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F-box receptor mediated control of substrate stability and subcellular location organizes cellular development of Aspergillus nidulans
No full textFungal growth and development are coordinated with specific secondary metabolism. This coordination requires 8 of 74 F-box proteins of the filamentous fungus Aspergillus nidulans. F-box proteins recognize primed substrates for ubiquitination by Skp1-Cul1-Fbx (SCF) E3 ubiquitin RING ligases and degradation by the 26S proteasome. 24 F-box proteins are found in the nuclear fraction as part of SCFs during vegetative growth. 43 F-box proteins interact with SCF proteins during growth, development or stress. 45 F-box proteins are associated with more than 700 proteins that have mainly regulatory roles. This corroborates that accurate surveillance of protein stability is prerequisite for organizing multicellular fungal development. Fbx23 combines subcellular location and protein stability control, illustrating the complexity of F-box mediated regulation during fungal development. Fbx23 interacts with epigenetic methyltransferase VipC which interacts with fungal NF-κB-like velvet domain regulator VeA that coordinates fungal development with secondary metabolism. Fbx23 prevents nuclear accumulation of methyltransferase VipC during early development. These results suggest that in addition to their role in protein degradation, F-box proteins also control subcellular accumulations of key regulatory proteins for fungal development
Blurring the distinction between the researcher and the researched: Doing Collective Memory-Work online in Covid times
No full textCollective-Memory Work (CMW) is a method of research and learning that relies on a
group working together on a topic of shared interest. It aligns with other qualitative
approaches such as participatory and feminist research methods, collaborative autoethnography, narrative inquiry, and emancipatory adult learning. In CMW participants
write short stories from their own memory on a theme agreed in advance. The stories
are subsequently scrutinized by the group via detailed textual analysis and recursive discussion. Due to COVID restrictions in 2020, a planned CMW workshop at an Irish
higher education institution had to be delivered online. The purpose of this case
study is two-fold: first it provides an overview of the CMW approach and how it is
implemented in practice, detailing the concrete activities carried out in the workshop.
Second, the case study provides insight into running a workshop of this kind online
and the perceived benefits identified by participants of adopting such an approach. We
argue that CMW generates an egalitarian group dynamic, encourages active listening,
and enables the co-creation of textual analysis in a spirit of collectivity and mutual
respect. We suggest that CMW is a versatile method that can be usefully deployed
within and beyond academic settings
Law enforcement spillover effects in the financial sector.
No full textRecipient firms but also comparable peer firms exhibit asizeable negative capital market reaction to UnitedKingdom's regulatory enforcement actions. This result isinvariant to the identification of peer firms as belongingto the same industry classification or as having com-parable propensity scores to attract a sanction. Indis-criminate regulatory contagion, however, is ruled out.As per expectation, enforcement actions which piercethe‘corporate veil’, that is, target an individual within afirm, are related to no significant firm‐level market re-actions. These findings, in the financial sector, indicatethat sanctions are associated with a material spillovereffect consistent with informed regulatory contagion
On the shoulders of giants': re-establishing the Moynagh Lough Project.
No full textResearch on material excavated from the County Meath crannog
is finally telling its story
Library resilience and leadership in a global crisis
No full textResearch Libraries, like other organisations during the COVID-19 pan-demic, have been facing difficult choices concerning which services to offer, whilst minimising risk to their staff, communities, and users. As the post COVID-19 era beckons, library leaders are urged to adapt flexible strate-gic plans that apply to every facet of library operation to ensure the organ-isations remain both safe and resilient in the future. This paper discusses leadership skills and practical techniques that can be applied to help build resilient libraries and deliver positive new change in the post-COVID-19 recovery period. Our findings indicate that leaders need to find ways to realign library ambitions to this uncertain new operating environment. The focus should be directed to digitisation and supporting systems, as well as on sustainability and transformative services. These are a must for the future of libraries
A systematic review and meta-analysis of longitudinal cohort studies comparing mental health before versus during the COVID-19 pandemic in 2020
No full textBackground: Increases in mental health problems have been observed during the COVID-19 pandemic. The ob-
jectives were to examine the extent to which mental health symptoms changed during the pandemic in 2020,
whether changes were persistent or short lived, and if changes were symptom specific.
Methods: Systematic review and meta-analysis of longitudinal cohort studies examining changes in mental health
among the same group of participants before vs. during the pandemic in 2020.
Results: Sixty-five studies were included. Compared to pre-pandemic outbreak, there was an overall increase in
mental health symptoms observed during March-April 2020 (SMC = .102 [95% CI: .026 to .192]) that signifi-
cantly declined over time and became non-significant (May-July SMC = .067 [95% CI: -.022 to .157]. Compared
to measures of anxiety (SMC = 0.13, p = 0.02) and general mental health (SMC = -.03, p = 0.65), increases in
depression and mood disorder symptoms tended to be larger and remained significantly elevated in May-July
[0.20, 95% CI: .099 to .302]. In primary analyses increases were most pronounced among samples with phys-
ical health conditions and there was no evidence of any change in symptoms among samples with a pre-existing
mental health condition.
Limitations: There was a high degree of unexplained heterogeneity observed (I2s > 90%), indicating that change
in mental health was highly variable across samples.
Conclusions: There was a small increase in mental health symptoms soon after the outbreak of the COVID-19
pandemic that decreased and was comparable to pre-pandemic levels by mid-2020 among most population
sub-groups and symptom types
Properties of the QCD thermal transition with Nf=2+1 flavors of Wilson quark
No full textWe study properties of the thermal transition in QCD, using anisotropic, fixed-scale lattice simulations with Nf=2+1 flavors of Wilson fermion. Observables are compared for two values of the pion mass, focusing on chiral properties. Results are presented for the Polyakov loop, various susceptibilities, the chiral condensate and its susceptibility, and the onset of parity doubling in the light and strange baryonic sector
Developing a Digital Framework for the Medieval Gaelic World: Project Report
No full textIn 2020, the Research Network entitled ‘Developing a Digital Framework for the Medieval
Gaelic World’ was established.1 This project was funded by UKRI-AHRC and the Irish
Research Council under the ‘UK-Ireland Collaboration in the Digital Humanities Networking
Call’ (grant numbers AH/V00235X/1 and IRC/V00235X/1). The network aimed to bring
together scholars working across various aspects of medieval Celtic Studies in order to assess
where we stand in terms of the digitisation of resources relating to medieval Ireland and
Scotland, and to work towards a consensus on the way forward
War against the Poor: Social Violence Against Roma in Eastern Europe During COVID-19 at the Intersection of Class and Race
No full textThis article positions the social violence against Roma in Eastern Europe during the COVID-19 pandemic in historical perspective. It is based on primary data derived from the project Marginality on the Margins of Europe – The Impact of COVID-19 on Roma Communities in Non-EU Countries in Eastern Europe, collected in 2020 by researchers in Albania, Bosnia and Herzegovina, Moldova, Montenegro, North Macedonia, Serbia, and Ukraine. This data is contextualised with the help of secondary literature on historical epidemics and pandemics, as well as societal responses to them, with a particular focus on the ensuing scapegoating of minorities in certain cases. The article first makes the case for the importance of historicising such responses to pandemics in different contexts as a safeguard against ‘exceptionalising’ either the ongoing pandemic or the Roma minority. Further, it argues against a reductionist perspective that treats the Roma primarily – or even exclusively – along the lines of their representing a ‘national minority’, a concept that is heavily tilted toward a cultural-linguistic definition of the group. In contrast, it posits that hate speech and racist incidents against the Roma in the context of the pandemic (and more generally) are better understood by factoring in the intersection of race and class, where the long-standing racialization of the Roma in Eastern Europe is inflected by the latter as much as the former. Finally, zooming out from the case study under consideration to consider other instances of ‘Othering’ encountered during the COVID-19 pandemic, it draws attention to the different scales at which exclusion operates, and to the advantages provided by an awareness of the multiple spatial and temporal layers constitutive of such a scalar approach