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Günter Blobel with Van Potter
No full textGünter Blobel with Van Potter, circa mid- 1960s
Courtesy of the Blobel family
In the Potter laboratory, Günter Blobel studied how polysomes, groups of ribosomes that translate mRNA molecules into proteins, were localized within cells and how they attached to cellular membranes. Enthusiastic and communicative by nature, Blobel took full advantage of the resources available to him at the University of Wisconsin for interdisciplinary research, working with various other labs and departments on campus. For example, one of the groundbreaking papers included in his thesis represented a fruitful collaboration formed between Blobel and zoologist Hans Ris, who together used electron microscopy techniques to visualize polysome distribution patterns in rat liver cells.https://digitalcommons.rockefeller.edu/blobel-molecular-biology/1017/thumbnail.jp
Letter from The Journal of Cell Biology
No full textLetter to Günter Blobel from The Journal of Cell Biology, 4 September, 1975https://digitalcommons.rockefeller.edu/blobel-molecular-biology/1027/thumbnail.jp
Transfer of proteins acroos membranes. With Palade\u27s correction
No full textTransfer of proteins across membranes. Manuscript with Palade\u27s correction
Blobel’s most influential papers were published together with his postdoctoral fellow Bernhard Dobberstein in 1975 in The Journal of Cell Biology. These papers established that N-terminal signal sequences direct nascent secretory proteins across the endoplasmic reticulum membrane, an idea previously proposed by Blobel and David D. Sabatini in 1971, with first experimental evidence provided by César Milstein and colleagues in 1972. The Blobel and Dobberstein papers rigorously showed that a secretory protein is co-translationally translocated across the membrane and that the signal sequence subsequently was cleaved off.https://digitalcommons.rockefeller.edu/blobel-molecular-biology/1026/thumbnail.jp
Harvey Lecture, 1981
No full textHarvey Lecture, 1981https://digitalcommons.rockefeller.edu/blobel-molecular-biology/1030/thumbnail.jp
Günter Blobel, 2006
No full textGünter Blobel, 2006. Photo by Zach Veilleux
In recent years, much of the focus of the Blobel laboratory has centered around characterizing components of the nuclear pore complex and protein transport into and out of the cell nucleus, an area of investigation that he also initiated in the mid-1970s.https://digitalcommons.rockefeller.edu/blobel-molecular-biology/1034/thumbnail.jp
Lab glassware
No full textGlassware from Günter Blobel \u27s laboratory, 2018
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/blobel-molecular-biology/1033/thumbnail.jp
Postdoctoral fellows
No full text“…I want to thank my two mentors, Van R. Potter and George E. Palade. David Sabatini was a particularly inspiring and forming influence, especially in the early stages of my career.
I was fortunate to have extremely talented graduate students and postdoctoral fellows working with me. Those who made seminal contributions on the ER translocation were mentioned in the text.”
-Günter Blobel, Nobel Lecture
Top (clockwise): David Sabatini (Research Professor, Department of Cell Biology, NYU School of Medicine), Bernhard Dobberstein (Professor and Research Group Head at the Centre for Molecular Biology of the Ruprecht–Karls University of Heidelberg), Vishwamath (Vishu) Lingappa (Professor, University of Washington), Peter Walter (Professor, University of California, San Francisco)
Bottom (clockwise): Reid Gilmore (Professor, University of Massachusetts Medical School), Christopher Nicchitts (Associate Dean for Research Training, Duke University School of Medicine), Sanford Simon (Professor, The Rockefeller University), Roland Beckmann (Professor, Gene Center and Department of Biochemistry Ludwig-Maximilians-Universität München)
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/blobel-molecular-biology/1045/thumbnail.jp
Members of the Blobel laboratory
No full textMembers of the Blobel laboratory, April 2018
First row (from left to right): Tita Isberto, Lourdes Quirolgico, Manindra Bera, Mara Gnadig
Second row (from left to right): Mahmudur Rahman, Carl Mitchell, Bartlomiej Blus, Alok Sharma, Linas Urnavicius, Elias Coutavas
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/blobel-molecular-biology/1051/thumbnail.jp
At the reconstruction site of the Frauenkirche
No full textDr. Blobel in 2001, at the reconstruction site of the Frauenkirche in Dresden, Germany. Photo by Matthias Rietschel/APhttps://digitalcommons.rockefeller.edu/blobel-molecular-biology/1056/thumbnail.jp
From the collection of Alfred Cohn (cont.)
No full textThe exhibit From the Collection of Alfred Einstein Cohn was on view at Level A on September 27-28 during the Markus Library Open House 2018
Idea, design: Olga Nilova, Outreach Librarian
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/alfred-cohn-collection/1024/thumbnail.jp