13468 research outputs found
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Cabaret (2023)
No full texthttps://digitalcommons.otterbein.edu/theatre_dance_gallery/5686/thumbnail.jp
Everybody (2023)
No full texthttps://digitalcommons.otterbein.edu/theatre_dance_gallery/5696/thumbnail.jp
Dance 2023: Escape to Wonderland
No full texthttps://digitalcommons.otterbein.edu/theatre_dance_gallery/5740/thumbnail.jp
Personal Health Questionnaire-9 and Interventions in Adults
Get PDFThis is an evaluation of the PHQ-9 depression screening and interventions in adults within an urban setting
miR125a as Molecular Target of Vitamin D Mediated Inhibition of CD4+ T Cell Differentiation into Th17 cells in MRL/lpr Lupus-prone Mice
Get PDFThe dynamic function of vitamin D in an array of immunomodulatory and anti-inflammatory mechanisms and its implication in the pathogenesis of autoimmune diseases has been the topic of much recent scholarship. Here I attempt to elucidate the molecular mechanism of vitamin D-mediated inhibition of the differentiation of CD4+ T cells into pro-inflammatory Th17 cells in MRL/lpr lupus prone mice by investigating how miR-125a expression is affected by dietary modulation of cholecalciferol (vitamin D3). MRL/MpJ and MRL/lpr mice were split into three experimental groups and fed specially formulated diets that varied in their concentrations of vitamin D. Plasma samples were tested for their concentrations of vitamin D, IL-6, and IL-17 by enzyme linked immunosorbent assay (ELISA). Additionally, Th17 cells in the mouse spleens were quantified via fluorescence activated cell sorting (FACS) analysis. Finally, miR-125a expression in spleens and inguinal lymph nodes was quantified using real time quantitative polymerase chain reaction (RTq-PCR). Ongoing studies, made possible by my work up and to this point, will contribute to our understanding of the mechanism by which vitamin D controls CD4+ T cell differentiation into Th17 cells and to our understanding of and ability to treat autoimmune and other chronic conditions such as systemic lupus erythematosus (SLE)
Gaming to Learn Genetics
Get PDFDigital game-based learning is an alternative to traditional lecture learning. It involves active engagement with concepts in a digital game setting and can apply to a variety of subjects, including STEM fields. We examined this type of learning in the context of an undergraduate introductory genetics course: specifically, use of a genetics video game for teaching. There were two groups: an experimental group that played the genetics game Geniventure, and a control group that read and studied Powerpoint lecture slides. Both groups took a pretest and posttest, as well as completed an I/D (interest/deprivation) scale and workload scale. There was no significant difference in pretest versus posttest score between the groups, and individuals in the experimental group had higher workload across all subscales compared to the control group. However, individuals with higher interest had higher test scores in the course’s first post-experiment major exam. Overall, although there was no significant difference in game-based learning transfer between the groups, this study could act as a preliminary study for further testing with genetics digital game-based learning
Evidence-based Practice Guidelines for the Optimal Assessment of the Airway in Predicting Difficult Intubation
Get PDFAdverse respiratory events are the most common injuries in anesthesia; difficult intubation and ventilation contribute to most cases. Injuries following inadequate airway management include cerebral hypoxia, aspiration, and cardiac arrest. Despite the risk and consequences following inadequate airway management, most medical facilities lack standardized airway assessments for anesthesia providers. Current evidence implicates that ultrasound measurement of the hyomental distance demonstrates the highest specificity and accuracy in predicting difficult intubation. The traditional approach to conducting airway assessments includes Mallampati classification, which shows high specificity for predicting difficult airways only when combined with other airway assessments. The purpose of this evidence-based project is to recommend clinical guidelines for standardized airway assessments with the combined use of ultrasound and Mallampati classifications. The Johns Hopkins Nursing Evidence-based Model will guide the project team through project planning, development, completion, and dissemination. A literature review, analysis, and critical appraisal of available evidence will be conducted to support recommendations regarding clinical practice protocols for airway assessments utilizing ultrasonography and Mallampati classifications. Project facilitators will engage with anesthesia providers using pre and post-implementation surveys and provide formal ultrasound training. Ultrasound evaluation for airway management is a new addition to preoperative airway assessments that will allow anesthesia providers to revolutionize patient care and reduce perioperative morbidity and mortality. Guidelines for standardized airway assessments have been established and will be recommended to the hospital of interest for review, discussion, and determination regarding the potential for implementation