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Registered Nurses\u27 Autism Knowledge and Preparedness to Care for Autistic Patients
No full textAutistic individuals frequently report negative experiences during healthcare interactions and numerous provider-level barriers to accessing quality care, including stereotyping, perceived lack of autism knowledge, challenges with communication, and insufficient accommodations. Reports of healthcare providers’ experiences caring for autistic patients in the U.S. have largely come from physicians, who endorse inadequate training, resources, and practical guidelines. Although patients spend far more time with nurses than other healthcare providers, registered nurses (RNs)’ perspectives on caring for autistic patients in the U.S. are largely unknown and autism-focused trainings for nurses are minimal. In the current study, a survey was nationally disseminated to a sample of RNs (n = 67) to assess their autism knowledge, employment information, professional development, and experiences caring for autistic patients. Quantitative analyses revealed that RNs in the U.S. have moderate levels of autism knowledge, but inadequate knowledge of behavioral function. The majority of participants felt at least somewhat competent, confident, comfortable, and prepared to provide care to autistic patients, but they also endorsed inadequate supports and an ill-equipped healthcare system. Many RNs reported that their nursing school education did not prepare them to care for autistic patients and nearly half reported experiencing an emotional toll caring for autistic patients within the current system. This project identified key content and targets of practical recommendations and future interventions for nurses
DEVELOPMENT OF NOVEL SMALL MOLECULES AS POTENTIAL ANTI CANCER AGENTS
No full textThis doctoral thesis explores the discovery and characterization of two novel small molecules, designated as KS100 and (R,S’)-MNF, with potential anti-cancer properties. The study encompasses a comprehensive investigation into the molecular mechanisms underlying the anti-cancer effects of these compounds, as well as their therapeutic potential in preclinical models. These findings highlight the potential of KS100 and (R,S’)-MNF as lead candidates for cancer therapy, paving the way for further preclinical development and clinical translation
Examining the Role of the M1 Motif of AbcR1 sRNA in Agrobacterium tumefaciens
No full textAgrobacterium tumefaciens is a gram-negative alphaproteobacterium that is one of the causative agents of crown gall tumors on plants. Its ability to transform plants using its T-DNA has been studied to improve plant-mediated transformation. sRNAs are small regulatory RNAs that play a role in gene expression in a variety of organisms and bind to target proteins or mRNAs. A. tumefaciens contains two sibling sRNAs, called AbcR1 and AbcR2, which are conserved among alphaproteobacteria. A. tumefaciens AbcR1 and AbcR2 are closely related, exhibiting 69% sequence identity, similar secondary and tertiary structure, and a conserved motif, M2, believed to direct target interactions. An important difference between these sRNAs in A. tumefaciens compared to other organisms is the presence of a motif called the M1 motif or CUCKOO motif (CUCCCA) in AbcR1 and its absence in AbcR2. It is theorized that the presence or absence of this motif is important for differential regulation of gene expression by AbcR1 and AbcR2. Using RNA sequencing and a suite of phenotypic assays, we examined the role of the M1 motif and of AbcR1 in bacterial fitness and gene expression
Synergistic Cefiderocol-Containing Antibiotic Combinations Active Against Highly Drug-Resistant Acinetobacter baumannii Patient Isolates with Diverse Resistance Mechanisms
No full textBACKGROUND: Acinetobacter baumannii is a nosocomial pathogen known for rapidly developing resistance to nearly all antibiotics, including last-line agents. Cefiderocol, a novel siderophore cephalosporin, has shown in vitro activity against A. baumannii and is now used clinically, but resistance is emerging. Data on cefiderocol-based antibiotic combinations are limited.
OBJECTIVES: To evaluate the in vitro activity of cefiderocol alone and in combination with other antibiotics against XDR and PDR A. baumannii clinical isolates, and to explore resistance mechanisms underlying cefiderocol synergy.
METHODS: We tested 21 XDR/PDR clinical isolates and one NDM-1-producing strain using broth microdilution and checkerboard assays with cefiderocol and 17 antibiotics, including ceftazidime/avibactam, sulbactam/durlobactam, and amikacin. Synergy was determined through checkerboard assays and calculating fractional inhibitory concentration indices (FICI). WGS was used to identify resistance genes in selected strains.
RESULTS: Cefiderocol alone was active against 66.7% of strains and demonstrated synergy with ceftazidime/avibactam and sulbactam/durlobactam in 100% and 95.2% of strains, respectively, and with amikacin, doxycycline and sulbactam in over half of strains. Cefiderocol-based combinations also reduced cefiderocol MICs against an NDM-1-producing strain. WGS revealed β-lactamases and resistance determinants among both susceptible and resistant isolates.
CONCLUSIONS: Several cefiderocol-containing combinations show strong in vitro synergy against XDR and PDR A. baumannii. These combinations, especially cefiderocol-ceftazidime/avibactam and cefiderocol-sulbactam/durlobactam, may enhance treatment of highly resistant A. baumannii strains and warrant further clinical investigation
Reading Lists: Integrating the Library into Canvas
No full textReading List enables you to add Rowan University Libraries’ resources, websites, or your own documents to a central location in Canvas where students can find and access course materials, all in one convenient location.
Reading List simplifies Rowan University Libraries’ Course Reserves system and makes it easy to use. Using Reading List you can: Link directly to electronic resources (articles, ebooks, ebook chapters, etc.) Easily place materials on Course Reserves. Review how your students use course materials
https://libguides.rowan.edu/readinglist
In Sources We Trust (Sometimes): Verifying Citations in the Age of AI
No full textLearning objective:
1.Learn strategies to determine if an AI generated citation is fake or real
AI tools like ChatGPT, Gemini, and Claude are powerful research aids—but they sometimes generate citations that don’t actually exist, a phenomenon known as “hallucination.” As these tools become more common in academic work, verifying the accuracy of citations is more important than ever.
Join Dan Kipnis, STEM Librarian at Rowan University Libraries, for a concise, hands-on workshop where you’ll learn practical strategies to identify fake citations and verify legitimate sources in navigating AI-generated content responsibly
Ethical Issues Involved in Solid Organ Xenotransplantation.
No full textXenotransplantation (specifically, genetically modified pig-to-human transplant of organs, tissues, or cells) clinical trials are set to begin in the United States after decades of pre-clinical studies and recent decedent and compassionate use investigations. This article provides a primer on the key ethical issues attendant with this emerging therapy. We explore four central areas of concern: (i) the use of animals to meet human transplant needs, as well as their welfare since they are housed in non-natural conditions, (ii) the risk of infectious disease transfer from the porcine graft to the human recipient, known as xenozoonosis, (iii) patient selection criteria for initial clinical trials when an unknown risk/benefit ratio exists, and (iv) the necessity of public engagement in order to increase acceptance and trust of this novel potential therapy. The article argues that the long-term success and social acceptance of xenotransplantation are contingent not only on overcoming immunological hurdles but also on thoughtfully considering the ethical issues
Primary Education in Nigeria: A Case Study of the Global Mandate on Inclusive Education
No full textThis dissertation examines how inclusive education, mandated by Article 24 of the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD), is implemented in primary schools in Oyo State, Nigeria. Using a qualitative case study, I explored administrators’ and teachers’ experiences within contexts shaped by colonial legacies, systemic ableism, and resource constraints. Data sources included policy documents, lesson notes, researcher journals, and interviews. Guided by postcolonial and decolonial theory, Disability Critical Race Theory (DisCrit), and Critical Disability Studies (CDS), the study identified five themes: (1) colonial residues in language and schooling; (2) deficit framings of disability; (3) systemic barriers such as inadequate training, accountability gaps, and scarce resources; (4) grassroots decolonial practices grounded in Indigenous knowledge and values; and (5) tensions between symbolic inclusion and authentic belonging. Findings reveal that while inequalities constrain inclusion, educators develop culturally rooted hybrid practices. The study proposes a framework for Indigenous inclusive practices and justice-oriented inclusion
Assessing the Availability of Adaptive Exercise for Adults with Ambulatory Disability
No full textBackground: Adults with an ambulatory disability are at higher risk of obesity and sequalae from obesity than aged-matched adults without disability. Research shows adults with an ambulatory disability are less likely to participate in the recommended 150 minutes of physical activity per week than non-disabledadults. Availability ofadaptive exercise could help increase physical activity participation in adults with ambulatory disability.
Objective: This observational study examines the availability of adaptive exercise programs throughout the United States and determines how it relates to the population of adults with an ambulatory disability.
Methods: Adaptive exercise sites (n=268) were identified via internet searches to form a comprehensive database. Population data were collected from the US Census Bureau. Statistical analysis (one-way ANOVA, Fisher’s LSD) was completed to determine the significance of adaptive exercise programing deficits among different regions of the United States.
Results: A total of 268 adaptive exercise sites throughout the United States were identified and evaluated. On average, 8.13% ± 1.65% of each state’s population ≥ 18 years of age has an ambulatory disability. Each state had an average of 2.68 ± 3.81 sites per 100,000 people with an ambulatory disability.
Conclusions: Areas within the United States with high populations of adults with ambulatory disability do not have sufficient availability of adaptive exercise programs.Increasing the availability of physical sports has a wide-range of impact – not only to reduce morbidity – but also to improve public health, foster social and community connections, and optimize mental health of vulnerable populations. This study found that the proportion of state population with an ambulatory disability and availability of adaptive exercise sites within each state were negatively correlated. Our research provides a novel understanding of the availability of adaptive exercise programs and the prevalence of ambulatory disability by geographic region. This work paves the way for more in-depth exploration of potential mismatches of need and resources within vulnerable populations