5430 research outputs found
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Simone Dinnerstein, Piano
No full text2018, February 16
Simone Dinnerstein, piano, Johann Sebastian Bach: Goldberg Variations, BWV 988 (Complete)
Photo by Lisa-Marie Mazzucco
Simone Dinnerstein EPK Bach Goldberg Variationshttps://digitalcommons.rockefeller.edu/tri-institutional-noon-recitals/1077/thumbnail.jp
Smetana Trio
No full text2018, February 23
Smetana Trio, piano trio: Jitka Cechová (piano); Jirí Vodicka (violin); Jan Pálenícek (cello), performing Haydn: Piano Trio in G Major “Gypsy”; Shostakovich: Piano Trio No. 1 in C minor, Op. 8; Mendelssohn: Piano Trio in D minor, Op. 49.
Photo credit: Duke Artshttps://digitalcommons.rockefeller.edu/tri-institutional-noon-recitals/1076/thumbnail.jp
4.1 Piano–Windtet
No full text2018, January 19
4.1 Piano–Windtet: Jörg Schneider, oboe; Alexander Glücksmann, clarinet; Fritz Pahlmann, horn; Christoph Knitt, bassoon; Thomas Hoppe, piano, performing Beethoven: Quintet in E-flat Major, Op. 16; Mozart: Quintet in E-flat Major, KV 452; Avner Dorman: Jerusalem Mix (2007) — Jerusalem Mix, The Wailing Wall, Wedding March, Blast, Adhan (the Islamic call to prayer).
Photo credit: 4.1 Piano–Windtet
Avner DORMAN - Jerusalem Mix (2007)https://digitalcommons.rockefeller.edu/tri-institutional-noon-recitals/1081/thumbnail.jp
Marjorie McCarty Oral History. Part 4: Proposal
No full textInterview recorded on September 14th, 2017. Part of the Rita and Frits Markus Library Oral History project.https://digitalcommons.rockefeller.edu/marjorie-mccarty/1003/thumbnail.jp
Victor J. Wilson Oral History. Part 7: Books on the vestibular system
No full textInterview recorded on December 21st, 2017. Part of the Rita and Frits Markus Library Oral History project.https://digitalcommons.rockefeller.edu/victor-wilson/1006/thumbnail.jp
Victor J. Wilson Oral History. Part 5: Working with D. Lloyd;Setting up the laboratory
No full textInterview recorded on December 21st, 2017. Part of the Rita and Frits Markus Library Oral History project.https://digitalcommons.rockefeller.edu/victor-wilson/1004/thumbnail.jp
The Characterization of a Novel Complex Implicated in the Initiation of Apoptosis
Get PDFApoptosis, which is one of many different types of programmed cell death, is widely utilized as a mechanism to eliminate unwanted cells. The ability of cells to undergo apoptosis is required not only for development in many organisms, but also to maintain proper homeostasis; too little apoptosis can result in cancer whereas too much can lead to degenerative diseases. Apoptosis has been well studied at events that take place at or downstream of the mitochondria; these steps are rigorous and predictable, making them easy to study. However, little is known about early, decision-making events that occur upstream of the mitochondria. It is important to understand these early decision-making steps because it is at these timepoints when cells are not yet committed to live or die, and therefore have great potential for therapeutic intervention. We have identified a novel ARTS-dependent complex that forms extremely early in apoptosis. After inducing mammalian cells to die, we fractionated the cell extracts using gel filtration and looked for changes in canonical apoptosis proteins. We observed that XIAP, the main caspase inhibitor in mammals, is recruited to a 5Mda complex as early as 30 minutes after stimulation of apoptosis. Furthermore, the recruitment of XIAP to the complex is dependent on the pro-apoptotic protein ARTS, as XIAP is not recruited to the complex when cells are knocked out for ARTS. Using mass spectrometry, we have identified the constituents of the complex. The identified subunits are Herc2, Neurl4, SSSCA1 and XIAP. None of the identified subunits, aside from XIAP, have been previously implicated in apoptosis. Using cell culture assays, we have shown that the novel complex acts to degrade XIAP, thus shifting the propensity of cells to undergo apoptosis early on in the decision-making process. We have shown that knocking down Neurl4 leads to the stabilization of XIAP during apoptosis and, consequently, reduces the number of cells that undergo apoptosis. The identification and elucidation of this novel complex in apoptosis not only increases our basic understanding of apoptosis, but also provides new therapeutic opportunities for modulating cell death
Remarks. Guests
No full textMarkus Library Open House, remarks.
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/open-house-2018/1018/thumbnail.jp
Tracts written by the honourable Robert Boyle
No full textBoyle, Robert. Tracts written by the honourable Robert Boyle: containing new experiments touching the relation betwixt flame and air: and about explosions: an hydrostatical discourse occasion\u27d by some objections of Dr. Henry More against some explications of new experiments made by the author of these tracts: to which is annex\u27t, an Hydrostatical letter, dilucidating an experiment about a way of weighing water in water. London, 1672
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/alfred-cohn-collection/1016/thumbnail.jp
Freiberg, Dom
No full textAfter the war, Blobel family settled in Freiberg, where Günter developed a great love for theater and music. Each week he listened to Bach cantatas performed in the magnificent gothic cathedral, the Dom, on an organ built by one of Bach’s friend, Gottfried Silbermann. Young Günter was taken with the great choral works, even participated in singing in the cantus firmus in Bach’s Matthäus Passionhttps://digitalcommons.rockefeller.edu/blobel-molecular-biology/1006/thumbnail.jp