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Interview with Dr. Feigenbaum for the American Institute of Physics, Oral History Collection, by David Campbell
Get PDFDetex Watch Clock Station
No full textDetex Watch Clock Station, circa late 1920s
Courtesy of Alex Kogan
Made in the USA, the Detex Newman Watch clock was first introduced in 1927. Security guards made their rounds every hour and had to turn the key attached to the station so that the hour was recorded on a piece of paper.
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/the-evolving-campus/1028/thumbnail.jp
Sarah J. Schlesinger Oral History. Part 1: Family of great expectations
No full textInterview recorded in spring 2019. Part of The Rita and Frits Markus Library Oral History project.https://digitalcommons.rockefeller.edu/sarah-schlesinger/1000/thumbnail.jp
Milben microscope
No full textMilben microscope, circa 1960s
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/the-evolving-campus/1056/thumbnail.jp
Sarah J. Schlesinger Oral History. Part2: From Holiday Lecture to Steinman\u27s laboratory
No full textInterview recorded in spring 2019. Part of The Rita and Frits Markus Library Oral History project.https://digitalcommons.rockefeller.edu/sarah-schlesinger/1001/thumbnail.jp
Binocular Microscope
No full textThe first Binocular Microscope by Ernst Leitz Wetzlar, circa 1913; solid brass and iron
Courtesy of Alex Kogan
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/the-evolving-campus/1020/thumbnail.jp
Vintage standpipe safety sign
No full textVintage standpipe safety sign
Courtesy of Jeff Prout
Photo by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/the-evolving-campus/1063/thumbnail.jp
Vintage porcelain enameled No Smoking sign
No full textVintage porcelain-enameled No Smoking sign
Courtesy of Jeff Prouthttps://digitalcommons.rockefeller.edu/the-evolving-campus/1076/thumbnail.jp
On the Interactions of Augmin with Microtubules and the Mechanics of the Cross-Linker PRC1
Get PDFCell division in eukaryotes requires the assembly and maintenance of a structure, the bipolar spindle, self-organized from microtubules and their associated proteins. A multitude of components have been identified to be involved in this organization, and solving the combinatorial of the conditions that lead to the specific set of configurations present in vivo remains an open question. This thesis presents reconstitutions from purified components used to study aspects of microtubule self-organization: first, the microtubule-nucleation-related augmin octameric complex was assessed at a single-molecule interaction level with microtubules; second, the cross-linker PRC1\u27s frictional response resisting motion between two microtubule filaments was analyzed to determine the dependence of the frictional force on the binding conditions of the cross-linker. For the augmin complexes studied sub-second interaction times were observed, yielding diffusive tracks on the lattice of microtubules. Microtubule bundles driven to slide showed GFP-PRC1 accumulation with a near-contant frictional force recorded. From the data, a theoretical model was produced linking the accumulation of GFP-PRC1 to the time evolution of the force trace. The observations on the reconstituted augmin complex establish constrains (diffusive and short lived) on an entity proposed to anchor newly-nucleated microtubules to pre-existing microtubules at a given branching angle. The observations on PRC1 mechanics lead to the hypothesis of a changing mechanical behavior of the cross-linker to its exchange kinetics, potentially modulated by external factors
Historic Laboratory. View no.16, January 2019
No full textFume hood in the historic laboratory, details. Flexner Hall, 1st floor, 2019
Photo by Zach Veilleuxhttps://digitalcommons.rockefeller.edu/historic-laboratory/1029/thumbnail.jp