19043 research outputs found
Sort by
Medical Intensive Care Unit Overflow Into the Cardiac Intensive Care Unit: Insights From CCCTN Registry
No full textBackground: Cardiac intensive care units (CICUs) typically manage critically ill patients with acute cardiovascular (CV) conditions but may serve patients with non-CV critical illness when medical ICU (MICU) beds are unavailable. Objectives: The purpose of this study was to characterize the clinical profiles and outcomes of “MICU overflow” admissions to the CICU. Methods: We used the Critical Care Cardiology Trials Network registry to compare CICU admissions without acute or major cardiac issues (MICU overflow) vs those with acute CV illness. Results: Among 19,912 CICU admissions (2018-2023), 923 (4.6%) were MICU overflow, ranging from 0% to 26% across centers. MICU overflow admissions had higher median Sequential Organ Failure Assessment scores than CV admissions (5 vs 3; P \u3c 0.001) and more commonly presented with respiratory failure (50.5% vs 24.6%; P \u3c 0.001) and noncardiogenic shock (30.9% vs 8.0%; P \u3c 0.001). MICU overflow status was associated with similar ICU mortality (adjusted OR: 1.13; 95% CI: 0.90-1.43; P = 0.28) but higher hospital mortality (adjusted OR: 1.80; 95% CI: 1.48-2.19; P \u3c 0.001) vs CV illness. In units where the CICU team managed all admissions, ICU mortality was higher among MICU overflow admissions than CV admissions (adjusted OR: 1.35; 95% CI: 1.02-1.80; P = 0.04), whereas in CICUs where off-unit MICU teams managed MICU overflow admissions, this mortality imbalance was not present (adjusted OR: 0.72; 95% CI: 0.47-1.11; P = 0.14; P interaction = 0.02). Conclusions: MICU overflow admissions constitute a meaningful proportion of the CICU population and present with more multisystem disease and experience higher hospital mortality compared with acute CV admissions, underscoring the need for multidisciplinary CICU teams with broad critical care expertise
Correlation Between Balanced Fast Field Echo Sequence and Intraoperative Findings in the Surgical Treatment of an Intradural Spinal Arachnoid Cyst: Illustrative Case
No full textBACKGROUND Spinal arachnoid cysts can cause myelopathy through spinal cord compression. While MRI is the standard for diagnosis, traditional sequences may not clearly define cyst borders and septations, which are important for guiding surgical intervention. Balanced fast field echo (B-FFE) is an MRI sequence that highlights small arachnoid membranes within and at the borders of CSF spaces. OBSERVATIONS The authors report the case of a 13-year-old female who presented with progressive lower extremity paresthesias and weakness and urinary incontinence. MRI revealed an intradural cervicothoracic arachnoid cyst (C7–T3) dorsal to the spinal cord. B-FFE was used to identify the upper and lower borders of the intradural arachnoid cyst and its internal septations. These findings corresponded precisely with intraoperative findings and guided fenestration at the cyst\u27s cranial, caudal, and internal septal ends. Postoperatively, the patient’s symptoms resolved, and MRI confirmed the resolution of mass effect. At the 10-and 30-month follow-ups, there was no evidence of cyst recurrence clinically or radiographically. LESSONS The authors raise awareness of the clinical utility of B-FFE imaging for intradural spinal arachnoid cysts. Due to its ability to demonstrate cyst borders and internal septations, it offers an alternative to more invasive tests, especially in the pediatric population
Inflammatory Modulation by Cord Blood Stem Cells Prevented Digit Deformation in Recessive Dystrophic Epidermolysis Bullosa
No full textUnrestricted somatic stem cells (USSCs) ameliorated fibrosis, enhanced motility, and improved survival in an RDEB mouse model by modulating IL-1-driven inflammation and promoting wound-healing macrophages. LIF secretion from USSCs suppressed IL-1α and increased IL-1Ra in macrophages, highlighting the therapeutic potential of stem cell-mediated paracrine signaling in RDEB
Intraoperative Fluorescence in Solid Head and Neck Cancer: A Scoping Review
No full textPurpose: Obtaining negative margins in primary tumor resection is essential to decreasing recurrence and mortality. Fluorescence imaging may aid in complete tumor removal. As fluorescent agents are still under clinical trial investigation for use in head and neck cancer (HNC), their effectiveness in intraoperative margin assessment (IMA) remains unclear. This scoping review examines the use of fluorescent-guided surgery (FGS) in the treatment of HNC, highlighting significant opportunities in this nascent field. Methods: PubMed, Scopus, CINAHL, and Cochrane Library were searched from inception through March 22, 2024. This study was conducted under PRISMA-ScR guidelines. Data on study characteristics, fluorescence and imaging techniques, imaging efficacy, and diagnostic accuracy were extracted. Results: Twenty-seven prospective studies from 2013 to 2024 on intraoperative FGS in HNC, involving 455 patients from six countries, were included. Studies ranged from preclinical to phase II trials, applying various fluorescent techniques, predominantly indocyanine green and IRDye800CW, to enhance surgical precision. Imaging assessments were conducted in-vivo, ex-vivo, or both, using a wide range of devices and taking an additional 0 to 30 min intraoperatively. Quantitative measures like signal-to-background ratio and mean fluorescent intensity suggested variable diagnostic accuracy across studies. FGS shows great potential in improving IMA, although standardization in methodologies and reporting is needed. Conclusion: This scoping review highlights the potential of intraoperative FGS to enhance treatment accuracy in solid HNC, though variability in diagnostic efficacy and a lack of standardized methodologies persist. Advancements in fluorophore technology and uniform procedural protocols are essential to optimize surgical outcomes and move towards personalized HNC interventions
InTouch Week of April 28, 2025
Get PDFSchool of Medicine Class of 2027 Takes Pivotal Step from Classroom to Clinic NYMC Takes Hard Hat Tour of Ellis Island NYMC Hosts 11th Annual Drs. Gabor and Harriette Kaley Endowed Lecture Students Celebrate Earth Day Holocaust Survivor and Former Sunshine Cottage TB Resident Visits NYMC NYMC Chapter of Building Next Generation of Academic Physicians Recognized with Chapter of the Year Award Student Spotlight: Rewan and Sewar Alrabadi Aspire to Make Double the Impact in Physical Therapyhttps://touroscholar.touro.edu/in_touch/1361/thumbnail.jp
Shifting From “What’s Wrong” to “What’s Strong”: Developing a Trauma-Informed Assessment of Student Character Strength Usage
No full textSelf-Perceived Oral Health in Older Adults With Visual Impairment: Disparities And Sociodemographic Influences – An Nhanes 2015–2018 Analysis
No full textPurpose of the Study: This research investigates the relationship between vision impairment and oral health perceptions of older adults through analysis of nationally representative data from the National Health and Nutrition Examination Survey between 2015 and 2018. The study aims to explore whether vision impairment leads to worse oral health outcomes alongside evaluating how preventive dental visits and socioeconomic conditions impact these health disparities.
Methods: The study analyzed cross-sectional data from 2,692 older adults who were 65 years or older. The study used survey-weighted bivariate analyses and logistic regression models to examine how vision impairment affects self-rated oral health while controlling for age, gender, race/ethnicity, education level, marital status, household income, dental visit reasons, and health insurance status.
Results: Older adults with vision impairment had significantly lower odds of reporting good oral health (OR: 0.63, 95% CI: 0.44–0.91, p = 0.015). Preventive dental visits were strongly associated with better oral health perceptions (OR: 2.31, 95% CI: 1.72–3.11, p \u3c 0.001). Education levels and income status together with racial/ethnic background heavily affected oral health disparities because people with higher education and income reported better oral health while Non-Hispanic Whites experienced better oral health than members of other racial/ethnic groups.
Conclusion: Research demonstrates substantial oral health inequities in visually impaired populations which require specialized interventions to improve dental health education and service accessibility. Healthcare policies should focus on increasing dental service availability for people with visual impairments while encouraging routine preventive dental visits and incorporating oral health approaches into disability and aging support services
InTouch Week of May 26, 2025
Get PDFSOM Faculty Recognized for Excellence with Dean’s Faculty Awards NYMC Gathers Experts for In-Depth Look at Vector-Borne Diseases Impacting New York TU Research Day 2025 Explores “Plasticity in Research: AI and Beyond” SHSP Formal 2025 was a Night to Remember Student Spotlight: Nicole DeSouza to Deliver Student Address at the 166th NYMC GSBMS Commencement Alumni Spotlight: Akshay Syal, M.D. ’21, Bridges Medicine and the Mediahttps://touroscholar.touro.edu/in_touch/1365/thumbnail.jp
InTouch Week of March 17, 2025
Get PDFSOM Continues Tradition of Distinction with 2025 Alpha Omega Alpha Induction Focused Ultrasound\u27s Promise for Neurological Disorders A Clinical Experience Abroadhttps://touroscholar.touro.edu/in_touch/1356/thumbnail.jp