelier to consider PrEP. Stigma (OR=0.40, p=0.028) served as a barrier, decreasing the likelihood of PrEP usage. These results highlight the need for targeted public health interventions aimed at increasing PrEP awareness, reducing stigma, and enhancing healthcare communication for heterosexual men. Addressing these barriers is crucial to ensuring greater inclusivity in HIV prevention efforts and expanding PrEP accessibility to all at-risk populations
