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Letter from John D. Rockefeller, Jr., to Dr. Herbert S. Gasser
No full textLetter from John D. Rockefeller, Jr., to Dr. Herbert S. Gasser, October 1950
Courtesy of The Rockefeller Archive Center
In 1959, John D. Rockefeller, Jr., retired as President of the Board of Trustees of the Rockefeller Institute for Medical Research after a half-century of association with the Institute. He is succeeded as President by his son, David Rockefeller.https://digitalcommons.rockefeller.edu/the-evolving-campus/1036/thumbnail.jp
Daniel Kiley
No full textThe campus landscape began to take shape around 1910, when the allée of London plane trees was planted along the driveway leading up to Founder’s Hall. In the late 1950s, the campus of old and new buildings was knitted together through a landscaping design by Daniel Kiley. Born in 1912, Kiley pioneered modernism in landscape design in 1930s. He has created some 800 landscapes, many of which include classical elements but regarded his work at the Rockefeller as one of his most interesting undertakings, for it offered opportunity for overall planning in conjunction with new construction and yet demanded constant attention to the need to harmonize the new buildings with those designed half a century ago.https://digitalcommons.rockefeller.edu/the-evolving-campus/1050/thumbnail.jp
Goniometer head
No full textGoniometer head, circa 1970s.
Courtesy of George Reeke
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/the-evolving-campus/1071/thumbnail.jp
Molecular Characterization of Novel Mutations in Fanconi Anemia Patients
Get PDFFanconi anemia (FA) is a rare disorder that is characterized by bone marrow failure in the first decade of life, developmental abnormalities, and predisposition to malignancies. The majority of patients have mutations in one of the 22 known FA genes, while a small number of patients have not been assigned to a complementation group. FA proteins are required for the proper repair of DNA interstrand crosslinks (ICL), a deleterious type of DNA damage that covalently binds DNA strands. We have used Whole Exome Sequencing (WES) in conjunction with cell-based assays to determine disease-causing mutations in a subset of patients enrolled in the International Fanconi Anemia Registry (IFAR) who are not assigned to a known complementation group. In this thesis, we present three cases that were the focus of study. We describe a new FA complementation group identified in a patient presenting with typical FA features and deficiency of the ubiquitin-conjugating enzyme (E2), UBE2T. No pathogenic gene variants were identified by WES, but RNA sequencing (RNA-seq) uncovered a significant decrease in UBE2T transcript, and western blot confirmed deficiency of UBE2T protein. Sanger sequencing of genomic DNA revealed a large paternal deletion and maternal duplication resulting from Alu-mediated recombination. In the absence of UBE2T, the patient cells are defective for FA pathway activation and are hypersensitive to crosslinking agents. These cellular defects are complemented by expression of wild type UBE2T demonstrating that deficiency of the protein UBE2T causes this individual\u27s FA. WES of a sibling pair with FA revealed biallelic mutations in FANCD1/BRCA2. Both siblings presented with multiple developmental abnormalities at birth, but did not develop any early childhood malignancies or hematological abnormalities typically associated with the FANCD1 complementation group. FANCD1/BRCA2 is best known for its role in homologous recombination directed repair of DNA double strand breaks, a function also required during the repair of ICLs. Each sibling inherited a LOF BRCA2 mutation in trans to a missense mutation of the BRCA2 DNA binding domain. Evaluation of BRCA2 DNA binding domain mutations revealed that this domain is important for replication fork protection, and to a lesser extent canonical homologous recombination. FA is a very heterogeneous disorder and as a consequence of overlapping clinical features, patients may be misdiagnosed with FA in lieu of another DNA repair or replication deficiency. Besides identifying FA mutations, we have identified non-FA patient enrolled in the IFAR. This individual has a defect in resolving DNA replication stress that presented in childhood as tri-lineage bone marrow failure, facial dysmorphia, and small stature. Our analysis demonstrated that the patient cells lack the hallmarks of FA, but are defective for cellular resistance to DNA replication stress
Liza Ferschtman, Solo Violin
No full text2019, November 8
Liza Ferschtman, solo violin, performing Eugène Ysaÿe: Violin Sonata No. 5 in G Major - 1. L\u27aurore; J. S. Bach: Violin Sonata No. 2 in A Minor, BWV 1003; Fritz Kreisler: Recitativo und Scherzo–Caprice, Op. 6; Eugène Ysaÿe: Sonata No. 2 in A Minorhttps://digitalcommons.rockefeller.edu/tri-institutional-noon-recitals/1017/thumbnail.jp
Aleksey Semenenko, Violin and Inna Firsova, Piano
No full text2019, March 8
Aleksey Semenenko, violin and Inna Firsova, piano, performed Mozart: Sonata No. 18 in G Major, K. 301; Clara Schumann: 3 Romances for Violin and Piano, Op. 22; Poulenc: Sonata for Violin and Piano, FP 119; Tchaikovsky: Romance for Piano in F Minor, Op. 5; Song Without Words for Piano in F Major, Op. 2, No. 3; Schubert (Arr. David Oistrakh): Valse-Caprice; Paganini: Violin Concerto No. 2, Op. 7, Rondo “La Campanella”.https://digitalcommons.rockefeller.edu/tri-institutional-noon-recitals/1038/thumbnail.jp
Horszowski Trio
No full text2019, January 11
Horszowski Trio, piano trio: Jesse Mills, violin; Raman Ramakrishnan, cello; Rieko Aizawa, piano, Performing Joseph Haydn (1732–1809): Trio in G Major, Hob. XV:25 “Gypsy”; Elliot Carter (1919–2012): Epigrams for piano, violin, and cello (2012) (selections), Elliot Carter′s final composition; Dmitri Shostakovich (1906–1975): Trio No. 2 in E Minor, Op. 67https://digitalcommons.rockefeller.edu/tri-institutional-noon-recitals/1046/thumbnail.jp
CONSTRUCTION 2018, MAY
No full textMain staircase [Kravis Research Building] and Welch Hall in the background, 2018
Photo by Olga Nilovahttps://digitalcommons.rockefeller.edu/river_campus/1064/thumbnail.jp
Bill Charlap, Jazz Pianist
No full text2018, October 5
Bill Charlap, Grammy-winning jazz pianist. Time magazine wrote, “Bill Charlap approaches a song the way a lover approaches his beloved … no matter how imaginative or surprising his take on a song is, he invariably zeroes in on its essence.” He is known for his interpretations of American popular songs and has recorded albums featuring the music of Hoagy Carmichael, Leonard Bernstein, and George Gershwin.https://digitalcommons.rockefeller.edu/tri-institutional-noon-recitals/1057/thumbnail.jp
David Krakauer, Clarinet and Kathleen Tagg, Piano
No full text2018, April 6
Grammy-nominated David Krakauer, clarinet; Kathleen Tagg, piano, performing Kinan Azmeh (arr. Tagg): November 22; Debussy: Première Rhapsodie; Brahms: Sonata No. 1 in F Minor, Op. 120. II. Andante un poco Adagio; Tagg: Berimbau; Green, Heyman, Sour, Eyton (arr. Krakauer, Tagg): Body and Soul; Abraham Ellstein: Chassidic Dance; John Zorn (arr. Tagg): Parzial; Emil Kroitor (arr. Tagg): Moldavian Voyage; Krakauer: Synagogue Wail; Traditional (arr. Krakauer, Tagg): Der Heyser Bulgar.https://digitalcommons.rockefeller.edu/tri-institutional-noon-recitals/1070/thumbnail.jp