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Xavier University Recreation Use and Physical Activity Participatio
Get PDFXavier University Recreation Center Use and Physical Activity Participation.
Ellie Schulz, Noah Giganti, David Wiley, Ashley Varol, Jeremy Steeves
Purpose: To describe Xavier University’s Recreation Center participation (who, what, when, why), and changes in usage across the year. Methods: An anonymous online Qualtrics Survey asking about physical activity habits was sent via email to all recreation center members and flyers were posted in recreation center with a QR-code to access the survey (January-March, 2025) and member entry swipe data were obtained (August, 2024 - March, 2025). Results: Participants included 722 students (n=644) and employees (n=78) who completed the survey, and 123,017 member swipes. On average, an individual spends 69.5 minutes in the recreation center, with most (40.8%) using it in the afternoon (12pm-5pm), and least (15.8%) using it the morning (9am-12pm). The most popular locations were the weight floor and cardio floor for students (75.6% and 67.5%) and employees (60.2% and 55.9%). Walking was the most popular activity participated in by females (43.3% of students and 56.3% of employees), and Core/Body weight was the most popular activity participated in by males (45.1% of students and 45.7% of employees). Fitness (93.5% of students and 91% of employees) and mental health (73.6% of students and 77.9% of employees) were the two most frequently listed reasons to work out. Lack of time was the biggest barrier to working out (61% of students and 66.7% of employees). Daily swipes peaked in August (900.7) and dropped in November (612.6). Conclusion: The recreation center is a valuable resource used by students and faculty to promote physical (cardiovascular and muscular strength) and mental health
Assessment of Sialylation in Skeletal Muscles of a Ground-Based Rat Model of Microgravity
No full textMuscle atrophy is a common issue for astronauts during spaceflight due to prolonged exposure to microgravity. These conditions affect muscle mass and strength, and while exercise helps combat atrophy, it is not entirely sufficient. One method being explored to counter this is the addition of sialic acid. Sialic acid (SA) is a terminal glycan attached to skeletal muscle cells. It helps with fusion and regeneration. Preliminary data shows that sialic acid depletion leads to muscle atrophy in conditions such as GNE myopathy and microgravity. Sialyltransferases (STs) add sialic acid to muscles while sialidases remove it. In this experiment, we aim to assess specific sialic acid linkages and the expression of STs and sialidases in a ground-based rodent model of microgravity. Wistar rats were subjected to hind limb suspension (HLS), which mimics microgravity. Meanwhile, a second group was subject to normal loading which acted as a control. Semiquantitative real-time polymerase chain reaction (qRT-PCR), was used to quantify RNA, and measured the relative gene expression of STs and sialidases. Western blot analysis compared STs and sialidases between the simulated microgravity and control groups. The same muscle tissues also underwent staining with the lectins PNA, WGA, MAA, and SNA, which bind to sialic acids or the underlying glycan chain. Mean fluorescence was quantified and normalized to the average cross-sectional area of muscle fibers. Findings from this study may help identify therapies to help astronauts maintain muscle mass in space
PK/PD Analysis of Empagliflozin in Healthy Egyptian Males
No full textEmpagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, is commonly used to treat Type 2 Diabetes by reducing renal glucose reabsorption. This study aimed to develop a stable pharmacokinetic/pharmacodynamic (PK/PD) model of empagliflozin and establish an optimal dosing regimen to reduce systolic blood pressure (SBP) by 10 mmHg. A dataset from 16 healthy Egyptian male participants was used, where each individual received a 10 mg morning and evening dose of empagliflozin, with a seven-day washout period between. Blood, urine, and vitals were collected for PK/PD analysis.
Model development included Monolix for base model fitting, Sycomore for model evolution tracking, and Simulx for dosing simulations. GraphPad Prism was used to determine EC50 values. A visual predictive check and observed vs. predicted plots confirmed model stability and predictive capability. A stable model was successfully created and can be confidently used in future dosing simulations. The EC50 for SBP reduction was calculated, and simulations supported a dosing regimen of 1.5 mg twice daily to maintain concentrations above the therapeutic goal of 0.007587 mg/L.
Results indicated that reduced doses of empagliflozin could effectively lower blood pressure with potentially fewer side effects. No relevant covariates were identified, and the findings aligned with previous studies. This study contributes to literature by focusing on Egyptian males, an underrepresented population in clinical research
Assertive Community Treatment Satisfaction for Clients with Schizophrenia
No full textAssertive Community Treatment (ACT) is a form of evidence-based treatment approach whose main goal is to provide adaptable client based treatment for clients who have severe mental health concerns. ACT treatment and the goals set for each individual client heavily vary, and these variations make each individual case unique and different. Knowing the intensive nature of ACT, looking into client satisfaction is very important to ensure that the services provided to each individual client are satisfactory and meet their needs and goals. The primary goal of this research is to determine the overall satisfaction rate of clients with schizophrenia who receive ACT services at the Clermont County Greater Cincinnati Behavioral Health Services (GCB) location as well as to identify specific aspects of the client’s care that influenced their responses to the questionnaire provided. This descriptive research study is sampled from 15 clients who currently receive ACT services from the Clermont County GCB location, and each client surveyed has also been diagnosed with schizophrenia in the past. The age ranges of the clients vary from the youngest client surveyed being in their 20’s and the oldest client being surveyed in their 50’s. This study used a questionnaire created by the researcher (Jaden Gaines) with each answer having a 1 to 5 scale. Each individual questionnaire was filled out during routine client meetings that the researcher of this project (Jaden Gaines) did as a part of his practicum placement at the Clermont County GCB location
Synthesis of Biased Dopamine Agonists for In Vivo Testing
No full textDopamine is a neurotransmitter that plays a role in various brain functions, including the regulation of behavior and cognition, voluntary movement, motivation, sleep, mood, attention, working memory, and learning. Dopamine receptors are expressed throughout the entire body, functioning both in the central and peripheral nervous system. Many drugs target dopamine receptors, with a variety of implications due to the binding and actions of these drugs. Dopamine agonists are drugs that bind to dopamine receptors and stimulate a response. Dopamine receptors are G protein-coupled receptors (GPCRs), meaning when a ligand binds to the receptor, intracellular signaling pathways are initiated. Two possible pathways that can be initiated are cyclic AMP (cAMP) accumulation and β-arrestin pathways. Agonists can be biased towards one pathway over another, meaning they will preferentially bind to a certain receptor, leading to a particular signaling pathway. Two biased dopamine agonists, N-Benzyl-2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide (cAMP biased) and 5-(3-(4-(2,3-Dichlorophenyl)piperazi-1-yl)propoxy)benzo[d]thiazole (β-arrestin biased), will be synthesized, then tested for bias in vivo, particularly in C. elegans. Based upon the ratio between the pathways, the bias of the agonist can be confirmed and an exact ratio determined
Prevention of Communicable Disease in the Primary School Population
Get PDFPrevention of Communicable Disease in the Primary School Population
Angela O’Leary BSN, RN, NCSN
Abstract
Primary-age students transmit communicable diseases more readily than older students, resulting in high absenteeism from school and increased healthcare visits. Poor hygienic behaviors and first-time classroom aggregation challenge young students\u27 immature immune systems. Primary-age students\u27 educators lack health guidance regarding the importance of hand and respiratory hygiene. These students and educators are the prime targets for hand and respiratory hygiene education. Using a Google Slide presentation, educators were taught about the transmission and prevention of communicable diseases. The presentation included the mode of transmission, the impact of disease on schools and families, strategies for decreasing transmission, and how to implement handwashing with 4–5-year-olds. Using a Google Slide presentation, students were taught how germs are spread and how to cover coughs, sneezes, and wash hands. Elmo\u27s handwashing song, coloring pages, poster, and footprints to the classroom sink reinforced newly taught handwashing behavior. Educators were given a pre and posttest with an answer and question period to evaluate learning. Students were asked to provide a return demonstration on handwashing to evaluate learning. Within two to four weeks following the educational offering, a decrease in absenteeism related to gastrointestinal and respiratory diseases is anticipated. A decrease in absenteeism will be evaluated by monitoring the attendance records of the preschool class that received the education and comparing the records to those that did not. If absenteeism decreases over the following weeks, it may be concluded that teaching proper hand and respiratory hygiene in conjunction with hygiene reinforcement can effectively decrease absenteeism related to communicable diseases in primary-age students.
Keywords: communicable disease, hand hygiene, primary-age students, absenteeism
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